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    • 95. 发明授权
    • Pyrazolopyrimidines
    • 吡唑并嘧啶
    • US07405220B2
    • 2008-07-29
    • US11136023
    • 2005-05-24
    • Qingjie DingNan JiangJohn Lawson Roberts
    • Qingjie DingNan JiangJohn Lawson Roberts
    • C07D239/70A61K31/4162
    • C07D487/04
    • Novel pyrazolopyrimidines of formula (I): are discussed. These pyrazolopyrimidines are capable of inhibiting the activity of cyclin-dependent kinases, most particularly cyclin-dependent kinase 1 (Cdk1), cyclin-dependent kinase 2 (Cdk2), and cyclin-dependent kinase 4 (Cdk4) and are thus useful, inter alia, in the treatment or control of cancer, in particular solid tumors. This invention also provides pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors.
    • 讨论式(I)的新型吡唑并嘧啶:。 这些吡唑并嘧啶能够抑制细胞周期蛋白依赖性激酶的活性,特别是细胞周期蛋白依赖性激酶1(Cdk1),细胞周期蛋白依赖性激酶2(Cdk2)和细胞周期蛋白依赖性激酶4(Cdk4)的活性,因此尤其有用 ,治疗或控制癌症,特别是实体瘤。 本发明还提供含有这些化合物的药物组合物以及治疗或控制癌症的方法,特别是治疗或控制乳腺癌,肺癌,结肠癌和前列腺肿瘤的方法。
    • 97. 发明申请
    • Reel apparatus
    • 卷盘装置
    • US20070045073A1
    • 2007-03-01
    • US11508875
    • 2006-08-24
    • Chengxin CaoNan JiangWeifeng Yu
    • Chengxin CaoNan JiangWeifeng Yu
    • H02G11/02
    • H02G11/02B65H75/4486
    • A reel apparatus for a moveable system comprises a base disposed on the moveable system; a rotatable drum rotatably supported on the base onto which a cable can be spooled; a speed reducer for rotating the drum; a motor drive the speed reducer; a first transmission device coupled between the motor and the speed reducer; a coupling coupled between the speed reducer and the motor, when a load of the drum exceeds a predetermined torque, the coupling slips so as to limit a drive torque transmitted from the motor to the speed reducer to stop the drum; and an electrical connector connected at one end to a power cord of the moveable system and slidably contacted with the other end thereof with one end of the cable. With the present invention, a commercial power supply can be connected to the moveable system directly, thus reducing components of the conventional power supplying apparatus. At the same time, the cable sheath is prevented from being damaging and potential safety hazards are eliminated.
    • 一种用于可移动系统的卷轴装置,包括设置在可移动系统上的基座; 可旋转的滚筒,可旋转地支撑在基座上,电缆可绕其上; 用于旋转滚筒的减速器; 电机驱动减速机; 耦合在电动机和减速器之间的第一传动装置; 耦合在所述减速器和所述电动机之间的联接器,当所述滚筒的负载超过预定扭矩时,所述联接器滑动以限制从所述马达传递到所述减速器的驱动转矩以停止所述滚筒; 以及电连接器,其一端连接到可移动系统的电源线,并与电缆的一端与其另一端滑动接触。 通过本发明,可以将商用电源直接连接到可移动系统,从而减少常规供电装置的部件。 同时,防止电缆护套受损,并消除潜在的安全隐患。