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91. 发明授权

US11672825B2 Acetic acid and hypochlorous acid compositions for treatment of biofilms and wound care 有权
公开(公告)号：US11672825B2
公开(公告)日：2023-06-13
申请号：US15612571
申请日：2017-06-02
申请人： WIAB WATER INNOVATION AB
发明人： Geir Hermod Almås
IPC分类号： A61K33/20 , A61K31/19 , C01B11/04 , A61L26/00 , A61L15/18 , A61L15/20 , A61L15/42 , A61L15/44 , A61K9/00 , A61K9/51 , A61K9/08
CPC分类号： A61K33/20 , A61K31/19 , C01B11/04 , A61K9/0014 , A61K9/08 , A61K9/5123 , A61K31/19 , A61K2300/00 , A61K33/20 , A61K2300/00
摘要： Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.

92. 发明申请

US20180177824A1 COMPOSITIONS AND METHODS FOR TREATING BIOFILMS 审中-公开
公开(公告)号：US20180177824A1
公开(公告)日：2018-06-28
申请号：US15852622
申请日：2017-12-22
申请人： SoftOx Solutions AS
发明人： Geir Hermod Almås
IPC分类号： A61K33/20 , A61K31/19 , A61K9/00 , C01B11/04
CPC分类号： A61K33/20 , A61K9/0014 , A61K31/19 , A61K33/42 , A61K2300/00 , C01B11/04
摘要： Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.

93. 发明申请

US20180177822A1 ACETIC ACID AND HYPOCHLOROUS ACID COMPOSITIONS FOR TREATMENT OF SKIN TRAUMA 审中-公开
公开(公告)号：US20180177822A1
公开(公告)日：2018-06-28
申请号：US15852603
申请日：2017-12-22
申请人： SoftOx Solutions AS
发明人： Geir Hermod Almås
IPC分类号： A61K33/20 , C01B11/04 , A61K9/00 , A61K31/19
CPC分类号： A61K33/20 , A61K9/0014 , A61K31/19 , A61K33/42 , A61K2300/00 , C01B11/04
摘要： Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.

94. 发明授权

US09492479B2 Compositions of hypochlorous acid (HOCI) and methods of manufacture thereof 有权
标题翻译：次氯酸（HOCI）的组成及其制造方法
公开(公告)号：US09492479B2
公开(公告)日：2016-11-15
申请号：US13770738
申请日：2013-02-19
申请人： WIAB WATER INNOVATION AB
发明人： Geir Hermod Almås , Adrian Bignami
IPC分类号： A61K33/20 , C01B11/04 , A61K31/19
CPC分类号： C01B11/04 , A61K31/19 , A61K33/20
摘要： The invention generally relates to compositions of hypochlorous acid (HOCl) and methods of manufacture thereof. In certain aspects, the invention provides air-free compositions of HOCl. In other aspects, the invention provides methods of making HOCl that involve mixing together in water in an air-free environment, a compound that generates a proton (H+) in water and a compound that generates a hypochlorite anion (OCl−) in water to thereby produce air-free hypochlorous acid.
摘要翻译：本发明一般涉及次氯酸（HOCl）的组合物及其制造方法。在某些方面，本发明提供无空气组合物的HOCl。在其它方面，本发明提供了制造HOCl的方法，其涉及在无空气环境中的水中混合在一起，在水中产生质子（H +）的化合物和在水中产生次氯酸根阴离子（OCl-）的化合物，从而产生无空气的次氯酸。

95. 发明授权

US09481575B2 Method for producing electrolyzed water 有权
标题翻译：电解水生产方法
公开(公告)号：US09481575B2
公开(公告)日：2016-11-01
申请号：US13441953
申请日：2012-04-09
申请人： Siu Ming Wong
发明人： Siu Ming Wong
IPC分类号： C01B11/04 , C02F1/461 , C25B1/26 , C25B15/08
CPC分类号： C01B11/04 , C02F1/4618 , C25B1/26 , C25B15/08 , Y02E60/366
摘要： This invention relates to a method for producing electrolyzed water. Firstly, HCl is injected into an area for electrolysis provided with a negative and positive electrode plate respectively on its two inner sides and several small-sized electrolyzers. Then water is led into an area for water transport communicating with an electrolytic cell compartment by a retaining valve. Herein, electrolytic reaction occurs in the area for electrolysis. During such process, when the positive and negative electrode plates are electrified, HCl is decomposed to chlorine and hydrogen bubbles, which float up and store into a gas buffer area. For the pressure difference between the electrolytic cell compartment and the cell compartment for water transport, the chlorine and hydrogen in the gas buffer area enter the cell compartment for water transport through the retaining valve and form HClO with high stable concentration, high production efficiency and environmental friendly functions of sterilization and disinfection.
摘要翻译：本发明涉及一种生产电解水的方法。首先，将HCl分别注入到具有负极板和正极板的两个内侧和几个小型电解器的电解区域中。然后将水引入通过保持阀与电解池室连通的水输送区域。这里，电解反应发生在电解区域。在这种过程中，当正极板和负极板通电时，HCl被分解成氯，氢气泡浮起并储存在气体缓冲区中。对于电解槽隔室与水运输池室之间的压力差，气体缓冲区内的氯气和氢气通过保持阀进入水箱输送，形成高浓度，高生产效率和环境的HClO 消毒和消毒的友好功能。

96. 发明申请

US20160265123A1 CELL AND SYSTEM FOR PREPARATION OF ANTIMICROBIAL SOLUTIONS 有权
标题翻译：用于制备抗微生物溶液的细胞和系统
公开(公告)号：US20160265123A1
公开(公告)日：2016-09-15
申请号：US15162076
申请日：2016-05-23
申请人： Clarentis Holding, Inc.
发明人： Duke van Kalken , Nathan Waldner
IPC分类号： C25B15/02 , C25B15/08 , C25B9/08 , C25B1/22
CPC分类号： C25B15/02 , A01N59/00 , C01B11/04 , C02F1/001 , C02F1/4674 , C02F2001/46138 , C02F2201/46135 , C02F2201/46145 , C02F2209/005 , C02F2209/04 , C02F2209/06 , C02F2209/40 , C25B1/22 , C25B1/26 , C25B9/04 , C25B9/08 , C25B15/08 , A01N59/08
摘要： A system to prepare an antimicrobial solution by the electrolysis of brine is presented where the antimicrobial solution is a solution comprising HOCl that contains a HOCl concentration in excess of 500 ppm or more at a pH of 6 to 6.8 with a low residual salt concentration and displays a stability in excess of 60 days and can have a HOCl concentration in excess of 450 for 180 days. The system includes an electrolysis cell that is improved by a superior anode and ceramic membrane such that when employed with a DC power supply controlled by a microprocessor and a controlled brine concentration provided to the cell at ambient temperature at a controlled rate, delivers a fluid that is continuously monitored by a pH probe and an ORP probe for input to the microprocessor.
摘要翻译：提出了通过电解盐水制备抗微生物溶液的系统，其中抗微生物溶液是包含HOCl的溶液，其中HOCl在pH6-6.8的条件下具有超过500ppm或更高的HOCl浓度，残留盐浓度低，显示稳定性超过60天，并且可以使HOCl浓度超过450天180天。该系统包括由优良的阳极和陶瓷膜改进的电解池，使得当以受控制的速率在环境温度下被供给由微处理器控制的DC电源和受控盐水浓度使用时，输送流体通过pH探针和ORP探头连续监测输入到微处理器。

97. 发明申请

US20150150906A1 COMPOSITIONS OF HYPOCHLOROUS ACID(HOCl) AND METHODS OF MANUFACTURE THEREOF 审中-公开
公开(公告)号：US20150150906A1
公开(公告)日：2015-06-04
申请号：US14618799
申请日：2015-02-10
申请人： Bengt Olle Hinderson , Geir Hermod Almås
发明人： Bengt Olle Hinderson , Geir Hermod Almås
IPC分类号： A61K33/20 , A61K31/19
CPC分类号： C01B11/04 , A61K31/19 , A61K33/20
摘要： The invention generally relates to compositions of hypochlorous acid (HOCl) and methods of manufacture thereof. In certain aspects, the invention provides air-free compositions of HOCl. In other aspects, the invention provides methods of making HOCl that involve mixing together in water in an air-free environment, a compound that generates a proton (H+) in water and a compound that generates a hypochlorite anion (OCl−) in water to thereby produce air-free hypochlorous acid.

98. 发明申请

US20120237616A1 STABILIZED HYPOHALOUS ACID SOLUTIONS 有权
标题翻译：稳定的高压酸溶液
公开(公告)号：US20120237616A1
公开(公告)日：2012-09-20
申请号：US13423822
申请日：2012-03-19
申请人： Svetlana Panicheva , Mark N. Sampson , Vadim Panichev , Gerald N. Dibello , Martyn James Rogers , Ronan Stapleton , Steven Lewis Short
发明人： Svetlana Panicheva , Mark N. Sampson , Vadim Panichev , Gerald N. Dibello , Martyn James Rogers , Ronan Stapleton , Steven Lewis Short
IPC分类号： A01N59/00 , A01P1/00 , A61P31/00 , A61K33/20
CPC分类号： A61K47/02 , A01N25/22 , A01N59/00 , A23L3/358 , A61K33/10 , A61K33/12 , A61K33/14 , A61K33/20 , A61K33/42 , C01B11/04 , A61K2300/00 , A01N2300/00
摘要： The present invention provides a stabilized hypohalous acid solution (or formulation thereof), which may be conveniently packaged for sale, or stored for later use on demand. The invention further provides methods of making the stabilized hypohalous acid solution, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, disinfecting or cleansing surfaces, or treating and/or preserving food products and cut flowers, among other uses.
摘要翻译：本发明提供了一种稳定的次卤酸溶液（或其制剂），其可以方便地包装出售，或储存以供以后使用。本发明还提供了制备稳定的次卤酸溶液的方法以及用于消毒哺乳动物组织的方法，包括伤口和烧伤，消毒或清洁表面，或治疗和/或保存食品和切花等用途。

99. 发明申请

US20110256243A1 SYSTEM AND METHOD FOR PREPARATION OF ANTIMICROBIAL SOLUTIONS 审中-公开
标题翻译：用于制备抗微生物溶液的系统和方法
公开(公告)号：US20110256243A1
公开(公告)日：2011-10-20
申请号：US13092653
申请日：2011-04-22
申请人： DUKE VAN KALKEN , Nathan Waldner
发明人： DUKE VAN KALKEN , Nathan Waldner
IPC分类号： A01N59/00 , A01P1/00 , C25B9/00 , C25B15/02 , C25B1/26
CPC分类号： C25B1/26 , A01N59/00 , C01B11/04 , C02F1/001 , C02F1/008 , C02F1/4618 , C02F1/4674 , C02F2001/46138 , C02F2001/46185 , C02F2201/46135 , C02F2201/46145 , C02F2209/005 , C02F2209/04 , C02F2209/06 , C02F2209/40 , C25B15/02
摘要： A system to prepare an antimicrobial solution by the electrolysis of brine is presented where the antimicrobial solution is a solution comprising HOCl that contains a HOCl concentration of 100 ppm or more at a pH of approximately 6.5. The system includes an electrolysis cell that is provided with a constant current by a digital DC power supply controlled by a microprocessor and a controlled brine concentration at a controlled rate, which can also be controlled by the microprocessor to deliver a fluid that is continuously observed by a pH probe and an ORP probe that provides input to the microprocessor to adjust voltage, pump rate and/or flow rate in a programmed manner by the microprocessor. A method to produce the antimicrobial solution, including a sporicidal solution, by the novel system is presented.
摘要翻译：提出了通过电解盐水制备抗微生物溶液的系统，其中抗微生物溶液是包含在约6.5的pH下含有100ppm或更高的HOCl浓度的HOCl的溶液。该系统包括通过由微处理器控制的数字直流电源提供恒定电流的电解池，并以受控的速率控制盐水浓度，其也可由微处理器控制，以输送由 pH探针和ORP探针，其向微处理器提供输入，以微处理器以编程的方式调节电压，泵速率和/或流速。提出了一种通过新系统生产抗菌溶液，包括杀孢子溶液的方法。

100. 发明申请

US20110135562A1 TWO STAGE PROCESS FOR ELECTROCHEMICALLY GENERATING HYPOCHLOROUS ACID THROUGH CLOSED LOOP, CONTINUOUS BATCH PROCESSING OF BRINE 审中-公开
标题翻译：通过闭合环路电化学产生高氯酸的两步法，连续加工
公开(公告)号：US20110135562A1
公开(公告)日：2011-06-09
申请号：US12952570
申请日：2010-11-23
申请人： Marilyn J. Niksa , Andrew J. Niksa , Marc J. Epstein , Steven Seiden
发明人： Marilyn J. Niksa , Andrew J. Niksa , Marc J. Epstein , Steven Seiden
IPC分类号： C25B1/26 , C01B11/04 , C25B9/00 , C25B15/00
CPC分类号： C25B1/26 , C01B11/04 , C01B11/062 , C25B15/00
摘要： High concentrations of hypochlorous acid can be produced from, most typically, brine using an system of simple design with minimum residual salt production, reduced power consumption, and at high operating efficiencies. This is accomplished by separating the system into two operations, each of which is preferably optimized. This process employs at least two electrochemical cells, the first of which has no separator between the anode and cathode and generates a high-strength hypochlorite solution. The hypochlorite is then diluted to a desired chlorine concentration and/or pH and fed into the anode compartment of a second electrochemical cell wherein the electrodes are separated by a barrier, such as, for example, a membrane or diaphragm. The separated cell produces a solution containing predominantly hypochlorous acid. Separation of the neutralization processes allows storage of hypochlorite which has a much greater stability in regards to temperature which can then be subsequently converted into hypochlorous acid at point of use or as needed or desired.
摘要翻译：可以使用简单设计的系统，最常见的盐水生产高浓度的次氯酸，具有最小的残留盐产量，降低的功率消耗和高运行效率。这通过将系统分离成两个操作来实现，每个操作优选地被优化。该方法采用至少两个电化学电池，其中第一个电池在阳极和阴极之间没有隔板，并产生高强度的次氯酸盐溶液。然后将次氯酸盐稀释至所需的氯浓度和/或pH，并进料到第二电化学电池的阳极室中，其中电极被隔离物隔离，例如隔膜或隔膜。分离的细胞产生主要含有次氯酸的溶液。中和过程的分离允许存储相对于温度具有更大稳定性的次氯酸盐，然后随后可以在使用点或根据需要或期望的情况下将其转化为次氯酸。

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