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92. 发明专利

JP2009077715A Method of screening for compounds inhibiting biosynthesis of gpi in malaria parasites 审中-公开
标题翻译：化合物的筛选方法抑制疟原虫中GPI的生物合成
公开(公告)号：JP2009077715A
公开(公告)日：2009-04-16
申请号：JP2008242395
申请日：2008-09-22
申请人： Eisai R & D Management Co Ltd , エーザイ・アール・アンド・ディー・マネジメント株式会社
发明人： HATA KATSURA , OGAWA KAORU , TSUKADA ITARU , NAKAMOTO KAZUTAKA , AINE YASUSHI , TANAKA KEIGO , TSUKAHARA KATSUHEI , HORII TOSHIHIRO
IPC分类号： C12N15/09 , A61K31/44 , A61K31/472 , A61K45/00 , A61P33/06 , C07D213/65 , C07D213/74 , C07D217/02 , C07D217/18 , C07D217/20 , C07K14/445 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12Q1/02 , C12Q1/18 , C12Q1/48 , G01N33/15 , G01N33/50 , G01N33/573
CPC分类号： G01N33/573 , C07K14/445 , C12N9/1029 , C12Q1/18 , C12Q1/48 , G01N2333/37 , G01N2333/445 , G01N2500/04 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide a degenerate mutant DNA encoding a protein involved in glycosylphosphatidylinositol (GPI) biosynthesis with a decreased AT content compared to an original DNA encoding a protein involved in GPI biosynthesis, and a method of screening for an antimalarial drug using the degenerate mutant DNA. SOLUTION: Provided are a DNA encoding a protein having activity of GPI acyltransferase which is one of GPI biosynthesis enzyme in a falciparum malaria parasite, a protein encoded by the DNA, a transformant holding a vector inserted with the DNA in expressable form (particularly, a yeast deficient in GPI synthase gene), and a method of screening for antimalarial drugs using the protein and transformant. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供与编码参与GPI生物合成的蛋白质的原始DNA相比，编码参与糖基磷脂酰肌醇（GPI）生物合成的蛋白质的简并突变DNA具有降低的AT含量，以及筛选抗疟疾的方法使用简并突变DNA的药物。解决方案：提供编码具有GPI酰基转移酶活性的蛋白质，其是恶性疟原虫寄生虫中的GPI生物合成酶之一，由DNA编码的蛋白质，保持以可表达形式插入DNA的载体的转化体（特别是缺乏GPI合酶基因的酵母），以及使用蛋白质和转化体筛选抗疟疾药物的方法。版权所有（C）2009，JPO＆INPIT

93. 发明授权

US12053455B2 Antigen-driven detection and treatment of coccidioidomycosis 有权
公开(公告)号：US12053455B2
公开(公告)日：2024-08-06
申请号：US17333255
申请日：2021-05-28
申请人： Mayo Foundation for Medical Education and Research , Arizona Board of Regents on behalf of Arizona State University
发明人： Thomas E. Grys , Douglas Lake , Natalie Michelle Mitchell
IPC分类号： A61K31/427 , A61K31/4196 , A61K31/496 , A61K31/506 , A61K31/7048 , G01N33/569 , G01N33/68
CPC分类号： A61K31/4196 , A61K31/427 , A61K31/496 , A61K31/506 , A61K31/7048 , G01N33/56961 , G01N33/6848 , G01N2333/37 , G01N2800/52
摘要： Materials and methods for detecting and treating Coccidioidomycosis (Valley Fever) are provided herein. For example, materials and methods for enriching and detecting biomarker antigens (e.g., polypeptides and/or glycans) from Coccidioides immitis and Coccidioides posadasii, the fungi that cause Valley Fever, are described herein, as are methods for treating an individual for Valley Fever based on the results of the described detection methods.

94. 发明公开

US20230273189A1 IMMUNOADSORBENT AND COMPOSITE AFFINITY COLUMN FOR PURIFYING FUMONISINS B1, ANGUIDIN, T-2 TOXIN, ZEARALENONE AND VOMITOXIN, METHOD FOR DETECTING THE SAME, AND PREPARATION METHOD OF COMPOSITE AFFINITY COLUMN 审中-公开
公开(公告)号：US20230273189A1
公开(公告)日：2023-08-31
申请号：US17777056
申请日：2020-11-16
申请人： OIL CROPS RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES
发明人： Qi ZHANG , Yizhen BAI , Nanri YIN , Fei MA , Peiwu LI
IPC分类号： G01N33/53 , G01N33/68 , G01N33/543
CPC分类号： G01N33/5308 , G01N33/5436 , G01N33/6848 , G01N2333/37
摘要： An immunoadsorbent and a composite affinity column for purifying fumonisin B1, anguidin, T-2 toxin, zearalenone, and vomitoxin. The immunoadsorbent includes a solid phase carrier, and a fumonisin B1 monoclonal antibody, an anguidin monoclonal antibody, a T-2 toxin monoclonal antibody, a zearalenone monoclonal antibody and a vomitoxin monoclonal antibody which are coupled to the solid phase carrier, the anguidin monoclonal antibody is a monoclonal antibody secreted by a hybridoma cell strain DAS5G11E7 having an accession number of CCTCCNO:C201881. The affinity column can be used for high performance liquid chromatography-mass spectrometry detection of the fumonisin B1, the anguidin, the T-2 toxin, the zearalenone and the vomitoxin, and has stable performance. Furthermore, an economical, quick, precise and safe detection method is established of the basis of the affinity column, and can be used for purifying and detecting samples of the five toxins without mutual interference and influence.

95. 发明申请

US20180208961A1 METHOD FOR DETERMINING WHETHER OR NOT TEST SAMPLE CONTAINS EXSEROHILUM PHYTOPATHOGENIC FUNGUS 审中-公开
公开(公告)号：US20180208961A1
公开(公告)日：2018-07-26
申请号：US15844629
申请日：2017-12-18
申请人： Panasonic Intellectual Property Management Co., Ltd.
发明人： Kaori Yamaguchi , Yoshitsugu Uriu
IPC分类号： C12Q1/06
CPC分类号： C12Q1/06 , G01N2333/37
摘要： The present invention provides a method for determining whether or not a test sample contains an Exserohilum phytopathogenic fungus. The method comprises: (a) putting the test sample on a front surface of a cellulose film having no through hole; (b) leaving the test sample at rest for a predetermined time; (c) observing a back surface of the cellulose film; and (d) determining that the test sample contains the Exserohilum phytopathogenic fungus, if a fungus which has penetrated the cellulose film is found on the back surface of the cellulose film in the step (c). The method further comprises a step of supplying a culture medium to the test sample before the step (b). The culture medium is a lactose casein hydrolysate agar medium containing carbendazim, captan, streptomycin sulfate, and neomycin sulfate. Alternatively, in the step (b), the test sample is left at rest while the back surface of the cellulose film is in contact with the culture medium.

96. 发明申请

US20170131300A1 METHODS OF IDENTIFYING AND QUANTIFYING SPHINGOLIPIDS 审中-公开
公开(公告)号：US20170131300A1
公开(公告)日：2017-05-11
申请号：US15131243
申请日：2016-04-18
申请人： Macau University of Science and Technology
发明人： Jing-Rong Wang , Jia-Ning Mi , Zhi-Hong Jiang
IPC分类号： G01N33/92 , G01N30/72 , B01D15/42 , C12Q1/04
CPC分类号： A61K36/068 , A61K31/133 , A61K31/164 , A61K31/688 , A61K2236/333 , A61K2236/39 , A61K2236/50 , A61K2236/53 , B01D15/426 , C12Q1/04 , G01N30/72 , G01N33/92 , G01N2030/027 , G01N2333/37 , G01N2405/08
摘要： The present invention relates to a method of identifying and preferably quantifying at least one sphingolipid, in particular the sphingolipid portion in wild-type Cordyceps or Cordyceps derivates. A further aspect relates to a method of identifying wild-type Cordyceps in a Cordyceps sample as well as for identifying Cordyceps derivates in a Cordyceps sample. The methods of the present invention, thus, allow for determining the quality and safety of Cordyceps products and for advantageously differentiating between wild-type Cordyceps and Cordyceps derivates via the ratio and/or presence of certain sphingolipids especially suitable as markers.

97. 发明申请

US20170128507A1 METHOD OF ISOLATING SPHINGOLIPIDS FROM CORDYCEPS AND THEIR USE 审中-公开
公开(公告)号：US20170128507A1
公开(公告)日：2017-05-11
申请号：US15131218
申请日：2016-04-18
申请人： Macau University of Science and Technology
发明人： Zhi-Hong Jiang , Jing-Rong Wang , Jia-Ning Mi , Junping Kou , Yuwei Han , Yingqiong Xu
IPC分类号： A61K36/068 , A61K31/164 , A61K31/688 , A61K31/133
CPC分类号： A61K36/068 , A61K31/133 , A61K31/164 , A61K31/688 , A61K2236/333 , A61K2236/39 , A61K2236/50 , A61K2236/53 , B01D15/426 , C12Q1/04 , G01N30/34 , G01N30/72 , G01N30/7233 , G01N33/92 , G01N2030/009 , G01N2030/027 , G01N2333/37 , G01N2405/08
摘要： A method of isolating at least one sphingolipid portion selected from a sphingoid base portion, a ceramide portion, a glycosphingolipid portion or a phosphosphingolipid portion from Cordyceps, in particular from wild-type Cordyceps, allows for obtaining sphingolipid portions having an increased amount of one of sphingoid bases, ceramides, glycosphingolipids or phosphosphingolipids. The sphingolipid portions isolated contained significant amounts of sphingolipids not reported so far, and possess exceptional immunosuppressive activities. A method of treating a subject suffering from an inflammatory disease like an autoimmune disease or an allergic disease includes administering sphingolipids isolated from Cordyceps, in particular from wild-type Cordyceps. A method of treating a subject suffering from an inflammatory disease includes administering certain sphingolipids to the subject. Still further in accordance with the present invention is a composition, in particular a pharmaceutical composition comprising at least one sphingolipid portion.

98. 发明申请

US20170037445A1 METHOD FOR DETERMINING WHETHER OR NOT TEST SAMPLE CONTAINS PHYTOPATHOGENIC OOMYCETE 有权
标题翻译：用于确定无论是否测试样品含有致病性蛋白质的方法
公开(公告)号：US20170037445A1
公开(公告)日：2017-02-09
申请号：US14948284
申请日：2015-11-21
申请人： Panasonic Intellectual Property Management Co., Ltd.
发明人： YOSHITSUGU URIU
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12M25/06 , C12M41/36 , C12N1/14 , C12N3/00 , G01N2333/37
摘要： The present invention provides a method for determining whether or not a test sample contains a phytopathogenic oomycete selectively from two kinds of oomycetes of a phytopathogenic oomycete and a non-phytopathogenic oomycete. The method according to the present invention comprises: (a) putting the test sample on a front surface of a cellulose film; wherein the cellulose film has a thickness of not less than 0.5 micrometers and not more than 3.7 micrometers; (b) leaving the test sample at rest for more than 8 hours and not more than 12 hours after the step (a); (c) observing a back surface of the film after the step (b); and (d) determining that the test sample contains the phytopathogenic oomycete, if an oomycete is found on the back surface of the film in the step (c).
摘要翻译：本发明提供了一种用于确定测试样品是否从植物病原性卵菌和非植物病原性卵菌的两种卵菌中选择性地含有植物致病性卵菌的方法。根据本发明的方法包括：（a）将测试样品放在纤维素膜的前表面上; 其中所述纤维素膜具有不小于0.5微米且不大于3.7微米的厚度; （b）在步骤（a）之后离开测试样品静置超过8小时但不超过12小时; （c）在步骤（b）之后观察膜的背面; 以及（d）如果在步骤（c）中在膜的后表面上发现卵菌纲，则确定测试样品含有植物致病性卵菌纲。

99. 发明授权

US09376703B2 Methods for detecting a xerophilic or osmophilic yeast or mold microorganism 有权
标题翻译：检测嗜酸性或渗透性酵母或霉菌微生物的方法
公开(公告)号：US09376703B2
公开(公告)日：2016-06-28
申请号：US14406538
申请日：2013-05-29
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： Sailaja Chandrapati , Tera M. Nordby
IPC分类号： C12Q1/04 , C12Q1/44
CPC分类号： C12Q1/04 , C12Q1/44 , G01N2333/37 , G01N2333/39
摘要： A method for detecting a xerophilic microorganism is provided. The method comprises providing a sample to be tested, an aqueous diluent comprising about 1.0 to about 10.2 weight percent glycerol, and a thin film culture device comprising a cold water-reconstitutable medium to facilitate the growth of a microorganism. The method further comprises mixing the sample with the aqueous diluent to form an inoculum, contacting a predefined amount of the inoculum with the reconstitutable medium to form an inoculated thin film culture device, incubating the inoculated thin film culture device for a period of time, and detecting a presence or an absence of colony of a microorganism. Kits for detecting a xerophilic microorganism according to the method are also provided.
摘要翻译：提供了一种用于检测嗜性微生物的方法。该方法包括提供待测样品，包含约1.0至约10.2重量％甘油的含水稀释剂和包含有助于微生物生长的冷水可重构培养基的薄膜培养装置。该方法还包括将样品与水性稀释剂混合以形成接种物，将预定量的接种物与可重构培养基接触以形成接种的薄膜培养装置，将接种的薄膜培养装置孵育一段时间，以及检测微生物存在或不存在菌落。还提供了用于根据该方法检测嗜性微生物的试剂盒。

100. 发明授权

US09274111B2 Method for the diagnosis of and/or monitoring mucormycosis 有权
标题翻译：诊断和/或监测毛霉菌病的方法
公开(公告)号：US09274111B2
公开(公告)日：2016-03-01
申请号：US13990784
申请日：2011-11-24
申请人： Mario Luppi , Patrizia Barozzi , Leonardo Potenza , Daniela Vallerini , Forghieri Fabio
发明人： Mario Luppi , Patrizia Barozzi , Leonardo Potenza , Daniela Vallerini , Forghieri Fabio
IPC分类号： G01N33/569
CPC分类号： G01N33/56961 , G01N33/56972 , G01N2333/37 , G01N2333/5406 , G01N2333/5428 , G01N2333/57
摘要： A method is described for the diagnosis and/or monitoring of active or previous infection by Mucor which consists in the identification of Mucorales-specific T cells in samples from biological fluids taken from the patient and put into contact with a Mucor antigen. These specific immune responses can be detected by the execution of immunoenzymatic assays (ELISPOT, Quantiferon) or of immunocytofluorimetric assays [Cytokine Secretion Assay (CSA), Intracellular Cytokine Staining (ICS)] in vitro. In greater detail, the method in question provides for checking for the presence of specific IFN-γ producing T cells, of specific IL-10 producing T cells and/or specific IL-4 producing T cells.
摘要翻译：描述了用于诊断和/或监测Mucor活性或先前感染的方法，该方法包括鉴定来自患者取自生物流体并与Mucor抗原接触的样品中的Mucorales特异性T细胞。这些特异性免疫反应可以通过免疫酶学检测（ELISPOT，Quantiferon）或免疫细胞荧光测定法[细胞因子分泌测定（CSA），细胞内细胞因子染色（ICS）]的体外检测。更详细地说，所述方法提供检查产生特异性IFN-γ的T细胞，产生特定IL-10的T细胞和/或产生特异性IL-4的T细胞的存在。

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