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91. 发明授权

US5854046A Human hyaluronidase 失效
公开(公告)号：US5854046A
公开(公告)日：1998-12-29
申请号：US8962
申请日：1998-01-20
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N1/21 , C12N9/26 , C12N15/56
CPC分类号： C12N9/2408 , A61K38/00
摘要： The present invention provides a polynucleotide (hhp) which identifies and encodes a novel human hyaluronidase (HHP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HHP. The invention also provides for the use of substantially purified HHP and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HHP. Additionally, the invention provides for the use of antisense molecules to hhp in pharmaceutical compositions for treatment of diseases associated with the expression of HHP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of hhp. The present invention also relates to anti-HHP antibodies which specifically bind to HHP.

92. 发明授权

US5846778A Human map kinase homolog 失效
标题翻译：人地图激酶同源物
公开(公告)号：US5846778A
公开(公告)日：1998-12-08
申请号：US920296
申请日：1997-08-28
申请人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
发明人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
IPC分类号： A61K38/00 , C12N9/12 , C12N15/00 , C07H21/04 , C07K14/435
CPC分类号： C12N9/1205 , C12N9/12 , A61K38/00 , Y10S530/827
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
摘要翻译：本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

93. 发明授权

US5817480A DNA encoding a histamine H2 receptor 失效
标题翻译：编码组胺H2受体的DNA
公开(公告)号：US5817480A
公开(公告)日：1998-10-06
申请号：US748485
申请日：1996-11-07
申请人： Lynn E. Murry , Janice Au-Young , Karl J. Guegler , Surya K. Goli
发明人： Lynn E. Murry , Janice Au-Young , Karl J. Guegler , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/00 , A61P25/00 , A61P29/00 , C07K14/705 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , C12N15/66
CPC分类号： C07K14/723 , A61K38/00
摘要： The present invention provides a novel histamine H2 receptor (H2RH) and polynucleotides which identify and encode H2RH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding H2RH and a method for producing H2RH. The invention also provides for agonists, antibodies, or antagonists specifically binding H2RH, and their use, in the prevention and treatment of diseases in which H2RH is expressed. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding H2RH for the treatment of diseases associated with the expression of H2RH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding H2RH.
摘要翻译：本发明提供了一种新型的组胺H2受体（H2RH）和识别和编码H2RH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码H2RH的核酸序列和生产H2RH的方法。本发明还提供了特异性结合H2RH的激动剂，抗体或拮抗剂及其在预防和治疗其中表达H2RH的疾病中的用途。另外，本发明提供了将反义分子用于编码H2RH的多核苷酸用于治疗与H2RH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合H2RH的抗体的诊断测定法。

94. 发明申请

US20080181895A1 SP16 protein 审中-公开
公开(公告)号：US20080181895A1
公开(公告)日：2008-07-31
申请号：US11979577
申请日：2007-11-06
申请人： Preeti G. Lal , Janice Au-Young , Roopa Reddy , Lynn E. Murry , Preete Mathur
发明人： Preeti G. Lal , Janice Au-Young , Roopa Reddy , Lynn E. Murry , Preete Mathur
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , A61P43/00 , C40B40/10 , G01N33/574
CPC分类号： G01N33/57484 , A61K38/00 , A61K39/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K2319/02 , C07K2319/036 , C07K2319/60 , C07K2319/61 , C07K2319/71 , C07K2319/80 , C12N15/625 , C12Q1/6886 , G01N33/574 , G01N33/57415
摘要： The invention provides cDNAs which encodes a signal peptide-containing proteins. It also provides for the use of a cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.

95. 发明授权

US07321023B2 SP16 protein 失效
标题翻译： SP16蛋白
公开(公告)号：US07321023B2
公开(公告)日：2008-01-22
申请号：US09968433
申请日：2001-10-01
申请人： Preeti G. Lal , Janice Au-Young , Roopa Reddy , Lynn E. Murry , Preete Mathur
发明人： Preeti G. Lal , Janice Au-Young , Roopa Reddy , Lynn E. Murry , Preete Mathur
IPC分类号： C07K14/435 , C07H21/00
CPC分类号： G01N33/57484 , A61K38/00 , A61K39/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K2319/02 , C07K2319/036 , C07K2319/60 , C07K2319/61 , C07K2319/71 , C07K2319/80 , C12N15/625 , C12Q1/6886 , G01N33/574 , G01N33/57415
摘要： The invention provides cDNAs which encodes a signal peptide-containing proteins. It also provides for the use of a cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.
摘要翻译：本发明提供了编码含信号肽的蛋白质的cDNA。它还提供了在癌症治疗的诊断，预后，治疗和评估中使用cDNA，蛋白质和抗体。本发明还提供用于生产蛋白质和转基因模型系统的载体和宿主细胞。

96. 发明授权

US06479630B1 Human purinergic P2U receptor 失效
标题翻译：人类嘌呤能P2U受体
公开(公告)号：US06479630B1
公开(公告)日：2002-11-12
申请号：US09102710
申请日：1998-06-22
申请人： Roger Coleman , Janice Au-Young , Susan G. Stuart , Karl J. Guegler
发明人： Roger Coleman , Janice Au-Young , Susan G. Stuart , Karl J. Guegler
IPC分类号： G07K14705
CPC分类号： C12N15/1096 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N9/6472
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.
摘要翻译：本发明提供鉴定和编码在人胎盘中表达的新型嘌呤能PU2受体（PNR）的核苷酸和氨基酸序列。本发明还提供了编码PNR的核苷酸序列的反义分子，用于产生纯化的PNR的表达载体，能够特异性结合PNR的抗体，用于检测PNR编码核苷酸序列的杂交探针或寡核苷酸的遗传工程化宿主用于表达PNR的细胞，以及基于编码PNR的核酸分子或针对多肽PNR产生的抗体的诊断测试。

97. 发明授权

US06309821B1 DNA encoding a PAC10 human homolog 失效
标题翻译：编码PAC10人类同源物的DNA
公开(公告)号：US06309821B1
公开(公告)日：2001-10-30
申请号：US08648736
申请日：1996-05-16
申请人： Janice Au-Young , Richard D. Goold
发明人： Janice Au-Young , Richard D. Goold
IPC分类号： C12Q168
CPC分类号： C07K14/47
摘要： The present invention provides nucleotide and amino acid sequences for a novel PAC10 human homolog. The present invention also provides for antisense molecules, diagnostic molecules, genetically engineered expression vectors and host cells for the production of purified PAC10 homologs; antibodies, agonists, antagonists and inhibitors of the PAC10 human homolog; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, ntagonists and inhibitors. The invention further provides diagnostic and theapeutic compositions for the detection and treatment of X-linked congenital abnormalities, such as centronuclear myopathy.
摘要翻译：本发明提供新型PAC10人类同源物的核苷酸和氨基酸序列。本发明还提供用于产生纯化的PAC10同源物的反义分子，诊断分子，遗传工程表达载体和宿主细胞; 抗体，激动剂，拮抗剂和PAC10人类同源物的抑制剂; 以及基于多肽，其抗体，抑制剂和抑制剂的药物组合物和治疗方法。本发明进一步提供了用于检测和治疗X联合先天性异常的诊断和治疗组合物，例如中脑核病。

98. 发明授权

US6037164A Human parvulin-like protein 失效
公开(公告)号：US6037164A
公开(公告)日：2000-03-14
申请号：US801743
申请日：1997-02-14
申请人： Janice Au-Young
发明人： Janice Au-Young
IPC分类号： A61K38/00 , C12N1/21 , C12N9/90 , C07H21/04 , C12N15/63
CPC分类号： C12N9/90 , A61K38/00
摘要： The present invention provides a human parvulin-like protein (HPVLP) and polynucleotides which identify and encode HPVLP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPVLP and a method for producing HPVLP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPVLP, and their use, in the prevention and treatment of diseases associated with expression of HPVLP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPVLP for the treatment of diseases associated with the expression of HPVLP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPVLP.

99. 发明授权

US5972649A Polynucleotide sequence encoding human multiple endocrine neoplasia type 1 protein 失效
标题翻译：编码人多发性内分泌肿瘤1型蛋白的多核苷酸序列
公开(公告)号：US5972649A
公开(公告)日：1999-10-26
申请号：US865337
申请日：1997-05-29
申请人： Janice Au-Young , Peter A. Covitz , Y. Tom Tang , Lynn E. Murry
发明人： Janice Au-Young , Peter A. Covitz , Y. Tom Tang , Lynn E. Murry
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P35/00 , A61P43/00 , C07K14/435 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/11 , C12N15/00 , C12N15/63
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides a human multiple endocrine neoplasia type 1 protein (MEND1) and polynucleotides which identify and encode MEND1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of MEND1.
摘要翻译：本发明提供了人多发性内分泌肿瘤1型蛋白（MEND1）和识别和编码MEND1的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与MEND1表达相关的疾病的方法。

100. 发明授权

US5922844A Human cAMP-dependent protein kinase inhibitor homolog 失效
标题翻译：人cAMP依赖性蛋白激酶抑制剂同源物
公开(公告)号：US5922844A
公开(公告)日：1999-07-13
申请号：US892150
申请日：1997-07-14
申请人： Phillip R. Hawkins , Jennifer L. Hillman , Janice Au-Young
发明人： Phillip R. Hawkins , Jennifer L. Hillman , Janice Au-Young
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K38/55 , A61K39/395 , A61K48/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C07K1/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention provides a polynucleotide (ipka) which identifies and encodes a novel human cAMP-dependent protein kinase A inhibitor homolog (IPKA). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKA. The invention also provides for the use of purified IPKA and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of IPKA. Additionally, the invention provides for the use of antisense molecules to ipka in pharmaceutical compositions for treatment of diseases associated with the expression of IPKA. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ipka. The present invention also relates to anti-IPKA antibodies which specifically bind to IPKA.
摘要翻译：本发明提供鉴定和编码新的人cAMP依赖性蛋白激酶A抑制剂同源物（IPKA）的多核苷酸（ipka）。本发明提供了包含编码IPKA的核酸序列的基因工程表达载体和宿主细胞。本发明还提供纯化的IPKA及其激动剂在商业生产重组蛋白质和用于治疗与IPKA表达相关的疾病的药物组合物中的用途。另外，本发明提供了用于治疗与IPKA表达相关的疾病的药物组合物中ipka的反义分子的用途。本发明还描述了使用包含其多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与ipka的基因组序列或转录物杂交。本发明还涉及特异性结合IPKA的抗IPKA抗体。

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