专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明申请

US20030176326A1 Photosensitzers for photodynamic therapy of microbial infections 审中-公开
标题翻译：用于光动力治疗微生物感染的光敏剂
公开(公告)号：US20030176326A1
公开(公告)日：2003-09-18
申请号：US10098669
申请日：2002-03-15
申请人： CeramOptec Industries Inc.
发明人： Nikolay E. Nifantiev
IPC分类号： A61K038/16 , A61K031/7052 , C07K014/47 , C08B037/00 , A61K031/739
CPC分类号： A61K41/0071
摘要： Molecular conjugates for the treatment and prevention of infectious diseases due to pathogenic microorganisms are provided. These conjugates comprise at least one photosensitizer coupled to a microorganism receptor (vector) that binds selectively to the surface of a microorganism, such as bacteria, viruses, mycoplasma, fungi, parasites and others. Complex aggregates formed by self-association of carbohydrate-photosensitizer conjugates or that are constructed on the base of a carrier form multiple interactions with the binding sites on the surface of the selected microorganism due to their polyligand carbohydrate surrounding. The property of the conjugates to bind selectively to sites on targeted microbes and to block these sites defines their ability to act as inhibitors of microbial cell adhesion and thereby provides an ability to prevent infectious disease. Methods for treatment and prevention of infectious diseases due to pathogenic microorganisms are also provided.
摘要翻译：提供了用于治疗和预防由病原微生物引起的感染性疾病的分子共轭物。这些缀合物包含与微生物受体（载体）偶联的至少一种光敏剂，微生物受体（载体）选择性地结合微生物如细菌，病毒，支原体，真菌，寄生虫等的表面。由碳水化合物 - 光敏剂共轭物的自缔合形成的复合聚集体或构建在载体的底部上的复合聚集体由于它们的聚合配体碳水化合物周围与选择的微生物的表面上的结合位点形成多重相互作用。缀合物选择性结合靶向微生物位点并阻断这些位点的性质限定了其作为微生物细胞粘附抑制剂的能力，从而提供预防感染性疾病的能力。还提供了用于治疗和预防由病原微生物引起的感染性疾病的方法。

92. 发明申请

US20030171308A1 Macrolide antibacterial compounds 审中-公开
标题翻译：大环内酯类抗菌化合物
公开(公告)号：US20030171308A1
公开(公告)日：2003-09-11
申请号：US10075011
申请日：2002-02-13
发明人： Richard Clark , Stevan Djuric , Zhenkun Ma , Sanyi Wang
IPC分类号： C07H017/08 , A61K031/7052
CPC分类号： C07H17/08
摘要： Antibacterial compounds having formula (I) 1 and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.
摘要翻译：公开了具有式（I）的抗菌化合物及其前体药物的前体药物和前体药物，其制备方法中使用的化合物和中间体，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。

93. 发明申请

US20030166582A1 Aryl fused azapolycyclic compounds 失效
标题翻译：芳基稠合的氮杂多环化合物
公开(公告)号：US20030166582A1
公开(公告)日：2003-09-04
申请号：US10306500
申请日：2002-11-27
申请人： Pfizer Inc.
发明人： Anne E. Hagen , R. Scott Obach
IPC分类号： A61K031/7052 , A61K031/517 , A61K031/502 , A61K031/498 , A61K031/473 , C07H017/02 , C07D43/02 , C07D417/02
CPC分类号： C07H13/12 , C07H7/033 , C07H19/23
摘要： This invention is directed to compounds of the formula (I): 1 and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of nicotine addiction/withdrawal and CNS disorders.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2和R 3如本文所定义; 用于合成这些化合物的中间体，含有这些化合物的药物组合物; 以及使用这些化合物治疗尼古丁成瘾/戒断和中枢神经系统疾病的方法。

94. 发明申请

US20030158125A1 Polysaccharidic esters of n-derivatives of glutamic acid 失效
标题翻译：谷氨酸的n-衍生物的多糖酯
公开(公告)号：US20030158125A1
公开(公告)日：2003-08-21
申请号：US10221703
申请日：2003-01-27
发明人： Giuliana Miglierini , Luca Stucchi , Alessandro Rastrelli
IPC分类号： A61K031/7052 , C07H017/02
CPC分类号： C08B37/0024 , A61K31/715 , C08B37/0072
摘要： The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.
摘要翻译：本发明涉及谷氨酸N-衍生物（N-GA衍生物）的多糖酯。这些多糖酯具有抗增殖活性，其特征在于低的全身毒性。本发明的酯用于预防和治疗由细胞过度增生引起的疾病，特别是牛皮癣，肿瘤，类风湿性关节炎或肠炎性病理学。

95. 发明申请

US20030152577A1 Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications 审中-公开
标题翻译：用于同时光学诊断和治疗应用的染料生物缀合物
公开(公告)号：US20030152577A1
公开(公告)日：2003-08-14
申请号：US10071779
申请日：2002-02-07
申请人： MALLINCKRODT INC.
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj
IPC分类号： A61K039/395 , A61K031/7052 , A61K031/428 , A61K031/423 , A61K031/4184
CPC分类号： A61K49/0032 , A61K41/0033 , A61K41/0057 , A61K41/0071 , A61K49/0056
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
摘要翻译：公开了新型肿瘤特异性光疗法和光诊断剂。该化合物包括用于可视化的碳菁染料，用于光动力学治疗的光敏剂和用于将位点特异性递送探针和光毒性剂到患病组织的肿瘤受体 - 鸟苷肽。这些元素的组合充分利用了每个组件的独特而有效的特性来进行有效的患者护理管理。

96. 发明申请

US20030148931A1 Pharmaceutical compositions containing dds compounds 失效
标题翻译：含有dds化合物的药物组合物
公开(公告)号：US20030148931A1
公开(公告)日：2003-08-07
申请号：US10332706
申请日：2003-01-13
发明人： Masayuki Takahashi , Shuichi Sugie , Masahito Takeuchi
IPC分类号： A61K038/14 , C07K009/00 , A61K031/7052
CPC分类号： A61K31/4745 , A61K9/0019 , A61K9/19 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/61
摘要： A pharmaceutical composition having an ensured preservation stability, which contains a compound, wherein a polysaccharide derivative having a carboxyl group is bonded to a camptothecin derivative via a spacer or without mediated by any spacer, and a sugar or a sugar alcohol optionally together with a pH-adjusting substance.
摘要翻译：具有确保的保存稳定性的药物组合物，其含有化合物，其中具有羧基的多糖衍生物通过间隔物与喜树碱衍生物键合或不经间隔基介导，糖或糖醇可选地与pH 调整物质。

97. 发明申请

US20030120065A1 2-aminopyridine and 2-pyridone C-nucleosides 失效
标题翻译： 2-氨基吡啶和2-吡啶酮C-核苷
公开(公告)号：US20030120065A1
公开(公告)日：2003-06-26
申请号：US10171270
申请日：2002-06-13
申请人： Isis Pharmaceuticals, Inc.
发明人： Brian C. Froehler , Arnold J. Gutierrez , Mark D. Matteucci
IPC分类号： A61K031/7052 , C07H007/06
CPC分类号： C07D405/04 , C07H19/00 , C12Q1/6839 , C12Q2525/113
摘要： The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonucleotide-based diagnosis and separation through triplex binding.
摘要翻译：本发明提供含有目标核苷的2-氨基吡啶和2-吡啶酮C-核苷和寡核苷酸。核苷可用于制备目标寡核苷酸。寡核苷酸可用于通过三重结合进行基于寡核苷酸的诊断和分离。

98. 发明申请

US20030119761A1 Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use 审中-公开
标题翻译：含有碳水化合物部分的新型药剂及其制备和使用方法
公开(公告)号：US20030119761A1
公开(公告)日：2003-06-26
申请号：US10198798
申请日：2002-07-18
发明人： Samuel T. Christian
IPC分类号： A61K031/7052 , A61K009/14 , A61K009/70
CPC分类号： A61K31/7052 , A61K9/006 , A61K9/08 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/549 , A61K47/61 , C07H17/00
摘要： Hydrophilic N-linked pharmaceutical compositions, methods of their preparation and use in neuraxial drug delivery comprising a glycosyl CNS acting prodrug compound covalently N-linked with a saccharide through an amide or an amine bond and a formulary consisting of an additive, a stabilizer, a carrier, a binder, a buffer, an excipient, an emollient, a disintegrant, a lubricating agent, an antimicrobial agent or a preservative, with the proviso that the saccharide moiety is not a cyclodextrin or a glucuronide.
摘要翻译：亲水性N-连接的药物组合物，其制备方法和用于神经轴转运药物的方法，其包括通过酰胺或胺键与糖共价N-连接的糖基CNS作用前药化合物和由添加剂，稳定剂，载体，粘合剂，缓冲剂，赋形剂，软化剂，崩解剂，润滑剂，抗微生物剂或防腐剂，条件是糖部分不是环糊精或葡糖苷酸。

99. 发明申请

US20030109463A1 Novel macrolides 失效
标题翻译：新型大环内酯类
公开(公告)号：US20030109463A1
公开(公告)日：2003-06-12
申请号：US10226760
申请日：2002-08-23
发明人： Hengmiao Cheng , Chao Li
IPC分类号： A61K031/7052 , C07H017/08
CPC分类号： C07H17/08 , C07H17/00
摘要： The invention relates to compounds of Formula 1 1 and to pharmaceutically acceptable salts, solvates, and prodrugs thereof, wherein X, Y, Z, R1, R2, R3, R4, and R5 are defined herein. The invention further relates to methods of making compounds of Formula 1 and to pharmaceutical compositions comprising compounds of Formula 1. The invention is also related to methods of treating diseases and disorders such as, but not limited to, bacterial and protozoal infections which comprise the administration of a compound of Formula 1, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
摘要翻译：本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物和前药，其中X，Y，Z，R 1，R 2，R 3，R 4和R 5在本文中定义。本发明还涉及制备式1化合物的方法和包含式1化合物的药物组合物。本发明还涉及治疗疾病和病症的方法，例如但不限于包含给药的细菌和原生动物感染的式1的化合物或其药学上可接受的盐，溶剂合物或前药。

100. 发明申请

US20030108595A1 Method for treating amyloidosis 审中-公开
标题翻译：治疗淀粉样变性的方法
公开(公告)号：US20030108595A1
公开(公告)日：2003-06-12
申请号：US10125063
申请日：2002-04-18
申请人： Queen's University at Kingston
发明人： Robert Kisilevsky , Walter Szarek , Donald Weaver
IPC分类号： A61K038/17 , A61K031/7052 , A61K031/7048 , A61K031/7024 , A61K009/127
CPC分类号： A61K31/185 , A61K31/255 , A61K31/41 , A61K31/70 , A61K31/737 , A61K31/795 , A61K47/51 , A61K47/54 , A61K47/549 , A61K47/55 , A61K47/555 , A61K47/58 , A61L33/08 , C07H11/00 , C07H15/04
摘要： Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.
摘要翻译：描述了用于抑制受试者中淀粉样蛋白沉积的治疗化合物和方法，无论其临床情况如何。通过给予受试者有效量的包含阴离子基团和载体分子或其药学上可接受的盐的治疗化合物或其淀粉样蛋白形成蛋白质与基底膜成分之间的相互作用被抑制来抑制淀粉样蛋白沉积。优选的阴离子基团是磺酸盐和硫酸盐。优选的载体分子包括碳水化合物，聚合物，肽，肽衍生物，脂族基团，脂环族基团，杂环基团，芳族基团及其组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式