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91. 发明授权

US08163755B2 Hexahydrooxazinopterine compounds 有权
标题翻译：六氢恶嗪蝶啶化合物
公开(公告)号：US08163755B2
公开(公告)日：2012-04-24
申请号：US12869452
申请日：2010-08-26
申请人： Bohan Jin , Nicholas Scorah , Qing Dong
发明人： Bohan Jin , Nicholas Scorah , Qing Dong
IPC分类号： A61K31/497 , C07D237/36
CPC分类号： C07D498/14
摘要： The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.
摘要翻译：本发明提供下式的mTOR抑制剂，其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 制备化合物及其中间体的方法; 和使用该化合物的方法。

92. 发明授权

US07737272B2 Diazaphosphacycle transition metal complexes 有权
标题翻译：二氮磷环过渡金属络合物
公开(公告)号：US07737272B2
公开(公告)日：2010-06-15
申请号：US12032350
申请日：2008-02-15
申请人： Clark R. Landis , Wiechang Jin , Jonathan S. Owen , Thomas P. Clark
发明人： Clark R. Landis , Wiechang Jin , Jonathan S. Owen , Thomas P. Clark
IPC分类号： C07D487/00 , C07D243/00 , C07D255/00 , C07D257/00 , C07D259/00 , C07D487/22 , C07D491/00 , C07D498/00 , C07D237/26 , C07D237/28 , C07D237/36 , C07D293/00 , C07D421/00 , C07D517/00 , C07F3/12
CPC分类号： C07F15/006 , C07F9/6584 , C07F15/0073 , C07F15/008 , C07F15/0086
摘要： Transition metal complexes include a diazaphosphacycle of formula III and a transition metal. The phosphorus atom of the diazaphosphacycle is bonded to the transition metal and the diazaphosphacycle of formula III has the following structure where the variables have the values set forth herein.
摘要翻译：过渡金属络合物包括式III的二氮杂磷酰基和过渡金属。二氮磷杂环磷的磷原子与过渡金属键合，式Ⅲ的二氮磷酰基具有以下结构，其中变量具有本文所述的值。

93. 发明申请

US20070010519A1 New pyridazines as 11B-HSD1 inhibitors 有权
标题翻译：新的哒嗪作为11B-HSD1抑制剂
公开(公告)号：US20070010519A1
公开(公告)日：2007-01-11
申请号：US11481330
申请日：2006-07-05
申请人： Kurt Amrein , Daniel Hunziker , Bernd Kuhn , Alexander Mayweg , Werner Neidhart
发明人： Kurt Amrein , Daniel Hunziker , Bernd Kuhn , Alexander Mayweg , Werner Neidhart
IPC分类号： A61K31/502 , C07D237/36 , C07D237/28
CPC分类号： C07D403/04 , C07D237/08 , C07D237/26 , C07D237/28 , C07D417/04
摘要： Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
摘要翻译：其中R 1至R 4具有权利要求1给出的含义的式及其药学上可接受的盐和酯的化合物可以以药物组合物的形式使用。

94. 发明授权

US5726176A Dihydropyridazinones, pyridazinones and related compounds as fungicides 失效
公开(公告)号：US5726176A
公开(公告)日：1998-03-10
申请号：US740546
申请日：1996-10-30
申请人： Enrique Luis Michelotti , Anne Ritchie Egan , Ronald Ross, Jr. , Willie Joe Wilson
发明人： Enrique Luis Michelotti , Anne Ritchie Egan , Ronald Ross, Jr. , Willie Joe Wilson
IPC分类号： A01N43/40 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/62 , A01N43/653 , A01N43/72 , A01N43/80 , A01N43/82 , A01N43/88 , B27K3/34 , C07D213/64 , C07D213/85 , C07D215/22 , C07D215/227 , C07D237/04 , C07D237/14 , C07D237/18 , C07D237/26 , C07D237/32 , C07D237/36 , C07D239/36 , C07D243/02 , C07D243/04 , C07D273/04 , C07D285/34 , C07D401/04 , C07D403/04 , C07D405/06 , C07D405/10 , C07D407/06 , C07D409/04 , C07D409/06 , C07D413/06 , C07D521/00 , C07F7/08 , A61K31/50 , C07D295/03
CPC分类号： A01N43/40 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/62 , A01N43/653 , A01N43/80 , A01N43/82 , A01N43/88 , C07D213/64 , C07D213/85 , C07D215/227 , C07D231/12 , C07D233/56 , C07D237/04 , C07D237/18 , C07D237/26 , C07D237/32 , C07D237/36 , C07D239/36 , C07D243/02 , C07D249/08 , C07D273/04 , C07D285/34 , C07D401/04 , C07D403/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/06 , C07D413/06 , C07F7/0812
摘要： This invention relates to substituted dihydropyridazinones, pyridazinones and related compounds, of the formula ##STR1## wherein A, Q, D and R1 are as defined within, compositions containing these compounds and methods of controlling agricultural and mammalian fungal diseases.

95. 发明授权

US4977152A Novel tricyclic derivatives which are agonists of cholinergic receptors, and drugs in which they are present 失效
标题翻译：作为胆碱能受体的激动剂的新型三环衍生物及其存在的药物
公开(公告)号：US4977152A
公开(公告)日：1990-12-11
申请号：US471680
申请日：1990-01-25
申请人： Kathleen Biziere , Camille G. Wermuth , Paul Worms , Jean-Jacques Bourguignon
发明人： Kathleen Biziere , Camille G. Wermuth , Paul Worms , Jean-Jacques Bourguignon
IPC分类号： A61K31/50 , A61K31/502 , A61K31/535 , A61P25/28 , C07D237/26 , C07D237/36 , C07D403/12 , C07D413/12
CPC分类号： C07D403/12 , C07D237/26 , C07D237/36 , C07D413/12
摘要： The invention relates to novel tricyclic derivatives which are agonists of cholinergic receptors and to drugs containing them.These derivatives have the following formula: ##STR1## in which: X represents a group (CH.sub.2).sub.n, n representing an integer equal to 2, 3 or 4, or alternatively a vinylene group or a methylvinylene group;R.sub.1 and R.sub.2, considered independently, represent hydrogen or a substituent occupying one of the free positions of the benzene ring and selected from the group comprising halogens, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a thiol group, a nitro group and an optionally substituted amino group;Y represents oxygen, sulfur or a group --NH--; andR.sub.3 is an amino groupApplication: agonists of the cholinergic receptors.
摘要翻译：本发明涉及作为胆碱能受体的激动剂的新型三环衍生物和含有它们的药物。这些衍生物具有下式：其中：X表示基团（CH 2）n，n表示等于2,3或4的整数，或者可选地是亚乙烯基或甲基亚乙烯基; 独立地考虑的R 1和R 2表示氢或占据苯环的一个游离位置的取代基，并且选自卤素，低级烷基，低级烷氧基，羟基，硫醇基，硝基基团和任选取代的氨基; Y表示氧，硫或基团-NH-; 并且R3是氨基应用：胆碱能受体的激动剂。

96. 发明授权

US4369318A Process for the production of colored photographic images by the silver dye-bleach process 失效
标题翻译：通过银染料漂白工艺生产彩色摄影图像的方法
公开(公告)号：US4369318A
公开(公告)日：1983-01-18
申请号：US169709
申请日：1980-07-17
申请人： Gerald Jan
发明人： Gerald Jan
IPC分类号： G03C7/02 , C07D237/34 , C07D237/36 , C07D471/04 , C07D471/14 , G03C7/28
CPC分类号： C07D471/04 , C07D237/36 , C07D471/14 , G03C7/28
摘要： A process for the production of colored photographic images by the silver dye-bleach process by image-wise exposure and subsequent processing by developing the silver image, dye-bleaching and silver bleaching, it being possible, optionally, for the last two steps to be combined, silver fixing and washing, in which process dye-bleaching and/or silver bleaching is carried out in the presence of at least one bleach catalyst of the formula ##STR1## In the formula, A and B are in each case the non-metallic atoms necessary to complete a benzene or pyridine ring, R.sub.1 and R.sub.3 are each hydrogen, hydroxyl, halogen, alkyl, carboxyl, carbalkoxy, carbalkoxyalkoxy, --CH.sub.2 OH, --O(CH.sub.2).sub.n OH, --O(CH.sub.2).sub.2 O(CH.sub.2).sub.2 OH, --CH.sub.2 Cl, --CH.sub.2 Br, --NR.sub.5 R.sub.6, --CH.sub.2 NR.sub.5 R.sub.6, --O(CH.sub.2).sub.n NR.sub.5 R.sub.6, --CH.sub.2 SO.sub.3 M, --O(CH.sub.2).sub.n SO.sub.3 M or --SO.sub.3 M, R.sub.2 and R.sub.4 are each hydrogen, hydroxyl, alkyl or alkoxy and R.sub.5 and R.sub.6 are each hydrogen or alkyl, M is hydrogen, an alkali metal, ammonium and alkylammonium and n is an integer from 2 to 4.
摘要翻译：通过图像曝光和随后的显影银图像，染色漂白和银漂白的银染色漂白工艺生产彩色摄影图像的方法，可选地，最后两个步骤是组合的银固定和洗涤，其中染色漂白和/或银漂白在至少一种下式的漂白催化剂的存在下进行。在该式中，A和B在每种情况下都是非 - 完成苯或吡啶环所需的金属原子，R 1和R 3各自为氢，羟基，卤素，烷基，羧基，烷氧基，烷氧基烷氧基，-CH 2 OH，-O（CH 2）n OH，-O（CH 2）2 O（CH 2），-CH2Cl，-CH2Br，-NR5R6，-CH2NR5R6，-O（CH2）nNR5R6，-CH2SO3M，-O（CH2）nSO3M或-SO3M，R2和R4各自为氢，羟基，烷基或烷氧基，R5和R6为每个氢或烷基，M是氢，碱金属，铵和烷基铵，n是2至4的整数。

97. 发明授权

US4139530A Benzo-[c]-cinnolinium dyestuffs 失效
标题翻译：苯并 - {8-β-噌啉染料
公开(公告)号：US4139530A
公开(公告)日：1979-02-13
申请号：US758183
申请日：1977-01-10
申请人： Walter Kalk , Karl H. Schundehutte
发明人： Walter Kalk , Karl H. Schundehutte
IPC分类号： C07D237/36 , C07D401/02 , C07D413/02
摘要： Cationic dyestuffs of the general formula ##STR1## IN WHICH THE SYMBOLS HAVE THE MEANING MENTIONED ABOVE INTERMEDIATES AND PROCESSES FOR THEIR PRODUCTION AND THEIR USE FOR DYEING AND PRINTING OF NATURAL AND SYNTHETIC MATERIALS.
摘要翻译：该符号具有上述意义上的意义及其生产及其用于自然和合成材料的染色和印刷的中间体和方法的通式的阳离子染料。

98. 发明授权

US3087929A Synthesis of benzo[c]cinnolines 失效
标题翻译：苯并[c]噌啉的合成
公开(公告)号：US3087929A
公开(公告)日：1963-04-30
申请号：US3340760
申请日：1960-06-02
申请人： DOW CHEMICAL CO
发明人： FRANCIS JOHNSON
IPC分类号： C07D237/36
CPC分类号： C07D237/36

99. 发明申请

WO2008013838A3 PYRIDIZINONE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO2008013838A3
公开(公告)日：2008-07-31
申请号：PCT/US2007016699
申请日：2007-07-25
申请人： CEPHALON INC , HUDKINS ROBERT L , JOSEF KURT A , TAO MING
发明人： HUDKINS ROBERT L , JOSEF KURT A , TAO MING
IPC分类号： C07D237/14 , A61K31/501 , A61K31/502 , A61K31/5025 , A61P25/28 , C07D237/26 , C07D237/32 , C07D237/36 , C07D403/04 , C07D403/12 , C07D495/04
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention provides compounds of formula (I*): their use as H 3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译：本发明提供式（I *）化合物：它们作为H 3 N 3抑制剂的用途，其制备方法及其药物组合物。

100. 发明申请

WO01096305A1 SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：WO01096305A1
公开(公告)日：2001-12-20
申请号：PCT/GB2001/002566
申请日：2001-06-12
IPC分类号： C07D233/64 , A61K31/166 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/405 , A61K31/4172 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/4465 , A61K31/454 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/08 , A61P13/10 , A61P15/00 , A61P15/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/06 , A61P27/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07C237/42 , C07C237/52 , C07D209/08 , C07D209/20 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/56 , C07D213/61 , C07D213/73 , C07D233/54 , C07D263/54 , C07D273/00 , C07D277/20 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/52 , C07D277/68 , C07D277/82 , C07D307/54 , C07D307/79 , C07D307/81 , C07D333/36 , C07D333/60 , C07D401/12 , C07D417/12 , A61K31/425 , C07D237/36 , C07D295/14
CPC分类号： C07D213/73 , C07B2200/07 , C07C237/42 , C07C2601/14 , C07C2602/08 , C07D209/08 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/56 , C07D213/61 , C07D233/64 , C07D273/00 , C07D277/30 , C07D277/40 , C07D277/46 , C07D277/52 , C07D277/68 , C07D277/82 , C07D307/54 , C07D307/79 , C07D333/36 , C07D333/60 , C07D401/12 , C07D417/12
摘要： Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
摘要翻译：其中R5，R6a，X，L，Cy和Lp如说明书中所定义的式（I）化合物是用作抗炎剂的类胰蛋白酶抑制剂。

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