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91. 发明申请

US20150086980A1 DEVICE AND METHOD FOR ANALYZING STREPTAVIDIN 有权
标题翻译：用于分析STREPTAVIDIN的装置和方法
公开(公告)号：US20150086980A1
公开(公告)日：2015-03-26
申请号：US14387431
申请日：2013-03-21
申请人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintaro Kato , Iwao Waga
发明人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintaro Kato , Iwao Waga
IPC分类号： G01N33/543 , G01N33/58 , G01N33/68 , C12N15/113 , C12N15/115
CPC分类号： G01N33/54306 , C12N9/0065 , C12N15/113 , C12N15/115 , C12Y111/01007 , G01N33/542 , G01N33/58 , G01N33/68 , G01N2333/36
摘要： The present invention provides a novel sensor for detecting streptavidin (SA). The nucleic acid sensor for analyzing SA of the present invention includes the following nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to SA. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order. In this nucleic acid element, in the absence of SA, the catalytic function of the catalyst nucleic acid molecule (D) is inhibited by stem formation in each of the stem-forming sequences (SA) and (SD), and in the presence of SA, the stem formation is released by a binding of the binding nucleic acid molecule (A) with the SA, and the catalytic function of the catalyst nucleic acid molecule (D) is exerted.
摘要翻译：本发明提供了用于检测链霉亲和素（SA）的新型传感器。用于分析本发明的SA的核酸传感器包括以下核酸元件，其包含发挥催化功能的催化剂核酸分子（D）和与SA结合的结合核酸分子（A）。核酸元件是包含第一链和第二链的双链核酸元件。第一链（ss1）包括依次连接的结合核酸分子（A），环形成序列（L1）和催化剂核酸分子（D）。第二链（ss2）包括以此顺序连接的茎形成序列（SA），环形成序列（L2）和茎形成序列（SD）。在该核酸元件中，在不存在SA的情况下，催化剂核酸分子（D）的催化功能受到每个茎形成序列（SA）和（SD）中的茎形成的抑制，并且在 SA，通过结合核酸分子（A）与SA的结合释放茎的形成，并且发挥催化剂核酸分子（D）的催化功能。

92. 发明申请

US20140348812A1 PROTOCOLS FOR TREATING AND PREVENTING OBESITY AND COMPLICATIONS ARISING THEREFROM 审中-公开
标题翻译：用于治疗和预防由此产生的肥胖和综合症的协议
公开(公告)号：US20140348812A1
公开(公告)日：2014-11-27
申请号：US14453017
申请日：2014-08-06
申请人： HEALTHLINX LIMITED
发明人： Antonio RAJIC , Dominic J. AUTELITANO , Ana K. VRKIC , Christopher G. HOSKING , Leodevico L. ILAG
IPC分类号： A61K38/17 , A61K38/44
CPC分类号： A61K38/1709 , A23J1/20 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K38/018 , A61K38/44 , C12Y111/01007 , A23V2200/332 , A23V2250/54252 , A23V2250/54246
摘要： The present invention relates generally to the field of obesity and complications arising therefrom and in particular to the control of obesity by inhibiting adipogenesis and related processes.
摘要翻译：本发明一般涉及由此产生的肥胖症和并发症领域，特别涉及通过抑制脂肪形成和相关过程来控制肥胖症。

93. 发明申请

US20140249094A1 SENSATION-IMPROVING AGENT 审中-公开
标题翻译：感觉改善剂
公开(公告)号：US20140249094A1
公开(公告)日：2014-09-04
申请号：US14349456
申请日：2012-10-02
申请人： MEGMILK SNOW BRAND CO., LTD.
发明人： Ken Katoh , Hiroshi Ueno , Yuko Ono , Noriko Ueda , Toshiya Kobayashi , Takahiro Moriya , Yutaro Obata
IPC分类号： C07K14/47 , C12N9/22 , C12N9/08
CPC分类号： A61K38/1709 , A23J3/343 , A23K10/12 , A23K10/28 , A23K20/142 , A23K20/147 , A23K50/40 , A23L2/66 , A23L29/281 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K8/64 , A61K8/66 , A61K8/986 , A61K35/20 , A61K38/018 , A61K38/40 , A61K38/44 , A61K38/47 , A61K2800/40 , A61Q19/00 , C07K14/47 , C12N9/0065 , C12N9/22 , C12Y111/01007 , C12Y301/27 , Y02P60/875 , A23V2200/306 , A23V2250/54246 , A23V2250/54248 , A23V2250/5488 , A23V2250/55 , A23V2250/70
摘要： An object of the present invention is to provide a safety sensation-improving agent that can improve dulled peripheral sensations through daily ingestion or application to the skin. Another object of the present invention is to provide a sensation-improving food, beverage, feed, or cosmetics that can improve dulled peripheral sensations through oral ingestion or application to the skin. A sensation-improving agent containing a milk-derived protein and/or a hydrolysate therefrom as an active ingredient is provided. The milk-derived protein and/or the hydrolysate therefrom can be orally ingested or applied direct to the skin to improve dulled sensations, particularly peripheral sensations, and be formed into a sensation-improving food, beverage, feed, or cosmetics.
摘要翻译：本发明的目的是提供一种安全感觉改善剂，其可以通过每日摄取或施用于皮肤来改善钝化的周围感觉。本发明的另一个目的是提供一种改善感觉的食品，饮料，饲料或化妆品，其可以通过口服摄入或施用于皮肤来改善钝化的周围感觉。提供了含有乳衍生蛋白质和/或其水解产物作为活性成分的感觉改善剂。乳源性蛋白质和/或其水解物可以直接口服摄取或直接施用于皮肤，以改善昏暗的感觉，特别是周围的感觉，并形成感觉改善的食物，饮料，饲料或化妆品。

94. 发明授权

US08679526B2 Antimicrobial peroxidase compositions 有权
标题翻译：抗微生物过氧化物酶组合物
公开(公告)号：US08679526B2
公开(公告)日：2014-03-25
申请号：US11917330
申请日：2006-06-13
申请人： Dave Van Den Plas , Kris De Smet , Philippe Sollie
发明人： Dave Van Den Plas , Kris De Smet , Philippe Sollie
IPC分类号： A61L15/22 , A61L15/00 , A61F13/00 , A61K38/44
CPC分类号： A61L26/008 , A01N31/16 , A01N35/04 , A01N37/40 , A61K31/05 , A61K33/40 , A61K38/44 , A61K38/443 , A61L26/0066 , A61L2300/11 , A61L2300/216 , A61L2300/254 , A61L2300/45 , A61L2300/802 , C12Y101/03004 , C12Y111/01007 , A01N37/46 , A01N59/00 , A01N59/16 , A01N61/00 , A01N2300/00 , A61K2300/00
摘要： The present invention discloses a class of compounds which have an enhancing effect on peroxidase based antimicrobial compositions. The invention relates to pharmaceutical compositions for prolonged topical use comprising enhancing agents such as methoxyphenols and substituted benzylaldehydes. Examples hereof are respectively guaiacol and vanillin.
摘要翻译：本发明公开了一类对基于过氧化物酶的抗微生物组合物具有增强作用的化合物。本发明涉及用于延长局部使用的药物组合物，其包括增强剂如甲氧基苯酚和取代的苄醛。其实例分别是愈创木酚和香草醛。

95. 发明授权

US08507246B2 Method of preparing a heat-treated product 有权
标题翻译：制备热处理产品的方法
公开(公告)号：US08507246B2
公开(公告)日：2013-08-13
申请号：US13352511
申请日：2012-01-18
申请人： Gitte Budolfsen , Morten Tovborg Jensen , Hans Peter Heldt-Hansen , Mary Ann Stringer
发明人： Gitte Budolfsen , Morten Tovborg Jensen , Hans Peter Heldt-Hansen , Mary Ann Stringer
IPC分类号： C12N9/82 , C12N9/02 , C12P1/00 , C07K1/00 , C08B37/00 , A21D2/00 , C13K1/06 , A23F3/00 , A23F3/16 , A23B4/12 , C07H21/04
CPC分类号： A21D8/042 , A23L5/25 , A23L7/117 , A23L19/19 , C12N9/82 , C12P1/00 , C12Y101/01118 , C12Y101/01119 , C12Y101/01124 , C12Y101/01147 , C12Y101/01148 , C12Y101/03009 , C12Y101/9901 , C12Y101/99011 , C12Y101/99018 , C12Y101/99028 , C12Y102/01003 , C12Y102/01004 , C12Y102/01005 , C12Y104/03002 , C12Y110/03002 , C12Y111/01007 , C12Y301/03004 , C12Y301/03005 , C12Y304/13018 , C12Y305/01001 , C12Y305/01002 , C12Y305/01026 , C12Y305/01043 , C12Y305/01052
摘要： The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of reacting on asparagine or glutamine (optionally substituted) as a substrate or is a laccase or a peroxidase.
摘要翻译：通过在热处理前用酶处理原料，可以减少在食品生产过程中热处理过程中丙烯酰胺的形成。该酶能够对天冬酰胺或谷氨酰胺（任选取代）作为底物或是漆酶或过氧化物酶进行反应。

96. 发明申请

US20130004477A1 Methods for Treating Inflammation and Oxidative Stress Related Diseases 审中-公开
标题翻译：治疗炎症和氧化应激相关疾病的方法
公开(公告)号：US20130004477A1
公开(公告)日：2013-01-03
申请号：US13504286
申请日：2010-10-22
申请人： Zhe Lu , Yanping Xu
发明人： Zhe Lu , Yanping Xu
IPC分类号： A61K31/26 , A61K38/44 , A61P29/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P1/18 , A61K33/18 , A61P11/08
CPC分类号： G01N33/84 , A23L33/10 , A61K8/23 , A61K31/26 , A61K31/275 , A61K38/44 , A61Q5/10 , A61Q19/08 , C12Y111/01007 , G01N2800/382 , A61K2300/00
摘要： This invention provides compositions and methods for treating inflammation related diseases. Particularly, the present invention provides methods and compositions of administering thiocyanate to treat inflammation related diseases, such as cystic fibrosis, lung disease, lung cancer, asthma, bronchitis, pancreatic disease, digestive track disease, diabetes, neurological disorder, cardio-vascular disease, atherosclerosis, arthritis, nephritis, or stroke, and neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, or autism. The invention provides the use of thiocyanate to diagnose inflammation related diseases.
摘要翻译：本发明提供了治疗炎症相关疾病的组合物和方法。特别地，本发明提供了硫氰酸盐治疗炎症相关疾病如囊性纤维化，肺部疾病，肺癌，哮喘，支气管炎，胰腺疾病，消化道疾病，糖尿病，神经障碍，心血管疾病，动脉粥样硬化，关节炎，肾炎或中风，以及诸如阿尔茨海默病，帕金森病，多发性硬化或自闭症的神经障碍。本发明提供了硫氰酸盐诊断炎症相关疾病的用途。

97. 发明申请

US20120315261A1 ANTIBACTERIAL AUXILIARY AGENT COMPRISING KOMBU EXTRACT AS ACTIVE INGREDIENT, ANTIBACTERIAL COMPOSITION, AND FOOD OR BEVERAGE 审中-公开
标题翻译：含有KOMBU提取物作为活性成分，抗菌组合物和食品或饮料的抗生素辅助剂
公开(公告)号：US20120315261A1
公开(公告)日：2012-12-13
申请号：US13581037
申请日：2011-02-23
申请人： Kouichirou Shin , Koji Yamauchi
发明人： Kouichirou Shin , Koji Yamauchi
IPC分类号： A61K36/02 , A61P31/04 , A61K38/54
CPC分类号： A61K38/44 , A23L2/44 , A23L3/3472 , A23L33/105 , A61K31/727 , A61K36/02 , A61K38/443 , A61K2236/50 , C12Y101/03004 , C12Y111/01007 , A61K2300/00
摘要： Disclosed are: a method for utilizing a kombu (kelp) extract as an antibacterial auxiliary agent; and a method for utilizing a combination of the antibacterial auxiliary agent, lactoperoxidase, glucose oxidase and glucose as an antibacterial composition having a potent antibacterial activity. Specifically disclosed are: an antibacterial auxiliary agent comprising a fraction having a molecular weight of 5000 or less and produced from a kombu extract as an active ingredient; an antibacterial composition comprising the antibacterial auxiliary agent, lactoperoxidase, glucose oxidase and glucose; an antibacterial composition as mentioned above, which additionally comprises xanthane gum; and a food or beverage containing the antibacterial composition.
摘要翻译：公开了一种利用kombu（海带）提取物作为抗菌助剂的方法; 以及利用抗菌辅助剂，乳过氧化物酶，葡萄糖氧化酶和葡萄糖的组合作为具有有效抗菌活性的抗菌组合物的方法。具体公开的是：抗菌助剂，其含有分子量为5000以下的级分，由作为活性成分的棉布提取物制成; 包含抗菌助剂，乳过氧化物酶，葡萄糖氧化酶和葡萄糖的抗菌组合物; 如上所述的抗菌组合物，其还包含黄原胶; 和含有抗菌组合物的食品或饮料。

98. 发明授权

US08241909B2 Method for manufacturing glycoproteins having human-type glycosylation 有权
标题翻译：制备具有人型糖基化的糖蛋白的方法
公开(公告)号：US08241909B2
公开(公告)日：2012-08-14
申请号：US12795316
申请日：2010-06-07
申请人： Tatsuji Seki , Kazuhito Fujiyama
发明人： Tatsuji Seki , Kazuhito Fujiyama
IPC分类号： C12N15/82 , A01H1/00 , A01H5/00
CPC分类号： C12N9/0065 , C12N9/1051 , C12N15/8242 , C12N15/8245 , C12N15/8257 , C12P21/005 , C12Y111/01007 , C12Y204/01038
摘要： The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
摘要翻译：本发明提供一种制造具有人型糖链的糖蛋白的方法，其包括通过向植物细胞中导入糖基转移酶的基因和外源糖蛋白的基因而获得转化的植物细胞的步骤，其中，培养获得的转化植物细胞。

99. 发明申请

US20110171264A1 Protein Formulation 有权
标题翻译：蛋白质配方
公开(公告)号：US20110171264A1
公开(公告)日：2011-07-14
申请号：US12913838
申请日：2010-10-28
申请人： Jan Jezek
发明人： Jan Jezek
IPC分类号： A61K38/02 , A61K31/7088 , A61K35/76 , A61K39/07 , A61K38/44 , A61K38/37 , C12Q1/70 , G01N33/68 , G01N33/48 , C12Q1/30 , C12Q1/28 , G01N33/86
CPC分类号： C12N9/96 , C07K14/32 , C07K14/57 , C12N9/0065 , C12Y111/01006 , C12Y111/01007 , Y10T436/143333
摘要： An aqueous composition which comprises a protein or other biological molecule and also (i) optionally comprises one or more metal ions at a concentration of 0.01 to 20 mM; (ii) comprises excipients which are weak ligands; and (iii) is substantially free of excipients which are medium-strength ligands or strong ligands.
摘要翻译：一种水性组合物，其包含蛋白质或其他生物分子，并且（i）任选地包含一种或多种浓度为0.01至20mM的金属离子; （ii）包含作为弱配体的赋形剂; 和（iii）基本上不含作为中等强度配体或强配体的赋形剂。

100. 发明申请

US20110059062A1 USE OF HYDROLYTIC AND OXIDATIVE ENZYMES TO DISSOLVE BIOFILM IN AIRWAY PASSAGES 审中-公开
标题翻译：使用水解和氧化酶在汽车通道中分解生物膜
公开(公告)号：US20110059062A1
公开(公告)日：2011-03-10
申请号：US12667977
申请日：2008-01-23
申请人： Michael A Pellico
发明人： Michael A Pellico
IPC分类号： A61K38/54 , A61K38/46 , A61K38/47 , A61P31/04 , A61P11/00
CPC分类号： A61K38/54 , A61K31/573 , A61K38/40 , A61K38/44 , A61K38/443 , A61K38/465 , A61K38/47 , A61K45/06 , C12Y111/01007 , C12Y302/01 , C12Y302/01011 , C12Y302/01015 , C12Y302/01017 , A61K2300/00
摘要： A composition for removal of biofilm in the airway passage is useful for the treatment of infections such as pneumonia cause by Mycoplasma pneumoniae. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond that connects two monosaccharides in a polysaccharide or that connects a monosaccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the airway; and (2) a pharmaceutically acceptable carrier suitable for administration into the airway. The composition can further include ingredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a peroxidase is included, the composition can further include an oxidase to generate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an infection based on the ability of the composition to dissolve biofilm in the airway.
摘要翻译：用于在气道通道中除去生物膜的组合物可用于治疗由肺炎支原体引起的肺炎等感染。通常，组合物包含：（1）一定量的至少一种酶，其催化连接多糖中的两个单糖的键的水解，或者连接单糖与蛋白质分子在足以分解生物膜中的蛋白质分子气道和（2）适于施用于气道的药学上可接受的载体。该组合物还可以包括成分如类固醇，溶菌酶，乳铁蛋白或过氧化物酶; 如果包括过氧化物酶，组合物还可以包括氧化酶以产生过氧化物以及用于氧化酶的底物。该组合物可用于基于组合物在气道中溶解生物膜的能力来治疗感染的方法。

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