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91. 发明公开

EP3006987A1 OPTICAL ELEMENT HAVING POLARIZATION DEPENDENCE ON INCIDENT LIGHT, FOR VARYING FOCUSED LIGHT PATTERN 审中-公开
标题翻译：偏振响应于入射光变革的聚焦光图案的光学元件
公开(公告)号：EP3006987A1
公开(公告)日：2016-04-13
申请号：EP13885904.6
申请日：2013-10-18
申请人： Kyungpook National University Industry-Academic Cooperation Foundation
发明人： KIM, Hak-Rin
IPC分类号： G02B26/00 , G02B5/00 , G02B3/00
CPC分类号： G02B5/3016 , G02B3/005 , G02B3/0068 , G02B27/285
摘要： Provided is an optical device with variable focused beam pattern depending on polarization of an incident beam. The optical device with variable focused beam pattern includes a first lens structure which is configured by arranging first lenticular lenses which are formed with liquid crystals or liquid crystal polymers having a first extraordinary refractive index axis direction and of which longitudinal axes are aligned with a first alignment direction, and a second lens structure which is laminated on a beam emitting surface of the first lens structure and configured by arranging second lenticular lenses which are formed with liquid crystals or liquid crystal polymers having a second extraordinary refractive index axis direction and of which longitudinal axes are aligned with a second alignment direction, wherein a beam pattern of output light output from the second lens structure is determined according to a polarization direction of the incident beam incident on the first lens structure, the first and second extraordinary refractive index axis directions of the first and second lens structures, and the first and second alignment directions of the first and second lens structures.

92. 发明公开

EP2984999A1 LOCALLY INVASIVE SURGICAL APPARATUS COMPRISING MANIPULATOR FOR BONE FRACTURE TREATMENT 有权
标题翻译： LOKAL INVASIVE CHIRURGISCHE VORRICHTUNG MIT EINEM操作员ZUR BEHANDLUNG VONKNOCHENBRÜCHEN
公开(公告)号：EP2984999A1
公开(公告)日：2016-02-17
申请号：EP14773741.5
申请日：2014-03-04
申请人： Kyungpook National University Industry-Academic Cooperation Foundation
发明人： PARK, Il Hyung , PARK, Chul Woo , JOUNG, Sanghyun
IPC分类号： A61B17/56 , A61B17/16 , A61B17/94
CPC分类号： A61B1/317 , A61B1/00087 , A61B1/00147 , A61B1/00149 , A61B1/0016 , A61B1/0055 , A61B1/0684 , A61B17/1659 , A61B17/320016 , A61B17/72 , A61B34/30 , A61B34/37 , A61B34/72 , A61B2090/309
摘要： The present invention provides a locally invasive surgical apparatus including a manipulator for scratching the bone at a fracture site, a drive arm on which the manipulator is mounted, and a controller for controlling the manipulator and the drive arm. Therefore, it is possible to carry out minimally invasive surgery during bone fracture surgery, thereby enabling simple and quick bone fracture surgery for a speedy recovery.
摘要翻译：本发明提供了一种局部侵入性手术装置，其包括用于在骨折部位刮伤骨骼的操纵器，安装有操纵器的驱动臂，以及用于控制操纵器和驱动臂的控制器。因此，可以在骨折手术中进行微创手术，从而能够进行简单快速的骨折手术以便迅速恢复。

93. 发明公开

EP2623500A1 MRI CONTRAST AGENT HAVING GADOLINIUM COMPLEX 有权
标题翻译： MRI-KONTRASTMITTEL MIT GADOLINIUM-KOMPLEX
公开(公告)号：EP2623500A1
公开(公告)日：2013-08-07
申请号：EP10857933.5
申请日：2010-12-21
申请人： Kyungpook National University Industry- Academic Cooperation Foundation
发明人： KIM, Tae-Jeong , CHANG, Yong Min , KIM, Hee-Kyung , GU, Sung-Wook
IPC分类号： C07D257/02 , A61K49/06 , A61K49/10
CPC分类号： C07F5/00 , A61K49/106 , C07D257/02
摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1.
A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.
摘要翻译：本发明涉及包含钆络合物的磁共振成像（MRI）造影剂，更具体地说，涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物可以根据本发明制备，并且可以使用该化合物制备钆络合物。包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。此外，根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。因此，由于包含本发明的钆络合物的MRI造影剂满足MRI造影剂所需的关键特性，因此可广泛用作MRI造影剂，与现有对比度相比可以提供增强的对比效果剂。

94. 发明公开

EP2537834A2 POLYAZAMACROCYCLIC COMPOUND, AND A PRODUCTION METHOD AND A BIOMEDICAL USE THEREFOR 失效
标题翻译：多氮大CONNECTION和方法与生物医学它们的用途
公开(公告)号：EP2537834A2
公开(公告)日：2012-12-26
申请号：EP11744868.8
申请日：2011-02-14
申请人： Kyungpook National University Industry- Academic Cooperation Foundation
发明人： YOO, Jeongsoo , PANDYA, Darpan Navinchandra
IPC分类号： C07D257/02 , A61K49/06 , A61K49/10 , A61P35/00
CPC分类号： C07D257/02 , A61K51/082 , A61K51/088 , A61K51/1051 , A61K51/1093
摘要： According to the present invention, a novel polyazamacrocyclic compound which is used as a bifunctional chelating agent (BFC) can be synthesized selectively and in high yield. The novel polyazamacrocyclic compound synthesized by this method chelates with metals and thus can be conjugated with bioactive molecules such as peptides, and can be used in the diagnosis and treatment of medical conditions.

95. 发明公开

EP2520281A2 TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 有权
标题翻译：目标靶向释放系统与PEPTIDMARKIERTEM脂质体特别在拟过程白细胞介素-4受体及其生产诊断和治疗癌症的
公开(公告)号：EP2520281A2
公开(公告)日：2012-11-07
申请号：EP10841275.0
申请日：2010-12-29
申请人： Kyungpook National University Industry- Academic Cooperation Foundation , Industrial Technology Research Institute
发明人： KIM, In San , LEE, Byung Heon , LU, Maggie JM , LIANG, Hsiang-Fa , KO, Yi-Ju , LO, Ya-Chin , CHANG, Li-Wen , WEI, Ming-Cheng
IPC分类号： A61K9/127 , A61K47/30 , A61K47/18 , A61K38/20 , A61P35/00
CPC分类号： A61K31/704 , A61K9/1271 , A61K38/00 , A61K47/6911
摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.
摘要翻译：本发明涉及一种靶向药物递送系统，用于诊断和治疗标记与肽癌症含脂质体特异性靶向白介素-4受体，以及它们的制造方法。其中包含标记有在雅舞蹈制备本发明可以对癌症细胞，在其中IL-4受体被IL4RPep缩氨酸肽过度表达的特异性结合IL-4受体的药物递送IL4RPep缩氨酸肽抗癌药物的脂质体，和药物递送可以识别癌特别是通过一个标签的细胞。因此，IL4RPep缩氨酸肽可以增加仅在癌组织和在Sametime大大减少对正常组织，在体内（分子）成像和肿瘤的早期诊断成为可能的副作用的药物的效果。因此，其中包含与标记的本发明的肽IL4Pep抗癌药物脂质体可以应用，作为靶向药物递送系统，有效地对癌症的诊断和治疗。

96. 发明公开

EP2491953A2 OPTICAL IMAGING CONTRAST AGENT, USE AND DEVICE THEREOF 有权
标题翻译：造影剂光学成像和它们的用途及其装置
公开(公告)号：EP2491953A2
公开(公告)日：2012-08-29
申请号：EP10825230.5
申请日：2010-10-22
申请人： Kyungpook National University Industry- Academic Cooperation Foundation
发明人： YOO, Jeong-Soo , PARK, Jeong Chan
IPC分类号： A61K51/00 , A61P35/00 , A61K103/30 , A61K101/00
CPC分类号： G01T1/164 , A61K49/0002 , A61K49/0067 , A61K49/1857 , A61K51/02 , A61K51/025 , A61K51/0491 , A61K51/1051 , A61K51/1244 , G01T7/08
摘要： Provided are a contrast agent for optical imaging, a use thereof and an apparatus using the same.
The contrast agent for optical imaging of the present disclosure allows optical imaging without requiring a fluorophore or a luminophore. As a result, the optical images can be acquired without changing the physicochemical properties of a substrate. The contrast agent for optical imaging of the present disclosure may be used as an optical/nuclear bimodal imaging contrast agent for many applications, and allows radiation therapy as well as monitoring of a therapeutic effect thereof through optical imaging at the same time. Further, when a fluorophore is attached thereto, light emission may be enhanced without energy input from outside since light is emitted from the fluorophore, thereby increasing luminescence intensity and improving tissue penetration.
摘要翻译：本发明提供用于光学成像的造影剂，其用途和装置使用相同的。用于本发明的光学成像造影剂允许光学成像，而不需要荧光团或发光团。其结果是，可以在不改变一个基片的物理化学性质来获得光学图像。用于本发明的光学成像的造影剂可以在光/核双峰成像造影剂被用作用于许多应用中，和允许放射治疗以及在在Sametime其治疗效果通过光学成像监控。此外，当与其连接荧光团，光发射可以在不能量输入，因为光从荧光团发射，从而增加了发光强度和改进的组织穿透增强从外部。

97. 发明公开

EP2325916A1 Organic light emitting diode display and method of manufacturing the same 审中-公开
标题翻译：有机发光二极管显示器及其制造方法
公开(公告)号：EP2325916A1
公开(公告)日：2011-05-25
申请号：EP10191279.8
申请日：2010-11-16
申请人： Samsung Mobile Display Co., Ltd. , Kyungpook National University Industry-Academic Cooperation Foundation
发明人： Lee, Sung-Hun , Lee, Gwan-Hyoung , Chu, Chang-Woong , Ju, Young-Gu
IPC分类号： H01L51/52
CPC分类号： H01L51/5262 , H01L51/5268 , H01L2251/5369
摘要： An organic light emitting diode (OLED) device is disclosed. In one embodiment, the OLED device includes: a substrate (110) and a first thin film (112) formed on the substrate, wherein the first thin film (112) comprises first and second surfaces opposing each other, wherein the first surface contacts the substrate (110), and wherein a plurality of protrusions and depressions (112a) are alternately formed on the second surface of the first thin film (112). The OLED device further includes a second thin film (114) formed on the protrusions and depressions (112a) of the first thin film (112), a first electrode (191) formed on the second thin film (114), an organic light emitting member (370) formed on the first electrode (191) and a second electrode (270) formed on the organic light emitting member (370).
摘要翻译：公开了一种有机发光二极管（OLED）器件。在一个实施例中，OLED器件包括：衬底（110）和形成在衬底上的第一薄膜（112），其中第一薄膜（112）包括彼此相对的第一和第二表面，其中第一表面接触衬底（110），并且其中多个凸起和凹陷（112a）交替地形成在第一薄膜（112）的第二表面上。 OLED装置还包括形成在第一薄膜（112）的凸起和凹陷（112a）上的第二薄膜（114），形成在第二薄膜（114）上的第一电极（191），有机发光形成在第一电极191上的构件370和形成在有机发光构件370上的第二电极270。

98. 发明授权

EP3858359B1 COMPOSITION, COMPRISING A THIAMINE DERIVATIVE, FOR PREVENTION OR TREATMENT OF HYPERCORTISOLEMIA 有权
公开(公告)号：EP3858359B1
公开(公告)日：2024-03-06
申请号：EP19864600.2
申请日：2019-09-30
发明人： LEE, In Kyu , JEON, Jae Han , KANG, Hyeon-Ji
IPC分类号： A61K31/51 , A61K31/10 , A61K31/675 , A61P5/38 , A61P9/12 , A61P3/10 , A61P3/04 , A61P5/42 , A23L33/10

99. 发明授权

EP3536272B1 MEDICAL INSERTION DEVICE 有权
公开(公告)号：EP3536272B1
公开(公告)日：2024-02-14
申请号：EP17881065.1
申请日：2017-12-04
发明人： KIM, Kyoungtae
IPC分类号： A61B5/24 , A61C8/00 , A61B17/70 , A61B17/86 , A61B17/88 , A61B5/053

100. 发明授权

EP3795169B1 BACTERIOPHAGE-DERIVED RECOMBINANT PROTEIN HAVING ANTIMICROBIAL ACTIVITY AGAINST PATHOGENIC GRAM-NEGATIVE BACTERIA 有权
公开(公告)号：EP3795169B1
公开(公告)日：2023-08-23
申请号：EP19797136.9
申请日：2019-04-30
发明人： KIM, Jung Min , KIM, Shukho
IPC分类号： A61K38/16 , A61K48/00 , A23L33/18 , A23K20/147 , C07K14/005 , A61P31/00 , C12N9/36

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