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91. 发明授权

US06458814B1 Vitronectin receptor antagonists 失效
标题翻译： Vitronectin受体拮抗剂
公开(公告)号：US06458814B1
公开(公告)日：2002-10-01
申请号：US09762406
申请日：2001-02-07
申请人： Peter J. Manley , William H. Miller
发明人： Peter J. Manley , William H. Miller
IPC分类号： C07D41312
CPC分类号： C07D413/12
摘要： Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
摘要翻译：公开了式（I）的化合物，其是玻连蛋白受体拮抗剂，可用于治疗骨质疏松症：或其药学上可接受的盐。

92. 发明授权

US6069158A Vitronectin receptor antagonists 有权
标题翻译： Vitronectin受体拮抗剂
公开(公告)号：US6069158A
公开(公告)日：2000-05-30
申请号：US331914
申请日：1999-06-29
申请人： William H. Miller , William E. Bondinell , Thomas Wen Fu Ku
发明人： William H. Miller , William E. Bondinell , Thomas Wen Fu Ku
IPC分类号： A61K31/4402 , A61P9/10 , A61P19/10 , A61P29/00 , A61P35/00 , C07C69/734 , C07C69/738 , C07D213/74 , C07D213/75 , C07D213/02 , A61K31/44
CPC分类号： C07D213/74 , C07C69/734 , C07C69/738 , C07D213/75
摘要： This invention relates to certain tricyclic compounds that are integrin receptor antagonists.
摘要翻译： PCT No.PCT / US98 / 00490 Sec。 371日期1999年6月29日第 102（e）1999年6月29日PCT PCT 1998年1月8日PCT公布。第WO98 / 30542号公报日期：1998年7月16日本发明涉及作为整联蛋白受体拮抗剂的某些三环化合物。

93. 发明授权

US5393756A 5H-[1,2]benzisothiazolo[2,3-a]quinoline-5-ones and analogs as antiinflammatory agents 失效
标题翻译： 5H- [1,2]苯并异噻唑并[2,3-a]喹啉-5-酮和类似物作为抗炎剂
公开(公告)号：US5393756A
公开(公告)日：1995-02-28
申请号：US51611
申请日：1993-04-22
申请人： William H. Miller
发明人： William H. Miller
IPC分类号： C07D513/04 , A61K31/44 , A61K31/495 , C07D241/36 , C07D513/14
CPC分类号： C07D513/04
摘要： The present invention relates to 5H-[1,2]benzisothiazolo[2,3-a]quinoline-5-ones, pharmaceutical compositions thereof and to methods of using these compounds for the treatment of inflammatory disorders.
摘要翻译：本发明涉及5H- [1,2]苯并异噻唑并[2,3-a]喹啉-5-酮及其药物组合物，以及使用这些化合物治疗炎症性疾病的方法。

94. 发明授权

US5344443A Heart pump 失效
标题翻译：心脏泵
公开(公告)号：US5344443A
公开(公告)日：1994-09-06
申请号：US946381
申请日：1992-09-17
申请人： Rodolfo Palma , William H. Miller
发明人： Rodolfo Palma , William H. Miller
IPC分类号： A61M1/10 , A61M1/12 , F04D3/02 , F04D13/06 , H02K5/12 , H02K5/167 , H02K5/22 , H02K7/14 , H02K11/00 , H02K21/46 , A61N1/362
CPC分类号： A61M1/1031 , A61M1/101 , F04D13/0673 , F04D3/02 , H02K11/01 , H02K11/33 , H02K21/46 , H02K5/1677 , H02K5/225 , H02K7/14 , H02K2205/03 , H02K5/12
摘要： A heart pump having a housing with a central longitudinal axis, inlet means and an outlet means is disclosed. A stationary shaft extends axially within the housing and the means are provided for supporting the shaft centrally located within the housing. A stator assembly is mounted about the stationary shaft and a shell assembly is rotatable about the stator assembly and shaft. The shell assembly is located between the housing and stator assembly and includes a spiral ridge located on the outerside thereof for pumping blood through the housing between the housing and shell assembly as the shell assembly rotates. Rotor laminations are located on an innerside of the shell assembly. The rotor laminations have a plurality of axially extending permanent magnets therebetween which are circumferentially spaced about the stationary shaft. A damper winding means is mounted within the rotor laminations. Blood may flow between the shell assembly and housing without exposure to magnetic fields.
摘要翻译：公开了具有具有中心纵向轴线的壳体，入口装置和出口装置的心脏泵。固定轴在壳体内轴向延伸，并且提供用于将轴支撑在壳体内的中心的装置。定子组件围绕固定轴安装，壳体组件可围绕定子组件和轴转动。壳体组件位于壳体和定子组件之间，并且包括位于其外侧的螺旋脊，其用于在壳体组件旋转时将血液通过外壳和外壳组件之间的壳体泵送。转子叠片位于壳体组件的内侧。转子叠片在它们之间具有多个轴向延伸的永磁体，它们围绕固定轴周向间隔开。减震器绕组装置安装在转子叠片内。血液可能在壳体组件和壳体之间流动，而不会暴露于磁场。

95. 发明授权

US5219588A Die assembly control 失效
标题翻译：模具组装控制
公开(公告)号：US5219588A
公开(公告)日：1993-06-15
申请号：US797636
申请日：1991-11-25
申请人： Todd A. England , William H. Miller
发明人： Todd A. England , William H. Miller
IPC分类号： B29C47/00 , B29C47/26 , B29C47/56 , B29C47/74
CPC分类号： B29C47/0035 , B29C47/003 , B29C47/26 , B29C47/56 , B29C47/70 , B29C47/74 , B29C47/025
摘要： A die assembly (10) for controlling extrudate profile dimension. The die assembly includes a die block (12) having a feed passage (16) for movably supporting a diverter member (13) within the die block, and first and second die block passages (18, 20). The diverter member (13) includes a diverter passage (32) and first and second feed openings (34, 36) interconnected by the diverter passage. One of the first or second feed openings (34, 36) has a larger diameter than the other of the first or second feed openings. The diverter member (13) is movable with respect to the die block (12) for directing extrudate flow via the diverter passage (32) through the second die block passage (20), to thereby vary the profile dimension of the extrudate exiting the die block. The die block (12) additionally includes a disposal passage (22). Movement of the diverter member (13) within the die block is provided between a first position providing communication between the first and second die block passages ( 18, 20), and a second position providing communication between the first die block passage (18) and the disposal passage (22). A die plate (14) may be readily changed by directing extrudate flow via the disposal passage (22).
摘要翻译：一种用于控制挤出物型材尺寸的模具组件（10）。模具组件包括具有用于可移动地支撑模块内的转向构件（13）的进给通道（16）的模块（12）以及第一和第二模块通道（18,20）。分流器构件（13）包括分流器通道（32）和通过分流器通道互连的第一和第二进料口（34,36）。第一或第二进料口（34,36）中的一个具有比第一或第二进料口中另一个更大的直径。分流器构件（13）可相对于模具块（12）移动，用于通过分流器通道（32）引导挤出物通过第二模具块通道（20），从而改变离开模具的挤出物的轮廓尺寸块。模块（12）还包括处置通道（22）。分流器构件（13）在模具块内的运动设置在提供第一和第二模块通道（18,20）之间的连通的第一位置和第二位置之间，提供第一模块通道（18）和处置通道（22）。通过经由处置通道（22）引导挤出物流可以容易地改变模板（14）。

96. 发明授权

US5206369A Process for the dehydration of dihydroxypiperidinedicarboxylates 失效
标题翻译：脱水二羟基哌啶二羧酸酯的方法
公开(公告)号：US5206369A
公开(公告)日：1993-04-27
申请号：US822791
申请日：1992-01-21
申请人： William H. Miller
发明人： William H. Miller
IPC分类号： C07B61/00 , C07D211/60 , C07D211/90
CPC分类号： C07D211/90
摘要： An improved process for dehydrating dialkyl 2,6-bis(trifluoromethyl)-2,6-dihydroxy-4-(alkyl)-3,5-piperidinedicarboxylates using concentrated sulfuric acid essentially in the absence of a solvent to prepare the corresponding dialkyl 2,6-bis(trifluoromethyl)dihydro-4-(alkyl)-3,5-pyridinedicarboxylates.

97. 发明授权

US5159563A Crack detection method for operating shaft 失效
标题翻译：用于操作轴的裂纹检测方法
公开(公告)号：US5159563A
公开(公告)日：1992-10-27
申请号：US585884
申请日：1990-09-19
申请人： William H. Miller , Warren R. Brook
发明人： William H. Miller , Warren R. Brook
IPC分类号： G01H17/00 , G01H13/00 , G01M13/02 , G01N3/32 , G01N29/12 , G21C17/00
CPC分类号： G01H13/00 , G01N29/12 , G01N2291/2693
摘要： The presence, size and location of a crack in a shaft is determined by comparing actual measured natural frequencies of the operating shaft system with the results of an analytical model. From a multi-station analytical model of an uncracked operating shaft system, natural frequencies and associated mode shapes are derived. A suspected axial location of a crack is defined, and a natural frequency of interest is selected which has an associated mode shape exhibiting significant localized bending at the suspected axial location of the crack and at a site of response measurement. The analytical model is modified to include a representation of an asymmetric crack at the suspected crack location. A predicted split and downward shift of a lateral natural frequency of interest as a function of crack depth and/or a predicted downward shift of a torsional natural frequency of interest as a function of crack depth is calculated from the modified model. The actual shaft system is subjected to an operating force excitation, and vibrational response measurements are taken with strain gages and then output through a short range telemetry system. A fast Fourier transform analyzer derives frequency response spectra from the measurements which indicate the actual natural frequencies of the shaft system. A comparison of actual natural frequency(s) in the region near the natural frequency of interest with frequency values predicted by the modified model is employed to determine the presence and severity of a crack in the shaft.
摘要翻译：通过将操作轴系统的实际测量固有频率与分析模型的结果进行比较来确定轴中裂纹的存在，尺寸和位置。从一个未裂缝的操作轴系统的多工位分析模型，推导出固有频率和相关模式形状。确定裂纹的可疑轴向位置，并且选择感兴趣的固有频率，其具有在裂纹的可疑轴向位置处和在响应测量位置处显示出显着的局部弯曲的相关模式形状。分析模型被修改为包括在可疑裂缝位置处的不对称裂纹的表示。根据修改的模型计算作为裂纹深度的函数的感兴趣的侧向固有频率和/或作为裂纹深度的函数的感兴趣的扭转固有频率的预测的向下偏移的预测的分裂和向下移位。实际轴系受到操作力激励，应变计采用振动响应测量，然后通过短距离遥测系统输出。快速傅立叶变换分析仪从测量中得出频率响应谱，表明轴系的实际固有频率。采用在修正模型预测的频率值附近的感兴趣自然频率附近的实际固有频率的比较来确定轴中裂纹的存在和严重程度。

98. 发明授权

US4804499A Process for the preparation of N-substituted aminomethylphosphonic acids 失效
标题翻译：制备N-取代氨基甲基膦酸的方法
公开(公告)号：US4804499A
公开(公告)日：1989-02-14
申请号：US778958
申请日：1985-09-23
申请人： William H. Miller , David B. Reitz , Mitchell J. Pulwer
发明人： William H. Miller , David B. Reitz , Mitchell J. Pulwer
IPC分类号： C07F9/38 , C07F9/40
CPC分类号： C07F9/3813
摘要： A process for the preparation of an N-substituted aminomethylphosphonic acid comprising reacting a 2,5-diketopiperazine compound with phosphorous acid and formaldehyde in an acidic medium.
摘要翻译：一种制备N-取代氨基甲基膦酸的方法，包括在酸性介质中使2,5-二酮哌嗪化合物与亚磷酸和甲醛反应。

99. 发明授权

US4694082A Compound 1,4-diisopropyl-2,5-diketopiperazine 失效
标题翻译：化合物1,4-二异丙基-2,5-二酮哌嗪
公开(公告)号：US4694082A
公开(公告)日：1987-09-15
申请号：US778818
申请日：1985-09-23
申请人： William H. Miller , William D. Taylor
发明人： William H. Miller , William D. Taylor
IPC分类号： C07C227/00 , C07C229/12 , C07D241/08 , C07D241/18 , C07F9/38 , C07F9/40
CPC分类号： C07D241/08 , C07F9/3813
摘要： The novel compound 1,4-diisopropyl-2,5-diketopiperazine can be hydrolytically cleaved to prepare N-isopropylglycine, which can be reacted with formaldehyde and prosphorous acid to produce N-isopropyl-N-phosphonomethylglycine. The latter compound can be dealkylated in the presence of base to produce N-phosphonomethylglycine, a well known herbicide.
摘要翻译：可以将新化合物1,4-二异丙基-2,5-二酮哌嗪水解裂解制备N-异丙基甘氨酸，其可以与甲醛和樟脑酸反应产生N-异丙基-N-膦酰基甲基甘氨酸。后一种化合物可以在碱的存在下脱烷基化，以产生N-膦酰甲基甘氨酸，众所周知的除草剂。

100. 发明授权

US4657705A Process for the preparation of N-substituted aminomethylphosphonic acids 失效
标题翻译：制备N-取代氨基甲基膦酸的方法
公开(公告)号：US4657705A
公开(公告)日：1987-04-14
申请号：US778839
申请日：1985-09-23
申请人： William H. Miller , David B. Reitz , Mitchell J. Pulwer
发明人： William H. Miller , David B. Reitz , Mitchell J. Pulwer
IPC分类号： C07F9/38 , C07F9/40
CPC分类号： C07F9/3813
摘要： A process for the preparation of an N-substituted aminomethylphosphonic acid comprising reacting a substituted amine, urea or carbamate substrate compound with phosphorous acid and formaldehyde in an acidic medium.
摘要翻译：一种制备N-取代的氨基甲基膦酸的方法，包括在酸性介质中使取代的胺，脲或氨基甲酸酯底物化合物与亚磷酸和甲醛反应。

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