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91. 发明专利

PL169452B1 METHOD OF OBTAINING NOVEL DERIVATIVES OF 4-SUBSTITUTED PHENYL-4-OXY-1-AMINOBUTANE 未知
公开(公告)号：PL169452B1
公开(公告)日：1996-07-31
申请号：PL31056291
申请日：1991-10-17
申请人： THERAMEX
发明人： BONNET PAULE , DELANSORNE REMI , FAURE MAURICE , LANQUETIN MICHEL , ZUNINO SERGE
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/522 , A61P11/14 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/46 , C07D235/30 , C07D295/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D473/08 , C07D403/04
摘要： PCT No. PCT/FR91/00811 Sec. 371 Date Feb. 8, 1993 Sec. 102(e) Date Feb. 8, 1993 PCT Filed Oct. 17, 1991 PCT Pub. No. WO92/06977 PCT Pub. Date Apr. 30, 1992. (I) The present invention concerns (4-substituted phenyl)4-oxy 1-aminobutane of the general formula (I) in which X is a nitrogen atom or >CH-CH, and R is a cyclic substituent chosen from the group comprising a) a xanthic substituent, b) a benzimidazolic substituent, as well as salts and optic isomers of the compounds of formula (I). The invention also concerns processes for obtaining the compounds of formula (I) and pharmaceutical compositions containing, as antihistamine ingredient, at least one compound of formula (I) or one of its salts with a mineral or organic acid.

92. 发明专利

NZ240274A BENZIMIDAZOLYL OR XANTHYL SUBSTITUTED PIPERDINE OR PIPERAZINE DERIVATIVES AND MEDICAMENTS 未知
公开(公告)号：NZ240274A
公开(公告)日：1995-07-26
申请号：NZ24027491
申请日：1991-10-17
申请人： THERAMEX
发明人： BONNET PAULE , DELANSORNE REMI , FAURE MAURICE , LANQUETIN MICHEL , ZUNINO SERGE
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/522 , A61P11/14 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/46 , C07D235/30 , C07D295/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D473/08 , C07D401/04 , C07D403/04 , C07D473/04 , A61K31/44
摘要： PCT No. PCT/FR91/00811 Sec. 371 Date Feb. 8, 1993 Sec. 102(e) Date Feb. 8, 1993 PCT Filed Oct. 17, 1991 PCT Pub. No. WO92/06977 PCT Pub. Date Apr. 30, 1992. (I) The present invention concerns (4-substituted phenyl)4-oxy 1-aminobutane of the general formula (I) in which X is a nitrogen atom or >CH-CH, and R is a cyclic substituent chosen from the group comprising a) a xanthic substituent, b) a benzimidazolic substituent, as well as salts and optic isomers of the compounds of formula (I). The invention also concerns processes for obtaining the compounds of formula (I) and pharmaceutical compositions containing, as antihistamine ingredient, at least one compound of formula (I) or one of its salts with a mineral or organic acid.

93. 发明专利

AP282A Novel derivatives of (p. substituted phenyl) oxybutane amines, their processes of production and the pharmaceutical compositions containing them. 未知
公开(公告)号：AP282A
公开(公告)日：1993-09-08
申请号：AP9100328
申请日：1991-10-17
申请人： LABORATOIRE THERAMEX
发明人： BONNET PAULE , DELANSORNE REMI , FAURE MAURICE , LANQUETIN MICHEL , ZUNINO SERGE
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/522 , A61P11/14 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/46 , C07D235/30 , C07D295/08 , C07D401/12 , C07D403/12 , C07D409/04 , C07D473/08 , C07D473/06
摘要： This invention relates to novel derivatives of phenyloxy butanes carrying in position 1 an amino group, processes for their production and pharmaceutical compositions containing them as active ingredients.

94. 发明专利

TNSN91090A1 NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT 未知
公开(公告)号：TNSN91090A1
公开(公告)日：1992-10-25
申请号：TNSN91090
申请日：1991-10-17
申请人： THERAMEX
发明人： BONNET PAULE , DELANSORNE REMI , FAURE MAURICE , LANQUETIN MICHEL , ZUNINO SERGE
摘要： LA PRESENTE INVENTION SE RAPPORTE AU DOMAINE DE LA CHIMIE ORGANIQUE ET PLUS PARTICULIEREMENT DE LA CHIMIE THERAPEUTIQUE. ELLE A POUR OBJET DE NOUVEAUX DERIVES (4-SUBSTITUE PHENYL) 4-OXY 1-AMINOBUTANE DE FORMULE GENERALE I DANS LAQUELLE X EST UN ATOME D'AZOTE OU > CH-NH, ET R EST UN SUBSTITUANT CYCLIQUE CHOISI DANS LE GROUPE CONSTITUE PAR a) UN SUBSTITUANT XANTHIQUE ; b) UN SUBSTITUANT BENZIMIDAZOLIQUE AINSI QUE LES SELS ET LES ISOMERES OPTIQUES DES COMPOSES DE FORMULE I. L'INVENTION CONCERNE AUSSI DES PROCEDES POUR OBTENIR LES COMPOSES DE FORMULE I AINSI QUE LES COMPOSITIONS PHARMACEUTIQUES RENFERMANT A TITRE DE PRINCIPE ACTIF AU MOINS UN COMPOSE DE FORMULE I OU UN DE SES SELS AVEC UN ACIDE MINERAL OU ORGANIQUE

96. 发明专利

CA2582180C INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS AND USE AS ESTROGENIC AGENTS 未知
公开(公告)号：CA2582180C
公开(公告)日：2013-04-30
申请号：CA2582180
申请日：2005-10-14
申请人： THERAMEX
发明人： RONDOT BENOIT , LAFAY JEAN , BONNET PAULE , CLERC THIERRY , DUC IGOR , DURANTI ERIC , PUCCIO FRANCOIS , SHIELDS JACQUELINE , BLOT CHRISTIAN , MAILLOS PHILIPPE
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4162 , A61K31/423 , A61K31/428 , A61P5/30 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.

97. 发明专利

AU2011226950B9 1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them 未知
公开(公告)号：AU2011226950B9
公开(公告)日：2013-04-11
申请号：AU2011226950
申请日：2011-09-29
申请人： LABORATOIRE THERAMEX
发明人： RONDOT BENOIT , BLOT CHRISTIAN , DURANTI ERIC , PUCCIO FRANCOIS , CLERC THIERRY , SHIELDS JACQUELINE , LAFAY JEAN , BONNET PAULE , MAILLOS PHILIPPE , DUC IGOR
IPC分类号： C07D233/54 , C07D409/12 , C07D419/12
摘要： 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them Abstract 5 The invention relates to the compounds of formula (1), in which RI, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds. The invention generally relates to the field of hormone- and non hormone-dependent cancer and endocrine disorders.

98. 发明专利

ES2368203T3 INDAZOLES, BENCISOXAZOLES Y BENCISOTIAZOLES Y SU USO COMO AGENTES ESTROGENICOS. 未知
公开(公告)号：ES2368203T3
公开(公告)日：2011-11-15
申请号：ES05794749
申请日：2005-10-14
申请人： THERAMEX
发明人： RONDOT BENOIT , LAFAY JEAN , BONNET PAULE , CLERC THIERRY , DUC IGOR , DURANTI ERIC , PUCCIO FRANCOIS , SHIELDS JACQUELINE , BLOT CHRISTIAN , MAILLOS PHILIPPE
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4162 , A61K31/423 , A61K31/428 , A61P5/30 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： Un compuesto de fórmula (I) o una sal de adición de ácidos o una forma estereoisomérica del mismo, en el que: - R1 es hidrógeno o un alquilo (C1-C6), cicloalquilo (C3-C6), trifluorometilo, -N=CR5R6, - SO2NR7R8, fenilo, fenilalquilo (C1-C3) o alquilo (C1-C3) sustituido por un radical heterocíclico saturado, en el que el fenilo está sin sustituir o sustituido por al menos un sustituyente seleccionado entre el grupo constituido por un hidroxilo, un halógeno, un nitro, un ciano, un alquilo (C1-C3), un alcoxi (C1-C3), y un trifluorometilo; R1 también puede ser una sal; - R2 y R3 son, cada uno independientemente, hidrógeno o un hidroxilo, halógeno, nitro, ciano, alquilo (C1-C6), cicloalquilo (C3-C6), alcoxi (C1-C6), trifluorometilo, un grupo -NR7R8, - CONR7R8, -COR9 o -CO2R9; R2 también puede ser un fenilo o un heterociclo saturado o insaturado, en el que el fenilo está sin sustituir o sustituido por al menos un sustituyente seleccionado entre el grupo constituido por un hidroxilo, un halógeno, un nitro, un ciano, un alquilo (C1-C3), un alcoxi (C1-C3), un trifluormetilo y un radical heterocíclico saturado; - X es O, S, SO, SO2 o NR4; - R4 es hidrógeno o un alquilo (C1-C6), cicloalquilo (C3-C6), fenilo, fenilalquilo (C1-C3), alquilo (C1-C3) sustituido por un radical heterocíclico saturado, un grupo -COR7, -CO2R7 o -SO2NR7R8, en el que el fenilo está sin sustituir o sustituido por al menos un sustituyente seleccionado entre el grupo constituido por un hidroxilo, un halógeno, un nitro, un ciano, un alquilo (C1-C3), un alcoxi (C1-C3), un trifluorometilo, un fenilalquilo (C1- C3) y un fenilalcoxi (C1-C3); - Y es un enlace directo, O, S, SO, SO2, NR4, CO, -(CR10R11)n- o -R10C=CR11-; - R5, R6, R7 y R8 son, cada uno independientemente, hidrógeno o un grupo alquilo (C1-C6) o cicloalquilo (C3- C6); - R9 es hidrógeno, un alquilo (C1-C6), un fenilo o un radical heterocíclico saturado o insaturado, en el que el fenilo está sin sustituir o sustituido por al menos un sustituyente seleccionado entre el grupo constituido por un hidroxilo, un halógeno, un nitro, un ciano, un alquilo (C1-C3), un alcoxi (C1-C3), un trifluormetilo y un radical heterocíclico saturado; - R10 y R11 son, cada uno independientemente, hidrógeno o un ciano, alquilo (C1-C6), -CO-fenilo, -CO (radical heterocíclico insaturado) o un grupo -CONR7R8, en el que el fenilo está sin sustituir o sustituido por al menos un sustituyente seleccionado entre el grupo constituido por un hidroxilo, un halógeno, un nitro, un ciano, un alquilo (C1-C3), un alcoxi (C1-C3), y un trifluorometilo; - n es 1 ó 2; - A es un cicloalquilo (C3-C15), un cicloalqueno (C3-C15), en el que el cicloalquilo o el cicloalqueno está sin sustituir o sustituido por al menos un alquilo (C1-C6); siempre que: 1/ cuando X es NR4 donde R4 es H o alquilo (C1-C6) y R1O es 6-OCH3, entonces Y no es CO; 2/ cuando X es O, R1O es 6-OH o 6-OCH3, Y es un enlace directo y A es ciclopentilo, entonces (R2,R3) o (R3,R2) es diferente de (H, Cl) en Posición 4,5; 3/ el compuesto no es

99. 发明专利

AT512952T 未知
公开(公告)号：AT512952T
公开(公告)日：2011-07-15
申请号：AT05794749
申请日：2005-10-14
申请人： THERAMEX
发明人： RONDOT BENOIT , LAFAY JEAN , BONNET PAULE , CLERC THIERRY , DUC IGOR , DURANTI ERIC , PUCCIO FRANCOIS , SHIELDS JACQUELINE , BLOT CHRISTIAN , MAILLOS PHILIPPE
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4162 , A61K31/423 , C07D261/20 , C07D275/04 , C07D275/06 , C07D491/06
摘要： The present invention relates to compounds of formula (I): in which R 1 , R 2 , R 3 , X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.

100. 发明专利

NO330337B1 未知
公开(公告)号：NO330337B1
公开(公告)日：2011-03-28
申请号：NO20052780
申请日：2005-06-08
申请人： THERAMEX
发明人： BONNET PAULE , DELANSORNE REMI , CARNIATO DENIS , LAFAY JEAN , PASCAL JEAN-CLAUDE , ADJE NATHALIE
IPC分类号： C07D233/54 , A01N43/56 , A61K31/4152 , A61K31/4164 , A61K47/06 , A61K47/10 , A61K47/44 , A61P33/10 , A61P43/00 , C07D231/14 , C07D231/16 , C07D231/38 , C07D231/40 , C07D233/61
摘要： A method and composition for the prevention, amelioration or control of external parasites on animals and humans utilizing a compound of formula I. wherein R is halogen, OR7, SOmR8, NO2, CN, C1-C6haloalkyl or an optionally substituted C1-C6alkyl group; n is 0 or an integer of 1, 2 or 3; m is 0 or an integer of 1 or 2; R1 is H, halogen, NO2, NR9R10, NR11COR12, NCHNR9R10 or NCHOR13; R2, R3, R4, R5 and R6 are each independently H, halogen or a C1-C4alkyl, aryl or heteroaryl group each optionally substituted; R7 is H or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted; R8 is a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group, each optionally substituted; R9 and R10 are each independently H, C1-C4haloalkyl or a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted or R9 and R10 may be taken together with the atom to which they are attached to form a 5- to 7-membered ring optionally containing 1 or 2 additional heteroatoms selected from O, N or S; R11 is H, COR12 or an optionally substituted C1-C4alkyl group; R12 is a C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, aryl or heteroaryl group each optionally substituted; and R13 is H or a C1-C6alkyl, aryl or heteroaryl group each optionally substituted; or a stereoisomer or tautomer thereof.

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