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91. 发明公开

EP0946505A1 FLUORINATED ALKYLTHIOCYANATE PROCESS 失效
标题翻译：用于生产氟化烷基硫氰酸
公开(公告)号：EP0946505A1
公开(公告)日：1999-10-06
申请号：EP97950908.0
申请日：1997-12-10
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： JACOBSON, Stephen, Ernest
IPC分类号： B01J31 , C07B61 , C07C331
CPC分类号： C07C331/10 , C07C331/04 , C07C331/12 , C07C331/14
摘要： A process for the preparation of a thiocyanate of the Formula (II): Rf-Am-(CH2)n-SCN wherein Rf is a C2-C20 perfluoroalkyl radical, or a C5-C38 perfluoroalkyl radical having at least one ether oxygen atom; n is 1 to 3; m is 0 or 1; A is O, S, CO2, N(R1)R2, CON(R1)R2, SO2N(R1)R2 or (OCH2CHR3)aO; wherein a is 3 to about 15; R1 is H or alkyl radical of 1 to about 4 carbon atoms; R2 is C1-C12alkylene; and R3 is H or CH2Cl; said process comprising reacting a fluorinated iodide of the Formula (I): Rf-Am-(CH2)n-I wherein Rf, A, m and n are as defined above, with a thiocyanate salt M+(SCN)- wherein M is sodium or potassium, in the presence of a catalyst comprising a quaternary ammonium salt of the Formula (R¿4?)3(R5)N?+Y-¿ wherein R¿4? is butyl; R5 is methyl or butyl; and Y is Cl, Br, I, or HSO4; to yield the fluorinated thiocyanate of Formula (II) as defined above is disclosed.

92. 发明公开

EP0470873A1 Nouveaux composés (méth)acryliques porteurs de fonction thiocyanate, leur procédé de préparation et leur application à l'obtention de nouveaux polymères 失效
标题翻译：硫氰酸基的（甲基）丙烯酸酯，它们的制备和它们在新聚合物的制备中使用的过程。
公开(公告)号：EP0470873A1
公开(公告)日：1992-02-12
申请号：EP91401843.7
申请日：1991-07-04
申请人： ELF ATOCHEM S.A.
发明人： Berthe, Marie-Christine , Caubere, Paul , Fort, Yves
IPC分类号： C07C331/10 , C07D251/38 , C08F28/00
CPC分类号： C07C331/10 , C08F20/38
摘要： Ces composés sont choisis parmi ceux de formule :
et ceux de formule
(n = 2-20 ; R = H, CH₃ ou CHOHR′ ou R′ = alkyle linéaire ou ramifié le cas échéant porteurs de substituants hydroxyles, alcoxy ou esters, alcényles linéaires, ramifiés ou cycliques, aryles le cas échéant porteurs de substituants halogénés, nitrés ou alcoxy, hétérocycles insaturés, alkylaryles et arylalkyles, R ≠ CH₃ dans la formule (I) si simultanément n = 2 ou 4).
摘要翻译： ; R = H“其中R” =直链或支链烷基，其任选携带羟基，烷氧基或酯CH 3或CHOHR 和那些式（N = 2-20的：这些化合物是从下式的那些选择取代基的直链，支链或环状链烯基，芳基任选带有卤原子，硝基或烷氧基取代的，不饱和的杂环，烷基芳基的芳基烷基和，R NotEqual CH3在式（I）同时，如果n = 2或4）。

93. 发明公开

EP0203608A1 Acrylsäureester und Fungizide, die diese Verbindungen enthalten 失效
标题翻译：丙烯酸酯和含有这些化合物的杀真菌剂。
公开(公告)号：EP0203608A1
公开(公告)日：1986-12-03
申请号：EP86107332.8
申请日：1986-05-30
申请人： BASF Aktiengesellschaft
发明人： Schirmer, Ulrich, Dr. , Karbach, Stefan, Dr. , Pommer, Ernst-Heinrich, Dr. , Ammermann, Eberhard, Dr. , Steglich, Wolfgang, Prof. Dr. , Schwalge, Barbara Agnes Maria , Anke, Timm, Prof. Dr.
IPC分类号： C07C69/734 , A01N37/38
CPC分类号： C07C255/00 , A01N37/38 , C07C205/35 , C07C205/56 , C07C309/66 , C07C311/16 , C07C317/22 , C07C323/19 , C07C331/10
摘要： Acrylsäureester der allgemeinen Formel
in der R' und R 2 Alkyl bedeuten,

X Wasserstoff, Alkyl, Halogen, Alkoxy, Halogenalkyl, Cyano oder Nitro bedeutet,
W einen gegebenenfalls substituierten, gegebenenfalls ungesättigten C 1 -C 10 -Alkylenrest bedeutet,
Y Wasserstoff, Alkyl, Halogenalkyl, Alkoxyalkyl, Cycloalkyl, Aralkyl, Aryl, Aryloxy, Halogen, eine gegebenenfalls substituierte an den Benzolrest annellierte C 4 H 4 -Kette, Alkoxy, Halogenalkoxy, Alkylthio, Thiocyanato, Cyano, NO 2 , Aralkyloxy,
bedeutet, wobei R' und R" jeweils unabhängig voneinander Wasserstoff, Alkyl, Alkoxy, Alkylthio, Cycloalkyl oder gegebenenfalls substituiertes Phenyl bedeuten
und n die Zahlen 1 bis 4 bedeutet und diese enthaltende Fungizide.
摘要翻译：是指式其中R 1和R 2是烷基的丙烯酸酯中，X为氢，烷基，卤素，烷氧基，卤代烷基，氰基或硝基，W为任选取代是指任选地不饱和的C 1 -C 10亚烷基，Y是氢，烷基，卤代烷基，烷氧基烷基，环烷基，芳烷基，芳基，芳氧基，卤素，任选取代的稠合到苯环自由基C4H4链，烷氧基，卤代烷氧基，烷硫基，氰硫基，氰基，NO 2，芳烷氧基，其中R“和R“ 各自独立地是氢，烷基，烷氧基，烷硫基，环烷基或任选取代的苯基和n是1至4，和含有这些化合物的杀真菌剂。

94. 发明公开

EP0190685A2 Heterocyclic amides 失效
标题翻译：杂环酰胺。
公开(公告)号：EP0190685A2
公开(公告)日：1986-08-13
申请号：EP86101300.1
申请日：1986-01-31
申请人： G.D. Searle & Co.
发明人： Mueller, Richard August , Partis, Richard Allen
IPC分类号： C07D295/18 , C07D207/16
CPC分类号： C07D295/185 , C07C319/02 , C07C331/10 , C07D207/16 , C07C323/20 , C07C323/52
摘要： The compounds of this invention are heterocyclic amides represented by the formula:
wherein: R 1 and R 2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a
group wherein q, r and t are independently an integer of from 1 to 8 provided that q + r + t is equal to or less than 10; Y is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene, and R 3 is a heterocyclic amine represented by the formula
wherein R 4 is selected from the group consisting of hydrogen, lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, carboxyl or carboxyloweralkyl; X is selected from the group consisting of N-R 4 , 0 and CH 2 ; m is 2 or 3; n is 2 or 3 when X is O or N-R 4 , and n is 1 to 3 when X is CH 2 ; p is 0 to 2; and the pharmaceutically acceptable salts thereof. The compounds are anti-inflammatory and anti-allergy agents.
摘要翻译：本发明的化合物是由下式表示的杂环酰胺：其中：R1和R2是卤素，苯基，取代的苯基和基团中相同或不同的成员，其中q，r和t 独立地为1〜8的整数，条件是q + r + t等于或小于10; Y是硫代，亚磺酰基或磺酰基; Alk是直链或支链低级亚烷基，R3是由式CHEM表示的杂环胺，其中R4选自氢，低级烷基，苯基，取代的苯基，苄基，取代的苄基，羧基或羧基低级烷基; X选自N-R 4，O和CH 2; m为2或3; 当X为O或N-R 4时，n为2或3，当X为CH 2时，n为1至3; p为0〜2; 及其药学上可接受的盐。这些化合物是抗炎和抗过敏剂。

95. 发明申请

US20160214932A1 ALKYL PHENYL SULFIDE DERIVATIVE AND PEST CONTROL AGENT 有权
公开(公告)号：US20160214932A1
公开(公告)日：2016-07-28
申请号：US15091125
申请日：2016-04-05
申请人： KUMIAI CHEMICAL INDUSTRY CO., LTD. , IHARA CHEMICAL INDUSTRY CO., LTD.
发明人： Kei DOMON , Keiji TORIYABE , Yutaka OGAWA , Junichiro BESSHO , Kei KAWAMOTO , Akira WATANABE , Masaaki KOMATSU , Takeshi MATSUDA , Seisuke ITO
IPC分类号： C07C321/28 , C07C317/14 , A01N41/10 , A01N41/12
CPC分类号： C07C321/28 , A01N31/16 , A01N33/20 , A01N37/10 , A01N37/32 , A01N37/34 , A01N37/38 , A01N39/00 , A01N41/10 , A01N41/12 , A01N43/08 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/78 , A01N47/02 , A01N47/48 , A01N55/00 , C07C317/14 , C07C317/22 , C07C317/32 , C07C317/46 , C07C323/12 , C07C323/18 , C07C323/20 , C07C323/25 , C07C323/62 , C07C331/10 , C07D213/34 , C07D231/12 , C07D233/64 , C07D239/26 , C07D249/08 , C07D277/26
摘要： An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.

96. 发明授权

US09332754B2 Alkyl phenyl sulfide derivative and pest control agent 有权
标题翻译：烷基苯基硫醚衍生物和害虫防治剂
公开(公告)号：US09332754B2
公开(公告)日：2016-05-10
申请号：US14394438
申请日：2013-04-11
申请人： KUMIAI CHEMICAL INDUSTRY CO., LTD. , IHARA CHEMICAL INDUSTRY CO., LTD.
发明人： Kei Domon , Keiji Toriyabe , Yutaka Ogawa , Junichiro Bessho , Kei Kawamoto , Akira Watanabe , Masaaki Komatsu , Takeshi Matsuda , Seisuke Ito
IPC分类号： C07C331/10 , C07C323/62 , C07C323/20 , C07C317/46 , A01N37/32 , A01N43/08 , A01N47/02 , A01N41/10 , A01N33/20 , A01N55/00 , A01N47/48 , A01N39/00 , A01N31/16 , A01N37/34 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/78 , C07C317/22 , A01N37/10 , A01N37/38 , A01N43/50 , C07C317/32 , C07C323/12 , C07C323/18 , C07C323/25 , C07D213/34 , C07D231/12 , C07D233/64 , C07D239/26 , C07D249/08 , C07D277/26
CPC分类号： C07C321/28 , A01N31/16 , A01N33/20 , A01N37/10 , A01N37/32 , A01N37/34 , A01N37/38 , A01N39/00 , A01N41/10 , A01N41/12 , A01N43/08 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/78 , A01N47/02 , A01N47/48 , A01N55/00 , C07C317/14 , C07C317/22 , C07C317/32 , C07C317/46 , C07C323/12 , C07C323/18 , C07C323/20 , C07C323/25 , C07C323/62 , C07C331/10 , C07D213/34 , C07D231/12 , C07D233/64 , C07D239/26 , C07D249/08 , C07D277/26
摘要： An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.
摘要翻译：由通式[I]表示的烷基苯基硫醚衍生物或其农业上可接受的盐，以及含有该衍生物或盐作为有效成分的害虫控制剂。 [在上式中，R 1为例如被卤素原子单取代或多取代的C 1 -C 6烷基; R2是例如卤素原子或C1〜C6烷基; R3是例如氢原子或卤素原子; R4为例如氢原子或C1〜C12烷基。]该衍生物或盐具有优异的防虫效果。

97. 发明申请

US20070066575A1 Methods and compositions for mitigating pain 审中-公开
标题翻译：减轻疼痛的方法和组合物
公开(公告)号：US20070066575A1
公开(公告)日：2007-03-22
申请号：US11507995
申请日：2006-08-22
申请人： Gregory Thatcher , Brian Bennett , James Reynolds , Khem Jhamandas
发明人： Gregory Thatcher , Brian Bennett , James Reynolds , Khem Jhamandas
IPC分类号： A61K31/66 , A61K31/54 , A61K31/426 , A61K31/21
CPC分类号： C07D207/337 , A61K31/00 , A61K31/04 , A61K31/21 , A61K31/275 , A61K31/381 , A61K31/385 , A61K31/39 , A61K31/426 , A61K31/5375 , C07C203/04 , C07C203/06 , C07C205/40 , C07C309/12 , C07C317/18 , C07C323/12 , C07C323/20 , C07C323/58 , C07C323/62 , C07C327/28 , C07C331/10 , C07D207/16 , C07D277/24 , C07D295/088 , C07D307/33 , C07D311/16 , C07D317/60 , C07D327/04 , C07D333/44 , C07D333/48 , C07D339/08 , C07D409/04 , C07D487/04 , C07D491/04 , C07F9/3808 , C07F9/4006 , C07J41/0055 , C07J41/0061
摘要： Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a nitrate ester. Novel pharmaceutical compositions are also described.
摘要翻译：描述了用于治疗疼痛，减轻炎症，进行镇痛和/或影响受试者镇静的方法和治疗化合物。给予受试者有效量的作为硝酸酯的治疗化合物。还描述了新的药物组合物。

98. 发明授权

US06916835B2 Nitrate esters and their use for neurological conditions 有权
标题翻译：硝酸酯及其用于神经病学条件
公开(公告)号：US06916835B2
公开(公告)日：2005-07-12
申请号：US10147808
申请日：2002-05-20
申请人： Gregory R. J. Thatcher , Brian M. Bennett , James N. Reynolds , Roland J. Boegman , Khem Jhamandas
发明人： Gregory R. J. Thatcher , Brian M. Bennett , James N. Reynolds , Roland J. Boegman , Khem Jhamandas
IPC分类号： A61K31/21 , A61K31/255 , A61K31/26 , A61K31/275 , A61K31/34 , A61K31/341 , A61K31/381 , A61K31/385 , A61K31/39 , A61K31/426 , A61K31/506 , A61K31/513 , A61K31/575 , A61K31/662 , A61P25/00 , A61P25/28 , A61P39/06 , A61P43/00 , C07C203/04 , C07C255/14 , C07C317/18 , C07C323/12 , C07C327/28 , C07C331/10 , C07C381/02 , C07D277/24 , C07D307/33 , C07D327/04 , C07D333/48 , C07D339/08 , C07D411/04 , C07F9/09 , C07F9/40 , C07J9/00 , C07J41/00 , A61K31/425 , A61K31/13 , A61K31/38
CPC分类号： C07D307/33 , A61K31/21 , A61K31/255 , A61K31/26 , A61K31/275 , A61K31/341 , A61K31/381 , A61K31/39 , A61K31/426 , A61K31/506 , A61K31/575 , A61K31/662 , A61K31/7068 , C07C203/04 , C07C255/14 , C07C317/18 , C07C323/12 , C07C327/28 , C07C331/10 , C07C381/02 , C07D277/24 , C07D327/04 , C07D333/48 , C07D339/08 , C07D411/04 , C07F9/091 , C07F9/4006 , C07J41/0061
摘要： Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：描述了用于减轻神经变性，影响神经保护和/或影响受试者的认知增强的化合物和方法。通过向受试者施用有效量的包含硝酸酯或其药学上可接受的盐或酯的治疗化合物来治疗神经或认知状况。

99. 发明申请

US20050137191A1 Nitrate esters and their use for mitigating cellular damage 审中-公开
标题翻译：硝酸酯及其用于减轻细胞损伤的用途
公开(公告)号：US20050137191A1
公开(公告)日：2005-06-23
申请号：US10943264
申请日：2004-09-17
申请人： Gregory Thatcher , Brian Bennett , James Reynolds , Roland Boegman , Khem Jhamandas
发明人： Gregory Thatcher , Brian Bennett , James Reynolds , Roland Boegman , Khem Jhamandas
IPC分类号： A61K31/00 , A61K31/04 , A61K31/21 , A61K31/255 , A61K31/26 , A61K31/275 , A61K31/341 , A61K31/381 , A61K31/385 , A61K31/39 , A61K31/426 , A61K31/506 , A61K31/5375 , A61K31/575 , A61K31/66 , A61K31/70 , C07C203/04 , C07C205/40 , C07C255/14 , C07C309/12 , C07C317/18 , C07C323/12 , C07C323/20 , C07C323/58 , C07C323/62 , C07C327/28 , C07C331/10 , C07C381/02 , C07D207/16 , C07D207/32 , C07D207/337 , C07D277/24 , C07D295/088 , C07D307/33 , C07D311/16 , C07D317/60 , C07D327/04 , C07D333/44 , C07D333/48 , C07D339/08 , C07D409/04 , C07D411/04 , C07D487/04 , C07D491/04 , C07F9/09 , C07F9/38 , C07F9/40 , C07J41/00 , A61K31/537 , A61K31/455 , C07D265/30 , C07D339/02
CPC分类号： C07D491/04 , A61K31/00 , A61K31/04 , A61K31/21 , A61K31/255 , A61K31/26 , A61K31/275 , A61K31/341 , A61K31/381 , A61K31/385 , A61K31/39 , A61K31/426 , A61K31/506 , A61K31/5375 , A61K31/575 , A61K31/662 , A61K31/7068 , C07C203/04 , C07C205/40 , C07C255/14 , C07C309/12 , C07C317/18 , C07C323/12 , C07C323/20 , C07C323/58 , C07C323/62 , C07C327/28 , C07C331/10 , C07C381/02 , C07D207/16 , C07D207/337 , C07D277/24 , C07D295/088 , C07D307/33 , C07D311/16 , C07D317/60 , C07D327/04 , C07D333/44 , C07D333/48 , C07D339/08 , C07D409/04 , C07D411/04 , C07D487/04 , C07F9/091 , C07F9/3808 , C07F9/4006 , C07J41/0055 , C07J41/0061
摘要： Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject are described. Neurological or cognitive conditions, or damage mediated by free radicals are treated by administering to a subject an effective amount of a therapeutic compound comprising a nitrate ester, or a pharmaceutically acceptable salt thereof.
摘要翻译：描述了用于减轻神经变性，影响神经保护，影响认知增强和/或预防或减轻受试者中的组织和/或细胞损伤的硝酸酯和方法。通过向受试者施用有效量的包含硝酸酯或其药学上可接受的盐的治疗化合物来治疗由自由基介导的神经或认知状况或损伤。

100. 发明授权

US06417009B1 Reservoir components 失效
标题翻译：水库组件
公开(公告)号：US06417009B1
公开(公告)日：2002-07-09
申请号：US09180489
申请日：1999-03-08
申请人： Burkhard Raguse , Christopher John Burns , Leslie David Field , Damon Donald Ridley
发明人： Burkhard Raguse , Christopher John Burns , Leslie David Field , Damon Donald Ridley
IPC分类号： G01N33543
CPC分类号： C07C323/12 , C07C331/10 , C07D339/04 , C07D339/08 , C07K7/28 , Y10S435/817 , Y10S436/806
摘要： A linker lipid for use in attaching a membrane including a plurality of ionophores to an electrode and providing a space between the membrane and the electrode in which the membrane is either in part or totally made up of the linker lipid. The linker lipid has within the same molecule a hydrophobic region capable of spanning the membrane, an attachment group used to attach the molecule to an electrode surface, a hydrophilic region intermediate the hydrophobic region and the attachment group, and a polar head group region attached to the hydrophobic region at a site remote from the hydrophilic region. The attachment group has a cross sectional area greater than the cross sectional area of the hydrophilic region, and has the structure recited in the specification.
摘要翻译：用于将包括多个离子载体的膜附着到电极并且在膜和电极之间提供空间的接头脂质，其中膜部分或全部由接头脂质组成。接头脂质在相同分子内具有能跨越膜的疏水区域，用于将分子连接到电极表面的附着基团，疏水区域和附着基团之间的亲水区域，以及附着于位于远离亲水区域的位置处的疏水区域。附着组的横截面积大于亲水区域的横截面积，具有说明书中记载的结构。

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