专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明申请

WO1992012201A1 MIXTURES OF HALS COMPOUNDS 审中-公开
标题翻译： HALS化合物的混合物
公开(公告)号：WO1992012201A1
公开(公告)日：1992-07-23
申请号：PCT/EP1992000023
申请日：1992-01-07
申请人： SANDOZ-PATENT-GMBH , SANDOZ LTD. , BECHTOLD, Karl , LIGNER, Gilbert , WOLF, Rainer
发明人： SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C08K05/3435
CPC分类号： C08K5/3435 , C09D7/48
摘要： A composition, suitable for stabilising a polymeric composition against the effects of light, comprising: a) an N-acylated 2,2,6,6-tetraalkylpiperidinyl group (hereinafter N-acylated HALS) containing compound; and b) an N-oxy-subst. 2,2,6,6-tetraalkylpiperidinyl group (hereinafter N-oxy-subst. HALS) containing compound. A further aspect of the invention relates to a composition, suitable for stabilising a polymeric composition against the effects of light comprising: a) an N-acylated 2,2,6,6-tetraalkylpiperidinyl-group-containing compound in which a spiro group is attached in the 4-position (hereinafter defined as component i); and b) an N-acylated 2,2,6,6-tetraalkylpiperidinyl-group-containing compound in which in the 4-position no spiro group is present (hereinafter defined as component ii). The compounds are suitable as light stabilizers in acid catalyzed lacquer system.
摘要翻译：一种适于稳定聚合物组合物以抵抗光的影响的组合物，其包含：a）N-酰化的2,2,6,6-四烷基哌啶基（以下称为N-酰化HALS）的化合物; 和b）N-氧基。 2,2,6,6-四烷基哌啶基（以下称为N-氧基，HALS）。本发明的另一方面涉及一种组合物，其适用于抵抗光的影响来稳定聚合组合物，其包含：a）N-酰化的2,2,6,6-四烷基哌啶基化合物，其中螺环是 4位（以下定义为组分i）; 和b）其中存在4-位没有螺环的N-酰化的2,2,6,6-四烷基哌啶基化合物（以下称为组分ii）。该化合物适用于酸催化漆体系中的光稳定剂。

92. 发明申请

WO1992003165A1 NEW USE OF A MONOCLONAL ANTIBODY 审中-公开
标题翻译：单克隆抗体的新用途
公开(公告)号：WO1992003165A1
公开(公告)日：1992-03-05
申请号：PCT/EP1991001510
申请日：1991-08-08
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , LOIBNER, Hans
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： A61K39/42
CPC分类号： C07K16/34 , A61K38/00 , C07K16/1045
摘要： Monoclonal antibody BR55-2 and fragments thereof having the specificity of monoclonal antibody BR55-2, and variants thereof, are useful in the treatment of HIV infections.

93. 发明申请

WO1992001447A1 2-CYCLOPROPYLACETIC ACID DERIVATIVES 审中-公开
标题翻译： 2-环丙基酸衍生物
公开(公告)号：WO1992001447A1
公开(公告)日：1992-02-06
申请号：PCT/EP1991001331
申请日：1991-07-16
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , REVESZ, Laszlo
IPC分类号： A61K31/085
CPC分类号： C07C233/10 , C07C33/05 , C07C57/26 , C07C59/72 , C07C2601/02
摘要： This invention concerns the compounds of formula (I) wherein R1 and R2 have various significances, in free form or salt form as appropriate. They possess antidiabetic and hypoglycemic activity and are therefore indicated for use in the treatment of diabetes and for lowering blood cholesterol and triglyceride level. They can be prepared by appropriate alcohol oxidation optionally follwed by ester or amide formation, or by deprotection.
摘要翻译：本发明涉及式（I）的化合物，其中R 1和R 2具有适当的游离形式或盐形式的各种含义。它们具有抗糖尿病和降血糖活性，因此被用于治疗糖尿病和降低血液胆固醇和甘油三酯水平。它们可以通过适当的醇氧化制备，任选地通过酯或酰胺形成或通过脱保护来制备。

94. 发明申请

WO1997012040A1 GENE THERAPY WITH MODIFIED p65 PROTEINS 审中-公开
标题翻译：用改良的p65蛋白进行基因治疗
公开(公告)号：WO1997012040A1
公开(公告)日：1997-04-03
申请号：PCT/EP1996004216
申请日：1996-09-26
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , ANRATHER, Josef , BACH, Fritz, B. , WINKLER, Hans
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0368 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： A method to render mammalian, particularly endothelial cells less susceptible to platelet- and leukocyte-mediated injury and inflammation is described, comprising genetically modifying the cells by inserting DNA encoding a transdominant inhibitor of a Re1A (p65) protein, and expression functional inhibitor in the modified cells under cellular activating conditions, whereby Re1A (i.e. NF kappa B) transactivation of genes is suppressed, and corresponding proteins and DNA therefor. The method, which can be carried out in vivo, ex vivo or in vitro, has use in allogeneic or xenogeneic transplantation as well as to treat systemic or local inflammatory conditions.
摘要翻译：描述了使哺乳动物，特别是对血小板和白细胞介导的损伤和炎症不敏感的内皮细胞的方法，包括通过将编码Re1A（p65）蛋白的跨主导抑制剂的DNA和表达功能抑制剂插入到基因修饰细胞中细胞激活条件下的修饰细胞，从而抑制基因的Re1A（即NFκB）反式激活，以及相应的蛋白质和DNA。该方法可以在体内，离体或体外进行，可用于同种异体移植或异种移植，也可用于治疗全身或局部炎性病症。

95. 发明申请

WO1996040910A1 HUMAN GROWTH FACTORS, NUCLEOTIDE SEQUENCE ENCODING GROWTH FACTORS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：人类生长因子，核苷酸序列编码生长因子及其使用方法
公开(公告)号：WO1996040910A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002455
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , VAN DEN BERG, David, John
IPC分类号： C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： This invention provides novel human growth factor polypeptides, nucleotides encoding the growth factor polypeptides, and uses for the growth factor polypeptides and polynucleotides.
摘要翻译：本发明提供了新的人生长因子多肽，编码生长因子多肽的核苷酸，以及生长因子多肽和多核苷酸的用途。

96. 发明申请

WO1996037233A1 POLYMYXIN CONJUGATES 审中-公开
标题翻译：聚甲基丙烯酸
公开(公告)号：WO1996037233A1
公开(公告)日：1996-11-28
申请号：PCT/EP1996002256
申请日：1996-05-24
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , KAPA, Prasad, Koteswara , KARDASH, Gleb , KUCEROVY, Andrew , LAKE, Philip , MATTNER, Paul, Gerard , PETTER, Russell, C. , PRASHAD, Mahavir , SHARMA, Sushill
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： Water-soluble polymyxin B/dextran conjugates (or salts thereof) having anti-endotoxin activity greater than unconjugated polymyxin B. They can be prepared by reacting polymyxin B or a salt thereof with dextran in an aqueous medium at a pH of from about 9.3 to about 10 and a temperature of from about 30 DEG to about 35 DEG C.
摘要翻译：具有大于未缀合的多粘菌素B的抗内毒素活性的水溶性多粘菌素B /葡聚糖缀合物（或其盐）。它们可以通过使多粘菌素B或其盐与葡聚糖在水性介质中反应制备，pH为约9.3〜约10℃，温度为约30℃至约35℃。

97. 发明申请

WO1996005150A1 CEMENT ACCELERATING ADMIXTURE 审中-公开
标题翻译：水泥加速粘合剂
公开(公告)号：WO1996005150A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003132
申请日：1995-08-07
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , LEIKAUF, Bernhard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C04B28/02
CPC分类号： C04B28/02 , C04B2103/10 , C04B2111/00146 , C04B14/303 , C04B22/082 , C04B22/124 , C04B24/2641 , C04B40/0039 , C04B22/148 , C04B24/122
摘要： An accelerating admixture for use with sprayable cementitious compositions such as shotcrete comprises a mixture of (a) amorphous aluminium hydroxide and/or aluminium hydroxysulphate, and (b) at least one amine, preferably an alkanolamine. In a preferred embodiment, the admixture also comprises an aqueous dispersion of at least one polymer which comprises pendant carboxylic moieties.
摘要翻译：与喷雾混凝土可喷涂水泥质组合物一起使用的加速混合物包括（a）无定形氢氧化铝和/或羟基硫酸铝的混合物，和（b）至少一种胺，优选链烷醇胺。在优选的实施方案中，混合物还包含至少一种包含羧酸部分的聚合物的水性分散体。

98. 发明申请

WO1996004785A1 LONG TERM XENOGENEIC MYELOID AND LYMPHOID CELL PRODUCTION IN CHIMERIC IMMUNOCOMPROMISED ANIMALS 审中-公开
标题翻译：长期免疫免疫动物中的长期XENOGENEIC MYELOID和LYMPHOID细胞生产
公开(公告)号：WO1996004785A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003198
申请日：1995-08-11
申请人： SANDOZ LTD. , SYSTEMIX INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
发明人： SANDOZ LTD. , SYSTEMIX INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , CHEN, Benjamin, P. , FRASER, Christopher, C.
IPC分类号： A01K67/027
CPC分类号： G01N33/56977 , A01K67/0271
摘要： Immunocompromised mammalian hosts are subcutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human fetal thymic fragment at the same site. Grafts contain cell populations expressing CD4 and CD8, CD19 or CD33, CD14 and CD15, all of which also express the HLA type of the fetal bone/spleen. T-cells derived from progenitors in the fetal bone/spleen contain both mature single positive CD4+CD8-, CD8+CD4- as well as a high percentage of immature double positive CD4+CD8+ populations.
摘要翻译：将免疫受损的哺乳动物宿主皮下植入人胎儿骨与脾的组合。当在同一位点提供同种异体的人胎儿胸腺胸腺片段时，嵌合动物可以在体内产生人B细胞，骨髓细胞和T细胞长达9个月。移植物包含表达CD4和CD8，CD19或CD33，CD14和CD15的细胞群体，所有这些细胞群体也表达胎儿骨/脾脏的HLA型。来自胎儿骨/脾脏祖细胞的T细胞既含有成熟的单一阳性CD4 + CD8-，CD8 + CD4-以及高比例的未成熟双阳性CD4 + CD8 +群体。

99. 发明申请

WO1995011306A1 ANTI-MICROBIAL PROTEINS 审中-公开
标题翻译：抗微生物蛋白
公开(公告)号：WO1995011306A1
公开(公告)日：1995-04-27
申请号：PCT/EP1994003449
申请日：1994-10-20
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , KRAGH, Karsten, Matthias , MIKKELSEN, Jorn, Dalgaard , NIELSEN, Klaus, Kristian
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/82
CPC分类号： C12N15/8282 , A01N65/08 , C07K14/415
摘要： An anti-microbial protein comprising a peptide having the amino acid sequence: AA1-AA2-AA3-Cys-AA5-AA6-AA7-AA8-AA9-Cys-AA11-AA12-AA13-AA14-Cys-Cys-AA17-AA18-AA19-AA20-AA21-Cys-AA23-AA24-AA25-AA26-AA27-AA28-Cys-AA30. An anti-microbial protein having the sequence depicted in any one of SEQ ID Nos. 1-3. Recombinant DNA encoding such proteins. A vector comprising such DNA which is expressible in plants and which is linked to a plant operable promoter and terminator. Plants transformed with such recombinant DNA; the progeny of such plants which contain the DNA stably incorporated and hereditable in a Mendelian manner, and/or the seeds of such plants or such progeny.
摘要翻译：包含具有氨基酸序列的肽的抗微生物蛋白质：AA1-AA2-AA3-Cys-AA5-AA6-AA7-AA8-AA9-Cys-AA11-AA12-AA13-AA14-Cys-Cys-AA17-AA18- AA19-AA20-AA21-CYS-AA23-AA24-AA25-AA26-AA27-AA28-CYS-AA30。具有SEQ ID No.3-1中任一项所示序列的抗微生物蛋白质。编码这种蛋白质的重组DNA。包含这样的DNA的载体，其在植物中可表达并与植物可操作的启动子和终止子连接。用这种重组DNA转化的植物; 这些植物的后代含有以孟德尔方式稳定掺入和遗传的DNA，和/或这种植物或其后代的种子。

100. 发明申请

WO1994025606A2 RECOMBINANT ALANINE RACEMASE AND GAPDH FROM TOLYPOCLADIUM 审中-公开
标题翻译：重组丙氨酸消旋酶和关机GAPDH弯颈Niveum
公开(公告)号：WO1994025606A2
公开(公告)日：1994-11-10
申请号：PCT/EP1994001272
申请日：1994-04-23
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD. , KOCHER, Hans, Peter , SCHNEIDER-SCHERZER, Elisabeth , SCHOERGENDORFER, Kurt , WEBER, Gerhard
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/61
CPC分类号： C12N9/0008 , C07K7/645 , C12N9/90 , C12Y102/01009
摘要： The invention concerns nucleotide suquences coding for enzymes which exhibit an alanine racemase activity, plus methods of preparing alanine racemase which use these sequences. The invention also concerns methods of preparing cyclosporin and cyclosporin derivatives. The invention further relates to DNA fragments with part or all of the gene for glycerinaldehyde-3-phosphate dehydrogenase (GAPDH) from Tolypocladium niveum, its promotor and termination region, and the use thereof. Another aspect of the invention relates to vectors, and cells transformed by these vectors.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式