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    • 92. 发明申请
    • PLASTER
    • 石膏
    • WO1991016044A1
    • 1991-10-31
    • PCT/JP1991000541
    • 1991-04-23
    • TEYSAN PHARMACEUTICALS CO., LTD.TEIJIN LIMITEDHIDAKA, OsafumiMURAKAMI, Satoshi
    • TEYSAN PHARMACEUTICALS CO., LTD.TEIJIN LIMITED
    • A61K09/70
    • A61K9/703A61F13/00063A61F13/0206A61F13/0223A61F13/0226A61F13/023A61F13/0253A61F13/0256A61F2013/00663A61F2013/00868A61F2013/00906A61K9/7061A61K9/7084
    • A plaster consisting of a film layer formed of a film wherein the thickness thereof is 0.5 - 4.9 mu m, the strengths in two directions intersecting substantially perpendicularly are 8 - 85 g/mm, respectively, the elongations in two directions intersecting substantially perpendicularly are 30 - 150 %, respectively, and, an elongation ratio of one direction to the other is 1.5 - 5.0 (provided that, when the elongations in the two directions are not equal, a smaller elongation is used as a denominator) and an adhesive layer (a) formed of an adhesive agent containing a percutaneous absorptive pharmaceutical, laminated on one of the surfaces of the film layer and having a thickness of 2 - 60 mu m. The possibility of skin poisoning is decreased and a pharmaceutical of a clinically effective amount can be percutaneously absorbed. Further, it is preferable to provide a layer such as a planar support member. For example, a plaster consisting of the film layer (3) and the adhesive layer (4), wherein a planar support member (1) and a peelable film (5) are further laminated through an adhesive layer (b) (2), is excellent to handle.
    • 由厚度为0.5-4.9μm的膜形成的薄膜层,基本上垂直相交的两个方向的强度分别为8〜85g / mm 2,两个方向上大致垂直相交的伸长率为30 - 150%,并且一个方向相对于另一个方向的伸长率为1.5-5.0(条件是当两个方向上的伸长率不相等时,使用较小的伸长率作为分母)和粘合剂层 a)由含有经皮吸收药物的粘合剂形成,层压在膜层的一个表面上,厚度为2-60μm。 皮肤中毒的可能性降低,可以经皮吸收临床有效量的药物。 此外,优选地,提供诸如平面支撑构件的层。 例如,通过粘合剂层(b)(2)进一步层压由薄膜层(3)和粘合剂层(4)组成的石膏,其中平面支撑构件(1)和可剥离薄膜(5) 非常好处理。