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91. 发明申请

WO1998028422A1 RAIDD, A NOVEL CELL DEATH ADAPTOR MOLECULE 审中-公开
标题翻译： RAIDD，一个新的细胞死亡适配器分子
公开(公告)号：WO1998028422A1
公开(公告)日：1998-07-02
申请号：PCT/US1997023548
申请日：1997-12-19
申请人： HUMAN GENOME SCIENCES, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： HUMAN GENOME SCIENCES, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , DIXIT, Vishva, M. , NI, Jian
IPC分类号： C12N15/12
CPC分类号： C12N9/6475 , A61K38/00 , C07K14/7151 , C12N2799/026 , G01N33/5008 , G01N33/68 , G01N2510/00
摘要： The present invention relates to a novel molecule involved in the process of apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human RAIDD protein and splice variants thereof - referred to as RAIDD-SV1 and RAIDD-SV2. RAIDD polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of RAIDD activity.
摘要翻译：本发明涉及参与凋亡过程的新型分子。特别地，提供了分离的核酸分子，其编码人类RAIDD蛋白及其剪接变体 - 称为RAIDD-SV1和RAIDD-SV2。还提供了RAIDD多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定RAIDD活性的激动剂和拮抗剂的筛选方法。

92. 发明申请

WO1998010159A1 OPTIMIZED GEOMETRIES OF FIBER REINFORCEMENTS OF CEMENT, CERAMIC AND POLYMERIC BASED COMPOSITES 审中-公开
标题翻译：水泥，陶瓷和聚合物复合材料纤维增强优化几何
公开(公告)号：WO1998010159A1
公开(公告)日：1998-03-12
申请号：PCT/US1997015434
申请日：1997-09-03
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NAAMAN, Antoine, E.
IPC分类号： E04C05/01
CPC分类号： C04B35/80 , B29C70/16 , E04C5/012 , E04C5/03 , E04C5/073 , Y10T428/2902 , Y10T428/2907 , Y10T428/2913 , Y10T428/2964 , Y10T428/2967 , Y10T428/2973
摘要： Fibers, continuous or discontinuous, and bars having optimized geometries for use in the reinforcement of cement, ceramic and polymeric based matrices are claimed. The geometries are designed to increase the ratio of surface area available for bond between the fiber and the matrix to the cross-sectional area of fiber. In the case of a continuous reinforcement comprised of a single fiber or a bar made out of a bundle of fibers, such as is the case in reinforced and prestressed concrete, increasing the surface area available for bond leads to a decrease in crack width, development length, and transfer length. The fibers or bars are also configured to be amenable for twisting or to have spiral like deformations along their longitudinal axis to further develop the mechanical component of bond between the fibers and the matrix. Additional methods of mechanical bond enhancement, such as crimping and/or addition of anchorages, such as hooked ends, paddles, buttons, etc., can be applied to the claimed fibers to further improve their bond characteristics.
摘要翻译：声称连续或不连续的纤维和具有优化几何形状的棒用于水泥，陶瓷和聚合物基质的增强。几何形状被设计成增加可用于纤维和基体之间的结合的表面积与纤维的横截面面积的比率。在由纤维束制成的单根纤维或棒制成的连续加固的情况下，例如在增强和预应力混凝土中的情况，增加可用于粘结的表面积导致裂缝宽度的减小，开发长度和传送长度。纤维或条还被构造成适于扭曲或沿其纵向轴线具有螺旋形变形，以进一步发展纤维和基质之间的机械结合部分。附加的机械结合增强方法，例如压接和/或添加锚固件，例如钩形端部，桨叶，钮扣等，可以应用于要求保护的纤维，以进一步改善它们的粘合特性。

93. 发明申请

WO1998007688A1 DIAMINOMALEONITRILE DERIVATIVE COMPOUNDS, POLYMERS, AND METHOD OF PRODUCING SAME 审中-公开
标题翻译：二亚胺衍生物衍生化合物，聚合物及其生产方法
公开(公告)号：WO1998007688A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014039
申请日：1997-08-08
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , RASMUSSEN, Paul, G. , REYBUCK, Sarah, E. , JANG, Taeseok , LAWTON, Richard, G.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C07C255/61
CPC分类号： C08G73/00 , C07C255/61 , C08F26/02
摘要： The invention provides a compound having conjugated double bonds in an acyclic structure formed by Schiff base reaction between an unsaturated aldehyde (RCHO) and diaminomaleonitrile (DAMN). The compound is a monoalkylated DAMN derivative having one unit of diaminomaleonitrile for every unit of alkyl (RC) derived from the unsaturated aldehyde. The invention also provides a polymer having an acyclic structure and containing monomeric units formed by Schiff base reaction between an unsaturated aldehyde and a diaminomaleonitrile.
摘要翻译：本发明提供了在不饱和醛（RCHO）和二氨基马来腈（DAMN）之间的席夫碱反应形成的无环结构中具有共轭双键的化合物。该化合物是一种单烷基化的DAMN衍生物，每个单位的由不饱和醛衍生的烷基（RC）单元为二氨基马来腈。本发明还提供一种具有无环结构且含有通过不饱和醛和二氨基马来腈之间的席夫碱反应形成的单体单元的聚合物。

94. 发明申请

WO1998002180A1 TWO-STEP IMMUNIZATION PROCEDURE AGAINST THE PYRAMYXOVIRIDAE FAMILY OF VIRUSES USING ATTENUATED VIRAL STRAINS AND SUBUNIT PROTEIN PREPARATION 审中-公开
标题翻译：使用衰减的病毒株和亚基蛋白质制备的吡虫啉病毒的两步免疫方法
公开(公告)号：WO1998002180A1
公开(公告)日：1998-01-22
申请号：PCT/CA1997000499
申请日：1997-07-11
申请人： CONNAUGHT LABORATORIES LIMITED , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KLEIN, Michel, H. , CATES, George, A. , EWASYSHYN, Mary, E. , HERLOCHER, M., Louise , MAASSAB, H., F.
发明人： CONNAUGHT LABORATORIES LIMITED , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： A61K39/155
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , C12N2760/18534
摘要： An immunization strategy to provide protection against disease caused by infection with paramyxoviridae viruses, specifically respiratory syncytial virus (RSV) and parainfluenza virus (PIV), is described. A priming administration of a live attenuated strain of RSV or PIV first is made to the host followed by a booster administration of at least one purified RSV or PIV protein or immunogenic fragment thereof, which may be adjuvanted with alum. This immunization strategy provides a safe and effective means of controlling disease caused by RSV and PIV infections. The strategy leads to a stronger protective immune response than other strategies and to the induction of a more balanced Th-1/Th-2 type response than previously attained.
摘要翻译：描述了针对由副粘病毒病毒，特别是呼吸道合胞病毒（RSV）和副流感病毒（PIV）感染引起的疾病的免疫策略。首先向宿主施用RSV或PIV的活减毒株，然后加强施用至少一种纯化的RSV或PIV蛋白或其免疫原性片段，其可以用明矾佐剂化。这种免疫策略为控制RSV和PIV感染引起的疾病提供了安全有效的手段。该策略导致比其他策略更强的保护性免疫应答，并且诱导比之前达到的更平衡的Th-1 / Th-2型反应。

95. 发明申请

WO1997027204A1 MODIFIED BENZIMIDAZOLE NUCLEOSIDES AS ANTIVIRAL AGENTS 审中-公开
标题翻译：改性的苯并咪唑核苷作为抗病毒剂
公开(公告)号：WO1997027204A1
公开(公告)日：1997-07-31
申请号：PCT/US1997000764
申请日：1997-01-22
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , GLAXO GROUP LIMITED , TOWNSEND, Leroy, B. , DRACH, John, C. , FREEMAN, George, A.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , GLAXO GROUP LIMITED
IPC分类号： C07H19/052
CPC分类号： C07D471/04 , C07H7/06 , C07H9/04 , C07H11/00 , C07H19/052
摘要： This invention pertains to nucleoside analogs which have antiviral activity and improved metabolic stability. More specifically, this invention pertains to modified sugar benzimidazole nucleosides, as exemplified by compounds such as benzimidazole nucleosides possessing a fluorinated sugar-like moiety (for example, a 2'-fluoro-furanosyl moiety or a 3'-fluoro-furanosyl moiety), and may be represented by formula (I) wherein R is a fluorinated sugar-like moiety; and R , R , R , R and R are benzimidazole substituents, such as -H, halogens (e.g., -F, -C1, -Br, -I), -NO2, -NR2 (where R is independently -H or an alkyl group having 1-6 carbon atoms), -OR (where R is -H or an alkyl group having 1-6 carbon atoms), -SR (where R is -H or a hydrocarbyl of 1-10 carbon atoms), and -CF3. In one embodiment, R is 2'-fluoro-furanosyl or 3'-fluoro-furanosyl; R is -H, -F, -C1, -Br, -I, or -NR2, wherein R is independently -H or an alkyl group having 1-6 carbon atoms; R , R , R and R are independently -H, -F, -C1, -Br, or -I.
摘要翻译：本发明涉及具有抗病毒活性和改善的代谢稳定性的核苷类似物。更具体地，本发明涉及改性糖苯并咪唑核苷，例如化合物例如具有氟化糖样部分的苯并咪唑核苷（例如2'-氟 - 呋喃糖基部分或3'-氟 - 呋喃糖基部分），并且可以由式（I）表示，其中R 1是氟化糖样部分; R 2，R 4，R 5，R 6和R 7是苯并咪唑取代基，例如-H，卤素（例如-F，-C1，-Br，-I），-NO 2，-NR 2（其中R独立地是-H或具有1-6个碳原子的烷基），-OR（其中R是-H或具有1-6个碳原子的烷基），-SR（其中R 是-H或1-10个碳原子的烃基）和-CF 3。在一个实施方案中，R 1是2'-氟 - 呋喃糖基或3'-氟 - 呋喃糖基; R 2是-H，-F，-C 1，-Br，-I或-NR 2，其中R独立地是-H或具有1-6个碳原子的烷基; R 4，R 5，R 6和R 7独立地是-H，-F，-C 1，-Br或-I。

96. 发明申请

WO1997009421A1 CHIMERIC FUCOSYLTRANSFERASE POLYPEPTIDES AND NUCLEIC ACID SEQUENCES ENCODING THEM 审中-公开
标题翻译： CHIMERIC FUCOSYLTRANSFERASE POLYPEPTIDES和核酸序列编码它们
公开(公告)号：WO1997009421A1
公开(公告)日：1997-03-13
申请号：PCT/US1996013816
申请日：1996-09-06
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , LOWE, John, B. , LEGAULT, Daniel, J.
IPC分类号： C12N09/10
CPC分类号： C12N9/1051 , C07K2319/00
摘要： A method for isolating a gene, comprising: (i) isolating a cell possessing a post-translational characteristic of interest, said post-translational characteristic being the presence of a membrane-bound oligosaccharide or polysaccharide of interest on the surface of said cell, the presence of a soluble oligosaccharide or polysaccharide of interest in an extract of said cell, or the presence of a particularly glycosyltransferase activity in an extract of said cell; (ii) creating a genetic library of either cDNA or genomic DNA from the genetic material of said isolated cell; (iii) transforming host cells with said genetic library; and (iv) screening said transformed host cells for a host cell containing said post-translational characteristic, thereby obtaining a cell containing said gene, is disclosed. The method can be used to obtain genes encoding glycosyltransferases.
摘要翻译：一种用于分离基因的方法，包括：（i）分离具有翻译后特征的细胞，所述翻译后特征是所述细胞表面上存在膜结合寡糖或目标多糖，在所述细胞的提取物中存在感兴趣的可溶性寡糖或多糖，或在所述细胞的提取物中存在特别的糖基转移酶活性; （ii）从所述分离的细胞的遗传物质中产生cDNA或基因组DNA的遗传文库; （iii）用所述遗传文库转化宿主细胞; 并且（iv）筛选所述转化的宿主细胞用于含有所述翻译后特征的宿主细胞，从而获得含有所述基因的细胞。该方法可用于获得编码糖基转移酶的基因。

97. 发明申请

WO1996034970A1 IMPROVED METHODS FOR TRANSFECTING T CELLS 审中-公开
标题翻译：改进T细胞的方法
公开(公告)号：WO1996034970A1
公开(公告)日：1996-11-07
申请号：PCT/US1996006200
申请日：1996-05-02
申请人： UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE NAVY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , JUNE, Carl, H. , THOMPSON, Craig, B. , KIM, Suil
IPC分类号： C12N15/87
CPC分类号： C07K16/2818 , A61K48/00 , C07K16/2809 , C12N15/87
摘要： A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.
摘要翻译：描述了用包含基因的核酸分子转染T细胞的方法，使得该基因在T细胞中表达。 T细胞在引入核酸分子之前被刺激并增殖。

98. 发明申请

WO1996028568A1 CD40 BINDING COMPOSITIONS AND METHODS OF USING SAME 审中-公开
标题翻译： CD40结合组合物及其使用方法
公开(公告)号：WO1996028568A1
公开(公告)日：1996-09-19
申请号：PCT/US1995006623
申请日：1995-05-24
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , DIXIT, Vishva, M.
IPC分类号： C12P21/02
CPC分类号： C07K14/4702 , A61K38/00
摘要： This invention provides a novel purified mammalian protein having the ability to bind the cytoplasmic region or domain of a CD40 receptor and the nucleic acid molecules coding for this protein. Also provided by this invention are antibodies which specifically bind CD40bp. Methods of using the proteins, nucleic acids and antibodies described above are further provided herein.
摘要翻译：本发明提供了具有结合CD40受体的细胞质区域或结构域的能力的新型纯化的哺乳动物蛋白质和编码该蛋白质的核酸分子。本发明还提供特异性结合CD40bp的抗体。本文进一步提供使用上述蛋白质，核酸和抗体的方法。

99. 发明申请

WO1996025501A2 METHOD AND COMPOSITION FOR REGULATING APOPTOSIS 审中-公开
标题翻译：用于调节疫苗的方法和组合物
公开(公告)号：WO1996025501A2
公开(公告)日：1996-08-22
申请号：PCT/US1996001882
申请日：1996-02-09
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , DIXIT, Vishva, M.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C12N15/57
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00
摘要： This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated Yama. This invention also provides the polypeptides and proteins encoded by these nucleic acids as well as the purified native polypeptides or proteins. Also provided by this invention is a non-naturally occurring nucleic acid molecule encoding mutant CrmA protein and a dominant inhibitory Yama. Vectors and host cells containing these nucleic acid molecules are further provided. Methods of modulating a cellular function regulated by the Fas receptor pathway in a cell is provided herein. In one aspect, this method comprises introducing into the cell a nucleic acid molecule coding for a gene product having CrmA biological activity such as dominant inhibitory Yama or alternatively, the CrmA gene product. Yama nucleic acid molecules and proteins also can be introduced into the cell to modulate the cellular function regulated by the Fas receptor.
摘要翻译：本发明提供非天然存在和分离的天然存在的编码Yama蛋白质的核酸分子。本发明还提供由这些核酸编码的多肽和蛋白质以及纯化的天然多肽或蛋白质。本发明还提供编码突变体CrmA蛋白和显性抑制性Yama的非天然存在的核酸分子。进一步提供含有这些核酸分子的载体和宿主细胞。本文提供调节由细胞中Fas受体途径调节的细胞功能的方法。一方面，该方法包括向编码具有CrmA生物活性的基因产物如显性抑制性山药或者CrmA基因产物的核酸分子引入细胞。也可以将Yama核酸分子和蛋白质引入细胞以调节由Fas受体调节的细胞功能。

100. 发明申请

WO1996007646A1 ANTIVIRAL NUCLEOSIDE ANALOGUES CONTAINING A SUBSTITUTED BENZIMIDAZOLE BASE ATTACHED TO A CARBOCYCLIC RING 审中-公开
标题翻译：含有取代的苯并咪唑基的偶氮核苷类似物与碳环结合
公开(公告)号：WO1996007646A1
公开(公告)日：1996-03-14
申请号：PCT/US1995011366
申请日：1995-09-11
申请人： THE WELLCOME FOUNDATION LIMITED , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TOWNSEND, Leroy, B. , DALUGE, Susan, Mary
发明人： THE WELLCOME FOUNDATION LIMITED , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C07D235/20
CPC分类号： C07D403/04 , C07D235/30
摘要： Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. In formulae (I) and (I-1), R is H, CH3 or CH2OH; R is H or OH; R is H or OH; or R and R together form a bond; R is amino, cyclopropylamino, cyclobutylamino, isopropylamino, tert-butylamino or -NR R where R and R together with the nitrogen atom to which they are attached form a 4, 5 or 6-membered heterocyclic ring; R is H and R and R are Cl, excluding the compound (+/-)-(1R*, 2S*, 3S*, 5S*)-5-[5,6-Dichloro-2-(cyclopropylamino)-1 H -benzimidazol-1-yl]-3-(hydroxymethyl)-1,2-cyclopentanediol and provided that at least one of R , R and R is or contains OH. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.
摘要翻译：抗病毒核苷类似物包含与碳环连接的取代的苯并咪唑碱代替常规的糖残基。在式（I）和（I-1）中，R 1是H，CH 3或CH 2 OH; R 2是H或OH; R 3是H或OH; 或R 2和R 3一起形成键; R 4是氨基，环丙基氨基，环丁基氨基，异丙基氨基，叔丁基氨基或-NR 8 R 9，其中R 8和R 9与它们所连接的氮原子一起形成4， 5或6元杂环; 不包括化合物（+/-） - （1R *，2S *，3S *，5S *） - 5- [5,6-二氯苯基]，R 5为H且R 6和R 7为Cl -2-（环丙基氨基）-1H-苯并咪唑-1-基] -3-（羟基甲基）-1,2-环戊二醇，条件是R 1，R 2， >和R 3是或含有OH。该化合物具有抗疱疹病毒特异性巨细胞病毒和乙型肝炎病毒感染的活性。

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