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    • 94. 发明公开
    • MRI CONTRAST AGENT HAVING GADOLINIUM COMPLEX
    • MRI-KONTRASTMITTEL MIT GADOLINIUM-KOMPLEX
    • EP2623500A1
    • 2013-08-07
    • EP10857933.5
    • 2010-12-21
    • Kyungpook National University Industry- Academic Cooperation Foundation
    • KIM, Tae-JeongCHANG, Yong MinKIM, Hee-KyungGU, Sung-Wook
    • C07D257/02A61K49/06A61K49/10
    • C07F5/00A61K49/106C07D257/02
    • The present invention relates to a magnetic resonance imaging (MRI) contrast agent including a gadolinium complex, more particularly to a DO3A-tranexamic acid or its ester compound, which is represented by the Chemical Formula 1.
      A DO3A-tranexamic acid or its ester compound may be prepared according to the present invention and a gadolinium complex may be prepared using the compound. An MRI contrast agent including the gadolinium complex prepared according to the present invention as an active ingredient has higher relaxivity as compared to the currently commercially available contrast agent. In addition, the MRI contrast agent according to the present invention has bifunctionality of liver-specific and blood-pool contrasting effect. Accordingly, since the MRI contrast agent including the gadolinium complex according to the present invention satisfies the key properties required for a contrast agent for MRI, it can be widely used as an MRI contrast agent and can provide enhanced contrasting effect as compared to the existing contrast agent.
    • 本发明涉及包含钆络合物的磁共振成像(MRI)造影剂,更具体地说,涉及由化学式1表示的DO3A-氨甲环酸或其酯化合物。DO3A-氨甲环酸或其酯化合物 可以根据本发明制备,并且可以使用该化合物制备钆络合物。 包含根据本发明制备的钆络合物作为活性成分的MRI造影剂与目前市售的造影剂相比具有更高的松弛度。 此外,根据本发明的MRI造影剂具有肝特异性和血池对比效果的双功能性。 因此,由于包含本发明的钆络合物的MRI造影剂满足MRI造影剂所需的关键特性,因此可广泛用作MRI造影剂,与现有对比度相比可以提供增强的对比效果 剂。