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91. 发明授权

US5653992A Liquid absorbable copolymers for parenteral applications 失效
公开(公告)号：US5653992A
公开(公告)日：1997-08-05
申请号：US429375
申请日：1995-04-26
申请人： Rao S. Bezwada , Stephen C. Arnold , Shalaby W. Shalaby , Bernard L. Williams
发明人： Rao S. Bezwada , Stephen C. Arnold , Shalaby W. Shalaby , Bernard L. Williams
IPC分类号： A61K9/08 , A61K9/00 , A61K45/00 , A61K47/34 , C08G63/08 , C08K5/151 , C08L67/00 , C08L67/04 , A61F2/00 , A61K9/14 , A61K31/785
CPC分类号： A61K9/0024 , A61K47/34
摘要： A sustained release parenteral composition comprising an admixture of at least one drug to be delivered in a therapeutically effective amount and a bioabsorbable lactone polymer containing one or more lactone monomers that is a liquid at body temperature, provided in an amount effective to sustain or extend the release rate of the drug and a method for administering said composition to an animal.

92. 发明授权

US5631015A Liquid absorbable copolymers for parenteral applications 失效
标题翻译：用于肠胃外应用的液体可吸收共聚物
公开(公告)号：US5631015A
公开(公告)日：1997-05-20
申请号：US650562
申请日：1996-05-20
申请人： Rao S. Bezwada , Stephen C. Arnold , Shalaby W. Shalaby , Bernard L. Williams
发明人： Rao S. Bezwada , Stephen C. Arnold , Shalaby W. Shalaby , Bernard L. Williams
IPC分类号： A61K9/08 , A61K9/00 , A61K45/00 , A61K47/34 , C08G63/08 , C08K5/151 , C08L67/00 , C08L67/04 , A61F13/00
CPC分类号： A61K9/0024 , A61K47/34
摘要： A sustained release parenteral composition comprising an admixture of at least one drug to be delivered in a therapeutically effective amount and a bioabsorbable lactone polymer containing one or more lactone monomers that is a liquid at body temperature, provided in an amount effective to sustain or extend the release rate of the drug and a method for administering said composition to an animal.
摘要翻译：一种持续释放的肠胃外组合物，其包含至少一种以治疗有效量递送的药物和含有一种或多种在体温下为液体的内酯单体的生物可吸收内酯聚合物的混合物，所述内酯单体以有效维持或延长药物的释放速率以及向动物施用所述组合物的方法。

93. 发明授权

US5491198A Process for phosphonylating the surface of an organic polymeric preform 失效
标题翻译：使有机聚合物预成型体的表面膦酰化的方法
公开(公告)号：US5491198A
公开(公告)日：1996-02-13
申请号：US188478
申请日：1994-01-28
申请人： Shalaby W. Shalaby , M. Scott McCaig
发明人： Shalaby W. Shalaby , M. Scott McCaig
IPC分类号： C08F8/40 , C08J7/12
CPC分类号： C08F8/40 , C08J7/12
摘要： A process for phosphonylating the surface of an organic polymeric preform and the surface-phosphonylated preforms produced thereby are provided. Organic polymeric preforms made from various polymers including polyethylene, polyetheretherketone, polypropylene, polymethylmethacrylate, polyamides, and polyester, and formed into blocks, films, and fibers may have their surfaces phosphonylated in a liquid-phase or gas phase reaction. Liquid phase phosphonylation involves the use of a solvent that does not dissolve the organic polymeric preform but does dissolve a phosphorus halide such as phosphorus trichloride. The solvent chosen must also be nonreactive with the phosphorus halide. Such solvents available for use in the present process include the fully-halogenated liquid solvents such as carbon tetrachloride, carbon tetrabromide, and the like. Gas phase phosphonylation involves treating the organic polymeric preform with a gaseous phosphorus halide such as phosphorus trichloride and oxygen. The inventive processes allow for surface phosphonylation of the organic polymeric preform such that up to about 30 percent of the reactive carbon sites in the polymer are phosphonylated. The inventive phosphonylated organic polymers are particularly useful as orthopedic implants because hydroxyapatite-like surfaces which can be subsequently created on the organic implants allow for co-crystallization of hydroxyapatite to form chemically-bound layers between prosthesis and bone tissue.
摘要翻译：提供了一种使有机聚合物预成型体的表面膦酰化和由此制备的表面膦酰化的预成型体的方法。由包括聚乙烯，聚醚醚酮，聚丙烯，聚甲基丙烯酸甲酯，聚酰胺和聚酯在内的各种聚合物制成的有机聚合物预成型体可以在液相或气相反应中形成嵌段，膜和纤维。液相膦酰化涉及使用不溶解有机聚合物预成型体但是溶解卤化磷如三氯化磷的溶剂。所选择的溶剂也必须与卤化磷无反应。可用于本方法的这些溶剂包括全卤代液体溶剂如四氯化碳，四溴化碳等。气相膦酰化包括用气态卤化磷如三氯化磷和氧气处理有机聚合物预型体。本发明的方法允许有机聚合物预型体的表面膦酰化，使得高达约30％的聚合物中的反应性碳位点被膦酰化。本发明的膦酰化有机聚合物特别可用作矫形植入物，因为随后可以在有机植入物上产生的羟基磷灰石样表面允许羟基磷灰石的共结晶以在假体和骨组织之间形成化学结合的层。

94. 发明授权

US5470340A Copolymers of (p-dioxanone/glycolide and/or lactide) and p-dioxanone 失效
标题翻译：（对二恶烷酮/乙交酯和/或丙交酯）和对二恶烷酮的共聚物
公开(公告)号：US5470340A
公开(公告)日：1995-11-28
申请号：US132595
申请日：1993-10-06
申请人： Rao S. Bezwada , Shalaby W. Shalaby , Donald F. Koelmel
发明人： Rao S. Bezwada , Shalaby W. Shalaby , Donald F. Koelmel
IPC分类号： A61B17/04 , A61B17/12 , A61L17/00 , A61L17/10 , A61L31/00 , A61L31/06 , C08G63/06 , C08G63/08 , C08G63/664 , C08G63/78 , D02G3/44
CPC分类号： C08G63/664 , A61L17/10 , A61L31/06 , C08G63/08
摘要： A copolymer of p-dioxanone and a prepolymer of p-dioxanone and lactide and/or glycolide, and absorbable surgical devices such as sutures, surgical meshes, surgical staples, hemostatic clips, suture knot clips, and the like made therefrom.
摘要翻译：对二恶烷酮和对二氧杂环己酮和丙交酯和/或乙交酯的预聚物的共聚物，以及由其制成的可吸收的手术装置如缝合线，手术网，外科缝合钉，止血夹，缝合结夹等。

95. 发明授权

US5427778A Gel formulations containing growth factors and acrylamide polymer 失效
标题翻译：含有生长因子和丙烯酰胺聚合物的凝胶制剂
公开(公告)号：US5427778A
公开(公告)日：1995-06-27
申请号：US974013
申请日：1992-11-10
申请人： Amy L. Finkenaur , Jonathan M. Cohen , Shalaby W. Shalaby , Elisabeth A. Sandoval , Rao S. Bezwada , Richard L. Kronenthal
发明人： Amy L. Finkenaur , Jonathan M. Cohen , Shalaby W. Shalaby , Elisabeth A. Sandoval , Rao S. Bezwada , Richard L. Kronenthal
IPC分类号： A61K9/08 , A61K9/00 , A61K38/18 , A61K38/22 , A61K38/27 , A61K47/10 , A61K47/30 , A61K47/32 , A61K47/36 , A61K47/38 , A61L26/00 , A61P17/00 , A61P43/00 , A61K38/00 , A61K38/43
CPC分类号： A61L26/0066 , A61K38/1808 , A61K47/10 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/0014 , A61L26/008 , A61K9/0048 , A61L2300/414 , A61L2300/602
摘要： Gel formulations containing polypeptide growth factors having human mitogenic or angiogenic activity are provided. The gel formulations are useful for topical or incisional wound healing for cutaneous wounds, in the anterior chamber of the eye and other ophthalmic wound healing. The gel formulations also comprise a water soluble, pharmaceutically or ophthalmically compatible polymeric material for providing viscosity within various ranges determined by the application of the gel. The gel formulations provide controlled release and increased contact time of the growth factor to the wound site.
摘要翻译：提供含有具有人促有丝分裂或血管生成活性的多肽生长因子的凝胶制剂。凝胶制剂可用于皮肤创伤局部或切口伤口愈合，眼睛前房和其他眼科伤口愈合。凝胶制剂还包含水溶性，药学上或眼睛相容的聚合物材料，用于通过施用凝胶确定的各种范围内提供粘度。凝胶制剂提供控制释放和增加生长因子对伤口部位的接触时间。

96. 发明授权

US5100433A Suture coated with a copolymer coating composition 失效
标题翻译：涂料用共聚物涂料组合物
公开(公告)号：US5100433A
公开(公告)日：1992-03-31
申请号：US613323
申请日：1990-11-08
申请人： Rao S. Bezwada , Alastair W. Hunter , Shalaby W. Shalaby
发明人： Rao S. Bezwada , Alastair W. Hunter , Shalaby W. Shalaby
IPC分类号： A61L17/00 , A61L17/14 , A61L31/00
CPC分类号： A61L17/145
摘要： A surgical suture having a coating thereon of a copolymer of a predominant amount of p-dioxanone and the balance .epsilon.-caprolactone, and a method for improving the knot tiedown performance of a suture by first coating a solution of the coating copolymer onto the surface of the suture and then removing the solvent from the coated suture.

97. 发明授权

US5019094A Crystalline copolymers of p-dioxanone and poly(alkylene oxides) 失效
标题翻译：对二恶烷酮和聚（环氧烷）的结晶共聚物
公开(公告)号：US5019094A
公开(公告)日：1991-05-28
申请号：US521212
申请日：1990-05-09
申请人： Rao S. Bezwada , Shalaby W. Shalaby
发明人： Rao S. Bezwada , Shalaby W. Shalaby
IPC分类号： A61L17/10 , A61L31/06 , C08G63/08 , C08G63/664
CPC分类号： C08G63/664 , A61L17/105 , A61L31/06 , C08G63/08
摘要： A crystalline copolymer of p-dioxanone and a poly(alkylene oxide), and absorbable surgical filaments and devices derived therefrom.
摘要翻译：对二恶烷酮和聚（环氧烷）的结晶共聚物，以及可吸收的外科细丝和由其衍生的装置。

98. 发明授权

US4649921A Poly(p-dioxanone) polymers having improved radiation resistance 失效
标题翻译：具有改善的耐辐射性的聚（对 - 二恶烷酮）聚合物
公开(公告)号：US4649921A
公开(公告)日：1987-03-17
申请号：US744833
申请日：1985-06-14
申请人： Donald F. Koelmel , Dennis D. Jamiolkowski , Shalaby W. Shalaby , Rao S. Bezwada
发明人： Donald F. Koelmel , Dennis D. Jamiolkowski , Shalaby W. Shalaby , Rao S. Bezwada
IPC分类号： A61L17/10 , A61L27/18 , C08G63/672 , A61L17/00
CPC分类号： C08G63/672 , A61L17/105 , A61L27/18
摘要： A sterile surgical suture comprising an absorbable, radiation sterilizable, normally solid polymer comprising a copolyester that comprises repeating divalent units of the formulas:(A) --O--CO--CH.sub.2 --O--CH.sub.2 CH.sub.2 --, and(B) --G--, and(C) --O--CO--CHR--O--.sub.m Ph--O--CHR--CO--O--wherein G represents the residue after removal of the hydroxyl groups of a dihydric alcohol, wherein Ph represents 1,2-, 1,3-, or 1,4-phenylene or alkyl- or alkoxy-substituted phenylene, wherein m represents a number having a value of 0 or 1, wherein R represents hydrogen or lower alkyl, and wherein the divalent units (A), (B), and (C) are bonded to each other through ester groups contained in said units.
摘要翻译：一种无菌外科缝合线，其包含可吸收的，可辐射灭菌的通常为固体的聚合物，其包含共聚酯，所述共聚酯包含重复下式的二价单元：（A）-O-CO-CH 2 -O-CH 2 CH 2 - 和（B）-G-，和（C）-O-CO-CHR-O-mPh-O-CHR-CO-O-其中G表示除去二元醇的羟基后的残基，其中Ph表示1,2-，或1,4-亚苯基或烷基或烷氧基取代的亚苯基，其中m表示数值为0或1的数，其中R表示氢或低级烷基，其中二价单元（A），（B），和（C）通过所述单元中所含的酯基彼此键合。

99. 发明授权

US4605730A Surgical articles of copolymers of glycolide and .epsilon.-caprolactone and methods of producing the same 失效
标题翻译：乙交酯和ε-己内酯共聚物的手术制品及其制备方法
公开(公告)号：US4605730A
公开(公告)日：1986-08-12
申请号：US743117
申请日：1985-06-10
申请人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
发明人： Shalaby W. Shalaby , Dennis D. Jamiolkowski
IPC分类号： A61F2/00 , A61L17/12 , C08G63/08 , C08G63/10
CPC分类号： C08G63/08 , A61L17/12
摘要： Novel copolymers of .epsilon.-caprolactone and glycolide useful in making surgical articles and particularly surgical sutures having Young's modulus of less than 250,000 psi. New and improved polymerization methods for producing the novel .epsilon.-caprolactone and glycolide copolymers.
摘要翻译： ε-己内酯和乙交酯的新型共聚物可用于制造外科用品，特别是具有小于250,000psi的杨氏模量的手术缝合线。用于生产新型ε-己内酯和乙交酯共聚物的新型改进的聚合方法。

100. 发明授权

US4559945A Absorbable crystalline alkylene malonate copolyesters and surgical devices therefrom 失效
标题翻译：可吸收的结晶亚烷基丙二酸酯共聚酯及其手术装置
公开(公告)号：US4559945A
公开(公告)日：1985-12-24
申请号：US652706
申请日：1984-09-21
申请人： Donald Koelmel , Shalaby W. Shalaby
发明人： Donald Koelmel , Shalaby W. Shalaby
IPC分类号： A61F2/00 , A61K9/20 , A61L17/10 , A61L17/12 , A61L27/18 , A61L31/06 , C08G63/66 , A61L17/00
CPC分类号： C08G63/66 , A61K9/204 , A61L17/105 , A61L17/12 , A61L27/18 , A61L31/06
摘要： Surgical devices such as filaments are made from a crystalline copolyester of glycolide, lactide, p-dioxanone, or mixture thereof, and poly(alkylene malonate).
摘要翻译：手术装置如长丝由乙交酯，丙交酯，对二恶烷酮或其混合物的结晶共聚酯和聚（丙烯酸亚烷基酯）制成。

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