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91. 发明授权

US06951630B2 Method and substance for obtaining surfaces with antimicrobial properties 有权
标题翻译：用于获得具有抗菌性能的表面的方法和物质
公开(公告)号：US06951630B2
公开(公告)日：2005-10-04
申请号：US09931265
申请日：2001-08-16
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： B65F1/00 , A01N25/04 , A01N25/06 , A01N25/18 , A61L2/08 , A61L2/16 , A61L2/00
CPC分类号： A61L2/088 , A61L2/16
摘要： The present invention involves the use of photosensitizers to provide antibacterial surfaces on consumer and industrial items. This approach avoids the used of chemicals and solutions that may be toxic. The inventions also avoids the use of chemical compositions that might form degradation products which may be unacceptable to healthy persons or irritating to persons who may have allergies or are otherwise sensitized. According to the invention, photosensitizers with specific properties and specific design features are selected to make practical use of photosensitizers in the consumer and industrial market place. It is important to select a photosensitizer with an activation spectrum that is matched to the environmental conditions under which the surface to be protected is required to exhibit its antimicrobial properties. This means that the illumination energy and intensity levels expected need to yield enough singlet oxygen to destroy the targeted microbes. It is also possible to select photosensitizers that are activated only by wavelengths prominently present in certain illumination lamps, such as those lamps commonly present in a laboratories, medical offices, pharmacies and food service areas, thereby making the surfaces antimicrobial only on demand when the illumination lamps are turned on.
摘要翻译：本发明涉及使用光敏剂以在消费品和工业物品上提供抗菌表面。这种方法避免使用可能有毒的化学品和溶液。本发明还避免使用可能形成降解产物的化学组合物，其可能对健康人不能接受或刺激可能具有过敏或其他敏化剂的人。根据本发明，选择具有特定性质和特定设计特征的光敏剂以在消费者和工业市场中实际使用光敏剂。选择具有与需要保护的表面需要展现其抗微生物性质的环境条件匹配的激活光谱的光敏剂是重要的。这意味着预期的照明能量和强度水平需要产生足够的单线态氧来破坏目标微生物。还可以选择仅由某些照明灯具中显着存在的波长激活的光敏剂，例如通常存在于实验室，医疗机构，药店和食品服务区域中的那些灯，从而使表面仅在照射灯已打开。

92. 发明申请

US20050024583A1 Laser safety contact lenses 失效
标题翻译：激光安全隐形眼镜
公开(公告)号：US20050024583A1
公开(公告)日：2005-02-03
申请号：US10628522
申请日：2003-07-28
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61F9/02 , G02C7/04
CPC分类号： G02C7/021 , A61F9/022 , G02C7/04
摘要： Individually marked contact lenses for protection of one's eyes from harmful radiation are provided. Contact lenses are coated or treated to be absorptive or reflective to a preselected wavelength or wavelength range. The lenses are for protection and generally do not provide vision correction. Because different lenses may protect against different wavelengths and are thus suitable only for certain applications, and because it is desirable to be able to visually confirm that all those in vicinity of the radiation are wearing the proper lenses, the lenses contain one or more identification areas on each lens to demonstrate that the lenses are being worn and to indicate the proper applications with which the lenses should be used. The identification area, which should be visible when worn to third parties and/or the person wearing the lenses, consists of markings such as colored bands or shaded areas in the region around the iris. Different colors or color patterns indicate which wavelengths the lens protects against. Other safety features are contemplated, such as fluorescent markers, added features and devices to facilitate placement in the eye, pick-up or release and to prevent the lens from accidentally dropping out.
摘要翻译：提供单独标记的隐形眼镜，用于保护人眼免受有害辐射。隐形眼镜被涂覆或处理成吸收或反射到预选的波长或波长范围。镜片用于保护，一般不提供视力矫正。因为不同的透镜可以防止不同的波长，并且因此仅适用于某些应用，并且因为期望能够目视地确认辐射附近的所有那些都佩戴适当的透镜，所以透镜包含一个或多个识别区域在每个镜头上，以证明镜片被磨损，并指出应使用镜片的适当应用。当佩戴到第三方和/或戴着镜片的人员时，识别区域应该可见，包括虹膜周围区域的彩色条纹或阴影区域等标记。不同的颜色或颜色图案表示镜头防止哪些波长。可以考虑其他安全特征，例如荧光标记，附加特征和装置，以便于放置在眼睛中，拾取或释放并防止镜片意外脱落。

93. 发明授权

US06758844B2 System and method for oral treatments 失效
标题翻译：口服治疗的系统和方法
公开(公告)号：US06758844B2
公开(公告)日：2004-07-06
申请号：US10056130
申请日：2002-01-24
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B1822
CPC分类号： A61B18/20 , A61B2018/00029
摘要： A system and method is disclosed for improved treatment of oral tissues using 980 nm laser radiation and a handpiece with means for concurrently delivering the laser radiation and a liquid/gas spray onto the treatment area to improve the treatment effects. Unwanted heating and carbonization of surrounding tissues is reduced. The liquid/gas spray may be mixed inside the handpiece or in a separate device. The combination of cooling sprays with radiation wavelengths having high absorption in water has previously been avoided due to the thought that energy absorption by the cooling fluid would render the energy delivered to the tissue uncontrollable and of minimal benefit. Preferably, pulsed laser light provides a localized energy deposition and heating to avoid unwanted heating of underlying tissue. The liquid spray flushes away tissue debris in addition to cooling the treated tissue.
摘要翻译：公开了一种用于使用980nm激光辐射改善口腔组织治疗的系统和方法，以及具有用于同时递送激光辐射和液体/气体喷雾到处理区域以提高治疗效果的手段的手持件。周围组织的不需要的加热和碳化减少。液体/气体喷雾可以在机头内部或在单独的装置中混合。由于认为冷却流体的能量吸收将使能量传递给组织的能量不受控制并且具有最小的益处，所以先前已经避免了冷却喷雾与具有在水中的高吸收的辐射波长的组合。优选地，脉冲激光提供局部能量沉积和加热以避免下层组织的不期望的加热。除了冷却经处理的组织之外，液体喷雾还冲掉组织碎片。

94. 发明授权

US06660000B2 Device for application of radiation 有权
标题翻译：辐射装置
公开(公告)号：US06660000B2
公开(公告)日：2003-12-09
申请号：US10115662
申请日：2002-04-04
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B2017/00199 , A61B2018/00452 , A61C19/004 , A61C19/066
摘要： A photonic scanning and delivery system capable of controllable transmission of light energy to an irregularly shaped treatment area are disclosed. The desired uniformity (controllability) of light energy application is ensured by a tracking device, which monitors the position of the radiation applicator and thereby prevents over- or under-radiation. The system employs a light energy delivery hand-piece. By these means, structures in the lower dermis are irradiated. Because of the large size of the treatment area, damage to surface tissue is avoided. The hand-piece can operate while in contact with the treatment surface. Treatment surfaces include non-medical work sites. Alternatively, the hand-piece can operate in a non-contact mode. The system can also be used in non-medical applications such as UV curing.
摘要翻译：公开了一种能够将光能可控地传输到不规则形状的处理区域的光子扫描和传送系统。通过跟踪装置确保光能施加的期望的均匀性（可控制性），跟踪装置监测辐射施加器的位置，从而防止辐射或辐射不足。该系统采用光能传递手段。通过这些方式，照射下层真皮中的结构。由于治疗面积大，避免了表面组织的损伤。手柄可以在与治疗表面接触的同时进行操作。治疗表面包括非医疗工作场所。或者，手持件可以以非接触模式操作。该系统也可用于非医疗应用，如紫外线固化。

95. 发明授权

US06485414B1 Color video diagnostic system for mini-endoscopes 有权
标题翻译：迷你内窥镜彩色视频诊断系统
公开(公告)号：US06485414B1
公开(公告)日：2002-11-26
申请号：US09525625
申请日：2000-03-14
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B107
CPC分类号： A61B1/05 , A61B1/063 , A61B1/0638 , A61B1/07
摘要： A color video diagnostic system for mini-endoscopes for viewing features of objects where access to the object is limited or where minimally invasive techniques are preferable, such as in medical or industrial applications. A black-and-white video chip mounted at the distal end of an endoscope body images an object sequentially illuminated by laser diode light sources having different wavelengths. More than one laser diode may be used within a color region to provide truer color representations. A controller controls the laser diode light sources for sequentially illuminating the object by color, and a video processor responsive to the controller receives signals from the black-and-white video chip for producing a color data signal. A display displays a color image of the object. At least one diagnostic laser diode light source, which can be tunable, may be included for enhancing selected features of the object being viewed, and it may emit in the visible, near infrared, or infrared wavelength regions. A beam-combining element can be included for combining the light beams from the laser diode light sources for provision to a fiber light transport element for transporting the light to illuminate the object.
摘要翻译：用于微型内窥镜的彩色视频诊断系统，用于观察对象的访问受限的物体的特征，或者在诸如医疗或工业应用中的最佳侵入技术中。安装在内窥镜主体的远端的黑白视频芯片对由具有不同波长的激光二极管光源顺序照射的物体进行成像。可以在颜色区域内使用多于一个的激光二极管，以提供更真实的颜色表示。控制器控制激光二极管光源以用颜色顺序照亮物体，并且响应于控制器的视频处理器接收来自黑白视频芯片的信号以产生彩色数据信号。显示器显示对象的彩色图像。可以包括至少一个可调谐的诊断激光二极管光源，用于增强被观察物体的选定特征，并且其可以在可见光，近红外或红外波长区域中发射。可以包括光束组合元件，用于组合来自激光二极管光源的光束用于提供用于传输光以照亮物体的光纤传输元件。

96. 发明授权

US06454790B1 Treatment for Barrett's syndrome 失效
标题翻译：治疗巴雷特综合征
公开(公告)号：US06454790B1
公开(公告)日：2002-09-24
申请号：US09621802
申请日：2000-07-21
申请人： Wolfgang Neuberger , Patrice Thierry
发明人： Wolfgang Neuberger , Patrice Thierry
IPC分类号： A61N506
CPC分类号： A61N5/062 , A61B18/22 , A61B2017/22054 , A61B2018/00982 , A61B2018/2261 , A61N5/0601 , A61N2005/0609
摘要： An apparatus and method for treating Barrett's tissue by removal of the mucosa through PhotoDynamic Therapy(PDT) is provided. A viscous gel is the medium used to carry the photosensitizer to the treatment site and allow sufficient time to transfer to the tissue. The gel's viscosity will allow it to adhere to the tissue for a sufficient amount of time to transfer the photosensitizer or sufficient time for a mechanical device such as an expanding balloon to press the gel into the tissue. The photosensitizer within the gel is activated by the corresponding wavelength of radiation. An extended multi-balloon system limits the area of treatment and localizes the spread of the gel. An endoscope with fiber optics may be used to view the operation. A preferred embodiment of the apparatus contains a catheter with at least two balloons, one to block drainage of the photosensitizer into the stomach and one to limit the height of the treatment area and to press the gel into the tissue. Included in this embodiment is a tube for the delivery of the gel, a tube for cooling purposes or aspiration, an image bundle and a diffuse light source. The apparatus and method may be used to treat various other diseases involving the gastrointestinal diseases of the mucosa. The most salient feature of this invention is the multi-balloon system used to limit the area of treatment, but effect the entire desired area at one time.
摘要翻译：提供了通过光动力治疗（PDT）去除粘膜来治疗巴雷特组织的装置和方法。粘性凝胶是用于将光敏剂携带到治疗部位并允许足够的时间转移到组织的培养基。凝胶的粘度将允许其粘附到组织足够的时间以转移光敏剂或足够的时间用于诸如膨胀气囊的机械装置以将凝胶压入组织。凝胶内的光敏剂被相应的辐射波长激活。延长的多气囊系统限制了治疗的面积，并定位了凝胶的扩散。可以使用具有光纤的内窥镜来观察操作。该装置的优选实施例包括具有至少两个气囊的导管，一个用于阻止光敏剂排入胃中，一个限制治疗区域的高度并将凝胶压入组织。在该实施例中包括用于输送凝胶的管，用于冷却目的或抽吸的管，图像束和漫射光源。该装置和方法可用于治疗涉及粘膜胃肠道疾病的各种其它疾病。本发明最突出的特征是用于限制治疗面积的多球囊系统，但一次影响整个所需区域。

97. 发明授权

US06416785B1 Molecular probes for targeting of cell density-indicating compounds 失效
标题翻译：用于靶向细胞密度指示化合物的分子探针
公开(公告)号：US06416785B1
公开(公告)日：2002-07-09
申请号：US09644952
申请日：2000-08-23
申请人： Dieter Riesenberg , Volker Schroeckh , Burkhard Gitter , Wolfgang Neuberger
发明人： Dieter Riesenberg , Volker Schroeckh , Burkhard Gitter , Wolfgang Neuberger
IPC分类号： A61K9127
CPC分类号： A61K31/00
摘要： A new approach for targeting chemotherapeutics to focal bacterial infections is provided. Such focal infections are characterized by high densities of different bacteria and thus high concentrations of their extracellular signal molecules sensing the cell density. In gram-negative bacteria, one of such signal molecules is acyl-homoserine lactone (acyl-HSL, member of the autoinducer family AI-1), wherein species-specificity is achieved by acyl-residues, and HSLs are common for all gram-negative bacteria. In gram-positive bacteria, oligopeptides secreted by the bacteria communicate the cell density. In addition, there are cell density signal molecules (members of the autoinducer family AI-2) which communicate between gram-positive and gram-negative bacteria. The general scheme of the present invention is molecular modules that comprise both a targeting component and a chemotherapeutical component which serves for photodynamic antimicrobial chemotherapy (PACT). One preferred embodiment of the present invention is to target photosensitizers to the extracellular signal molecules instead of on the bacteria themselves. Targeting of the photosensitizers is mediated via molecules with efficient binding to the HSL-moiety of the acyl-HSL, so that a broad spectrum of gram-negative bacteria can be knocked out. Photosensitizers used in the present invention can be packed into special liposomes with lipid chelators or multiple coupled to dendrimers, so that they are especially effective for PACT. In addition, selected molecules with high affinity to a common moiety of such signal molecules, like HSL, may be used as molecular probes for the search of yet undiscovered cell density dependent signals.
摘要翻译：提供了一种将化学治疗剂靶向局灶性细菌感染的新方法。这种局部感染的特征在于不同细菌的高密度，因此其细胞外信号分子的高浓度感测细胞密度。在革兰氏阴性细菌中，这种信号分子之一是酰基高丝氨酸内酯（酰基-HSL，自身诱导者家族AI-1的成员），其中通过酰基残基实现物种特异性，并且HSL对于所有革兰氏阴性细菌是常见的，阴性细菌。在革兰氏阳性细菌中，由细菌分泌的寡肽传播细胞密度。此外，存在细胞密度信号分子（自体诱导者家族成员AI-2），其在革兰氏阳性和革兰氏阴性细菌之间进行通信。本发明的一般方案是包含用于光动力学抗微生物化疗（PACT）的靶向组分和化学治疗组分的分子模块。本发明的一个优选实施方案是将光敏剂靶向细胞外信号分子而不是细菌本身。光敏剂的靶向通过与酰基HSL的HSL-部分有效结合的分子介导，从而可以敲除广谱的革兰氏阴性细菌。本发明中使用的光敏剂可以用脂质螯合剂或多个偶联至树状聚合物的特殊脂质体包装，使得它们对于PACT特别有效。此外，对这种信号分子（如HSL）的共同部分具有高亲和力的选择的分子可以用作搜索尚未发现的细胞密度相关信号的分子探针。

98. 发明授权

US06355054B1 Laser system for improved transbarrier therapeutic radiation delivery 失效
标题翻译：激光系统，用于改善横隔离治疗辐射传递
公开(公告)号：US06355054B1
公开(公告)日：2002-03-12
申请号：US09435229
申请日：1999-11-05
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N500
CPC分类号： A61M37/0015 , A61B18/203 , A61B2017/00765 , A61B2018/00452 , A61B2018/00458 , A61B2018/2005 , A61B2018/2261 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： The present invention describes a system and method to improve radiation delivery through a barrier that may be encountered during therapeutic laser procedures, particularly where the objective of treatment is to produce thermal damage or alterations to subsurface tissue constituents without destroying or altering the overlying barrier. To achieve this result, a bio-compatible fluid is preoperatively administered to the tissue. The bio-compatible fluid is a light-scattering fluid that will scatter light primarily at the desired site thereby achieving a more uniform, enhanced heating over a relatively large treatment area. In addition, a second fluid, a dispersion fluid, can be added to the tissue to function in distributing the light scattering fluid throughout the treatment site. Laser radiation is then administered, through micro pores created for example by a device such as a micro-needle patch, into the treatment site. When a micro-needle patch is employed to deliver the fluid and the radiation, it can be a single patch for both functions, or a separate patch for each function.
摘要翻译：本发明描述了一种用于改善在治疗激光程序期间可能遇到的屏障的辐射传递的系统和方法，特别是在治疗目的是对地下组织成分产生热损伤或改变而不破坏或改变上覆屏障的情况下。为了实现该结果，将生物相容性流体在术前施用于组织。生物相容性流体是光散射流体，其将主要散射在期望的位置处，从而在相对较大的处理区域上实现更均匀的增强的加热。此外，可将第二流体，分散流体添加到组织中，以在整个处理部位分配光散射流体。然后通过例如通过诸如微针补片的装置产生的微孔将激光辐射施用到治疗部位。当使用微针贴片来输送流体和辐射时，它可以是两个功能的单个贴片，或者用于每个功能的单独贴片。

99. 发明授权

US06208781B1 Fiber optic transmission system for high power laser 失效
标题翻译：高功率激光光纤传输系统
公开(公告)号：US06208781B1
公开(公告)日：2001-03-27
申请号：US09115057
申请日：1998-07-14
申请人： Wolfgang Neuberger , Alexander Kharschak
发明人： Wolfgang Neuberger , Alexander Kharschak
IPC分类号： G02B626
CPC分类号： G02B6/25 , G02B6/241 , G02B6/262 , G02B6/3818 , G02B6/4207 , G02B6/4296
摘要： A fiber optic transmission system for high laser power transmission is described. A micro-structure, whose pre-determined features are characterized by a preferred shape, depth, and peak-to-peak distance, is introduced into an input end surface of an optical fiber. Such micro-structure reduces Fresnel reflection at the modified optical fiber end surface improving the damage threshold at the surface. Micro-structuring of the optical fiber output end surface in a similar fashion further enhances transmission of high laser powers. A method is disclosed where the optical fiber end surfaces are structured into a pre-determined micro-structure by a suitable stamp. The micro-structure increases the damage threshold of each optical fiber end surface, raising it closer to the theoretical damage threshold of the material within the fiber and thereby increases transmission of high laser power density that is available at a work or treatment site.
摘要翻译：描述了用于高激光功率传输的光纤传输系统。将其预定特征由优选形状，深度和峰 - 峰距离表征的微结构引入光纤的输入端面。这种微结构降低了改性光纤端面处的菲涅尔反射，提高了表面的损伤阈值。以类似的方式微结构化光纤输出端面进一步增强了高激光功率的传输。公开了一种方法，其中光纤端面通过合适的印模构造成预定的微结构。微结构增加了每个光纤端面的损伤阈值，使其更接近光纤内材料的理论损伤阈值，从而增加了在工作或处理部位可获得的高激光功率密度的透射。

100. 发明授权

US06138478A Method of forming an optical fiber preform using an E.sub.020 plasma field configuration 失效
标题翻译：使用E020等离子体场配置形成光纤预制棒的方法
公开(公告)号：US06138478A
公开(公告)日：2000-10-31
申请号：US122831
申请日：1998-07-27
申请人： Wolfgang Neuberger , Vladimir V. Volodjko , Leonid M. Blinov
发明人： Wolfgang Neuberger , Vladimir V. Volodjko , Leonid M. Blinov
IPC分类号： C03B37/014 , C03B37/018
CPC分类号： C03B37/01426 , C03B2201/10 , C03B2201/12
摘要： The present invention is directed at a method and device for manufacturing a preform. The method involves arranging a starting body within a channel as defined by a vessel. Then, the channel is supplied with a reactive gas containing a coating material precursor. A resonator then generates a plasma zone within the channel. The starting body is aligned in the channel such that the plasma zone concentrically surrounds the starting body. The axial movement of the resonator relative to the starting body is controlled such that a desired layer of coating material precursor reactively deposits on the starting body to form the preform. The method suppresses deposition on the inside of the vessel via suppressing means, which may involve inducing nodes in the E-field at the vessel walls, or using an suppressing gas on the inner surface of the vessel, or a combination of the two. The present invention is also directed at a device to facilitate the aforementioned method.
摘要翻译：本发明涉及用于制造预制件的方法和装置。该方法包括在由容器限定的通道内布置起始体。然后，向通道供应含有涂料前体的反应性气体。谐振器然后在通道内产生等离子体区域。起始体在通道中对准，使得等离子体区同心地围绕起始体。控制谐振器相对于起始体的轴向移动，使得所需的涂层材料层前体在起始体上反应沉积以形成预成型体。该方法通过抑制装置抑制容器内部的沉积，这可能涉及在容器壁处的E场中诱导节点，或者在容器的内表面上使用抑制气体，或两者的组合。本发明还涉及一种便于上述方法的装置。

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