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91. 发明授权

US4804518A Device for occult blood testing 失效
标题翻译：潜血试验装置
公开(公告)号：US4804518A
公开(公告)日：1989-02-14
申请号：US704962
申请日：1985-02-25
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： G01N33/50 , C12Q1/28 , G01N33/48 , G01N33/52 , G01N33/72
CPC分类号： G01N33/726 , G01N33/528 , Y10S435/805
摘要： The device consists of a base sheet of impermeable plastic such as vinyl, or the like, and a guaiac stool receptor sheet adhesively secured thereto. The base sheet is sufficiently larger than the receptor sheet so to form an impermeable skirt which surrounds the receptor sheet so as to form an hermetic barrier protecting the receptor sheet on the underneath one of two of the devices when stacked one on top of the other. A performance/control monitor is included on the device. The monitor includes a peroxidatively active material such as hematin, or the like, which confirms the reactively of the guaiac-impregnated sheet, as well as the activity of the peroxide developing solution. The monitor material is kept out of reactive contact with the guaiac receptor sheet until the developer reagent is applied to the device. A stack of the devices is packed in a sealed container of plastic, or the like, so that the individual devices can be removed from the container one at a time. The devices are designed for use in the physician's office for reception of stool smears taken manually on a rubber glove or finger cot by the physician from patients.

92. 发明申请

US20200278341A1 METHOD AND APPARATUS FOR PERFORMING HEMATOLOGIC ANALYSIS USING AN ARRAY-IMAGING SYSTEM FOR IMAGING AND ANALYSIS OF A CENTRIFUGED ANALYSIS TUBE 审中-公开
公开(公告)号：US20200278341A1
公开(公告)日：2020-09-03
申请号：US16812959
申请日：2020-03-09
申请人： Joshua D. Levine , Robert A. Levine , Stephen C. Wardlaw , Craig Stout , David A. Clipper
发明人： Joshua D. Levine , Robert A. Levine , Stephen C. Wardlaw , Craig Stout , David A. Clipper
IPC分类号： G01N33/49 , B01L3/00 , G01N15/04 , G01N15/05 , B01L9/06 , G06T7/00
摘要： A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region.

93. 发明申请

US20140084055A1 QUALITY CONTROL METHOD AND APPARATUS FOR AUTOMATED ANALYSES OF BIOLOGIC FLUID SAMPLE 审中-公开
标题翻译：生物流体样品自动分析的质量控制方法和装置
公开(公告)号：US20140084055A1
公开(公告)日：2014-03-27
申请号：US14111980
申请日：2012-04-13
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： G01N35/00
CPC分类号： G01N35/00613 , B01L3/508 , B01L3/545 , B01L2300/021 , G01N2035/00851
摘要： An apparatus and method for analyzing a biologic sample is provided. The apparatus includes a capillary tube, a machine readable identity tag, and an analysis device. The tube is operable to hold the biologic sample. The machine readable identity tag is disposed on the tube, and indicates a production source of the tube. The analysis device is operable to analyze the biologic sample. The analysis device includes a reader adapted to read the identity tag, and the analysis device is operable to authenticate the tube based on the identity tag read from the tube.
摘要翻译：提供了用于分析生物样品的装置和方法。该装置包括毛细管，机器可读身份标签和分析装置。管可操作以保持生物样品。机器可读身份标签设置在管上，并指示管的生产源。分析装置可操作以分析生物样品。分析装置包括适于读取身份标签的读取器，并且分析装置可操作以基于从管中读取的身份标签来认证管。

94. 发明授权

US08383419B2 Harvesting target materials from centrifuged suspensions 失效
标题翻译：从离心悬浮液中收获目标物质
公开(公告)号：US08383419B2
公开(公告)日：2013-02-26
申请号：US12817012
申请日：2010-06-16
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： B01D21/26
CPC分类号： G01N33/491 , Y10T436/25 , Y10T436/25375
摘要： Embodiments of the present invention are directed to harvesting a target material from a suspension using a tube and float system. A suspension suspected of containing a target material is combined with a solution having one or more labels that distinguish the target material from other materials in the suspension. The tube, float, and suspension are centrifuged to separate various materials in the suspension according to associated specific gravities. The float expands the axial length of the target material layer and displaces the target material to a narrow space between the float and the inner wall of the tube. The space is illuminated with light that causes the labels to emit light identifying the location of the target material within the tube. One or more openings can then be formed in the tube at or near the point where the target material is located and the target material harvested.
摘要翻译：本发明的实施方案涉及使用管和浮子系统从悬浮液中收获目标材料。怀疑含有目标材料的悬浮液与具有一种或多种将目标材料与悬浮液中的其它材料区分开的标签的溶液合并。将管，浮子和悬浮液离心以根据相关的比重分离悬浮液中的各种材料。浮子膨胀目标材料层的轴向长度，并将目标材料移位到浮子和管内壁之间的狭窄空间。该空间用光照亮，导致标签发光，以识别目标材料在管内的位置。然后可以在管中或其附近位于目标材料所在的点附近形成一个或多个开孔，并且收集目标材料。

95. 发明申请

US20090253218A1 METHOD FOR SEROLOGIC AGGLUTINATION AND OTHER IMMUNOASSAYS PERFORMED IN A THIN FILM FLUID SAMPLE 有权
标题翻译：在薄膜液体样品中进行血液动力学和其他免疫测定的方法
公开(公告)号：US20090253218A1
公开(公告)日：2009-10-08
申请号：US12417353
申请日：2009-04-02
申请人： Stephen C. Wardlaw , Robert A. Levine
发明人： Stephen C. Wardlaw , Robert A. Levine
IPC分类号： G01N33/566
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： A method and system for performing a serological agglutination assay in a liquid sample. The system provides a simple method for creating an in-situ sample/reagent admixture within a sample analysis chamber without the use of any precision fluid-handling components.
摘要翻译：用于在液体样品中进行血清学凝集测定的方法和系统。该系统提供了在样品分析室内创建原位样品/试剂外加剂的简单方法，而不使用任何精密的流体处理组件。

96. 发明授权

US6004821A Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample 有权
标题翻译：用于对尿样进行化学，定性，定量和半定量分析的方法和装置
公开(公告)号：US6004821A
公开(公告)日：1999-12-21
申请号：US236168
申请日：1999-01-25
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： G01N33/48 , B01L3/00 , G01N33/493 , G01N33/50 , G01N33/52
CPC分类号： G01N33/523 , B01L3/5027 , G01N33/493 , G01N33/5002 , B01L2300/0663 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0481 , B01L2400/0611 , B01L3/50273 , Y10S436/808 , Y10S436/809 , Y10T436/25125 , Y10T436/25375
摘要： A urine sample is analyzed for urine chemistry, formed bodies, and rare event evidence, all in a single sample container and under low power magnification. The sample container includes a urine sample receiving chamber which is connected to a urine chemistry chamber, to a formed body isolation chamber, and to a rare events detection chamber, so that the urine can flow from the receiving chamber to the other three chambers. The container may also include a sterile chamber for receiving an auxiliary portion of the urine which may be used for further analysis by the clinician if necessary. The chemistry chamber contains a miniaturized urine dip stick which is scanned by an optical scanning instrument for color emissions. The formed body isolation chamber can be precoated with one or more stains, and is formed with a plurality of different through plane thicknesses whereby smaller formed bodies will be isolated in the smaller thickness regions of the chamber which the larger formed bodies cannot enter. The scanning instrument will scan the isolation chamber and can identify formed bodies by their characteristic light wave emission properties which result from the formed bodies exposure to the stains. The formed bodies can also be morphologically examined in the isolation chamber. The rare event detection chamber will include a component which will absorb essentially all of the water in the urine thus concentrating formed bodies on a surface in the chamber. This chamber can also be provided with one or more stains which will differentially highlight any rare events noted in the chamber by the scanning instrument. Rare events such as casts can be detected in this chamber.
摘要翻译：分析尿液样品的尿液化学成分，成形体和罕见的事件证据，全部在单个样品容器中，在低功率放大下。样品容器包括尿液接收室，尿液接收室连接到尿化学室，形成体隔离室，并且与稀有事件检测室相连，使得尿液可以从接收室流到另外的三个室。容器还可以包括用于接收尿的辅助部分的无菌室，如果需要，其可以用于临床医生的进一步分析。化学室包含一个小型化的尿液浸渍棒，由一个光学扫描仪扫描，用于颜色排放。成型体隔离室可以预涂一个或多个污渍，并且形成有多个不同的通过平面厚度，从而较小的成形体将在较大的成形体不能进入的室的较小厚度区域中被隔离。扫描仪器将扫描隔离室，并且可以通过其形成的物体暴露于污渍产生的特征性光波发射特性来识别成形体。成型体也可以在隔离室中进行形态学检查。罕见事件检测室将包括将吸收尿液中基本上所有的水的成分，从而将成形体集中在腔室的表面上。该室还可以具有一个或多个污渍，其将通过扫描仪器差异地突出腔室中注明的罕见事件。在这个房间里可以检测到诸如铸件的罕见事件。

97. 发明授权

US5759794A Assay of blood or other biologic samples for target analytes 失效
公开(公告)号：US5759794A
公开(公告)日：1998-06-02
申请号：US771506
申请日：1996-12-23
申请人： Robert A. Levine , Stephen C. Wardlaw , Rodolfo R. Rodriguez
发明人： Robert A. Levine , Stephen C. Wardlaw , Rodolfo R. Rodriguez
IPC分类号： G01N33/543 , B01L3/14 , G01N33/49 , G01N33/537 , G01N33/569 , G01N33/58 , G01N33/558
CPC分类号： B01L3/5021 , G01N33/491 , G01N33/5375 , G01N33/56972 , G01N33/585 , Y10S435/81 , Y10S435/967 , Y10S435/971 , Y10S435/973 , Y10S436/805 , Y10S436/81 , Y10S436/824 , Y10S436/829 , Y10T436/111666
摘要： A patient's health may be diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more bodies or groups of bodies such as floats, inserts, liposomes, or plastic beads of different densities. Each density-defined body carries analyte-capture binding materials such as antigens or antibodies, which are specific to an epitope, or other specific high affinity binding site on a target analyte which target analyte may be in the blood or other sample being tested; and the level of which analyte is indicative of the patient's health. At least one labeled binding material which is also specific to an epitope, or other specific high affinity binding site on the target analyte is added to the sample so as to form labeled binding material/analyte/body complexes in the sample. Upon centrifugation, the complexes will settle out in different areas in the tube according to the respective density of the body or bodies; and the degree of label emission of the complex layers can enable qualitative and/or quantitative analyses of the sample to be made. Unbound labeled binding materials will be separated from the complexed layers by the washing action of ascending or descending components of the sample during the centrifugation step. Unbound labeled binding material will thus not interfere with the analysis.

98. 发明授权

US5064766A Method for differentiating the source of occult gastrointestinal bleeding 失效
标题翻译：用于区分隐匿性胃肠道出血的来源的方法
公开(公告)号：US5064766A
公开(公告)日：1991-11-12
申请号：US423181
申请日：1989-10-18
申请人： Stephen C. Wardlaw , Robert A. Levine
发明人： Stephen C. Wardlaw , Robert A. Levine
IPC分类号： G01N33/72
CPC分类号： G01N33/726 , G01N33/725 , Y10S435/805 , Y10T436/25125 , Y10T436/255
摘要： The specification discloses a fecal occult blood test device capable of determining whether the blood found during the test originated in the upper or lower gastrointestinal track. A fecal sample is applied to a test medium charged to be differentially attractive to blood components originating in the upper and lower gastrointestinal track respectively. A solvent is applied to the test specimen to cause differential migration of the blood components and an indicator is then applied to indicate the presence of the blood components, if any.
摘要翻译：本说明书公开了一种能够确定测试期间发现的血液是否起源于上胃肠道或下胃肠道的粪便潜血检测装置。将粪便样品应用于分别对源自上胃肠道和下胃肠道的血液成分具有差异吸引力的测试介质。将溶剂施加到测试样品上以引起血液成分的差异迁移，然后施加指示剂以指示血液成分的存在（如果有的话）。

99. 发明授权

US4953975A Correction of material layer volume measurements 失效
标题翻译：材料层体积测量的校正
公开(公告)号：US4953975A
公开(公告)日：1990-09-04
申请号：US303125
申请日：1989-01-30
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： B01L3/14
CPC分类号： B01L3/50215
摘要： Centrifuged material layer volume measurements are made in a transparent capillary tube containing an elongated float which expands the layers being measured. The extent of layer expansion will vary depending on the tube bore diameter and the float diameter. The tube bore diameter and float diameter for each tube/float pair are measured, and an indication of the difference between the two is marked on the tube. When the volume determinations are made, the measured difference between the tube bore diameter and the float diameter is taken into account before calculating actual layer volume malues.
摘要翻译：离心材料层体积测量是在含有细长浮子的透明毛细管中进行的，该细长的浮子膨胀所测量的层。层膨胀的程度将根据管孔直径和浮子直径而变化。测量每个管/浮子对的管孔直径和浮子直径，并在管上标出两者之间的差异指示。当进行体积确定时，在计算实际层体积误差之前，考虑管孔直径和浮子直径之间的测量差。

100. 发明授权

US4823624A Material layer volume determination with correction band 失效
标题翻译：材料层体积确定与校正带
公开(公告)号：US4823624A
公开(公告)日：1989-04-25
申请号：US248632
申请日：1988-09-26
申请人： Rodolfo R. Rodriguez , Matthew W. Lesniesky , Charles F. Galanaugh , Robert A. Levine , Stephen C. Wardlaw , Theodore Juraschek
发明人： Rodolfo R. Rodriguez , Matthew W. Lesniesky , Charles F. Galanaugh , Robert A. Levine , Stephen C. Wardlaw , Theodore Juraschek
IPC分类号： B01L3/14 , G01N15/05 , A61B5/14
CPC分类号： B01L3/50215 , G01N15/05
摘要： A centrifuge tube is used to hold a mixture of several constituents, and also contains a generally cylindrical float. The float settles, after centrifugation, into the zone occupied by the constituent whose volume is to be measured. The constituent layer will settle, after centrifugation, into the annular space between the tube bore and the outside of the float, and will be expanded axially due to the restricted volume of the annular space. The degree of expansion is dependent upon the respective sizes of the float O.D. and the tube bore ID, both of which must be closely controlled for accurate results. A known volume of a control material is placed in the tube to settle into the annular space during centrifugation in an area thereof outside of the constituent layer zone. The length of the band of the control material is measured after centrifugation and is compared to a known length which will result if the annular space is of the proper target volume. A correction factor is thus obtained and applied to all of the other constituent layers which were measured. The band thus forms a varying reference which reflects the actual volume of the annulus.
摘要翻译：离心管用于容纳几种成分的混合物，并且还包含一般为圆柱形的浮子。离心后，浮子沉降到被测量体积所占据的区域内。构成层在离心后将沉淀到管孔和浮体外部之间的环形空间中，并且由于环形空间的体积受限制而将轴向膨胀。膨胀程度取决于浮子O.D的各自尺寸。和管孔ID，两者都必须严格控制以获得准确的结果。将已知体积的对照材料放置在管中，以便在构成层区域外的区域中离心期间沉降到环形空间中。在离心后测量对照材料带的长度，并将其与已知的长度进行比较，如果环形空间具有适当的目标体积，则该长度将产生。因此获得校正因子并将其应用于所测量的所有其它构成层。因此，带形成变化的参考，其反映环的实际体积。

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