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91. 发明授权

US08163281B2 Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis 有权
标题翻译：通过靶向CD24-HMGB1-Siglec10轴治疗药物相关的副作用和组织损伤
公开(公告)号：US08163281B2
公开(公告)日：2012-04-24
申请号：US12716842
申请日：2010-03-03
申请人： Yang Liu , Pan Zheng , Guo-Yun Chen , Xincheng Zheng , Xi Chen , Steve Kunkel
发明人： Yang Liu , Pan Zheng , Guo-Yun Chen , Xincheng Zheng , Xi Chen , Steve Kunkel
IPC分类号： A61K39/395 , A61K39/00 , A61K38/16
CPC分类号： C07K16/18 , A61K31/351 , A61K38/177 , A61K45/06 , A61K2039/505 , C07K14/70596 , C07K16/2803 , C07K16/2896 , C07K2319/30 , A61K2300/00
摘要： The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.
摘要翻译：本技术提供了通过施用包含一种或多种CD24的组合物来治疗组织损伤相关免疫失调调节的方法和组合物; CD24片段，变体和衍生物，CD24Fc融合蛋白; HMBG1结合蛋白，HMBG1盒B结合蛋白; HMGB1的多肽，单克隆，重组，嵌合，人源化scFv抗体和HMGB1抗体片段或HMGB1片段的抗体以及结合并抑制HMGB1盒B活性的抗体的拮抗剂; Siglec 10激动剂如抗Siglec 10抗体; 及其组合。

92. 发明授权

US08116357B2 Methods and circuits for power management in a transceiver 有权
标题翻译：收发器电源管理的方法和电路
公开(公告)号：US08116357B2
公开(公告)日：2012-02-14
申请号：US11440151
申请日：2006-05-25
申请人： Xi Chen
发明人： Xi Chen
IPC分类号： H04B1/38
CPC分类号： H04L1/243
摘要： A transceiver circuit having 10 mb and 100 mb transmit and receive circuitries using the power saving methods of the present invention is disclosed. The power consumption of the transceiver circuit can be significantly reduced by providing each defined subcircuit with its own power supply and means of activation and deactivation. However, the method for activating and deactivating digital subcircuits and analog subcircuits are different and therefore different types of control signals and methods are provided. Furthermore, there are two general types of power-saving situations. The first type is near total circuit power-down and the second type is partial circuit power-down. The present invention in yet another embodiment discloses a method for minimizing energy usage during idle period.
摘要翻译：公开了使用本发明的省电方法的具有10mb和100mb发送和接收电路的收发器电路。通过为每个定义的子电路提供自己的电源和激活和停用的手段，可以显着减少收发器电路的功耗。然而，用于激活和停用数字子电路和模拟子电路的方法是不同的，因此提供了不同类型的控制信号和方法。此外，省电情况有两种。第一种类型是接近总电路掉电，第二种是部分电路掉电。在另一个实施例中的本发明公开了一种在空闲时段期间最小化能量使用的方法。

93. 发明申请

US20110283106A1 METHOD FOR REALIZING AUTHENTICATION CENTER AND AUTHENTICATION SYSTEM 有权
标题翻译：实现认证中心和认证系统的方法
公开(公告)号：US20110283106A1
公开(公告)日：2011-11-17
申请号：US13145222
申请日：2009-09-15
申请人： Zhenfeng Cui , Zhijun Bian , Xi Chen
发明人： Zhenfeng Cui , Zhijun Bian , Xi Chen
IPC分类号： G06F21/20 , H04L9/32
CPC分类号： H04L63/08
摘要： A method for realizing an authentication center (AC) and an authentication system are disclosed. The method comprises: a UE sends an authentication request to an AC and applies for temporary authentication information, the AC assigns a first authentication random code to the UE, then the UE calculates a first response code and sends it to the AC, the AC assigns the temporary authentication information to the UE after authentication and authorization; the UE sends a login request to the application system (AS) which assigns a second authentication random code to the UE, and the UE uses it and the temporary authentication information to calculate a second response code, and sends this code to the AS; the AS sends the second response code to the AC for authentication and authorization; the AC returns the authentication result to the AS which in turn returns the authentication result to the UE.
摘要翻译：公开了一种用于实现认证中心（AC）和认证系统的方法。该方法包括：UE向AC发送认证请求，申请临时认证信息，AC向UE分配第一认证随机码，然后UE计算第一个响应码并发送给AC，AC分配认证授权后向UE提供临时认证信息; UE向UE分配了第二认证随机码的应用系统（AS）登录请求，UE使用该请求和临时认证信息来计算第二响应码，并将该代码发送给AS; AS将第二个响应代码发送给AC进行认证和授权; AC将认证结果返回给AS，AS又将认证结果返回给UE。

94. 发明授权

US08008252B2 Factor VII: remodeling and glycoconjugation of Factor VII 失效
标题翻译：因子VII：因子VII的重塑和糖结合
公开(公告)号：US08008252B2
公开(公告)日：2011-08-30
申请号：US10411044
申请日：2003-04-09
申请人： Shawn DeFrees , David Zopf , Robert Bayer , Caryn Bowe , David Hakes , Xi Chen
发明人： Shawn DeFrees , David Zopf , Robert Bayer , Caryn Bowe , David Hakes , Xi Chen
IPC分类号： A61K38/16
CPC分类号： C12N9/647 , C12N9/6437 , C12P21/005 , C12Y304/21021
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
摘要翻译：本发明包括用于重组肽分子的方法和组合物，包括向肽添加或缺失一个或多个糖基，和/或向肽中加入修饰基团。

95. 发明申请

US20110171093A1 ACIDIC GAS REMOVAL BY AQUEOUS AMINE SOLVENTS 有权
标题翻译：酸性溶液除去酸性气体
公开(公告)号：US20110171093A1
公开(公告)日：2011-07-14
申请号：US13004606
申请日：2011-01-11
申请人： Gary Rochelle , Stephanie Freeman , Xi Chen , Thu Nguyen , Alexander Voice , Humera Rafique
发明人： Gary Rochelle , Stephanie Freeman , Xi Chen , Thu Nguyen , Alexander Voice , Humera Rafique
IPC分类号： B01D53/62 , B01F1/00
CPC分类号： B01D53/1456 , B01D53/1493 , B01D2251/80 , B01D2257/304 , B01D2257/306 , B01D2257/308 , B01D2257/504
摘要： Compositions and methods related to the removal of acidic gas. In one embodiment, compositions and methods are provided for the removal of acidic gas from a gas mixture using an aqueous amine solvent comprising water, a first amine, and a second amine, wherein the first amine contributes at least 50% by weight of the solvent's total amine concentration.
摘要翻译：与去除酸性气体相关的组成和方法。在一个实施方案中，提供组合物和方法用于使用包含水，第一胺和第二胺的含水胺溶剂从气体混合物中除去酸性气体，其中第一胺占溶剂的至少50重量％总胺浓度。

96. 发明申请

US20110117565A1 SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER 有权
标题翻译：血清或血浆MICRORNA作为非小细胞肺癌的生物标志物
公开(公告)号：US20110117565A1
公开(公告)日：2011-05-19
申请号：US12996967
申请日：2009-12-14
申请人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
发明人： Chenyu Zhang , Ke Zeng , Junfeng Zhang , Yi Ba , Xi Chen , Haijin Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides non-small cell lung cancer markers and the use thereof. The non-small cell lung cancer markers in the present invention include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides a probe combination, kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting microRNAs in the serum of lung cancer patients. By detecting the variations of microRNAs in the serum of lung cancer patients, the disease can be diagnosed in vitro; the progression course of the disease can be predicted; the occurrence of complications, the rate of relapse and the prognosis of the disease can be monitored; the drug efficacy and therapeutic effects can be analyzed. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases, all of which make it an effective means for diagnosing diseases at an early stage.
摘要翻译：本发明提供非小细胞肺癌标志物及其用途。本发明中的非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。本发明还提供了用于检测非小细胞肺癌标志物的探针组合，试剂盒和生物芯片。本发明还提供了一种检测肺癌患者血清中微小RNA的方法。通过检测肺癌患者血清中microRNAs的变化，可以在体外诊断该疾病; 可以预测疾病的进展过程; 可以监测并发症的发生，复发率和预后; 可以分析药物的疗效和治疗效果。本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。该方法可应用于疾病综合调查，解决了以前单个标记物所遇到的低特异性和敏感性问题，并大大增加了疾病的临床检出率，这些都成为早期诊断疾病的有效手段阶段。

97. 发明申请

US20110112855A1 SYSTEM AND METHOD FOR ASSISTING IN MAKING A TREATMENT PLAN 审中-公开
标题翻译：用于协助制定治疗计划的系统和方法
公开(公告)号：US20110112855A1
公开(公告)日：2011-05-12
申请号：US12991717
申请日：2009-05-08
申请人： Xi Chen , Xin Zhang , Declan Patrick Kelly , Anouk Charlotte O'Prinsen
发明人： Xi Chen , Xin Zhang , Declan Patrick Kelly , Anouk Charlotte O'Prinsen
IPC分类号： G06Q50/00 , G06Q90/00 , G06Q10/00
CPC分类号： G06F19/3481 , A61B5/11 , A63B24/0062 , A63B24/0075 , A63B24/0087 , A63B71/0622 , A63B2024/0065 , A63B2024/0093 , G06Q50/22 , G06Q99/00 , G16H10/20 , G16H50/20 , G16H50/70
摘要： The present invention provides a method and device for assisting in making a patient treatment plan. The method comprises: a step of acquiring first data reflecting the self-training condition of a patient in the recent past stage, and a medical record of the patient; a step of analyzing said first data based on said medical record and a first professional knowledge; and a step of generating a training guide based on the result of said step of analyzing and a second professional knowledge, said training guide serving to guide said patient in performing the next stage of training.
摘要翻译：本发明提供一种辅助制定患者治疗计划的方法和装置。该方法包括：获取反映最近过去阶段患者的自我训练状况的第一数据和病人的医疗记录的步骤; 基于所述医疗记录和第一专业知识来分析所述第一数据的步骤; 以及基于所述分析步骤的结果和第二专业知识产生训练指南的步骤，所述训练指南用于引导所述患者执行下一阶段的训练。

98. 发明申请

US20110080913A1 APPARATUS AND METHOD FOR LAYER-2 TO 7 SEARCH ENGINE FOR HIGH SPEED NETWORK APPLICATION 有权
标题翻译：用于高速网络应用的第2至第7搜索引擎的装置和方法
公开(公告)号：US20110080913A1
公开(公告)日：2011-04-07
申请号：US12966940
申请日：2010-12-13
申请人： Yung-Chung Liu , Xi Chen , Yu-Chih Tsao , Chien-Hsiung Chang , Chien-Chih Chen , Xiaochong Cao , Chih-Hsien Hsu
发明人： Yung-Chung Liu , Xi Chen , Yu-Chih Tsao , Chien-Hsiung Chang , Chien-Chih Chen , Xiaochong Cao , Chih-Hsien Hsu
IPC分类号： H04L12/56
CPC分类号： H04L12/4641
摘要： High-speed networking application equipments with a layer-2 to layer-7 hardware search engine and method are with flexibility and performance improvement. The multi-layer switches/routers, network address translation (NAT) gateway, firewall/VPN router and network attached storage (NAS) may use the search engine for fast and efficient search requirement.
摘要翻译：具有二层到七层硬件搜索引擎和方法的高速网络应用设备具有灵活性和性能提升。多层交换机/路由器，网络地址转换（NAT）网关，防火墙/ VPN路由器和网络连接存储（NAS）可以使用搜索引擎进行快速有效的搜索需求。

99. 发明申请

US20110064746A1 TREATMENT OF DRUG-RELATED SIDE EFFECT AND TISSUE DAMAGE BY TARGETING THE CD24-HMGB1-SIGLEC10 AXIS 有权
标题翻译：通过靶向CD24-HMGB1-SIGLEC10轴治疗药物相关的副作用和组织损伤
公开(公告)号：US20110064746A1
公开(公告)日：2011-03-17
申请号：US12716842
申请日：2010-03-03
申请人： Yang Liu , Pan Zheng , Guo-Yun Chen , Xi Chen , Steve Kunkel , Xincheng Zheng
发明人： Yang Liu , Pan Zheng , Guo-Yun Chen , Xi Chen , Steve Kunkel , Xincheng Zheng
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K16/18 , A61K31/351 , A61K38/177 , A61K45/06 , A61K2039/505 , C07K14/70596 , C07K16/2803 , C07K16/2896 , C07K2319/30 , A61K2300/00
摘要： The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.
摘要翻译：本技术提供了通过施用包含一种或多种CD24的组合物来治疗组织损伤相关免疫失调调节的方法和组合物; CD24片段，变体和衍生物，CD24Fc融合蛋白; HMBG1结合蛋白，HMBG1盒B结合蛋白; HMGB1的多肽，单克隆，重组，嵌合，人源化scFv抗体和HMGB1抗体片段或HMGB1片段的抗体以及结合并抑制HMGB1盒B活性的抗体的拮抗剂; Siglec 10激动剂如抗Siglec 10抗体; 及其组合。

100. 发明授权

US07898746B2 Extended depth-of-field lenses and methods for their design, optimization and manufacturing 有权
标题翻译：扩展的景深透镜及其设计，优化和制造的方法
公开(公告)号：US07898746B2
公开(公告)日：2011-03-01
申请号：US12167741
申请日：2008-07-03
申请人： Nicholas George , Xi Chen
发明人： Nicholas George , Xi Chen
IPC分类号： G02B13/18 , G02B3/02 , G02B3/10
CPC分类号： G02B27/0012 , G02B9/34 , G02B13/18 , G02B27/0075
摘要： For rotationally symmetric aspheric lenses, one can establish lens design and layout based upon the phase delay function exp[−iφ(ρ)]. An embodiment of the invention is a method for calculating a corresponding variation in focal length denoted by f(ρ). According to an aspect, one can also assert a shape for the focal length f(ρ) and thereafter calculate a phase delay function in order to synthesize a novel lens. New EDoF lens designs are obtained by selection of an inner and outer focal length connected by a simple curve that can be approximate by a polynomial. From the selected f(ρ), one can synthesize a finished EDoF lens design and fabricate the lens. Another aspect of this invention is directed to a method to tailor prior-art EDoF lenses so that their performance over some range is improved.
摘要翻译：对于旋转对称非球面透镜，可以基于相位延迟函数exp [-i＆phgr（（＆rgr））]建立透镜设计和布局。本发明的实施例是用于计算由f（＆rgr;）表示的焦距的相应变化的方法。根据一个方面，还可以为焦距f（＆rgr）设置形状，然后计算相位延迟函数，以便合成新颖的透镜。通过选择通过可以通过多项式近似的简单曲线连接的内焦距和外焦距来获得新的EDoF透镜设计。从选择的f（＆rgr;），可以合成完成的EDoF镜头设计并制作镜头。本发明的另一方面涉及一种定制现有技术的EDoF透镜的方法，使得它们在一些范围上的性能得到改善。

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