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91. 发明专利

TW200526783A 以磷酸二酯9抑制劑治療肥胖相關疾病 PHOSPHODIESTERASE 9 INHIBITION AS TREATMENT FOR OBESITY-RELATED CONDITIONS 审中-公开
简体标题：以磷酸二酯9抑制剂治疗肥胖相关疾病 PHOSPHODIESTERASE 9 INHIBITION AS TREATMENT FOR OBESITY-RELATED CONDITIONS
公开(公告)号：TW200526783A
公开(公告)日：2005-08-16
申请号：TW093133068
申请日：2004-10-29
申请人：輝瑞產品公司 PFIZER PRODUCTS INC.
发明人：尚恩克里維布雷克 BLACK, SHAWN CLIVE , 俄爾麥克吉比斯 GIBBS, EARL MICHAEL , 約翰道格拉斯麥尼希 MCNEISH, JOHN DOUGLAS
IPC分类号： C12N , A01K
CPC分类号： C12N15/1137 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K31/505 , C12N5/0606 , C12N9/16 , C12N15/8509 , C12N2510/00 , C12N2517/00
摘要：本發明係關於減少動物體重及／或體脂肪之方法，例如用於治療過重或肥胖病患(例如人類或伴侶動物)，或作為產製糧食動物(例如牛、雞或豬)中產製瘦肉之方法，及關於投予PDE9抑制劑治療飲食障礙(例如暴食行為或暴食症)之需要此等治療病患之方法。本發明特徵亦在於進一步研究PDE9功能之生物學工具，例如具有PDE9基因中斷之基因改造老鼠及動物細胞。
简体摘要：本发明系关于减少动物体重及／或体脂肪之方法，例如用于治疗过重或肥胖病患(例如人类或伴侣动物)，或作为产制粮食动物(例如牛、鸡或猪)中产制瘦肉之方法，及关于投予PDE9抑制剂治疗饮食障碍(例如暴食行为或暴食症)之需要此等治疗病患之方法。本发明特征亦在于进一步研究PDE9功能之生物学工具，例如具有PDE9基因中断之基因改造老鼠及动物细胞。

92. 发明申请

WO2017049178A1 METHOD OF MAKING TRABECULAR BONE 审中-公开
标题翻译：制造骨质疏松的方法
公开(公告)号：WO2017049178A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/052277
申请日：2016-09-16
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , UNIVERSITY OF CHICAGO , WASHINGTON UNIVERSITY IN ST. LOUIS
发明人： BLAIR, Harry, Colbert , LARROUTURE, Quitterie , TOURKOVA, Irina, L. , NELSON, Deborah, J. , SCHLESINGER, Paul
IPC分类号： C12N5/071 , C12N5/077 , C12N15/113
CPC分类号： C12N5/0654 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2510/00 , C12N2517/00
摘要： Provided herein are methods of producing trabecular bone material, such as trabecular bone or trabecular bone matrix and cells useful in preparing the trabecular bone material.
摘要翻译：本文提供了生产小梁骨材料的方法，例如小梁骨或小梁骨基质和可用于制备骨小梁骨材料的细胞。

93. 发明申请

WO2016075697A1 FUNCTIONAL SEX-REVERSAL OF DECAPOD CRUSTACEAN FEMALES 审中-公开
标题翻译：功能性反转的DECAPOD CRUSTACEAN FEMALES
公开(公告)号：WO2016075697A1
公开(公告)日：2016-05-19
申请号：PCT/IL2015/051096
申请日：2015-11-13
申请人： ENZOOTIC HOLDINGS LTD.
发明人： SHECHTER, Assaf , ROSEN, Ohad , SAGI, Amir
IPC分类号： A01K61/00 , A01K67/033 , C12N15/873 , C12N5/07 , C12N5/16
CPC分类号： C12N5/0601 , A01K67/033 , A01K2227/70 , A01K2267/02 , C12N5/0683 , C12N2500/02 , C12N2510/00 , C12N2517/00
摘要： The present invention provides a primary cell culture which combines a cell culture medium and cells derived from a hypertrophied androgenic gland (AG) of a decapod crustacean. The invention also provides methods for obtaining an all-female progeny by initially injecting/transplanting the primary cell culture to a genetic-female to obtain a male-Neo-male.
摘要翻译：本发明提供了将细胞培养基与来源于十足甲状腺素的肥大雄激素腺（AG）的细胞组合的原代细胞培养物。本发明还提供了通过将初级细胞培养物初次注射/移植到遗传雌性以获得雄性新雄性来获得全雌性后代的方法。

94. 发明申请

WO2015200805A2 METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATIONS AND METHODS OF USE 审中-公开
标题翻译：用于目标基因改变的方法和组合物及其使用方法
公开(公告)号：WO2015200805A2
公开(公告)日：2015-12-30
申请号：PCT/US2015038001
申请日：2015-06-26
申请人： REGENERON PHARMA
发明人： FRENDEWEY DAVID , DROGUETT GUSTAVO , GAGLIARDI ANTHONY , KUNO JUNKO , AUERBACH WOJTEK , VALENZUELA DAVID M
IPC分类号： C12N5/0735
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2217/075 , A01K2227/105 , A01K2267/02 , A01K2267/0393 , C12N5/0606 , C12N15/907 , C12N2500/60 , C12N2517/00
摘要： Methods and compositions are provided for generating targeted genetic modifications on the Y chromosome or a challenging target locus. Compositions include an in vitro culture comprising an XY pluripotent and/or totipotent animal cell (i.e., XY ES cells or XY iPS cells) having a modification that decreases the level and/or activity of an Sry protein; and, culturing these cells in a medium that promotes development of XY F0 fertile females. Such compositions find use in various methods for making a fertile female XY non-human mammal in an F0 generation.
摘要翻译：提供了用于在Y染色体上或挑战性目标基因座上产生靶向遗传修饰的方法和组合物。组合物包括具有降低Sry蛋白的水平和/或活性的修饰的XY多能和/或全能动物细胞（即，XYES细胞或XY iPS细胞）的体外培养物; 并且在促进XY F0肥沃雌性发育的培养基中培养这些细胞。这样的组合物可用于在F0代中制备可育雌性XY非人哺乳动物的各种方法。

95. 发明申请

WO2010026277A1 MODELO ANIMAL PARA EL ESTUDIO DE LA ANGIOGÉNESIS Y LINFOANGIOGÉNESIS IN VIVO 审中-公开
标题翻译：用于研究血管生成和血管生成的动物模型
公开(公告)号：WO2010026277A1
公开(公告)日：2010-03-11
申请号：PCT/ES2009/070372
申请日：2009-09-08
申请人： FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III , ORTEGA JIMENEZ, Sagrario , MARTINEZ CORRAL, Ines , OLMEDA CASADOME, Daniel , DIEGUEZ HURTADO, Rodrigo
发明人： ORTEGA JIMENEZ, Sagrario , MARTINEZ CORRAL, Ines , OLMEDA CASADOME, Daniel , DIEGUEZ HURTADO, Rodrigo
IPC分类号： C12N15/85 , A01K67/027 , C12N5/10
CPC分类号： C07K14/71 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/0368 , A01K2267/0375 , A01K2267/0393 , C07K14/43595 , C12N9/0069 , C12N15/8509 , C12N2510/00 , C12N2517/00 , C12N2840/203
摘要： La presente invención se encuentra dentro del campo de Ia biología molecular y Ia biotecnología, y se refiere a un mamífero no humano modificado genéticamente cuyas células integran Ia construcción IRES- EGFP-Luciferasa en Ia región 3'UTR del gen Flt4, y que es capaz de reportar Ia expresión del gen Flt4 con un patrón idéntico al de Ia expresión del receptor VEGFR-3. Dicho mamífero no humano es útil en el estudio y evaluación de Ia progresión de las enfermedades que cursan con linfoangiogénesis, angiogénesis y/o inflamación, así como para el ensayo de fármacos dirigidos a modular estos procesos, y por tanto, para el desarrollo de terapias antiangiogénicas, antitumorales y antimetastásicas.
摘要翻译：本发明适用于分子生物学和生物技术领域，涉及一种遗传修饰的非人类哺乳动物，其细胞在Flt4基因的3'UTR区域中并入IRES-EGFP-荧光素酶构建体，其能够以与VEGFR-3受体表达相同的模式报告Flt4基因的表达。所述非人哺乳动物可用于研究和评估涉及淋巴管生成，血管发生和/或炎症的疾病的进展，并且还用于测试旨在调节所述过程并因此用于发展抗血管生成，抗肿瘤和抗转移疗法。

96. 发明申请

WO2005120222A3 GENETICALLY MODIFIED NON-HUMAN MAMMALS AND CELLS 审中-公开
标题翻译：遗传修饰的非人类哺乳动物和细胞
公开(公告)号：WO2005120222A3
公开(公告)日：2006-02-02
申请号：PCT/GB2005050086
申请日：2005-06-08
申请人： UNIV LEICESTER , FUJITA TEIZO , SCHWAEBLE HANS-WILHELM , STOVER CORDULA MARGARET
发明人： FUJITA TEIZO , SCHWAEBLE HANS-WILHELM , STOVER CORDULA MARGARET
IPC分类号： C12N15/85 , A01K67/027 , A61K38/00 , C07K16/40 , C12N5/10 , C12N9/64
CPC分类号： A01K67/0278 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K38/00 , C07K16/2851 , C07K16/40 , C07K2317/14 , C12N9/6424 , C12N15/8509 , C12N2510/00 , C12N2517/00 , C12N2800/30
摘要： Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein Map 19; such mammals may also lack MASP-2.
摘要翻译：描述了缺乏甘露聚糖结合凝集素相关丝氨酸蛋白酶MASP-2的遗传修饰的哺乳动物，以及用于其生产的方法和构建体。这样的哺乳动物可用作补体系统紊乱的模型，以及鉴定这种病症的治疗。还描述了缺乏相关蛋白质图19的哺乳动物; 这样的哺乳动物也可能缺乏MASP-2。

97. 发明申请

WO2005111075A2 CRYSTAL STRUCTURE OF FACTOR VAi AND METHOD FOR IDENTIFYING BLOOD FACTOR Va MODULATORS 审中-公开
标题翻译：因子VAi的晶体结构和鉴定血液因子Va调节剂的方法
公开(公告)号：WO2005111075A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/017406
申请日：2005-05-18
申请人： UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE , EVERSE, Stephen, J. , ADAMS, Ty, E. , HOCKIN, Matthew, F. , MANN, Kenneth, G.
发明人： EVERSE, Stephen, J. , ADAMS, Ty, E. , HOCKIN, Matthew, F. , MANN, Kenneth, G.
IPC分类号： C07K14/745
CPC分类号： C12Q1/56 , A61K38/00 , C07K14/745 , C12N2517/00 , G01N33/86 , G01N2333/7456 , G01N2500/00
摘要： The present invention shows the crystal structure of protein C inactivated factor Va (A1.A3.-C1-C2) that depicts a novel domain arrangement. The newly disclosed orientation has implications for binding to membranes essential for function. A high-affinity calcium binding site and a copper binding site have been identified, neither of which show a direct involvement in chain association. This structure represents the largest physiologically relevant fragment of factor Va solved to date and provides a new scaffold for generation of models of coagulation factors.
摘要翻译：本发明显示了描绘新颖结构域的蛋白C失活因子Va（A1.A3.-C1-C2）的晶体结构。新公开的方向对结合功能必不可少的膜有影响。已经鉴定了高亲和力钙结合位点和铜结合位点，这两者都不直接参与链结合。该结构代表迄今为止解决的因子Va的最大的生理相关片段，并提供用于产生凝血因子模型的新支架。

98. 发明申请

WO03024200A8 PRODUCTION OF TRANSGENIC BIRDS USING STAGE X PRIMORDIAL GERM CELLS 审中-公开
标题翻译：使用阶段X原始细胞生产转基因生物
公开(公告)号：WO03024200A8
公开(公告)日：2004-05-06
申请号：PCT/US0230195
申请日：2002-09-23
申请人： AVIGENICS INC , SUTRAVE PRAMOD
发明人： SUTRAVE PRAMOD
IPC分类号： A01K67/027 , C12N5/074 , C12N15/873 , A01K67/00
CPC分类号： A01K67/0275 , A01K2217/05 , C12N5/0611 , C12N15/873 , C12N2510/02 , C12N2517/00
摘要： The present invention relates to methods for isolating primordial germ cells (PGCs) from the blastoderm of a stage X avian embryo. The present invention further relates to methods for producing a transgenic bird by modifying the isolated PGCs, such that the cells incorporate at least one transgene into their genetic material; transferring the modified PGCs into a suitable recipient, such as a blastoderm of an avian embryo, hatching the embryo; and testing for the presence of the transgene or expression of the protein encoded by the transgene.
摘要翻译：本发明涉及从X级禽胚胎的胚盘分离原始生殖细胞（PGCs）的方法。本发明还涉及通过修饰分离的PGC来生产转基因鸟的方法，使得细胞将至少一种转基因掺入其遗传物质中; 将修饰的PGC转移到合适的接受者，例如禽胚的胚盘，孵化胚胎; 并测试转基因的存在或由转基因编码的蛋白质的表达。

99. 发明申请

WO2002077175A2 METHOD FOR GENERATING CLONED ANIMALS USING CHROMOSOME SHUFFLING 审中-公开
标题翻译：使用染色体沉淀法生成克隆动物的方法
公开(公告)号：WO2002077175A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008842
申请日：2002-03-25
申请人： ADVANCED CELL TECHNOLOGY, INC. , WEST, Michael, D. , CIBELLI, Jose
发明人： WEST, Michael, D. , CIBELLI, Jose
IPC分类号： C12N
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/101 , C12N15/873 , C12N15/877 , C12N15/8771 , C12N2517/00 , C12N2517/04
摘要： The present invention concerns the use of chromosomal replacement techniques in the context of producing cloned and transgenic animals, in order to correct chromosome abnormalities or alter autosomal genotypes, and provide for novel breeding pairs by replacing the sex chromosome in animals to be cloned. Replacement of a sex chromosome, or an X or Y chromosome, will result in animals that are autosomally isogenic and sexually non-isogenic (AISN), with ''autosomally isogenic'' meaning that the paired sets of autosomes (non-sex chromosomes) in each animal are isogenic or identical. Also included in the invention are animals that are both ''autosomally'' and ''allelically'' isogenic whereby each particular pair of chromosomes is internally isogenic or identical within a single animal as well as between animals. Such animals are particularly useful in generating a line of cloned mammals using sexual reproduction, without having to undergo nuclear transfer in order to propagate cloned animals.
摘要翻译：本发明涉及在产生克隆和转基因动物的背景下使用染色体替代技术，以便校正染色体异常或改变常染色体基因型，并通过替代待克隆的动物中的性染色体来提供新的育种对。更换性染色体或X或Y染色体将导致常染色体同源异体和性别非同基因（AISN）的动物，具有“常染色体同源基因”，这意味着成对的常染色体组（非性染色体）在每只动物中都是同基因的或相同的。本发明还包括既“常染色体”和“等位性”同源的动物，由此每一个特定的一对染色体在单个动物内部以及动物之间内部是同基因的或相同的。这样的动物特别可用于使用有性繁殖产生一系列克隆的哺乳动物，而不必经受核转移以繁殖克隆的动物。

100. 发明申请

WO0190313A3 METHODS FOR ASSAYING GENE IMPRINTING AND METHYLATED CpG ISLANDS 审中-公开
标题翻译：用于测定基因印迹和甲基化CpG岛的方法
公开(公告)号：WO0190313A3
公开(公告)日：2002-05-16
申请号：PCT/US0116253
申请日：2001-05-22
申请人： UNIV JOHNS HOPKINS , FEINBERG ANDREW , STRICHMAN ALMASHANU LIORA , JIANG SHAN
发明人： FEINBERG ANDREW , STRICHMAN-ALMASHANU LIORA , JIANG SHAN
IPC分类号： A01K67/027 , A61P35/00 , C12N5/074 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , C12N5/06 , C12N15/11 , G01N33/50
CPC分类号： C12N5/0611 , C12N2501/115 , C12N2501/125 , C12N2501/235 , C12N2501/385 , C12N2502/13 , C12N2503/00 , C12N2503/02 , C12N2510/00 , C12N2517/00 , C12Q1/6827 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154
摘要： Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for genomic imprinting using pluripotent 8.5 d.p.c. mouse embryonic germ (EG) cell lines derived from an interspecific cross. We find that allele-specific imprinted gene expression has been lost in these cells. However, partial restoration of allele-specific silencing can occur for some imprinted genes after in vitro differentiation of EG cells into somatic cell lineages, indicating the presence of a gametic memory that is separable from allele-specific gene silencing. We have also generated a library containing most methylated CpG islands. A subset of these clones was analyzed and revealed a subdivision of methylated CpG islands into 4 distinct subtypes: CpG islands belonging to high copy number repeat families; unique CpG islands methylated in all tissues; unique methylated CpG islands that are unmethylated in the paternal germline; and unique CpG islands methylated in tumors. This approach identifies a methylome of methylated CpG islands throughout the genome.
摘要翻译：基因印记是起源依赖基因沉默的亲本，其涉及在种系中标记等位基因和在后代的体细胞中的差异表达。印迹基因和异常印记涉及发育，人类疾病和胚胎干细胞移植。我们已经建立了使用多能8.5 d.p.c的基因组印迹模型系统。来自种间交叉的小鼠胚胎胚芽（EG）细胞系。我们发现在这些细胞中已经丢失了等位基因特异性印记的基因表达。然而，在体外将EG细胞分化为体细胞谱系后，一些印迹基因可能部分恢复等位基因特异性沉默，表明存在可与等位基因特异性基因沉默分离的配子记忆。我们还生成了一个包含大多数甲基化CpG岛的文库。分析了这些克隆的一个子集，并揭示了甲基化CpG岛分为4个不同的亚型：属于高拷贝数重复家族的CpG岛; 所有组织中独特的CpG岛甲基化; 在父系种系中未甲基化的独特的甲基化CpG岛; 和独特的CpG岛在肿瘤中甲基化。该方法鉴定整个基因组中的甲基化CpG岛的甲基化。

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