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91. 发明授权

US06008409A Method for obtaining 2-hydroxy-4-methylthiobutyric acid (MHA) which is stable in storage 失效
标题翻译：获得储存稳定的2-羟基-4-甲硫基丁酸（MHA）的方法
公开(公告)号：US06008409A
公开(公告)日：1999-12-28
申请号：US999000
申请日：1997-12-29
申请人： Hans-Albrechl Hasseberg , Hans-Joachim Hasselbach , Klaus Huthmacher , Volker Hafner , Harald Heinzel , Axel Ronneburg
发明人： Hans-Albrechl Hasseberg , Hans-Joachim Hasselbach , Klaus Huthmacher , Volker Hafner , Harald Heinzel , Axel Ronneburg
IPC分类号： C07C319/20 , A23K20/105 , C07C319/26 , C07C319/28 , C07C323/52 , C07C315/00
CPC分类号： C07C319/28 , A23K20/105 , C07C319/26
摘要： A method for obtaining 2-hydroxy-4-methylthiobutyric acid (methionine-hydroxy analog, MHA) in primarily free form which is stable in storage by distilling a product solution containing MHA and by producing MHA product mixtures with improved storage stability from such a distillate. The distillate can be produced directly starting from MHA raw products from any MHA production process, which can optionally also contain solvent or water. The starting material may also be a commercial MHA product.
摘要翻译：获得主要游离形式的2-羟基-4-甲硫基丁酸（甲硫氨酸 - 羟基类似物，MHA）的方法，其通过蒸馏含有MHA的产物溶液并通过生产具有改善的储存稳定性的这种馏出物的MHA产物混合物而在储存中稳定。馏出物可以从任何MHA生产过程的MHA原始产品直接生产，其可任选地还含有溶剂或水。起始材料也可以是商业MHA产品。

92. 发明授权

US5191085A Optically active salts of a substituted thiazolidine-4-carboxylate and 3-cyano-hydroxypropyl trimethyl-ammonium, their production and uses 失效
标题翻译：取代的噻唑烷-4-羧酸酯和3-氰基 - 羟丙基三甲基氨基铵的光学活性物质，其生产和用途
公开(公告)号：US5191085A
公开(公告)日：1993-03-02
申请号：US675623
申请日：1991-03-27
申请人： Harald Jakob , Klaus Huthmacher , Herbert Klenk
发明人： Harald Jakob , Klaus Huthmacher , Herbert Klenk
IPC分类号： C07B53/00 , C07C255/26 , C07D277/06
CPC分类号： C07D277/06
摘要： Optically active salts are disclosed of the formula (I): ##STR1## wherein Ac represents an acyl group, R.sup.1 hydrogen or methyl, R.sup.2 and R.sup.3 identical or different substitutes, preferably methyl. The salts can be obtained from the corresponding optically active carbonic acid and DL-3-cyano-2-hydroxypropyl trimethylammonium hydroxide. The diastereomeric salt pairs are easily split from one another and separated again, so that the process is suited for producing optically active 3-cyano-2-hydroxypropyl trimethylammonium salts.
摘要翻译：公开了式（I）的光学活性盐：其中Ac表示酰基，R 1氢或甲基，R 2和R 3相同或不同的取代基，优选甲基。盐可以从相应的光学活性碳酸和DL-3-氰基-2-羟丙基三甲基铵氢氧化物获得。非对映体盐对彼此容易分离并再次分离，因此该方法适用于制备光学活性3-氰基-2-羟丙基三甲基铵盐。

93. 发明授权

US5041655A Method of preparing 1,6-di(N.sup.3 -cyano-N.sup.1 -guanidino) hexane 失效
标题翻译：制备1,6-二（N 3 - 氰基-N 1胍基）己烷的方法
公开(公告)号：US5041655A
公开(公告)日：1991-08-20
申请号：US241116
申请日：1988-09-06
申请人： Klaus Huthmacher , Axel Kleemann , Horst Bethge , Rolf Braun
发明人： Klaus Huthmacher , Axel Kleemann , Horst Bethge , Rolf Braun
IPC分类号： C07C67/00 , C07C239/00 , C07C277/08 , C07C279/28
CPC分类号： C07C279/28
摘要： An improved method of preparing 1,6-di(N.sup.3 -cyano-N.sup.1 -guanidino) hexane from alkali dicyanamide and a hexamethylene diammonium salt in alcoholic solution or suspension. The reaction is carried out in the presence of a limited amount of water and of a catalytic amount of a base, preferably a tertiary amine. The pH of the reaction mixture at the start of the reaction is 8 to 10. After the reaction is over, the reaction mixture is compounded with water at a temperature above 80.degree. C. and the coarse product which crystallizes out is separated from the liquid phase.Preferably, sodium dicyanamide and hexamethylene diamine dihydrochloride, preferably formed in situ from aqueous 1,6-diaminohexane and aqueous hydrochloric acid, are reacted at pH 9-9.5 in n-butanol in the presence of 0.1 to 20% by wt. water in relation to the solvent including water.1,6-di(N.sup.3 -cyano-N.sup.1 -guanidino) hexane is obtained in a high yield (85-86%) and with great purity (95-97%) and with a considerably improved space-time yield.
摘要翻译：一种在醇溶液或悬浮液中由碱二氰胺和六亚甲基二铵盐制备1,6-二（N 3 - 氰基-N 1胍基）己烷的改进方法。反应在有限量的水和催化量的碱，优选叔胺的存在下进行。反应开始时反应混合物的pH值为8〜10。反应结束后，将反应混合物在高于80℃的温度下与水混合，将结晶出来的粗产物与液体分离相。优选地，优选在1,6-二氨基己烷水溶液和盐酸水溶液中原位形成的二氰胺钠和六亚甲基二胺盐酸盐在pH为9-9.5的正丁醇中，在0.1-20重量％的存在下反应。相对于包括水在内的溶剂的水。以高产率（85-86％）和高纯度（95-97％）获得1,6-二（N 3 - 氰基-N 1胍基）己烷，并具有显着提高的时空产率。

94. 发明授权

US07874064B2 Device for positioning and fixing wires in tubes 有权
标题翻译：用于在管中定位和固定电线的装置
公开(公告)号：US07874064B2
公开(公告)日：2011-01-25
申请号：US11185330
申请日：2005-07-20
申请人： Achim Fischer , Werner Burkhardt , Klaus Huthmacher
发明人： Achim Fischer , Werner Burkhardt , Klaus Huthmacher
IPC分类号： H01R43/00 , B23Q15/00 , A41H37/06
CPC分类号： G01K1/146 , G01K7/02 , Y10T29/49171 , Y10T29/53091 , Y10T29/532 , Y10T29/53213 , Y10T29/53239 , Y10T29/533
摘要： A device for fixing and positioning in tubes and its use in tubular reactors.
摘要翻译：用于固定和定位在管中的装置及其在管式反应器中的应用。

95. 发明申请

US20100324331A1 MIXED OXIDE CATALYSTS MADE OF HOLLOW SHAPES 审中-公开
标题翻译： HOLLOW形状的混合氧化物催化剂
公开(公告)号：US20100324331A1
公开(公告)日：2010-12-23
申请号：US12528407
申请日：2008-01-28
申请人： Achim Fischer , Werner Burkhardt , Stefan Röder , Klaus Huthmacher
发明人： Achim Fischer , Werner Burkhardt , Stefan Röder , Klaus Huthmacher
IPC分类号： C07C51/265 , B01J27/192 , B01J23/28 , C07C51/25 , C07C45/32
CPC分类号： B01J23/002 , B01J23/8876 , B01J23/8885 , B01J23/8892 , B01J23/8993 , B01J27/199 , B01J35/08 , B01J37/0018 , B01J2523/00 , C07C45/34 , C07C45/35 , C07C45/36 , C07C51/252 , C07C47/22 , C07C57/04 , B01J2523/13 , B01J2523/72 , B01J2523/842 , B01J2523/845 , B01J2523/847 , B01J2523/31 , B01J2523/3737 , B01J2523/51 , B01J2523/54 , B01J2523/68
摘要： The invention relates to mixed oxide catalysts made of hollow shapes for the catalytic gas phase oxidation of olefins, and to a method for producing the catalysts by applying them as a layer to a carrier made of organic material and removing said organic material. The reaction into aldehydes and carboxylic acids occurs by air or oxygen in the presence of inert gases in different quantity ratios, at elevated temperatures and pressure in the presence of said catalysts.
摘要翻译：本发明涉及由用于烯烃的催化气相氧化的中空形状的混合氧化物催化剂，以及通过将它们作为层施加到由有机材料制成的载体上并除去所述有机材料的方法。在惰性气体存在下，在所述催化剂存在下，在升高的温度和压力下，通过空气或氧气在不同量的比例存在下发生醛和羧酸的反应。

96. 发明授权

US06924134B2 Nucleotide sequences which code for the gorA gene 失效
标题翻译：编码gorA基因的核苷酸序列
公开(公告)号：US06924134B2
公开(公告)日：2005-08-02
申请号：US09946764
申请日：2001-09-06
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Achim Marx
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Achim Marx
IPC分类号： C12N9/02 , C12P13/08 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00
CPC分类号： C12N9/0036 , C12P13/08
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the gorA gene, and a host-vector system having a coryneform host bacterium in which the gorA gene is present in attenuated form and a vector which carries at least the gorA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码gorA基因的多核苷酸序列的分离的多核苷酸，以及具有其中gorA基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带gorA基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

97. 发明授权

US06777206B2 Nucleotide sequences which code for the RodA protein 失效
标题翻译：编码RodA蛋白的核苷酸序列
公开(公告)号：US06777206B2
公开(公告)日：2004-08-17
申请号：US09950071
申请日：2001-09-12
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Brigitte Bathe
IPC分类号： C12P2106
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention provides nucleotide sequences from Coryneform bacteria which code for the RodA protein and a process for the fermentative preparation of amino acids using bacteria in which the rodA gene is enhanced.
摘要翻译：本发明提供了编码RodA蛋白质的棒状细菌的核苷酸序列和使用其中rodA基因增强的细菌发酵制备氨基酸的方法。

98. 发明授权

US06482964B1 Process for the preparation of &bgr;-isophorone epoxide 失效
标题翻译： β-异佛尔酮环氧化物的制备方法
公开(公告)号：US06482964B1
公开(公告)日：2002-11-19
申请号：US09855837
申请日：2001-05-16
申请人： Steffen Krill , Klaus Huthmacher , Alexander Möller
发明人： Steffen Krill , Klaus Huthmacher , Alexander Möller
IPC分类号： C07D30114
CPC分类号： C07D303/32
摘要： Process for the selective preparation of &bgr;-isophorone epoxide by epoxidation of &bgr;-isophorone with organic percarboxylic acids at a water content of less than 5 wt. %.
摘要翻译：通过β-水溶性有机过羧酸与β-异佛尔酮环氧化物的水解含量小于5wt％的选择性制备方法。％。

99. 发明授权

US06441199B2 Process for the production of &agr;-tocopherol acetate by condensation of trimethylhydroquinone with isophytol with recycling of an acetic catalyst solution 失效
标题翻译：通过三甲基氢醌与异麦芽糖醇的缩合制备乙酸α-生育酚的方法，再循环乙酸催化剂溶液
公开(公告)号：US06441199B2
公开(公告)日：2002-08-27
申请号：US09801091
申请日：2001-03-08
申请人： Steffen Krill , Stepahn Kretz , Klaus Huthmacher
发明人： Steffen Krill , Stepahn Kretz , Klaus Huthmacher
IPC分类号： C07D31176
CPC分类号： C07D311/72 , Y02P20/584
摘要： A process for the production of &agr;-tocopherol acetate in a recirculating process by condensation of trimethylhydroquinone and isophytol in the presence of a catalyst system of a zinc halide and an aqueous protonic acid and, optionally, an elemental metal, in a polar solvent/water mixture extractable or miscible with water, and subsequent acylation of the resultant &agr;-tocopherol and recirculation of the catalyst system.
摘要翻译：一种在循环过程中通过在极性溶剂/水中在卤化锌和质子酸水溶液和任选的元素金属的催化剂体系存在下，通过三甲基氢醌和异麦芽糖醇的缩合来生产α-生育酚乙酸酯的方法混合物可与水混溶，随后酰化生成的α-生育酚和催化剂体系的再循环。

100. 发明授权

US06417409B1 Process for the production of 2,3,5-trimethylhydroquinone diesters 失效
标题翻译：制备2,3,5-三甲基氢醌二酯的方法
公开(公告)号：US06417409B1
公开(公告)日：2002-07-09
申请号：US09502229
申请日：2000-02-11
申请人： Steffen Krill , Klaus Huthmacher
发明人： Steffen Krill , Klaus Huthmacher
IPC分类号： C07C3700
CPC分类号： C07C67/00 , Y02P20/582 , C07C69/017 , C07C69/16
摘要： The invention relates to an improved process for the production of 2,3,5-trimethylhydroquinone diesters by rearrangement of 2,6,6-trimethyl-2-cyclohexene-1,4-dione (4-oxoisophorone, ketoisophorone) in the presence of a dissolved, acidic catalyst and an acylating agent, such as for example carboxylic anhydrides or carboxylic acid halides. The 2,3,5-trimethylhydroquinone diester can optionally then be saponified to give free 2,3,5-trimethylhydroquinone (TMHQ), which is a valuable building block in the synthesis of vitamin E.
摘要翻译：本发明涉及通过在2,6,6-三甲基-2-环己烯-1,4-二酮（4-氧代异佛尔酮，酮异佛尔酮）的存在下重排来制备2,3,5-三甲基氢醌二酯的改进方法溶解的酸性催化剂和酰化剂，例如羧酸酐或羧酸卤化物。可以任选地将2,3,5-三甲基氢醌二酯皂化，得到游离的2,3,5-三甲基氢醌（TMHQ），其是维生素E合成中的有价值的结构单元。

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