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91. 发明公开

EP2121109A1 METHODS, SYSTEMS, AND APPARATUSES FOR HEAT TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权转让
标题翻译：方法，系统和设备功能障碍睑板腺的热处理
公开(公告)号：EP2121109A1
公开(公告)日：2009-11-25
申请号：EP08727830.5
申请日：2008-01-17
申请人： Tearscience, Inc.
发明人： KORB, Donald R. , GRENON, Stephen M. , WILLIS, Timothy R. , GRAVELY, Benjamin, Tyson , JANS, John Martin , HUTCHINSON, Jordan W. , GAUSMANN, Keith
IPC分类号： A61M35/00
CPC分类号： A61F7/02 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0086
摘要： Apparatuses, systems, and methods of treating meibomian gland dysfunction. Heat is applied to the patient's eyelid or surrounding tissue to apply heat to the patient's meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the patient's eyelid or surrounding tissue to improve conductive heat transfer and reduce blood flow in the tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reached desired temperature levels and/or aid in reducing discomfort to the patient during treatment.

92. 发明公开

EP2066227A1 MEIBOMIAN GLAND IMAGING 审中-公开
标题翻译：梅波姆腺概要
公开(公告)号：EP2066227A1
公开(公告)日：2009-06-10
申请号：EP07716444.0
申请日：2007-01-09
申请人： Tearscience, Inc.
发明人： GRENON, Stephen M. , WILLS, Timothy R. , GRAVELY, Benjamin T. , KORB, Donald R.
IPC分类号： A61B3/14
CPC分类号： A61B3/10 , A61B5/0066 , A61B5/0073 , A61B5/411 , A61B5/4261
摘要： A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland (20) in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland (20). This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

93. 发明授权

US11844586B2 Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis 有权
公开(公告)号：US11844586B2
公开(公告)日：2023-12-19
申请号：US17498102
申请日：2021-10-11
申请人： TearScience, Inc.
发明人： Stephen M. Grenon , Donald R. Korb , Joshua Grenon , Scott Liddle , Steve Bacich , John M. Jans
IPC分类号： A61B5/00 , A61B3/00 , A61B3/10
CPC分类号： A61B5/0082 , A61B3/0008 , A61B3/101 , A61B5/0077 , A61B5/6821
摘要： Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured, showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray-like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

94. 发明授权

US10980413B2 Apparatuses and methods for determining tear film break-up time and/or for detecting lid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms 有权
公开(公告)号：US10980413B2
公开(公告)日：2021-04-20
申请号：US16557276
申请日：2019-08-30
申请人： TearScience, Inc.
发明人： Donald R. Korb , Stephen M. Grenon , Caroline Blackie , Timothy R. Willis , Steve Bacich
IPC分类号： A61B3/10 , G06T7/00 , A61B3/00 , G06T7/11 , A61B3/14 , G06T7/90 , G06K9/00 , G06K9/62 , G06K9/78
摘要： Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.

95. 发明授权

US10278587B2 Eyelid illumination systems and method for imaging meibomian glands for meibomian gland analysis 有权
公开(公告)号：US10278587B2
公开(公告)日：2019-05-07
申请号：US14269646
申请日：2014-05-05
申请人： TEARSCIENCE, INC.
发明人： Stephen M. Grenon , Donald R. Korb , Joshua Grenon , Scott Liddle , Steve Bacich , John M. Jans
IPC分类号： A61B5/00
摘要： Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

96. 发明授权

US09408534B2 Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权
公开(公告)号：US09408534B2
公开(公告)日：2016-08-09
申请号：US14299504
申请日：2014-06-09
申请人： TearScience Inc.
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05 , A61B3/00 , G06T7/00
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

97. 发明授权

US09339177B2 Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography 有权
标题翻译：用于确定泪膜厚度和/或提供眼部形貌的眼泪膜的全眼照明眼表面成像
公开(公告)号：US09339177B2
公开(公告)日：2016-05-17
申请号：US14543931
申请日：2014-11-18
申请人： TearScience, Inc.
发明人： Stephen M. Grenon , Donald R. Korb
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05 , A61B3/00
CPC分类号： A61B3/101 , A61B3/0008 , A61B3/0025 , A61B3/0058 , A61B3/1005 , A61B3/107 , A61B3/14 , G02B26/023
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 TFLT可用于诊断干眼综合征（DES）。某些实施例还包括眼部地形设备，用于通过捕获从角膜表面反射的目标的图像来推导角膜形状的系统和方法。目标的图像包含地形信息，临床医生可以通过检测角膜畸形和/或角膜形状的异常来诊断患者眼睛的健康状况。某些实施方案还包括OSI和眼部形貌设备的组合，用于提供可用于产生患者的泪膜和角膜形状的组合诊断的成像的系统和方法。

98. 发明授权

US09060843B2 Method and apparatus for treating gland dysfunction employing heated medium 有权
标题翻译：使用加热培养基治疗腺体功能障碍的方法和装置
公开(公告)号：US09060843B2
公开(公告)日：2015-06-23
申请号：US11931398
申请日：2007-10-31
申请人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61B7/00 , A61F9/007 , A61H7/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H15/00 , A61N7/00
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以便恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动其后清除阻塞物。

99. 发明授权

US08950405B2 Treatment of obstructive disorders of the eye or eyelid 有权
标题翻译：治疗眼睛或眼睑的阻塞性疾病
公开(公告)号：US08950405B2
公开(公告)日：2015-02-10
申请号：US11928681
申请日：2007-10-30
申请人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis
IPC分类号： A61F7/00 , A61F7/02 , A61F9/007
CPC分类号： A61B17/22004 , A61B17/22 , A61F7/02 , A61F9/00772 , A61F2007/0004 , A61F2007/0261
摘要： In accordance with certain illustrative embodiments, methods and apparatuses of treating obstructive disorders of the structure of an eye or eyelid are disclosed. The treating may involve applying heat to the structure containing the obstructive disorder to melt an obstruction in the structure and place the obstruction in a melted state. The heat may be maintained for a time period to melt the obstruction and place the obstruction in the melted state. The structure may be treated by expressing the melted obstruction from the structure. The treating may be carried out either during the time period or after the time period when heat is applied but while the obstruction is in the melted state. In certain embodiments, the method further involves subsequently treating the structure by use of a pharmacological agent. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：根据某些示例性实施例，公开了治疗眼睛或眼睑结构的阻塞性疾病的方法和装置。治疗可以涉及对包含阻塞性病症的结构施加热量，以便熔化结构中的梗阻并将阻塞置于熔化状态。可以将热量保持一段时间以融化阻塞物并将阻塞物置于熔化状态。可以通过从结构中表达熔化的阻塞来处理结构。处理可以在施加热量但是阻塞处于熔化状态的时间段期间之后或者在施加热量的时间段之后进行。在某些实施方案中，该方法还涉及随后通过使用药理学剂处理该结构。该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

100. 发明申请

US20140330129A1 EYELID ILLUMINATION SYSTEMS AND METHODS FOR IMAGING MEIBOMIAN GLANDS FOR MEIBOMIAN GLAND ANALYSIS 审中-公开
标题翻译：用于成像墨西哥甘蓝分析的眼睛照射系统和方法
公开(公告)号：US20140330129A1
公开(公告)日：2014-11-06
申请号：US14269646
申请日：2014-05-05
申请人： TEARSCIENCE, INC.
发明人： Stephen M. Grenon , Donald R. Korb , Joshua Grenon , Scott Liddle , Steve Bacich
IPC分类号： A61B5/00
CPC分类号： A61B5/0082 , A61B5/0077 , A61B5/6821
摘要： Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.
摘要翻译：公开了眼睑照射系统和用于睑板腺分析成像睑板腺的方法。在一个实施例中，患者的眼睑用红外（IR）光IR反照射。捕获患者眼睑的透射照明图像，显示黑色轮廓区域中的睑板腺，而非腺体材料显示在浅色区域。这提供了像X射线的睑板腺的高对比度图像。可以分析睑板腺的盖反照明图像，以确定诊断患者眼睑中的睑板腺。眼睑可以由构造成抓住并翻转眼睑的盖翻转装置反照，以对眼睑的内表面进行成像。此外，还可以捕获睑板腺的IR表面记录图像并与睑板腺的反照明图像组合，以提供睑板腺的较高对比度图像。

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