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91. 发明申请

US20060198847A1 Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis 审中-公开
标题翻译：调节内皮细胞表面受体活性调节血管生成
公开(公告)号：US20060198847A1
公开(公告)日：2006-09-07
申请号：US11416492
申请日：2006-05-02
申请人： Thomas Daniel , Takamune Takahashi , Raymond Mernaugh
发明人： Thomas Daniel , Takamune Takahashi , Raymond Mernaugh
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/28 , C07K16/2896 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C12N9/16 , C12Q1/42 , G01N33/574 , G01N33/6872 , G01N2333/515 , G01N2500/04
摘要： A method of modulating angiogenesis in a vertebrate subject, the method comprising administering to the vertebrate subject an ECRTP/DEP-1 activity-modulating amount of a composition, whereby an ECRTP/DEP-1 within the vertebrate subject is contacted by the composition; and modulating angiogenesis through the contacting of the ECRTP/DEP-1 with the composition. Optionally, the composition includes a monoclonal antibody which preferentially binds ECRTP/DEP-1. Methods for screening for modulators of ECRTP/DEP-1 are also disclosed.
摘要翻译：一种调节脊椎动物受试者血管发生的方法，所述方法包括对脊椎动物受试者施用ECRTP / DEP-1活性调节量的组合物，由此使脊椎动物受试者内的ECRTP / DEP-1与组合物接触; 并通过ECRTP / DEP-1与组合物的接触调节血管发生。任选地，组合物包含优先结合ECRTP / DEP-1的单克隆抗体。还披露了用于筛选ECRTP / DEP-1的调节剂的方法。

92. 发明申请

US20060155057A1 (Meth)acrylic esters of monoalkoxylated polyols, and production thereof 有权
标题翻译：（Meth）单烷氧基化多元醇的丙烯酸酯及其制备
公开(公告)号：US20060155057A1
公开(公告)日：2006-07-13
申请号：US10562239
申请日：2004-06-30
申请人： Dieter Hermeling , Thomas Daniel , Mark Elliott , Ulrich Riegel , Frank Dietsche , Reinhold Schwalm
发明人： Dieter Hermeling , Thomas Daniel , Mark Elliott , Ulrich Riegel , Frank Dietsche , Reinhold Schwalm
IPC分类号： C08L67/00 , C08G63/00 , B32B27/00
CPC分类号： C08G65/332 , A61L15/60 , C08G65/2606 , C08G65/3322 , Y10S524/916
摘要： Disclosed are novel (meth)acrylic esters of monoalkoxylated polyols, a process for their preparation and their use for preparing crosslinked swellable hydrogel-forming polymers and crosslinked swellable hydrogel-forming polymers.
摘要翻译：公开了单烷氧基化多元醇的新型（甲基）丙烯酸酯，其制备方法及其用于制备交联的可溶胀水凝胶形成聚合物和交联的可膨胀的水凝胶形成聚合物。

93. 发明申请

US20060019347A1 Biosynthetic polypeptides utilizing non-naturally encoded amino acids 失效
公开(公告)号：US20060019347A1
公开(公告)日：2006-01-26
申请号：US11187687
申请日：2005-07-21
申请人： Ho Cho , Thomas Daniel , Anna-Maria Hays , Troy Wilson , David Litzinger , Roberto Mariani , Bruce Kimmel , William Keefe
发明人： Ho Cho , Thomas Daniel , Anna-Maria Hays , Troy Wilson , David Litzinger , Roberto Mariani , Bruce Kimmel , William Keefe
IPC分类号： C12P21/06 , C07H21/04 , C07K14/00
CPC分类号： C07K14/005 , C07K14/575 , C07K14/57563 , C07K14/605 , C07K2319/02 , C07K2319/20 , C12N15/62 , C12N2740/16122
摘要： Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.

94. 发明申请

US20050245713A1 Method for producing polymers 审中-公开
标题翻译：生产聚合物的方法
公开(公告)号：US20050245713A1
公开(公告)日：2005-11-03
申请号：US10521292
申请日：2003-07-18
申请人： Thomas Daniel , Ulrich Riegel , Mark Elliott
发明人： Thomas Daniel , Ulrich Riegel , Mark Elliott
IPC分类号： C08F20/06 , C08F118/02
CPC分类号： C08F20/06
摘要： A process for producing sodium acrylate polymers by free-radical polymerization of sodium acrylate with or without other monomers in an aqueous medium, which comprises using sodium acrylate in the form of an aqueous solution or dispersion obtainable by dissolving or dispersing solid sodium acrylate in an aqueous medium. The polymers thus obtainable have an improved color number and a lower residual monomer content than conventional comparable polymers.
摘要翻译：一种通过在水性介质中自由基聚合具有或不含其它单体的丙烯酸钠制备丙烯酸钠聚合物的方法，该方法包括使用可通过将固体丙烯酸钠溶解或分散在水溶液或分散体中的水溶液或分散体形式的丙烯酸钠中。这样获得的聚合物具有比常规可比较的聚合物更好的颜色数目和更低的残留单体含量。

95. 发明申请

US20050113526A1 Crosslinking agent based on linear hydroxypolyallyl ether 有权
标题翻译：基于线性羟基聚烯丙基醚的交联剂
公开(公告)号：US20050113526A1
公开(公告)日：2005-05-26
申请号：US11025976
申请日：2005-01-03
申请人： Shin-ichiro Nakamura , Yasumi Shimizu , Tohru Matsutomi , Thomas Daniel
发明人： Shin-ichiro Nakamura , Yasumi Shimizu , Tohru Matsutomi , Thomas Daniel
IPC分类号： A61L15/60 , C07C43/178 , C08F220/04 , C08F275/00
CPC分类号： C07C43/178 , A61L15/60 , C08F220/04
摘要： An allyl type crosslinking agent for use in production of a super water-absorbent polymer comprising a polymerizable compound having a carbon-carbon double bond or a salt thereof. The crosslinking agent comprises a linear hydroxypolyallyl ether having at least one hydroxyl group and at least two allyl groups obtained by allyletherification of hydroxyl groups in a linear polyol compound selected from the group consisting of erythritol, xylitol and sorbitol. This allyl type crosslinking agent is highly soluble in an aqueous solvent, and can give an excellent super water-absorbent polymer, which cannot be obtained in the prior arts, having high levels of both of water absorptivity under atmospheric pressure and water absorptivity under pressurized conditions.
摘要翻译：一种用于生产含有碳 - 碳双键的聚合性化合物或其盐的超级吸水性聚合物的烯丙基型交联剂。交联剂包含具有至少一个羟基的直链羟基聚烯丙基醚和至少两个通过选自赤藓糖醇，木糖醇和山梨糖醇的直链多元醇化合物中羟基进行烯丙基化获得的烯丙基。这种烯丙基型交联剂在水性溶剂中高度溶解，并且可以得到在现有技术中无法获得的极好的超吸水性聚合物，其具有在大气压下的高吸水率和加压条件下的吸水率。

96. 发明授权

US06559239B1 Method for the secondary cross-linking of hydrogels with N-acyl-2-oxazolidinones 失效
标题翻译：水凝胶与N-酰基-2-恶唑烷酮二次交联的方法
公开(公告)号：US06559239B1
公开(公告)日：2003-05-06
申请号：US09831920
申请日：2001-05-29
申请人： Ulrich Riegel , Matthias Weismantel , Volker Frenz , Thomas Daniel , Fritz Engelhardt
发明人： Ulrich Riegel , Matthias Weismantel , Volker Frenz , Thomas Daniel , Fritz Engelhardt
IPC分类号： C08F830
CPC分类号： C08F8/30 , C08J3/245 , C08J2300/14 , C08J2333/02 , C08F220/06
摘要： Liquid-absorbent polymers are prepared by a process for the gel and/or surface postcrosslinking of water-absorbent polymers by the polymer being treated with a surface postcrosslinking solution and being postcrosslinked and dried during and after the treatment by raising the temperature, wherein the surface postcrosslinking solution comprises as crosslinker a compound of the formula I where R1, R2, R3 and R4 are independently hydrogen, C1-C12-alkyl, C1-C12-alkenyl, C6-C12-aryl or C1-C12-alkoxy, R5 is C1-C16-alkyl, C1-C4-hydroxyalkyl, C6-C12-aryl, C1-C16-alkenyl or a group of the formula —(CH2)n—COOH or —(CH2)n—SO3H in the form of the acid or a respective metal salt, ammonium salt or triethanolammonium salt thereof or —(CH2—CH2—O—)m—R6, R6 is hydrogen or C1-C16-alkyl, n is from 1 to 10, m is from 1 to 20 dissolved in an inert solvent, and are used in hygiene articles, packaging materials and nonwovens.
摘要翻译：通过用表面后交联溶液处理的聚合物进行凝胶和/或表面后吸附吸水性聚合物的方法制备液体吸收聚合物，并且在处理之间和之后通过升高温度进行后交联和干燥，其中表面后交联溶液包含作为交联剂的式I化合物，其中R 1，R 2，R 3和R 4独立地是氢，C 1 -C 12 - 烷基，C 1 -C 12 - 烯基，C 6 -C 12 - 芳基或C 1 -C 12 - 烷氧基，R 5是C 1 -C 16 - 烷基，C 1 -C 4 - 羟基烷基，C 6 -C 12 - 芳基，C 1 -C 16 - 烯基或式 - （CH 2）n -COOH或 - （CH 2）n -SO 3 H的基团，其形式为酸或相应的金属盐，铵盐或三乙醇铵盐或 - （CH 2 -CH 2 -O-）m -R 6，R 6是氢或C 1 -C 16 - 烷基，n为1至10，m为1至20，溶于惰性溶剂，用于卫生用品，包装材料和无纺布。

97. 发明授权

US5945495A Use of surfactants in the drying of hydrophilic highly swellable hydrogels 失效
标题翻译：在亲水性高度溶胀性水凝胶的干燥中使用表面活性剂
公开(公告)号：US5945495A
公开(公告)日：1999-08-31
申请号：US785723
申请日：1997-01-17
申请人： Thomas Daniel , Norbert Herfert , Gustav Remmel , Ulrich Riegel , Uwe Stuven , Fritz Engelhardt
发明人： Thomas Daniel , Norbert Herfert , Gustav Remmel , Ulrich Riegel , Uwe Stuven , Fritz Engelhardt
IPC分类号： C08J3/00 , C08J3/075 , C08F20/06
CPC分类号： C08J3/075
摘要： The present invention relates to the use of surfactants for improving the drying properties of hydrophilic, highly swellable hydrogels in the course of drying with the aid of contact dryers.
摘要翻译：本发明涉及使用表面活性剂来改善亲水性高度溶胀性水凝胶在干燥过程中借助于接触式干燥器的干燥性能。

98. 发明授权

US09833769B2 Process for producing water-absorbing polymer particles with high free swell rate 有权
公开(公告)号：US09833769B2
公开(公告)日：2017-12-05
申请号：US13365807
申请日：2012-02-03
申请人： Thomas Daniel , Volker Braig , Asif Karim
发明人： Thomas Daniel , Volker Braig , Asif Karim
IPC分类号： C08F20/10 , C09K3/00 , B01J20/26 , B29C49/00 , B01J20/30 , B01J20/28
CPC分类号： B01J20/3021 , B01J20/264 , B01J20/267 , B01J20/28004 , B01J20/28047 , B01J20/3078 , B01J20/3085 , B01J2220/68
摘要： The invention relates to a process for producing water-absorbing polymer particles with high free swell rate, comprising the steps of polymerization, drying, grinding, classification and thermal surface postcrosslinking, remoisturization and drying again.

99. 发明授权

US09150483B2 Aqueous solution comprising acrylic acid and the conjugate base thereof 有权
标题翻译：包含丙烯酸及其共轭碱的水溶液
公开(公告)号：US09150483B2
公开(公告)日：2015-10-06
申请号：US13483705
申请日：2012-05-30
申请人： Frank Huetten , Otto Machhammer , Thomas Daniel , Markus Ottenbacher , Daniel Pfeiffer , Stefanie Herzog , Manfred Heilig , Klaus Joachim Mueller-Engel
发明人： Frank Huetten , Otto Machhammer , Thomas Daniel , Markus Ottenbacher , Daniel Pfeiffer , Stefanie Herzog , Manfred Heilig , Klaus Joachim Mueller-Engel
IPC分类号： C07C51/25 , C07C51/42 , C07C57/04 , C07C51/47
CPC分类号： C08G63/81 , C07C51/252 , C07C51/42 , C07C51/47 , C07C57/04 , Y02P20/582
摘要： An aqueous solution comprising acrylic acid and the conjugate base thereof in a total amount of at least 10% by weight, based on the weight of the aqueous solution, and propionic acid and the conjugate base thereof, formic acid and the conjugate base thereof, acetic acid and the conjugate base thereof, benzoic acid and the conjugate base thereof, maleic anhydride, maleic acid and the conjugate bases thereof, phthalic anhydride, phthalic acid and the conjugate bases thereof, acrolein, benzaldehyde, 2-furaldehyde, and at least 20 mol % of at least one alkali metal cation; process for preparing this solution; and the use of this solution for preparation of polymer by free-radical polymerization.
摘要翻译：包含丙烯酸及其共轭碱的水溶液的总量为至少10重量％，基于水溶液的重量，丙酸及其共轭碱，甲酸及其共轭碱，乙酸酸及其共轭碱，苯甲酸及其共轭碱，马来酸酐，马来酸及其共轭碱，邻苯二甲酸酐，邻苯二甲酸及其共轭碱，丙烯醛，苯甲醛，2-糠醛，和至少20摩尔％的至少一种碱金属阳离子; 制备该溶液的方法; 以及使用该溶液通过自由基聚合制备聚合物。

100. 发明授权

US08846565B2 Water-absorbing polymeric particles and method for the production thereof 有权
标题翻译：吸水性聚合物颗粒及其制备方法
公开(公告)号：US08846565B2
公开(公告)日：2014-09-30
申请号：US12668183
申请日：2008-07-21
申请人： Ulrich Riegel , Thomas Daniel , Dieter Hermeling , Mark Elliott , Stefan Bruhns
发明人： Ulrich Riegel , Thomas Daniel , Dieter Hermeling , Mark Elliott , Stefan Bruhns
IPC分类号： B01J20/26 , B01J20/22 , A61L15/60 , A61L15/42 , A61L15/58
CPC分类号： A61L15/60 , A61L15/42 , A61L15/58
摘要： The present invention relates to a water absorbing material obtainable by a process comprising the steps of bringing particles of a non surface-crosslinked water-absorbing polymer in contact with a) at least one postcrosslinker, b) 10-1000 ppm, based on the non surface-crosslinked water-absorbing polymer, of at least one Nitrogen-containing water-soluble polymer of which the Nitrogen can be protonated, and c) at least one hydrophobic polymer and heat-treating the particles thus obtained at a temperature in the range from 120° C. to 300° C. and a method for the production thereof.
摘要翻译：本发明涉及一种吸水材料，该方法包括以下步骤：使非表面交联的吸水聚合物的颗粒与a）至少一个后交联剂接触，b）10-1000ppm，基于非 - 表面交联的吸水聚合物，其至少一种含氮的水溶性聚合物，其中氮可以被质子化，和c）至少一种疏水性聚合物，并且在如下得到的温度下热处理由此获得的颗粒： 120℃〜300℃及其制造方法。

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