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91. 发明申请

US20070259348A1 Lyophilized pellets 审中-公开
标题翻译：冻干颗粒
公开(公告)号：US20070259348A1
公开(公告)日：2007-11-08
申请号：US11417668
申请日：2006-05-03
申请人： Nikhil Phadke , Michelle Manente , Kalyan Handique
发明人： Nikhil Phadke , Michelle Manente , Kalyan Handique
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/33 , C12Q1/00
CPC分类号： F26B5/065 , C12Q1/6806 , F26B5/06 , C12Q2527/125
摘要： Lyophilized pellets, suitable for use in a microfluidic device, and a method for preparing the same are described. The lyophilized pellets contain various biological reagents, or microparticles, and a cryoprotectant. The lyophilized pellets have a high degree of sphericity and are in the size range 0.5 to 35 μL. The pellets are prepared by dispensing drops of reagent solution on to a cryogenically cooled plate, followed by subjecting to a vacuum.
摘要翻译：描述了适用于微流体装置的冻干颗粒及其制备方法。冻干颗粒含有各种生物试剂或微粒，以及冷冻保护剂。冻干颗粒具有高度的球形度，其尺寸范围为0.5至35μm。颗粒通过将试剂溶液滴到低温冷却板上，然后进行真空来制备。

92. 发明授权

US06931888B2 Lyophilization method and apparatus for producing particles 有权
标题翻译：冻干方法和生产颗粒的装置
公开(公告)号：US06931888B2
公开(公告)日：2005-08-23
申请号：US10434435
申请日：2003-05-08
申请人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Jeffrey S. Seitzinger
发明人： Boris Y. Shekunov , Pratibhash Chattopadhyay , Jeffrey S. Seitzinger
IPC分类号： A61K9/16 , A61K9/19 , F25B9/02 , F25D3/10 , F26B5/06 , B01D9/04 , B01D37/00 , B01D43/00 , C02F1/22
CPC分类号： F25D3/102 , A61K9/1623 , A61K9/1694 , A61K9/19 , F25B9/02 , F26B5/065
摘要： A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
摘要翻译：一种用于生产颗粒的方法和装置，该装置包括提供溶液的溶液源和供应流体的流体源。溶液包括溶剂和溶质。混合器接收来自源的溶液和流体，并将溶液和流体混合在一起形成混合物。混合物在第一压力下从混合器供应到膨胀组件。膨胀组件基本上同时喷雾和膨胀混合物以形成冷冻液滴，并且优选地形成冷冻液滴的低密度粉末。冷冻干燥装置使颗粒中的溶剂升华。粉末床的高质量转移率和均匀的开放结构提高了冷冻干燥过程。获得具有受控尺寸分布的固体颗粒。颗粒优选具有适于不同药物递送应用的中空或多孔形态以包括气溶胶制剂。

93. 发明申请

US20050178020A1 Lyophilization method and apparatus for producing particles 有权
公开(公告)号：US20050178020A1
公开(公告)日：2005-08-18
申请号：US11078554
申请日：2005-03-11
申请人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
发明人： Boris Shekunov , Pratibhash Chattopadhyay , Jeffrey Seitzinger
IPC分类号： A61K9/16 , A61K9/19 , F25B9/02 , F25D3/10 , F26B5/06 , A23F5/00
CPC分类号： F25D3/102 , A61K9/1623 , A61K9/1694 , A61K9/19 , F25B9/02 , F26B5/065
摘要： A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.

94. 发明申请

US20030041602A1 Process for production of nanoparticles and microparticles by spray freezing into liquid 有权
标题翻译：通过喷雾冷冻成液体生产纳米颗粒和微粒的方法
公开(公告)号：US20030041602A1
公开(公告)日：2003-03-06
申请号：US10062648
申请日：2002-01-30
发明人： Robert O. Williams III , Keith P. Johnston , Timothy J. Young , True L. Rogers , Melisa K. Barron , Zhongshui Yu , Jiahui Hu
IPC分类号： F25D017/02 , F25C001/00
CPC分类号： F26B5/065 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/1688 , A61K9/1694 , F25B19/005 , F25C1/00 , F25D2400/30 , F26B3/08
摘要： The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.
摘要翻译：本发明提供了可以溶解的材料的微粒和纳米粒子的制造系统和方法。本发明的系统和方法提供更快的冷冻时间，其又产生更均匀的粒度分布，较小的颗粒，具有增加的孔隙率的颗粒和颗粒组分的更加紧密的混合。本发明的系统和方法还产生比常规方法具有更大表面积的颗粒。本发明的一种形式提供了制备颗粒的方法。将有效成分与水，一种或多种溶剂或其组合混合，并将所得混合物通过位于或低于低温液体水平的绝缘喷嘴喷雾。喷雾产生冷冻颗粒。

95. 发明申请

US20030000228A1 Method for producing particulate goods 有权
公开(公告)号：US20030000228A1
公开(公告)日：2003-01-02
申请号：US10182715
申请日：2002-08-08
发明人： Hans Leuenberger , Armin Karl Theodor Prasch , Bernhard Luy
IPC分类号： F25D017/02 , F25C001/00 , F26B005/06
CPC分类号： F26B3/08 , B01J2/16 , F26B5/065
摘要： In the method for producing a particulate material (58) from an at least partially liquid material (35) containing a solvent and/or dispersant, this material (35) is atomized in a process chamber (21) into droplets which are frozen to particles (131) by contact with a freezing fluid. The particles (131) are then dried by freeze-drying in the or in another process chamber (22) having a filter (18) at the top. For the freeze-drying, cooled process gas is passed upward from below through the process chamber (22) and through the filter (18) in such a way that at least a substantial part of the particles (131) rest against the filter (18) at least for a substantial part of the freeze-drying taking place in the process chamber (22). This makes it possible to dry a batch of particles (131) in a short time.

96. 发明申请

US20020189127A1 Apparatus for freeze-drying foodstuffs, medicaments, and so forth 有权
标题翻译：用于冷冻食品，药物等的装置
公开(公告)号：US20020189127A1
公开(公告)日：2002-12-19
申请号：US10035421
申请日：2002-01-04
申请人： KYOWA VACUUM ENGINEERING CO., LTD.
发明人： Hiromichi Akimoto , Ryoji Sunama
IPC分类号： F26B013/30 , F26B019/00 , F26B025/06 , F26B005/06
CPC分类号： F26B5/065 , F26B5/06
摘要： By directly distributing liquid material into upright cylindrical tubes, such liquid material for foodstuffs, medicaments, etc. is kept in its state of being isolated from external atmosphere so as to be perfectly sterilized. That is to say, while simply and adequately securing the controlled cooling of the tube, by means of the heat medium which circulates within the jacket, the liquid material supplied into the tube is caused to freeze with uniform thickness onto the inner wall surface of the tube, with further possibility of uniform heating of the freeze-dried layer. The main body part of this freeze-drying apparatus is assembled with upright cylindrical tubes for freezing liquid material onto the inner wall surface of the tube and jackets to surround the outer periphery of each of the tubes surrounding the tubes in a substantially concentric outer cylindrical shape, within which to circulate the heat medium; then, on the upper end side of these tubes in this main body part, there is connected a duct which communicates to the vacuum exhaust system; while, on the lower end side of the tubes, there is connected a recovery chamber provided with an opening-and-closing valve, or equipped with a valve on the bottom part thereof; and, on the upper part of the lower part of the tube, there is defined an inlet port, through which the liquid material is fed into the inner cavity of the tube, the inlet port being formed contiguous to the downstream side of the tube-passageway for feeding the liquid material.
摘要翻译：通过将液体材料直接分配到直立的圆柱形管中，用于食品，药物等的这种液体材料保持与外部气氛隔离的状态，从而被完全消毒。也就是说，虽然通过在套管内循环的热介质简单且充分地确保管的受控制冷却，使供给到管中的液体材料以均匀的厚度冷冻到内壁表面上具有进一步的冷冻干燥层加热的可能性。该冷冻干燥装置的主体部分组装有直立的圆柱形管，用于将液体材料冷冻到管的内壁表面和夹套上，围绕围绕管的每个管的外围以基本同心的外圆柱形状，在其内循环热介质; 然后，在该主体部分的这些管的上端侧，连接有与真空排气系统连通的管道; 而在管的下端侧，连接有设置有开关阀的回收室，或者在其底部配备有阀; 并且在管的下部的上部限定有入口，液体材料通过该入口进入管的内腔中，入口端口邻近管状管的下游侧形成，用于供给液体材料的通道。

97. 发明授权

US06447553B1 Vacuum-deposited colorants 有权
标题翻译：真空沉积着色剂
公开(公告)号：US06447553B1
公开(公告)日：2002-09-10
申请号：US09695746
申请日：2000-10-24
申请人： Michael G. Mikhael , Angelo Yializis
发明人： Michael G. Mikhael , Angelo Yializis
IPC分类号： C09B6200
CPC分类号： C08F2/44 , B01J19/1887 , B01J2219/00128 , B01J2219/0013 , F26B5/041 , F26B5/048 , F26B5/065 , F26B17/023
摘要： A radiation curable monomer and a dystuff are mixed in a curable formulation and fed into a hot evaporator under vacuum. The blend is flash evaporated through a nozzle and recondensed onto a moving substrate in contact with a temperature-controlled rotating drum. The condensed film is then crosslinked with a high-energy ultraviolet or electron-beam radiation source to effect cross-linking of the monomer. The resulting product consists of a crosslinked polymer matrix incorporating dyestuff molecules within its structure, which dramatically enhances the durability, solvent resistance, heat stability and migration fastness of the product. These properties can be further improved by chemically bonding the dyestuff molecules with the crosslinked polymer network, which can be accomplished by judiciously functionalizing the dyestuff with appropriate functional groups designed to polymerize or to react with the curable monomer.
摘要翻译：将可辐射固化的单体和吸收剂混合在可固化制剂中并在真空下进料到热蒸发器中。混合物通过喷嘴快速蒸发并重新凝结到与受温度控制的旋转鼓接触的移动基板上。然后将冷凝的膜与高能量紫外线或电子束辐射源交联以实现单体的交联。所得产品由在其结构内掺入染料分子的交联聚合物基质组成，其显着提高了产品的耐久性，耐溶剂性，热稳定性和迁移牢度。通过将染料分子与交联聚合物网络化学键合可以进一步改善这些性能，这可以通过用设计为聚合或与可固化单体反应的合适的官能团明智地使染料官能化来实现。

98. 发明授权

US06194136B1 Cryoprotective solutions comprising DMSO, PG, 2,3-butanediol,raffinose and PVP 失效
标题翻译：包含DMSO，PG，2,3-丁二醇，棉子糖和PVP的冷冻保护溶液
公开(公告)号：US06194136B1
公开(公告)日：2001-02-27
申请号：US09114433
申请日：1998-07-13
申请人： Stephen A. Livesey , Anthony A. del Campo , Abhijit Nag , Ken B. Nichols , Carmen Piunno , David P. Ross
发明人： Stephen A. Livesey , Anthony A. del Campo , Abhijit Nag , Ken B. Nichols , Carmen Piunno , David P. Ross
IPC分类号： A01N102
CPC分类号： A01N1/0221 , A01N1/02 , A01N1/0257 , A61K35/18 , A61K39/12 , A61K39/13 , A61L2430/40 , C12N1/04 , C12N2770/32634 , F25C1/142 , F26B5/065
摘要： This invention relates to methods, apparatus and solutions for cryopreserving microscopic biological materials for biologically extended periods of time. The method comprises treating a suspension of biological material, in an appropriate buffer, with a cryoprotectant or combination of cryoprotectants which raises the glass transition temperature range of the sample. One or more dry protectants may be added to the cryosolution. The cryosolution is then nebulized and rapidly cooled with novel apparatus, dried by molecular distillation, stored and then rehydrated in a buffer prior to its use. The solutions comprise novel mixtures of cryoprotectants.
摘要翻译：本发明涉及用于在生物学上延长的时期内冷冻保存微生物材料的方法，装置和解决方案。该方法包括在适当的缓冲液中用冷冻保护剂或冷冻保护剂的组合处理生物材料的悬浮液，这提高了样品的玻璃化转变温度范围。可以将一种或多种干燥保护剂加入到冷冻溶液中。然后将冷冻溶液雾化并用新型装置快速冷却，通过分子蒸馏干燥，储存，然后在其使用前在缓冲液中再水化。该溶液包含冷冻保护剂的新型混合物。

99. 发明授权

US5614107A Method of freeze drying sewage sludge 失效
标题翻译：冷冻干燥污泥的方法
公开(公告)号：US5614107A
公开(公告)日：1997-03-25
申请号：US543037
申请日：1995-10-13
申请人： Albert T. Mallia, Jr.
发明人： Albert T. Mallia, Jr.
IPC分类号： A61L11/00 , C02F1/02 , C02F1/22 , C02F1/30 , C02F1/32 , C02F11/20 , F26B5/04 , F26B5/06 , F26B5/08 , C02F1/12
CPC分类号： A61L11/00 , C02F1/02 , C02F1/22 , C02F1/30 , C02F1/302 , C02F11/20 , F26B5/04 , F26B5/065 , F26B5/08 , C02F1/32 , Y10S159/05 , Y10S159/16 , Y10S159/905 , Y10S203/05
摘要： A method for processing sewage eliminates chemical "treatment", or, the addition of chemicals that are as harmful or more so to the environment as raw sewage. The method of processing sewage disintegrates the generally solid components of sewage into a highly de-moisturized powder via alternative processes of either (i) a freeze-drying process, or (ii) a combination centrifugal separation and an evacuated "bake-out" process, both which substantially drive out the vaporizable components of the sewage. In consequence, there are no resultant effluent and/or exhausting vapors from this method which would impact the environment.
摘要翻译：处理污水的方法消除了化学“处理”，或者添加与原污水一样有害或更为环境的化学物质。处理污水的方法通过（i）冷冻干燥过程或（ii）组合离心分离和抽空的“烘烤”过程的替代方法将污水的大体固体组分分解成高度脱保湿的粉末两者都基本上驱除污水的可汽化组分。因此，没有这种方法产生的流出物和/或排出的蒸汽将影响环境。

100. 发明授权

US5208998A Liquid substances freeze-drying systems and methods 失效
标题翻译：液体物质冷冻干燥系统及方法
公开(公告)号：US5208998A
公开(公告)日：1993-05-11
申请号：US770456
申请日：1991-10-03
申请人： James R. Oyler, Jr.
发明人： James R. Oyler, Jr.
IPC分类号： F26B3/12 , F26B5/06
CPC分类号： F26B5/065 , F26B3/12
摘要： Spray-freeze-drying systems and methods are disclosed for converting a wide variety of liquid substances into dry powder that may be reconstituted into the original substance by addition of water or other liquid that had been removed therefrom. Such systems and methods involve repetitive cycles of four operational steps, i.e., freezing, drying, defrosting and resetting and are characterized by: spraying the liquid substance downwardly in a vessel while surrounding the spray with a downward flow of process gas during the freezing step and by utilizing a heat pump for energy recapture to increase efficiency of operation.
摘要翻译：公开了喷雾冷冻干燥系统和方法，用于将各种各样的液体物质转化为干粉，其可以通过加入从其中除去的水或其它液体重构成原始物质。这种系统和方法涉及四个操作步骤的重复循环，即冷冻，干燥，除霜和重新设置，其特征在于：在冷冻步骤期间，将液体物质向下喷射在容器中，同时围绕喷雾器，同时处理气体向下流动; 通过利用热泵进行能量重新捕获以提高操作效率。

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