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    • 91. 发明申请
    • Selection of genotyped transfusion donors by cross-matching to genotyped recipients
    • 通过与基因型受体的交叉匹配来选择基因分型的输血供体
    • US20070100557A1
    • 2007-05-03
    • US11298763
    • 2005-12-09
    • Yi ZhangMichael Seul
    • Yi ZhangMichael Seul
    • G06F19/00
    • G06F19/3456G06F19/3481G16B20/00G16B25/00G16B30/00G16B40/00G16H10/60G16H50/70
    • Disclosed are methods for establishing the compatibility between two bloodtypes on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of bloodtypes constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.
    • 公开的是基于接受者和潜在供体的次要血型基因型的交叉匹配(在指定的严格规定)的基础上建立两种血型之间的相容性的方法。 为了确定相容性,根据与一组潜在单倍型相关的表达状态,将血型基因型映射到相应的表型,并通过建立构成为构成表型的组合的血型的相容性来建立相容性。 比特串匹配,最好使用算法表达式。 如果存在将基因型映射到单倍型的歧义,则可以根据样本群体中单倍型的发生频率来减少,或者通过配子定相来解决。 在组成单元型表达的抗原中的错配具有更大的临床意义的情况下,这种模糊的减少或解决是特别理想的。
    • 94. 发明申请
    • Transfusion registry and exchange network
    • 输血注册和交换网络
    • US20060205001A1
    • 2006-09-14
    • US11412667
    • 2006-04-27
    • Yi ZhangMichael Seul
    • Yi ZhangMichael Seul
    • G06F19/00C12Q1/68
    • G06F19/327G06F19/00G06Q30/02G06Q30/0202G06Q50/22G06Q50/24G16H40/20
    • Disclosed is a registry for candidate transfusion donors, which invokes an inventory management policy to create and actively manage lists of candidate donors in order to minimize imbalances between demand and supply across multiple regions and across multiple categories of donors and recipients. Together with a genotyping laboratory, the registry does targeted recruitment of prospective donors who are typed for a set of genetic markers relating to clinically relevant antigens including mutations of Human Erythrocyte Antigens (HEA), genetic variants of Rh, and possibly additional antigens such as HLA and HPA. The registry monitors incoming demand for transfusion antigen genotypes, preferably stratify the demand into a set of categories representing stable subpopulations, and will apply strategies, disclosed herein, to tune the composition of candidate donor lists to match the demand, thereby avoiding excess, and unnecessary, typing of candidate donors.
    • 公布了候选人输血捐助者的登记册,该登记处援引了库存管理政策,以创建和主动管理候选人捐助者名单,以便最大限度地减少多个地区和多个捐助者和接受者之间的需求与供应之间的不平衡。 与基因分型实验室一起,注册管理机构确实针对招募潜在的捐赠者,这些捐赠者是针对一系列与临床相关抗原相关的遗传标记,包括人类红细胞抗原(HEA)的突变,Rh的遗传变体和可能的其他抗原如HLA 和HPA。 注册管理机监测输血抗原基因型的输入需求,最好将需求分为一组代表稳定亚群体的类别,并将应用本文所披露的策略来调整候选捐献者名单的组成以匹配需求,从而避免过多和不必要的 ,候选人捐款人的打字。
    • 100. 发明授权
    • Fault tolerant bus for clustered system
    • 集群系统的容错总线
    • US06397345B1
    • 2002-05-28
    • US09169361
    • 1998-10-09
    • Paul EdmondsYi ZhangChang XuPriyen DoshiStephen CoMichael P. TelAndy Chan
    • Paul EdmondsYi ZhangChang XuPriyen DoshiStephen CoMichael P. TelAndy Chan
    • H02H305
    • G06F11/2007G06F11/2005G06F11/2053G06F2201/85H04B1/74
    • A computer system includes a plurality of interdependent processors. Each interdependent processor executes an independent operating system image without sharing file system state information, and each interdependent processor further has a network access card with a first network connection and a second network connection. The computer system has a first active backplane coupled to each first network connection of each processor; a second active backplane coupled to each second network connection of each processor, the second active backplane operating in lieu of the first active backplane in case of a fail-over; and one or more peripherals connected to each of the first and second active backplanes and responsive to data requests transmitted over the first and second active backplanes.
    • 计算机系统包括多个相互依赖的处理器。 每个相互依赖的处理器在不共享文件系统状态信息的情况下执行独立的操作系统映像,并且每个相互依赖的处理器还具有具有第一网络连接和第二网络连接的网络访问卡。 计算机系统具有耦合到每个处理器的每个第一网络连接的第一有源底板; 耦合到每个处理器的每个第二网络连接的第二有源背板,在故障转移的情况下第二主动背板代替第一有源背板操作; 以及连接到第一和第二活动背板中的每一个的一个或多个外围设备,并响应于在第一和第二活动背板上传输的数据请求。