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    • 91. 发明授权
    • Battery system
    • 电池系统
    • US06452361B2
    • 2002-09-17
    • US09912675
    • 2001-07-23
    • Thomas J. DoughertyWilliam P. SegallMichael E. Iverson
    • Thomas J. DoughertyWilliam P. SegallMichael E. Iverson
    • H02J700
    • H02J7/0031G08B29/181H02J7/1423Y02T10/7005
    • A battery system for use in a vehicle is disclosed having a first battery for selectively powering the motor to start the engine, and having a first voltage level and a charge level. The system includes a second battery to operate and maintain the accessory electrical loads, and having a second voltage level. The system includes a charging switch coupling the first battery to the alternator. The system also includes a charge maintenance device coupling the first battery to the second battery to maintain the charge level of the first battery to a predefined magnitude in response to a control signal. The system also includes a controller coupled to both the first battery and the second battery to monitor the first voltage level and the second voltage level, and operating the charging switch and the charge maintenance device in response to the first voltage level and the second voltage level.
    • 公开了一种用于车辆的电池系统,其具有用于选择性地为马达启动发动机并且具有第一电压电平和充电水平的第一电池。 该系统包括用于操作和维护附件电负载并具有第二电压电平的第二电池。 该系统包括将第一电池耦合到交流发电机的充电开关。 该系统还包括将第一电池耦合到第二电池的电荷维持装置,以响应于控制信号将第一电池的充电水平维持在预定的大小。 该系统还包括耦合到第一电池和第二电池的控制器以监测第一电压电平和第二电压电平,以及响应于第一电压电平和第二电压电平来操作充电开关和充电维持装置 。
    • 92. 发明授权
    • Center point vent cover for battery
    • 电池中心点通风盖
    • US06255014B1
    • 2001-07-03
    • US09232542
    • 1999-01-18
    • Thomas J. DoughertyMichael G. AndrewJames A. Lenz
    • Thomas J. DoughertyMichael G. AndrewJames A. Lenz
    • H01M212
    • H01M2/1211H01M2/043H01M2/1229H01M6/10
    • The apparatus of the present invention provides a cover for venting gases from thin metal film battery cells having vents disposed at the center of one end of the cells. The vents comprise cylindrical wells that recess into, and substantially fill, the top portions of battery cell cavities within a battery housing. The cavities are sized to hold the battery cells securely and are configured to provide an electrical serial connection. The wells include pipes which extend outward from the bottom of the wells and lead from openings in the bases of the wells. The openings in the pipes are covered with flexible valve caps and well lids cover the wells. The center point arrangement of the recessed wells permit gases from the battery cells to escape through the openings, yet restrict the electrolyte from exiting the housing. The base of the battery housing does not have vent openings and is interchangeable with the cover so that the battery housing may be oriented with the terminals near the top or the bottom of the case.
    • 本发明的装置提供了一种用于从具有设置在单元的一端的中心的通气孔的薄金属膜电池单元排出气体的盖。 通风口包括凹入电池壳体内的电池单元腔的顶部并基本上填充的圆柱形孔。 空腔的尺寸被设计成牢固地保持电池单元并且被配置成提供电串联连接。 井包括从井的底部向外延伸并从井的底部的开口引出的管。 管道中的开口被柔性阀盖覆盖,井盖覆盖井。 凹槽的中心点布置允许来自电池单元的气体通过开口逸出,但是限制电解液离开壳体。 电池壳体的底部没有通气口并且可与盖互换,使得电池壳体可以被定位成使得端子靠近壳体的顶部或底部。
    • 95. 发明授权
    • Long wavelength absorbing photosensitizers related to purpurin-18,
bacteriopurpurin-18 and related compounds with imide linkages
    • 长紫外线吸收光紫外线吸收剂与紫草素-18,细菌尿素-18以及与酰亚胺连接的相关化合物
    • US5591847A
    • 1997-01-07
    • US247866
    • 1994-05-23
    • Ravindra K. PandeyThomas J. DoughertyKevin M. SmithFuu-Yau Shiau
    • Ravindra K. PandeyThomas J. DoughertyKevin M. SmithFuu-Yau Shiau
    • A61K41/00C07D487/22C07D491/22
    • C07D487/22A61K41/0071C07D491/22
    • Compounds having utility as light absorbing compounds, especially in the area of photodynamic therapy.Such compounds have the formula: ##STR1## where Z is .dbd.O or .dbd.NR.sub.6, where R.sub.6 is lower alkyl of from 1 to 8 carbon atoms or ##STR2## R.sub.1 is ##STR3## where R.sub.7 is ##STR4## or --ORS, where R.sub.8 is hydrogen or lower alkyl of 1 to 8 carbon atoms, or R.sub.7 is an amino acid residue connected at a nitrogen atom of such residue; R.sub.2 is lower alkyl or lower alkylene of from 2 to 4 carbon atoms or a formal or carbonyl containing group of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are --H or --OR.sub.8 or are joined together so that each represents one-half of a chemical bond and R.sub.4 may be taken together with R.sub.5 to form .dbd.O; and R.sub.5 is ethyl or is taken together with R.sub.4 to form .dbd.O; provided that when Z is --O-- the sum of the number of carbon atoms in R.sub.1 through R.sub.5 is from 12 to 20 and when Z is .dbd.NR.sub.6, the sum of the number of carbon atoms in R.sub.1 through R.sub.6 is 8 to 20.
    • 具有作为光吸收化合物用途的化合物,特别是在光动力疗法领域。 这样的化合物具有下式:其中Z是=或NR 6,其中R 6是1至8个碳原子的低级烷基或者其中R 7是<或>,或者-OR,其中 R8是氢或1〜8个碳原子的低级烷基,或R7是在这种残基的氮原子上连接的氨基酸残基; R 2是2至4个碳原子的低级烷基或低级亚烷基或含有1至4个碳原子的形式或含羰基的基团; R 3和R 4是-H或-OR 8或连接在一起,使得各自表示化学键的一半,并且R 4可以与R 5一起形成= O; 并且R 5是乙基或与R 4一起形成= O; 条件是当Z为-O-时,R 1至R 5中的碳原子数之和为12至20,当Z为NR 6时,R 1至R 6中的碳原子数之和为8至20。
    • 97. 发明授权
    • Methods for treatment of tumors
    • 肿瘤治疗方法
    • US4932934A
    • 1990-06-12
    • US236603
    • 1988-08-24
    • Thomas J. DoughertyWilliam R. PotterKenneth R. Weishaupt
    • Thomas J. DoughertyWilliam R. PotterKenneth R. Weishaupt
    • A61B5/00A61K31/40A61K41/00A61K49/00A61K51/00A61N5/06A61P35/00A61P43/00C07D487/22C07D519/00C09B47/00G02B6/04G02B6/26G02B6/42
    • A61K31/40A61B5/411A61B5/416A61K41/0071A61N5/0601A61N5/062C07D519/00G02B6/262G02B6/4204A61B5/0071A61B5/0084G02B6/4298Y10S607/901
    • To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophillic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4. Neoplastic tissue retains the drug after it has cleared normal tissues and illumination results in necrosis. Moreover, other photosensitizing materials may be combined with a carrier that enters undesirable tissues and cells of the reticular endothelial system such as macrophages. These photosensitizing materials: (1) must have a triplet energy state above 3.5 kilocalories per mole; (2) cannot be easily oxidized; and (3) not physically quench any required energy state. Preferably, this photosensitizing material should be lipophilic.
    • 为了获得肿瘤选择性的光敏药物,可用于肿瘤组织的定位和治疗异常肿瘤组织如肿瘤,使用两种方法之一。 在第一种方法中,血卟啉与乙酸和硫酸的反应产物的水解混合物循环通过微孔膜系统以排除低分子量产物。 在第二种方法中,合成或衍生自其他吡咯化合物的药物。 药物:(1)包括两个共价结合的基团,每个具有四个环,其中一些是吡咯,例如卟啉,卟啉,二氢卟酚,取代的吡咯,取代的二氢卟酚或取代的藜芦烯,每个组排列成环结构,共价连接 到另一组,并具有高于每摩尔37.5千卡的三线态能量状态; (2)可溶于水,与血清蛋白质相比,在水中形成了超过10,000分子量的聚集体,并且与血清蛋白质具有亲和力,使得10%至100%在血清蛋白中保持自我聚集; 和(3)是脂肪性的并且能够分解并附着于细胞血浆,核膜,线粒体,溶酶体和组织。 通过第一种方法获得的药物具有约C68H70N8O11或C68H66N8O11Na4的经验式。 肿瘤组织清除正常组织后保留药物,照明会导致坏死。 此外,其它光敏材料可以与进入网状内皮系统的不希望的组织和细胞如巨噬细胞的载体组合。 这些光敏材料:(1)必须具有每千克3.5千卡以上的三线态能量状态; (2)不易氧化; 和(3)不能物理地淬灭任何所需的能量状态。 优选地,该光敏材料应该是亲脂的。