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91. 发明公开

EP3216879A1 PNA PROBE, KIT AND METHOD FOR DETECTING HUMAN PAPILLOMAVIRUS GENOTYPE 无效
标题翻译： PNA探针，试剂盒和检测人类乳头状瘤病毒基因型的方法
公开(公告)号：EP3216879A1
公开(公告)日：2017-09-13
申请号：EP15857492.1
申请日：2015-10-29
申请人： Panagene Inc.
发明人： CHOI, Bo Ra , KANG, Jae Hyun , CHOI, Jae Jin , KIM, Sung Kee , PARK, Doo San
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/68 , C12N2310/3181 , C12Q1/6816 , C12Q1/6818 , C12Q1/6851 , C12Q1/6888 , C12Q1/708 , C12Q2525/107 , C12Q2565/1015
摘要： The present invention relates to methods for detecting HPV using PNA detection probes. More specifically, it relates to detection probes capable of genotype specifically binding to Human Papillomavirus (hereinafter referred to as "HPV") DNA, detection kits comprising them, methods for detecting HPV genotypes using them. The present invention is capable of accurately detecting 22 HPV genotypes found in cervix, diagnosing coinfection with one or more HPV genotypes, detecting the presence or absence of other HPV genotypes than the 22 genotypes, and detecting HPV genotypes with high sensitivity and specificity.
摘要翻译：本发明涉及使用PNA检测探针检测HPV的方法。更具体地，涉及能够特异性结合人乳头瘤病毒（以下称为“HPV”）DNA的基因型检测探针，包含它们的检测试剂盒，使用它们检测HPV基因型的方法。本发明能够准确检测在宫颈中发现的22种HPV基因型，诊断与一种或多种HPV基因型的共感染，检测除22种基因型之外是否存在其他HPV基因型，并以高灵敏度和特异性检测HPV基因型。

92. 发明授权

EP1501812B1 PNA MONOMER AND PRECURSOR 有权
标题翻译： PNA单体和前体
公开(公告)号：EP1501812B1
公开(公告)日：2009-12-30
申请号：EP03718981.8
申请日：2003-04-28
申请人： Panagene, Inc.
发明人： Kim, Sung Kee c/o Panagene Inc. , Lee, Hyunil , Lim, Jong Chan , Choi, Hoon , Jeon, Jae Hoon , Ahn, Sang Youl c/o Panagene Inc. , Lee, Sung Hee , Yoon, Won Jun
IPC分类号： C07D277/76 , C07D413/12 , C07D417/12 , C07D417/14 , C07D473/26 , C07D473/34 , C07D263/58 , C07D405/12 , A61K31/522 , A61P35/00
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55

93. 发明授权

EP1651642B1 PNA MONOMER AND PRECURSOR 有权
标题翻译： PNA单体和PRE-PRESS
公开(公告)号：EP1651642B1
公开(公告)日：2009-11-04
申请号：EP04726242.3
申请日：2004-04-07
申请人： Panagene Inc.
发明人： KIM, Sung Kee , LEE, Hyunil , LIM, Jong Chan , LEE, Sung Hee
IPC分类号： C07D413/12 , C07D417/12 , C07D263/46 , C07D271/113
CPC分类号： C07D271/113 , C07D263/46 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers,wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae (A, B) wherein A1, A2, A3, A4, A5, is independently selected from H, halogen such as F, Cl, Br or I, CF3, alkyl, preferably C1,-C4 alkyl, nitro, nitrile, alkoxy, preferably C1,-C4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C1-C4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated Ci-C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I) phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

94. 发明授权

EP1470114B1 PEPTIDE NUCLEIC ACID OLIGOMERS FROM 1-BENZENESULFONYL-3-AMINO ACID SIDE CHAIN-4-(2-NUCLEOBASE(ACETYL))-PIPERAZIN-2-ONES 有权
标题翻译：的1-苯磺酰基-3-氨基酸侧链基-4-（2-核蛋白基（乙酰基））哌嗪-2-酮的肽核酸寡聚物
公开(公告)号：EP1470114B1
公开(公告)日：2009-08-19
申请号：EP03700408.2
申请日：2003-01-23
申请人： Panagene, Inc.
发明人： KIM, Sung Kee , LEE, Hyunil , LIM, Jong Chan , CHOI, Hoon , JEON, Jae Hoon , AHN, Sang Youl c/o Panagene, Inc. , LEE, Sung Hee
IPC分类号： C07D241/08 , C07D473/18 , C07D473/34 , C07D239/47 , C07D239/54 , C07D403/06 , C07C311/18
CPC分类号： C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/003 , Y02P20/55
摘要： This application relates to monomers of general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein R1, R2, R3, R4, R5 is independently H, halogen, C1-C4 alkyl, nitro, nitrile, C1-C4 alkoxy, halogenated C1-C4 alkyl, or halogenated C1-C4 alkoxy, wherein at least one of R1, R3, and R5 is nitro; R6 is H or protected or unprotected side chain of natural or unnatrual α-amino acid; and B is a natural or unnatrual nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases.

95. 发明公开

EP3216879A4 PNA PROBE, KIT AND METHOD FOR DETECTING HUMAN PAPILLOMAVIRUS GENOTYPE 无效
公开(公告)号：EP3216879A4
公开(公告)日：2018-07-25
申请号：EP15857492
申请日：2015-10-29
申请人： PANAGENE INC
发明人： CHOI BO RA , KANG JAE HYUN , CHOI JAE JIN , KIM SUNG KEE , PARK DOO SAN
IPC分类号： C12Q1/70 , C12Q1/68 , C12Q1/6888
CPC分类号： C12Q1/68 , C12N2310/3181 , C12Q1/6816 , C12Q1/6818 , C12Q1/6851 , C12Q1/6888 , C12Q1/708 , C12Q2525/107 , C12Q2565/1015
摘要： The present invention relates to methods for detecting HPV using PNA detection probes. More specifically, it relates to detection probes capable of genotype specifically binding to Human Papillomavirus (hereinafter referred to as "HPV") DNA, detection kits comprising them, methods for detecting HPV genotypes using them. The present invention is capable of accurately detecting 22 HPV genotypes found in cervix, diagnosing coinfection with one or more HPV genotypes, detecting the presence or absence of other HPV genotypes than the 22 genotypes, and detecting HPV genotypes with high sensitivity and specificity.

96. 发明公开

EP3126511A1 MELTING CURVE ANALYSIS USING PNA PROBE, METHOD AND KIT FOR ANALYZING NUCLEOTIDE POLYMORPHISM USING MELTING CURVE ANALYSIS 有权
标题翻译：熔解曲线分析使用分析NUKLEOTIDPOLYPOLYMORPHISMUS使用熔解曲线分析PNA探针，方法和试剂盒
公开(公告)号：EP3126511A1
公开(公告)日：2017-02-08
申请号：EP14887849.9
申请日：2014-04-04
申请人： Panagene Inc.
发明人： JOE, Goon Ho , KIM, Sung-Kee , PARK, Heekyung , PARK, Chwang Siek , KIM, Se Ryun , KIM, Yongtae , KIM, Su Nam
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2525/107 , C12Q2527/107 , C12Q2563/173
摘要： Provided are a PNA probe for detecting nucleotide polymorphism of a target gene, a melting curve analysis method for detecting the nucleotide polymorphism of the target gene using the same, a nucleotide polymorphism analysis method of a target gene including the melting curve analysis method, and a kit for detecting the nucleotide polymorphism of the target gene containing the PNA probe. It is characterized that the PNA probe according to the present invention contains negative charge molecules. The modified PNA probe according to the present invention contains the negative charge molecules to have a high recognition ability with respect to a target DNA and a high coupling ability to the target DNA and to be rapidly dissociated by heat, such that the nucleotide polymorphism analysis may be relatively easily performed even in a heterozygous sample showing two melting curve graphs, and two or more adjacent single nucleotide polymorphisms may be simultaneously analyzed.
摘要翻译：本发明提供一种PNA探针用于检测靶标基因，使用相同的，靶基因包括解链曲线分析的方法的一个核苷酸多态性分析方法检测靶基因的核苷酸多态性的熔解曲线分析的方法的单核苷酸多态性，以及试剂盒用于检测目标基因通过含有PNA探针的核苷酸多态性。它的特点是做了PNA探针gemäß到本发明包含负电荷的分子。经修饰的PNA探针雅丁到含有本发明的负电荷分子，以具有相对于靶DNA和高耦合能力与靶DNA和因热而快速解离的高的识别能力，检查做了核苷酸多态性分析可比较容易地进行是偶数的杂合样品中示出了两个熔解曲线的曲线图，以及两个或更多个相邻的单核苷酸多态性，可以同时进行分析。

97. 发明公开

EP2912176A4 METHOD FOR THE DETECTION OF MULTIPLE TARGET NUCLEIC ACIDS USING CLAMPING PROBES AND DETECTION PROBES 有权
标题翻译：为了检测多靶核酸的方法使用终端探针和检测探针
公开(公告)号：EP2912176A4
公开(公告)日：2016-07-27
申请号：EP14860780
申请日：2014-10-14
申请人： PANAGENE INC
发明人： JOE GOON HO , KIM YONG TAE , KIM SUNG KEE , KIM JIN WOO , CHOI JAE JIN , WO IN SEONG , YOON JI HYE , KIM SU NAM , PARK JUN HO
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6827 , C12Q1/6818 , C12Q1/6832 , C12Q1/6858 , C12Q1/686 , C12Q1/6886 , C12Q2600/156 , C12Q2549/126 , C12Q2561/113
摘要： Disclosed is a probe mixture for real-time detection of target nucleic acids comprising at least one detection probe and at least one clamping probe for inhibiting amplification of wild type genes or unwanted genes, a kit using the same and a method for real-time detection of target nucleic acids using the mixture and the kit.

98. 发明公开

EP2520649A3 MicroRNA antisense PNAs, compositions comprising the same, and methods for using and evaluating the same 审中-公开
标题翻译：微RNA的反义肽核酸，组合物，并且因此它们的使用和评价方法
公开(公告)号：EP2520649A3
公开(公告)日：2013-02-20
申请号：EP12174714.1
申请日：2008-11-24
申请人： Panagene, Inc.
发明人： PARK, Hee Kyung , OH, Su Young
IPC分类号： C12N15/09 , C07K14/00 , C12Q1/68 , C12N15/113
CPC分类号： C07K14/003 , C12N15/113 , C12N2310/113 , C12N2310/3181 , C12N2310/3513 , C12Q1/6897 , C12Q2525/207
摘要： Disclosed are a microRNA antisense PNA capable of inhibiting the activity or function of microRNA, a composition for inhibiting the activity or function of microRNA containing the same, a method for inhibiting the activity or function of microRNA using the same, and a method for evaluating the effectiveness thereof.

99. 发明公开

EP2227561A2 METHOD FOR SELECTIVE LABELING AND DETECTION OF TARGET NUCLEIC ACIDS USING IMMOBILIZED PEPTIDE NUCLEIC ACID PROBES 审中-公开
标题翻译： FOR选择性打标和靶核酸的证明方法，使用固定肽是核酸探针
公开(公告)号：EP2227561A2
公开(公告)日：2010-09-15
申请号：EP08856928.0
申请日：2008-12-04
申请人： Panagene, Inc.
发明人： PARK, Hee Kyung , CHOI, JAE JIN
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6837 , C12Q2525/107 , G01N33/532 , G01N2333/9015 , G01N2333/9127 , C12Q2565/537 , C12Q2521/131 , C12Q2521/501
摘要： Disclosed are a method for selective labeling of target nucleic acids on an array having nucleic acid analogue, e.g. PNA (peptide nucleic acid), probes immobilized on a support or supports, comprising adding to the array a detectable label and an agent for introducing the label into the target nucleic acids, after hybridization between the target nucleic acids and the nucleic acid analogue probes, and a method for detection of target nucleic acids using the same.

100. 发明公开

EP2174936A1 PNA monomer and precursor 有权
标题翻译： PNA-Monomer和Vorläufer
公开(公告)号：EP2174936A1
公开(公告)日：2010-04-14
申请号：EP09015826.2
申请日：2003-04-28
申请人： Panagene, Inc.
发明人： Kim, Sung Kee , Lee, Hyunil , Lim, Jong Chan , Choi, Hoon , Jeon, Jae Hoon , Ahn, Sang Youl , Lee, Sung Hee , Yoon, Won Jun
IPC分类号： C07D277/76 , C07D413/12 , C07D417/12 , C07D417/14 , C07D473/26 , C07D473/34 , C07D263/58 , C07D405/12 , A61K31/522 , A61P35/00
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: (I) wherein E is nitrogen or C-R'; J is sulfur or oxygen; R', R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural a-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：（I）其中E为氮或C- R'; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或被保护或未被保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

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