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91. 发明申请

WO2006015303A3 STRONG, FLEXIBLE SUTURE MATERIAL 审中-公开
标题翻译：强力，灵活的材料
公开(公告)号：WO2006015303A3
公开(公告)日：2009-04-09
申请号：PCT/US2005027219
申请日：2005-07-29
申请人： CP MEDICAL INC , FERGUSON PATRICK J
发明人： FERGUSON PATRICK J
IPC分类号： A61B17/04 , A61L17/00
CPC分类号： A61L17/105 , A61L17/145
摘要： A suture comprising a flexible foraminous cover made of a polymeric material and a core within the cover made of a cushioning material. The cover material is preferably formed of ultra high molecular weight polyethylene, nylon or polypropylene. The cushioning material is preferably polyester, PTFE or nylon. Preferably, the core is twisted at about 1.5 turns per inch and comprises about 22% of the suture.
摘要翻译：一种缝合线，其包括由聚合物材料制成的柔性多孔覆盖物和由衬垫材料制成的覆盖物内的芯体。覆盖材料优选由超高分子量聚乙烯，尼龙或聚丙烯形成。缓冲材料优选为聚酯，PTFE或尼龙。优选地，芯以约1.5匝/英寸扭转，并且包含约22％的缝合线。

92. 发明申请

WO2007030464A2 BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES 审中-公开
标题翻译：可生物降解的生物成分聚氨酯和医用器件的聚酰胺
公开(公告)号：WO2007030464A2
公开(公告)日：2007-03-15
申请号：PCT/US2006034584
申请日：2006-09-06
申请人： BEZWADA BIOMEDICAL LLC , BEZWADA RAO S
发明人： BEZWADA RAO S
IPC分类号： A61K31/405 , A61K31/192 , A61K31/353
CPC分类号： A61L27/18 , A61K47/34 , A61L17/105 , A61L24/043 , A61L24/046 , A61L31/10 , C08G18/10 , C08G18/711 , C08G18/771 , C08G69/26 , C08G69/44 , C08G2230/00 , C09J175/06 , C08L67/04 , C08L77/00 , C08L75/04
摘要： Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: Rn .COO-(X)P-R' Rn O-(X)p-R' W. .O- (X)p-R' OCN Rn Rn NH-(Y)P-R' ,,COO-(X)P-R' V^. ^0-(Y)P-R1 OCN H 2 N or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from -CH 2 COO- (glycolic acid moiety), -CH(CH 3 )COO- (lactic acid moiety), -CH 2 CH 2 OCH 2 COO- (dioxanone), -CH 2 CH 2 CH2CH 2 CH 2 COO- (caprolactone moiety), -(CH 2 )yCOO- where y is one of the numbers 2, 3, 4 or 6- 24 inclusive, and -( CH 2 CH 2 O)Z CH 2 COO- where z' is an integer between 2 and 24, inclusive; each Y represents a member independently selected from -COCH2O- (glycolic ester moiety), -COCH(CH 3 )O- (lactic ester moiety), -COCH 2 OCH 2 CH 2 O- (dioxanone ester), -COCH 2 CH 2 CH 2 CH 2 CH 2 O- (caprolactone ester), -CO(CH 2 )mO- where m is an integer between 2, 3, 4 or 6 - 24 inclusive, -COCH 2 O(CH 2 CH 2 O)n- where n is an integer between 2 and 24, inclusive; R' is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and -NO 2 , which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable poly¬ mers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.
摘要翻译：由选自以下的至少一种化合物制备的可吸收聚氨酯，聚酰胺和聚酯聚氨酯：Rn.COO-（X）PR'Rn O-（X）pR'W.O-（X）pR'OCN Rn Rn NH-（Y ）PR'，COO-（X）PR'V ^。其中每个X表示独立地选自-CH 2 COO-（乙醇酸）的成员，其中每个X代表独立地选自-CH 2 COO-（乙基）酸部分），-CH（CH 3）COO-（乳酸部分），-CH 2 CH 2 CH 2 OCH 2， CO 2 - （二恶烷酮），-CH 2 CH 2 CH 2 CH 2 CH 2 COO-（己内酯部分）， - （CH 2 2）y COO-，其中y是数字2,3,4或6-24中的一个，其中 - （CH 2 CH 2）_{2 O）Z CH 2 COO - 其中z'是2和24之间的整数，包括端值; 每个Y表示独立地选自-COCH 2 O-（乙醇酸酯部分），-COCH（CH 3 O 3）O-（乳酸酯部分），-COCH 2 OCH 2， O 2 - （二恶烷酮酯），-COCH 2 CH 2 CH 2 2/2 CH 2 CH 2 CH 2 O-（己内酯酯），-CO（CH 2 CH 2）m O - ，其中m是2,3之间的整数，4或6-24，-COCH 2 O（CH 2 CH 2 O）n - ，其中n是介于2和 24，包括 R'是氢，苄基或烷基，烷基是直链或支链的; p是1到4之间的整数，包括1和4; 并且R n表示选自H，烷氧基，苄氧基，醛，卤素，羧酸和-NO 2 2的一个或多个成员，其直接连接到芳族环上或通过脂族链连接。由这些化合物制备的可吸收聚合物可用于药物递送，组织工程，组织粘合剂，防粘连和其他可植入医疗器械。}

93. 发明申请

WO2006015303A2 STRONG, FLEXIBLE SUTURE MATERIAL 审中-公开
标题翻译：强力，灵活的材料
公开(公告)号：WO2006015303A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/027219
申请日：2005-07-29
申请人： CP MEDICAL, INC. , FERGUSON, Patrick, J.
发明人： FERGUSON, Patrick, J.
IPC分类号： A61L17/00
CPC分类号： A61L17/105 , A61L17/145
摘要： A suture comprising a flexible foraminous cover made of a polymeric material and a core within the cover made of a cushioning material. The cover material is preferably formed of ultra high molecular weight polyethylene, nylon or polypropylene. The cushioning material is preferably polyester, PTFE or nylon. Preferably, the core is twisted at about 1.5 turns per inch and comprises about 22% of the suture.
摘要翻译：一种缝合线，包括由聚合物材料制成的柔性多孔覆盖物和由缓冲材料制成的覆盖物内的芯部。覆盖材料优选由超高分子量聚乙烯，尼龙或聚丙烯形成。缓冲材料优选为聚酯，PTFE或尼龙。优选地，芯以约1.5匝/英寸扭转，并且包含约22％的缝合线。

94. 发明申请

WO2004054503A2 ANTIMICROBIAL FATTY ACID CONTAINING SUTURE COATING 审中-公开
标题翻译：抗微生物脂肪酸含有涂层
公开(公告)号：WO2004054503A2
公开(公告)日：2004-07-01
申请号：PCT/US2003/038442
申请日：2003-12-04
申请人： TYCO HEALTHCARE GROUP LP
发明人： ROBY, Mark
IPC分类号： A61K
CPC分类号： A61L17/105 , A61B17/06166 , A61B2017/06028 , A61L17/145 , A61L31/10 , A61L31/16 , A61L2300/22 , A61L2300/404 , A61L2300/606 , C08L67/04
摘要： Compositions with antimicrobial properties contain a metal salt of a fatty acid mixed a bioabsorbable copolymer. These compositions are useful in forming coatings for surgical articles, including multifilament sutures.
摘要翻译：具有抗微生物性质的组合物含有混合生物可吸收共聚物的脂肪酸的金属盐。这些组合物可用于形成外科用品的包衣，包括复丝缝线。

95. 发明申请

WO0008999A9 BRAIDED SUTURE 审中-公开
公开(公告)号：WO0008999A9
公开(公告)日：2000-08-10
申请号：PCT/IB9902069
申请日：1999-02-26
申请人： TYCO GROUP SARL
发明人： HUTTON JEFFREY D , DUMICAN BARRY L
IPC分类号： A61L17/00 , A61B17/06 , A61L17/10 , A61L27/00 , D01F6/62 , D02G3/44 , D04B21/20 , D04C1/12
CPC分类号： A61L17/105 , A61B17/06166 , A61B2017/00526 , D01F1/06 , D01F6/62
摘要： A braided polyester suture made from polyester yarn filaments having a tenacity of from about 7 to about 11 g/denier, a percent elongation to break of less than about 30 percent and the polymer from which the filaments are made has an intrinsic viscosity greater than about 0.95. The invention also provides an implantable medical device constructed from yarn filaments having these properties.
摘要翻译：由聚酯纱线制成的编织聚酯缝合线具有约7至约11g /旦尼尔的强度，小于约30％的断裂伸长率和长丝制成的聚合物的特性粘度大于约 0.95。本发明还提供了一种由具有这些性质的纱线细丝构成的可植入医疗装置。

96. 发明申请

WO1998008876A1 HYALURONIC ACID ESTERS, THREADS AND BIOMATERIALS CONTAINING THEM, AND THEIR USE IN SURGERY 审中-公开
标题翻译：包含它们的香草酸酯，螺纹和生物材料及其在外科手术中的应用
公开(公告)号：WO1998008876A1
公开(公告)日：1998-03-05
申请号：PCT/EP1997004684
申请日：1997-08-28
申请人： FIDIA ADVANCED BIOPOLYMERS S.R.L. , CALLEGARO, Lanfranco , BELLINI, Davide
发明人： FIDIA ADVANCED BIOPOLYMERS S.R.L.
IPC分类号： C08B37/08
CPC分类号： A61L17/105 , C08B37/0072
摘要： The application discloses esters of hyaluronic acid, wherein a first part of the carboxy functions is esterified with an araliphatic alcohol and a second part is esterified with long-chain, straight aliphatic alcohols with between 10 and 22 carbons atoms. The possible remaining non-esterified carboxy functions, if present, are salified. The application further discloses biodegradable threads constituted by the aforesaid esters, and their use in the fields of medicine and surgery.
摘要翻译：本申请公开了透明质酸的酯，其中羧基官能团的第一部分用芳脂族醇酯化，第二部分被具有10至22个碳原子的长链直链脂族醇酯化。可能残留的非酯化羧基官能团（如果存在）成盐。本申请进一步公开了由上述酯构成的生物降解性丝，以及它们在医学和外科领域中的应用。

97. 发明申请

WO2017156531A1 ULTRA-THIN, HIGH STRENGTH, DRUG-LOADED SUTURES AND COATINGS THEREOF 审中-公开
标题翻译：超薄，高强度，药物负载的缝合物及其涂层
公开(公告)号：WO2017156531A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/022093
申请日：2017-03-13
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： PARIKH, Kunal, S. , HANES, Justin , ENSIGN, Laura
IPC分类号： A61L17/10 , A61L17/12 , D01H7/02 , A61L17/00 , D01D5/00 , D01F1/10
CPC分类号： A61L17/005 , A61B17/06166 , A61K31/5383 , A61L17/105 , A61L17/12 , A61L31/06 , A61L31/148 , A61L2300/216 , A61L2300/402 , A61L2300/41 , A61L2300/416 , A61L2400/12 , D01D5/0076 , D01D5/0084 , D01F1/10 , D01F1/103 , D01H7/02 , D04C1/06 , D10B2331/04 , D10B2331/041 , D10B2401/12 , D10B2509/04 , D10B2509/06
摘要： Small-diameter suture materials and suture coating materials made from the twisting or braiding of biocompatible polymeric fibers have been developed, which support drug delivery and maintain a high tensile strength. The fibers entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month. While monofilament fibers lose tensile strength with the inclusion of active agents, twisting the drug-loaded, multifilament fibers allows for an increase in the tensile strength for the overall composites, while still retaining a small diameter. The methods of making these materials and using them for ocular surgery and vasculature repair have also been developed.
摘要翻译：已开发出由生物相容性聚合物纤维的捻合或编织制成的小直径缝合材料和缝合线涂覆材料，其支持药物递送并保持高拉伸强度。纤维包埋（例如包封）一种或多种治疗剂，预防剂或诊断剂，并在至少一周，优选一个月的时间内提供延长的释放。尽管单纤维纤维在包含活性剂的情况下失去拉伸强度，但加载药物的复丝纤维允许增加整个复合材料的拉伸强度，同时仍保持小直径。制作这些材料并将其用于眼科手术和血管修复的方法也已经开发出来。

98. 发明申请

WO2017127331A1 SEGMENTED, P-DIOXANONE-RICH, POLY(P-DIOXANONE-CO-EPSILON-CAPROLACTONE) COPOLYMERS FOR MEDICAL APPLICATIONS AND DEVICES MADE THEREFROM 审中-公开
标题翻译：用于医疗应用的分段的富含p-二氧杂环己烷的聚（对 - 二氧杂环己烯 - 共 - 聚硅氧烷 - 己内酯）共聚物和由此制备的装置
公开(公告)号：WO2017127331A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/013665
申请日：2017-01-16
申请人： ETHICON, INC.
发明人： ANDJELIC, Sasa , KEILMAN, Kenneth
IPC分类号： A61L31/06 , A61L17/10 , C08L67/04
CPC分类号： A61L17/105 , A61L17/005 , A61L31/06 , A61L2300/404 , C08G63/664 , C08G81/00 , C08L67/04
摘要： Novel semi-crystalline, p -dioxanone -rich ABA triblock copolymers of p -dioxanone and epsilon -caprolactone, where "B" block is a random copolymer of p -dioxanone and epsilon -caprolactone, and absorbable devices for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices.
摘要翻译：新的半结晶，对二氧杂环己酮富集的对二氧环己酮和ε-己内酯的ABA三嵌段共聚物，其中“B” 嵌段是对二酮和ε-己内酯的无规共聚物，公开了用于长期医学应用的可吸收装置。新型聚合物组合物可用于长期可吸收外科缝合线和其他医疗装置。

99. 发明申请

WO2016094669A1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
标题翻译：聚-4-羟基丁酸酯及其共聚物的多元纤维和单体的定向方法
公开(公告)号：WO2016094669A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065015
申请日：2015-12-10
申请人： TEPHA, INC.
发明人： GANATRA, Amit , FELIX, Fabio , SHAH, Bhavin , BERNASCONI, Matthew , RIZK, Said , MARTIN, David, P. , WILLIAMS, Simon, F.
IPC分类号： D01F6/62
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yams and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yams and fibers are produced by cold drawing the multifilament yams and monofilament fibers before hot drawing the yams and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yams and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yams have tenacities higher than 8.1 grams per denier, and in vivo , retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo . The monofilament fibers have tensile strengths higher than 500 MPa. These yams and fibers may be used to make various medical devices for various applications.
摘要翻译：已经开发了可再吸收的复丝纱线和包括聚-4-羟基丁酸酯的单丝纤维及其具有高强度或高拉伸强度的共聚物。在高于聚合物或共聚物的熔融温度的温度下，在拉伸纱线和纤维的拉伸下，通过冷拉丝复丝纱线和单丝纤维来生产纱线和纤维。这些纱线和纤维在体内具有延长的强度保持性，使得它们适用于需要高强度和强度保持性的软组织修复。复丝纱具有高于8.1克/旦尼尔的强度，并且体内在2周时保持其初始强度的至少65％。单丝纤维在体内4周时保持其初始强度的至少50％。单丝纤维的拉伸强度高于500MPa。这些纱线和纤维可用于制造用于各种应用的各种医疗装置。

100. 发明申请

WO2015080939A1 ABSORBABLE POLYMERIC BLEND COMPOSITIONS WITH PRECISELY CONTROLLABLE ABSORPTION RATES, PROCESSING METHODS, AND DIMENSIONALLY STABLE MEDICAL DEVICES THEREFROM 审中-公开
标题翻译：可吸收的聚合物混合组合物具有精确的可控制吸收率，加工方法和尺寸稳定的医疗装置
公开(公告)号：WO2015080939A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/066602
申请日：2014-11-20
申请人： ETHICON, INC.
发明人： JAMIOLKOWSKI, Dennis D. , STEIGER, Daniel , KELLY, Brian M. , DEFELICE, Christopher , ANDJELIC, Sasa , ERNETA, Modesto
IPC分类号： A61L27/26 , A61L27/58 , A61L31/04 , A61L31/14 , A61B17/064 , A61L17/10 , C08L67/04
CPC分类号： A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
摘要： Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
摘要翻译：公开了新颖的可吸收聚合物共混物。共混物具有第一可吸收聚合物类型，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及聚（对二恶烷酮）的第二可吸收聚合物类型，其中第一可吸收聚合物类型或第二可吸收聚合物类型或第一可吸收聚合物类型可吸收聚合物类型和第二可吸收聚合物类型另外包含第一聚合物组分和第二聚合物组分。第一聚合物组分具有比第二聚合物组分更高的重均分子量，并且至少一种所述组分至少部分地被羧酸封端。新型聚合物共混物可用于制造具有尺寸稳定性，具有工程化降解和体内断裂强度保持性的医疗装置。还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。

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