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91. 发明申请

US20100021425A1 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT 有权
标题翻译： 1'-取代的CARBA-核苷类似物用于抗病毒治疗
公开(公告)号：US20100021425A1
公开(公告)日：2010-01-28
申请号：US12428176
申请日：2009-04-22
申请人： Thomas Butler , Aesop Cho , Choung U. Kim , Jay Parrish , Oliver L. Saunders , Lijun Zhang
发明人： Thomas Butler , Aesop Cho , Choung U. Kim , Jay Parrish , Oliver L. Saunders , Lijun Zhang
IPC分类号： A61K38/21 , C07H21/00 , C07D487/00 , A61K31/70 , A61P31/12 , A61K31/675
CPC分类号： C07H19/23 , C07D487/04
摘要： Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译：提供吡咯并[1,2-f] [1,2,4]三嗪基，咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷，其核苷磷酸酯和前药，其中核苷糖的1'位置被取代。所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

92. 发明授权

US07645747B2 Therapeutic phosphonate compounds 有权
标题翻译：治疗性膦酸酯化合物
公开(公告)号：US07645747B2
公开(公告)日：2010-01-12
申请号：US11258621
申请日：2005-10-25
申请人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/661 , A61K31/662 , C07F9/06 , C07F9/28
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译：本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。

93. 发明授权

US07642339B2 Antiviral compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US07642339B2
公开(公告)日：2010-01-05
申请号：US11184429
申请日：2005-07-18
申请人： Kleem Chaudhary , Melissa Fleury , Choung U. Kim , Darren J. McMurtrie , Xiaoning C. Sheng
发明人： Kleem Chaudhary , Melissa Fleury , Choung U. Kim , Darren J. McMurtrie , Xiaoning C. Sheng
IPC分类号： A61K38/00
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/572 , C07F9/65583 , C07K5/06191 , C07K5/0808
摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

94. 发明申请

US20090317361A1 CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT 有权
标题翻译：用于抗病毒治疗的CARBA-核苷类似物
公开(公告)号：US20090317361A1
公开(公告)日：2009-12-24
申请号：US12428234
申请日：2009-04-22
申请人： Aesop Cho , Choung U. Kim , Jay Parrish , Jie Xu
发明人： Aesop Cho , Choung U. Kim , Jay Parrish , Jie Xu
IPC分类号： A61K38/21 , C07H19/12 , A61K31/706 , A61P31/12
CPC分类号： C07H19/23 , C07D487/04
摘要： Provided are imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译：提供咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4]三嗪基和[1,2,4]三唑并[4,3- f] [1,2,4]三嗪基核苷，其核苷磷酸酯及其前药。所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

95. 发明申请

US20090253648A1 Tricyclic-Nucleoside Compounds for Treating Viral Infections 审中-公开
标题翻译：用于治疗病毒感染的三环核苷化合物
公开(公告)号：US20090253648A1
公开(公告)日：2009-10-08
申请号：US12415335
申请日：2009-03-31
申请人： Jesse Daniel Keicher , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
发明人： Jesse Daniel Keicher , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/14
CPC分类号： C07D487/16 , C07H19/00 , C07H19/22 , C07H19/23
摘要： Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus.
摘要翻译：公开了由式I，II和III表示的化合物及其用于治疗由黄病毒科家族病毒引起的病毒感染的组合物和方法。

96. 发明申请

US20090227491A1 ANTIVIRAL PHOSPHINATE COMPOUNDS 审中-公开
标题翻译：抗磷酸化合物
公开(公告)号：US20090227491A1
公开(公告)日：2009-09-10
申请号：US12303219
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyung-Jung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K38/12 , C07K5/083 , C07K5/12 , A61K38/06 , A61K38/21
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

97. 发明申请

US20090048189A1 TRICYCLIC-NUCLEOSIDE COMPOUNDS FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译：用于治疗病毒感染的TRICYCLIC-NUCLEOSIDE化合物
公开(公告)号：US20090048189A1
公开(公告)日：2009-02-19
申请号：US11839380
申请日：2007-08-15
申请人： Jesse Daniel KEICHER , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
发明人： Jesse Daniel KEICHER , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Xiaoling Zheng , Marija Prhavc , Vivek Kumar Rajwanshi , Ronald Conrad Griffith , Choung U. Kim
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/14
CPC分类号： C07H19/23
摘要： Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus.
摘要翻译：公开了式（I）的三环核苷化合物及其至少部分由黄病毒科家族病毒介导的病毒感染的方法。

98. 发明申请

US20090029939A1 Pre-organized tricyclic integrase inhibitor compounds 审中-公开
标题翻译：预先组织的三环整合酶抑制剂化合物
公开(公告)号：US20090029939A1
公开(公告)日：2009-01-29
申请号：US11807303
申请日：2007-05-25
申请人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
发明人： James M. Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung U. Kim , Laura N. Schacherer
IPC分类号： A61K31/7072 , C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/496 , A61P31/18 , A61K31/675 , C07F9/58 , C12N5/06 , C07D487/04
CPC分类号： C07D207/404 , C07D471/04 , C07D487/04
摘要： Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl, Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
摘要翻译：公开了根据以下结构的三环化合物，其受保护的中间体和用于抑制HIV整合酶的方法。 A1和A2是形成五，六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O，S或取代的氮。 Ar是芳基或杂芳基，Q是N，+ NR或CR 4。芳基碳可以独立地被除氢以外的取代基取代。化合物可以包括共价连接在任何位点的前药部分。

99. 发明授权

US07462721B2 Aza-quinolinol phosphonate integrase inhibitor compounds 有权
标题翻译：氮杂 - 羟基喹啉膦酸酯整合酶抑制剂化合物
公开(公告)号：US07462721B2
公开(公告)日：2008-12-09
申请号：US10944118
申请日：2004-09-17
申请人： Haolun Jin , Choung U. Kim , Peter H. Nelson
发明人： Haolun Jin , Choung U. Kim , Peter H. Nelson
IPC分类号： C07J1/00 , C07D471/02
CPC分类号： A61K31/4985 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/519 , A61K31/53 , C07D471/04 , C07D513/04 , C07F9/6512 , C07F9/6561 , C07F9/65744 , Y02A50/411
摘要： Aza-quinolinol phosphonate compounds and methods for inhibition of HIV-integrase are disclosed. Ar is aryl or heteroaryl connecting R6 to L. L is a bond or a linker connecting a ring atom of Ar to N. The ring atoms, X1-X5 may be N, substituted nitrogen, or substituted carbon, and form rings. The compounds include at least one phosphonate group covalently attached at any site.
摘要翻译：公开了氮杂 - 羟基喹啉膦酸酯化合物和抑制HIV整合酶的方法。 Ar是将R 6连接到L的芳基或杂芳基.L是连接Ar与N的环原子的键或连接体。环原子X 1 -X 5可以是N，取代的氮或取代的碳，并形成环。所述化合物包括至少一个共价连接在任何位点的膦酸酯基团。

100. 发明申请

US20080287471A1 4'-Substituted Carbovir And Abacavir-Derivatives As Well As Related Compounds With Hiv And Hcv Antiviral Activity 审中-公开
标题翻译： 4'-取代的卡博维尔和阿巴卡韦衍生物以及与Hiv和Hcv抗病毒活性相关的化合物
公开(公告)号：US20080287471A1
公开(公告)日：2008-11-20
申请号：US10583573
申请日：2004-12-22
申请人： Maria Fardis , Choung U. Kim
发明人： Maria Fardis , Choung U. Kim
IPC分类号： A61K31/52 , C07D473/00 , C12N5/06 , A61P31/18
CPC分类号： C07D473/18 , C07D473/16 , C07H19/06 , C07H19/16
摘要： The application relates to compounds with activity against infectious viruses. Accordingly, in one embodiment the invention provides a compound of the invention which is a compound of Formula I: (I) wherein: B is adenine, guanine cytosine, uracil, thymine, 7-deazaadenine, 7-deazaguanine, 7-deaza-8-azaguanine, 7-deaza-8-azaadenine, inosine, nebularine, nitropyrrole, nitroindole, 2-aminopurine, 2-amino-6-chloropuriine, 2,6-diaminopurine, hypoxanthine, pseudouridine, pseudo-cytosine, pseudoisocytosine, 5-propynylcytosine, isocytosines, isoguanine, 7-deazaguanine, 2-thiopyrimidine, 6-thioguanine, 4-thiothymine, 4-thiouracil O6-methylguanine, N6-methyladenine, O4-methylthymine, 5,6-dihydrothymine, 5,6-dihydroucacil, 4-methylindole, triazole, or pyrazolo[3,4-d]pyrimidine; and B is optionally substituted with one or more alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, hydroxy, or halo; and R1 is alkyl, alkenyl, alkynyl, cyano, azido, or fluoromethyl; or a pharmaceutically acceptable salt or solvate thereof.
摘要翻译：本申请涉及具有抗感染性病毒活性的化合物。因此，在一个实施方案中，本发明提供了本发明化合物，其为式I化合物：（I）其中：B为腺嘌呤，鸟嘌呤胞嘧啶，尿嘧啶，胸腺嘧啶，7-脱氮腺嘌呤，7-脱氮鸟嘌呤，7-脱氮-8 2-氮杂鸟嘌呤，7-脱氮-8-氮杂腺嘌呤，肌苷，星云碱，硝基吡咯，硝基吲哚，2-氨基嘌呤，2-氨基-6-氯嘌呤，2,6-二氨基嘌呤，次黄嘌呤，假尿苷，假胞嘧啶，假异胞嘧啶，5-丙炔基胞嘧啶，异胞嘧啶，异鸟嘌呤，7-脱氮鸟嘌呤，2-硫代嘧啶，6-硫鸟嘌呤，4-硫代胸腺嘧啶，4-硫尿嘧啶O 6 - 甲基鸟嘌呤，N 6 - 甲基腺嘌呤， 5,6-二氢胸腺嘧啶，5,6-二氢尿嘧啶，4-甲基吲哚，三唑或吡唑并[3,4-d]嘧啶; 并且B任选被一个或多个烷基，烯基，炔基，环烷基，（环烷基）烷基，羟基或卤素取代; R 1是烷基，烯基，炔基，氰基，叠氮基或氟甲基; 或其药学上可接受的盐或溶剂合物。

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