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91. 发明公开

KR1020050045770A 메트릭스 메탈로프로테이나제-9의 발현과 파골세포 형성을억제하는 에피갈로카테친 갈레이트 无效
标题翻译： EPIGALLOCATECHIN GALLATE抑制MMP-9的表达和骨质疏松的形成
公开(公告)号：KR1020050045770A
公开(公告)日：2005-05-17
申请号：KR1020030079959
申请日：2003-11-12
申请人： 윤정호 , 최성호
发明人： 윤정호 , 최성호
IPC分类号： A61K31/353 , A61P1/02
CPC分类号： A61K31/353 , A61K38/4886 , A61K2300/00 , C07D311/74 , Y10S514/90
摘要： 본원발명은 MMP-9(matrix metalloproteinase 9)의 활성을 억제하는 에피갈로카테친 갈레이트(EGCG)에 관한 것이다. 또한, 본원발명은 파골세포의 형성을 억제하는 에피갈로카테친 갈레이트(EGCG)에 관한 것이다. 또한, 본원발명은 에피갈로카테친 갈레이트(EGCG)를 함유하는 치주질환 치료용 약학 조성물에 관한 것이다.

92. 发明公开

KR1020020018102A 크로만 카르복실산의 제조 방법 无效
标题翻译：生产氯羧酸的方法
公开(公告)号：KR1020020018102A
公开(公告)日：2002-03-07
申请号：KR1020010052440
申请日：2001-08-29
申请人： 주식회사 쿠라레
发明人： 하야시바라다츠히코 , 사토준코 , 도리하라마사히로
IPC分类号： C07D311/58
CPC分类号： C07D311/74
摘要： PURPOSE: Provided are a method for producing chroman-carboxylic acid and a novel intermediate useful for the synthesis of chroman-carboxylic acid. The chroman-carboxylic acid is useful as, for example, a starting material of pharmaceutical products showing beta 3-adrenoreceptor activity, a starting material of pharmaceutical products having alpha 2-antagonism, and a starting material for the synthesis of a fungicide. CONSTITUTION: The method for producing a chroman-carboxylic acid of the formula(2), wherein R3 is a hydrogen atom or an alkyl group, comprises reacting a dialkylchroman-carboxylic acid of the formula(1), wherein R1 and R2 are each independently an alkyl group and R3 is as defined above, with an aromatic hydrocarbon in the presence of a Lewis acid.
摘要翻译：目的：提供色满酐羧酸的制备方法和可用于合成色满羧酸的新型中间体。色满羧酸可用作例如显示β3肾上腺素受体活性的药物的原料，具有α2-拮抗作用的药物的起始原料和用于合成杀真菌剂的原料。构成：式（2）的色满酐羧酸的制备方法，其中R3是氢原子或烷基，包括使式（1）的二烷基苯并二氢吡喃羧酸与其中R1和R2各自独立地烷基和R 3如上所定义，与路易斯酸存在下的芳烃。

93. 发明公开

US20230257679A1 ODORANTS AND COMPOSITIONS COMPRISING ODORANTS 审中-公开
公开(公告)号：US20230257679A1
公开(公告)日：2023-08-17
申请号：US18014465
申请日：2021-07-30
申请人： S H KELKAR AND COMPANY LIMITED
发明人： Avdhoot D. VELANKAR , Kedar Ramesh VAZE , Mayur S. MUKIM , Vivek S. GAWARE
IPC分类号： C11B9/00 , C07D311/74 , C07D307/79
CPC分类号： C11B9/0076 , C07D311/74 , C07D307/79 , C11B9/008
摘要： The present invention relates to substituted hexahydro-5H-chromen-5-one and/or substituted tetrahydrobenzofuran-4(2H)-one derivatives which are useful as fragrance or flavor materials.

94. 发明授权

US09957246B2 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same 有权
公开(公告)号：US09957246B2
公开(公告)日：2018-05-01
申请号：US15374281
申请日：2016-12-09
申请人： Zynerba Pharmaceuticals, Inc.
发明人： Audra Lynn Stinchcomb , Miroslaw Jerzy Golinski , Dana Carmel Hammell , Jeffery Lynn Howard
IPC分类号： A61K31/35 , C07D311/80 , A61K47/10 , A61K31/352 , A61K9/70 , A61K9/00
CPC分类号： C07D311/80 , A61K9/0014 , A61K9/7023 , A61K31/352 , A61K47/10 , C07D311/74 , C07D405/12 , C07F9/65522
摘要： Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the transdermal administration of a Δ9-THC prodrug for treating and preventing diseases and/or disorders.

95. 发明授权

US09745280B2 Compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient 有权
公开(公告)号：US09745280B2
公开(公告)日：2017-08-29
申请号：US15216838
申请日：2016-07-22
申请人： SNU R&DB FOUNDATION
发明人： Young-Ger Suh , Hongchan An , Seungbeom Lee , Kyu-Won Kim , Ho-Young Lee , Sang Geon Kim , Jeong Hun Kim
IPC分类号： C07D407/06 , C07D311/74 , C07D311/58 , C07D493/12 , C07D493/04 , C07D493/14 , C07D407/10
CPC分类号： C07D311/58 , C07D311/74 , C07D407/06 , C07D407/10 , C07D493/04 , C07D493/12 , C07D493/14
摘要： A compound inhibiting Hsp90 and a pharmaceutical composition including the same as an active ingredient are described, which compound is represented by formula 2 and suppresses the expression of Hsp90, inhibits the accumulation of HIF-1α, the Hsp90 client protein, and efficiently inhibits the activation of VEGF. The compound displays low cytotoxicity and can be effectively used as an active ingredient of an anti-cancer agent, a diabetic retinopathy treating agent, and an anti-arthritic agent.

96. 发明授权

US09718800B2 Chromenone derivatives 有权
公开(公告)号：US09718800B2
公开(公告)日：2017-08-01
申请号：US15079633
申请日：2016-03-24
申请人： AstraZeneca AB
发明人： Bernard Christophe Barlaam , Sebastien Louis Degorce , Christine Marie Paul Lambert-Van Der Brempt , Remy Robert Morgentin , Patrick Ple
IPC分类号： C07D311/74 , C07D405/06 , C07D311/22 , A61K31/5377 , A61K31/277 , A61K31/337 , A61K45/06 , C07D413/06
CPC分类号： C07D311/74 , A61K31/277 , A61K31/337 , A61K31/5377 , A61K45/06 , C07D311/22 , C07D405/06 , C07D413/06
摘要： The invention concerns chromenone derivatives of Formula I or a pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, R6, R7, R8, n and R9 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

97. 发明授权

US09695143B2 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same 有权
公开(公告)号：US09695143B2
公开(公告)日：2017-07-04
申请号：US14620016
申请日：2015-02-11
申请人： Zynerba Pharmaceuticals, Inc.
发明人： Audra Lynn Stinchcomb , Miroslaw Jerzy Golinski , Dana Carmel Hammell , Jeffrey Lynn Howard
IPC分类号： A61K31/35 , A61K31/665 , C07D311/80 , C07D311/74 , A61K31/352 , C07D405/12 , C07F9/655
CPC分类号： C07D311/80 , A61K9/0014 , A61K9/7023 , A61K31/352 , A61K47/10 , C07D311/74 , C07D405/12 , C07F9/65522
摘要： Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the transdermal administration of a Δ9-THC prodrug for treating and preventing diseases and/or disorders.

98. 发明授权

US09588423B2 Acid diffusion control agent, radiation-sensitive resin composition, resist pattern-forming method, compound, and production method 有权
标题翻译：酸扩散控制剂，辐射敏感树脂组合物，抗蚀剂图案形成方法，化合物和制备方法
公开(公告)号：US09588423B2
公开(公告)日：2017-03-07
申请号：US14541946
申请日：2014-11-14
申请人： JSR CORPORATION
发明人： Hayato Namai , Norihiko Ikeda
IPC分类号： G03F7/039 , C07C227/08 , C07C229/12 , G03F7/004 , C07D307/94 , C07D215/06 , C07H9/04 , C07D493/10 , C07D211/14 , C07D311/74 , C07D223/10 , C07D405/06 , C07D411/12 , C07C229/08 , C07D493/04 , C07D277/60 , C07D295/15 , C07D307/20 , C07D215/04 , C07D295/108
CPC分类号： G03F7/0045 , C07C227/08 , C07C229/08 , C07C229/12 , C07C2103/74 , C07C2603/74 , C07D211/14 , C07D215/04 , C07D215/06 , C07D223/10 , C07D277/60 , C07D295/108 , C07D295/15 , C07D307/00 , C07D307/20 , C07D307/94 , C07D311/74 , C07D317/24 , C07D327/04 , C07D405/06 , C07D411/12 , C07D493/04 , C07D493/10 , C07H9/04 , G03F7/038 , G03F7/0397 , G03F7/091 , G03F7/11 , G03F7/162 , G03F7/168 , G03F7/2041 , G03F7/322 , G03F7/38 , G03F7/40
摘要： An acid diffusion control agent includes a compound represented by a formula (1), a compound represented by a formula (2) or both thereof. R1 represents a hydrocarbon group comprising a monovalent alicyclic structure, or the like. R2 and R3 each independently represent a monovalent hydrocarbon group, or the like. R4 and R5 each independently represent a monovalent hydrocarbon group, or the like. R6 and R7 each independently represent a monovalent hydrocarbon group, or the like. R8 represents a monocyclic heterocyclic group together with the ester group and with the carbon atom. n is an integer of 1 to 6. R9 represents a monovalent hydrocarbon group, or the like. R10 represents a monovalent hydrocarbon group having 1 to 10 carbon atoms. R11 and R12 each independently represent a monovalent hydrocarbon group, or the like. R13 and R14 each independently represent a monovalent hydrocarbon group, or the like.
摘要翻译：酸扩散控制剂包括由式（1）表示的化合物，由式（2）表示的化合物或其二者。 R1表示包含一价脂环族结构的烃基等。 R2和R3各自独立地表示一价烃基等。 R4和R5各自独立地表示一价烃基等。 R6和R7各自独立地表示一价烃基等。 R8表示与酯基和碳原子一起的单环杂环基。 n为1〜6的整数.R 9表示一价烃基等。 R10表示碳原子数为1〜10的一价烃基。 R 11和R 12各自独立地表示一价烃基等。 R 13和R 14各自独立地表示一价烃基等。

99. 发明授权

US09518038B2 Condensation product of theanine derivative and carboxylic acid coumarin derivative, its intermediate, preparation method and use thereof 有权
标题翻译：茶氨酸衍生物和羧酸香豆素衍生物的缩合产物，其中间体，其制备方法和用途
公开(公告)号：US09518038B2
公开(公告)日：2016-12-13
申请号：US14431707
申请日：2013-09-25
申请人： SHANDONG YINGDONG YINGHAO BIOTECHNOLOGY, INC.
发明人： Guoying Zhang , Ying Zhang , Benhao Wu , Guohua Zhang
IPC分类号： A01N43/16 , A61K31/355 , A61K9/127 , C07D311/12 , C07C237/06 , A61K31/223 , A61K31/37 , C07D311/74 , C07C229/22
CPC分类号： C07D311/12 , A61K31/223 , A61K31/37 , A61K49/0039 , C07B2200/07 , C07C229/22 , C07C237/06 , C07D311/74
摘要： The present invention relates to a compound as represented by formula (I), which is a condensation product of a theanine derivative and a carboxylic acid coumarin derivative, compounds as represented by formula (II) and formula (III), both of which are intermediates of the condensation product, a method for preparing these compounds, a pharmaceutical composition comprising the compounds, and a use thereof in preparing a medicament for prevention and treatment of tumors, inflammation, cardiovascular diseases, immune deficiency diseases and the like. Wherein, (Ia)R═CH3R1═HR2═H (Ib)R═CH2CH3R1═HR2═H (Ic)R═CH2CH3R1═ClR2═H (Id)R═CH2CH3R1═BrR2═H (Ie)R═CH2CH3R1═FR2═H (If)R═CH2CH3R1═NO2R2═H (Ig)R═CH2CH3R1═ClR2═Cl (Ih)R═CH2CH3R1═BrR2═Br (Ii)R═CH2CH3R1═NH2R2═H Wherein, (IIa)R═CH3 (IIb)R═CH2CH3 Wherein, (IIIc)R1═ClR2═H (IIId)R1═BrR2═H (IIIe)R1═FR2═H (IIIf)R1═NO2R2═H (IIIg)R1═ClR2═Cl (IIIh)R1═BrR2═Br
摘要翻译：本发明涉及由式（I）表示的化合物，其是茶氨酸衍生物和羧酸香豆素衍生物的缩合产物，由式（II）和式（III）表示的化合物，它们都是中间体的缩合产物，制备这些化合物的方法，包含该化合物的药物组合物及其在制备用于预防和治疗肿瘤，炎症，心血管疾病，免疫缺陷疾病等的药物中的用途。其中，其中，其中

100. 发明申请

US20150376224A1 USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS 审中-公开
标题翻译：用于实施催化反应的特殊金属累积植物获得的组合物的使用
公开(公告)号：US20150376224A1
公开(公告)日：2015-12-31
申请号：US14769246
申请日：2014-02-21
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
发明人： Claude GRISON , Vincent ESCANDE
IPC分类号： C07H19/20 , B01J27/122 , B01J27/06 , B01J21/16 , B01J37/00 , B01J37/08 , C07C1/32 , C07D239/22 , C07D493/14 , C07C23/38 , C07D243/00 , C07D311/74 , C07D311/92 , C07D311/94 , C07C209/24 , B01J27/128
CPC分类号： C07H19/20 , B01J21/16 , B01J23/06 , B01J23/72 , B01J23/755 , B01J23/8892 , B01J27/053 , B01J27/06 , B01J27/122 , B01J27/128 , B01J27/20 , B01J31/00 , B01J35/002 , B01J37/009 , B01J37/06 , B01J37/082 , B01J37/084 , B01J38/74 , B09C1/105 , C02F3/327 , C02F2101/006 , C02F2101/20 , C07B37/10 , C07C1/321 , C07C23/38 , C07C209/24 , C07D239/22 , C07D243/00 , C07D311/74 , C07D311/92 , C07D311/94 , C07D493/14 , C07H21/00 , Y02P20/584
摘要： The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.
摘要翻译：使用金属积聚植物实现化学反应，特别是催化反应。

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