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91. 发明申请

WO2014005153A9 METHODS FOR TREATING MDS1-EVI1 MEDIATED CANCER 审中-公开
公开(公告)号：WO2014005153A9
公开(公告)日：2014-01-03
申请号：PCT/US2013/048971
申请日：2013-07-01
申请人： UNIVERSITY OF ROCHESTER , PERKINS, Archibald S. , ZHANG, Yi
发明人： PERKINS, Archibald S. , ZHANG, Yi
IPC分类号： A61K39/385
摘要： The present invention relates to a method of treating a cancerous condition mediated by the protein MDS1 -EVI1 (ME). The method includes administering to a patient an amount of an inhibitor of ME protein activity that is effective to cause cell death of cancer cells that are ME-dependent, thereby treating the cancerous condition. The present invention further relates to a method of causing cell death of a cancer cell that requires MDS1-EVI1 (ME) for survival. The method includes introducing an inhibitor of ME activity into a cancer cell that requires ME for survival, whereby said introducing is effective to cause cancer cell death. Novel agents that can inhibit the activity of ME in vitro or in vivo are also disclosed.

92. 发明申请

WO2013185286A1 RADIO LINK FAILURE INFORMATION 审中-公开
标题翻译：无线链路故障信息
公开(公告)号：WO2013185286A1
公开(公告)日：2013-12-19
申请号：PCT/CN2012/076766
申请日：2012-06-12
申请人： NOKIA SIEMENS NETWORKS OY , ZHANG, Yi , SEBIRE, Benoist Pierre
发明人： ZHANG, Yi , SEBIRE, Benoist Pierre
IPC分类号： H04W24/10
CPC分类号： H04W52/0261 , H04W24/10 , H04W52/0212 , H04W52/0264 , H04W72/0413 , H04W76/18 , H04W76/28 , Y02D70/24
摘要： A technique, comprising: including in a radio link failure report from a communication device information about the power saving state of the communication device.
摘要翻译：一种技术，包括：在来自通信设备的无线电链路故障报告中包括关于所述通信设备的省电状态的信息。

93. 发明申请

WO2013143097A1 CURABLE COMPOSITIONS 审中-公开
标题翻译：可固化组合物
公开(公告)号：WO2013143097A1
公开(公告)日：2013-10-03
申请号：PCT/CN2012/073232
申请日：2012-03-29
申请人： DOW GLOBAL TECHNOLOGIES LLC , JI, Minglei , LI, Yongjiang , ZHANG, Yi
发明人： JI, Minglei , LI, Yongjiang , ZHANG, Yi
IPC分类号： C08L63/00 , H01B3/40 , C08K5/09 , C08K3/22 , C08K3/34
CPC分类号： H01B3/40 , C08G59/42 , C08G59/68 , C08K3/22 , C08K3/34 , C08K5/1539 , C08L63/00 , C08L2203/20 , C08L2205/025 , C08L2205/03 , C08L63/04
摘要： A curable epoxy resin formulation useful for making an insulator for a high-voltage gas insulated switchgear, the curable formulation including (A) an epoxy resin composition comprising a mixture of: (Al) at least one solid epoxy resin, (A2) at least one novolac epoxy resin, and (A3) at least one cycloaliphatic epoxy resin; (B) at least one anhydride hardener; (C) at least one filler; and (D) optionally, at least one catalyst or at least one accelerator.
摘要翻译：一种可用于制造用于高压气体绝缘开关装置的绝缘体的可固化环氧树脂配方，该可固化配方包括（A）环氧树脂组合物，其包含以下混合物：（A1）至少一种固体环氧树脂，（A2）至少一种酚醛清漆环氧树脂，和（A3）至少一种脂环族环氧树脂; （B）至少一种酸酐固化剂; （C）至少一种填料; 和（D）任选的至少一种催化剂或至少一种促进剂。

94. 发明申请

WO2013028358A1 A METHOD OF MAKING A SPLIT GATE NON-VOLATILE FLOATING GATE MEMORY CELL HAVING A SEPARATE ERASE GATE, AND A MEMORY CELL MADE THEREBY 审中-公开
标题翻译：制造具有单独擦除闸门的分离栅门非挥发性闸门存储单元的方法及其存储单元
公开(公告)号：WO2013028358A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/050022
申请日：2012-08-08
申请人： SILICON STORAGE TECHNOLOGY, INC. , WANG, Chunming , QIAO, Baowei , ZHANG, Zufa , ZHANG, Yi , WANG, Shiuh, Luen , LU, Wen-Juei
发明人： WANG, Chunming , QIAO, Baowei , ZHANG, Zufa , ZHANG, Yi , WANG, Shiuh, Luen , LU, Wen-Juei
IPC分类号： H01L21/4763
CPC分类号： H01L29/788 , H01L21/28273 , H01L27/11521 , H01L29/42328 , H01L29/66825 , H01L29/66833
摘要： A non-volatile memory cell having a floating gate and a separate erase gate and more particularly wherein the floating gate has an enhanced edge to facilitate erase operation. The floating gate has a lower surface separated from the channel region by a second insulating layer, and an upper surface opposite the lower surface. The floating gate has a first side wall adjacent to but separated from the word line gate; and a second side wall opposite the first side wall. The second side wall and the upper surface form a sharp edge, with the second side wall greater in length than the first side wall. The upper surface slopes 20 upward from the first side wall to the second side wall. A coupling gate is positioned over the upper surface of the floating gate and is insulated therefrom by a third insulating layer.
摘要翻译：一种具有浮动栅极和单独的擦除栅极的非易失性存储单元，更具体地，其中浮置栅极具有增强的边沿以便于擦除操作。浮栅具有通过第二绝缘层与沟道区分离的下表面和与下表面相对的上表面。浮栅具有与字线门相邻但与字线门隔开的第一侧壁; 以及与第一侧壁相对的第二侧壁。第二侧壁和上表面形成锋利的边缘，第二侧壁的长度大于第一侧壁。上表面从第一侧壁向第二侧壁向上倾斜20°。耦合栅极位于浮动栅极的上表面上方，并通过第三绝缘层与其隔离。

95. 发明申请

WO2013010134A2 SYSTEMS, APPARATUS AND METHODS FOR BIOCHEMICAL ANALYSIS 审中-公开
标题翻译：系统，设备和生物化学分析方法
公开(公告)号：WO2013010134A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046776
申请日：2012-07-13
申请人： CELULA, INC. , AHN, Keunho , LAI, Benjamin , PYFER, Andree, J. , ZHANG, Yi , ZHANG, Haichuan
发明人： AHN, Keunho , LAI, Benjamin , PYFER, Andree, J. , ZHANG, Yi , ZHANG, Haichuan
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： C12Q1/6837 , B01J2219/00317 , B01J2219/00351 , B01J2219/0036 , B01J2219/00495 , B01J2219/00704 , B01J2219/00722 , B01L3/5027 , B01L3/508 , B01L3/50851 , B01L3/5088 , B01L7/52 , B01L2200/0673 , B01L2300/0816 , B01L2300/0822 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822
摘要： Systems, apparatus and methods are provided for biochemical analysis of a sample (e.g., a cell or nucleic acids). Samples are analyzed for molecular information and remain accessible for subsequent analysis or testing. The systems, apparatus and methods and systems provided are useful for performing quantitative and highly parallel biochemical reactions on biological samples in a high-throughput manner.
摘要翻译：提供了用于样品（例如细胞或核酸）的生物化学分析的系统，装置和方法。分析样品以获得分子信息，并保持可用于随后的分析或测试。提供的系统，装置和方法和系统可用于以高通量方式对生物样品进行定量和高度平行的生物化学反应。

96. 发明申请

WO2012095113A1 TERMINAL MEASUREMENT CONFIGURATION IN CARRIER AGGREGATION 审中-公开
标题翻译：运输工具集中终端测量配置
公开(公告)号：WO2012095113A1
公开(公告)日：2012-07-19
申请号：PCT/EP2011/000056
申请日：2011-01-10
申请人： NOKIA SIEMENS NETWORKS OY , BODOG, Gyula , TOMALA, Malgorzata , ZHANG, Yi
发明人： BODOG, Gyula , TOMALA, Malgorzata , ZHANG, Yi
IPC分类号： H04W24/10
CPC分类号： H04W24/00 , H04W24/02 , H04W24/08 , H04W24/10
摘要： There are provided measures for terminal measurement configuration in carrier aggregation, said measures exemplarily comprising a configuration of one or more carriers for automatic terminal measurements relating to network performance on said one or more carriers, said one or more carriers being carriers in a carrier aggregation for one or more terminals, wherein said configuration may be dependent on the one or more terminals' capabilities in terms of single- or multi-carrier terminal measurements. According to such configuration, automatic terminal measurements may be performed simultaneously on the configured one or more carriers or on the configured one or more carriers based on a predetermined priority of each carrier. Said measures may exemplarily be applied for in an MDT context.
摘要翻译：提供了载波聚合中的终端测量配置的措施，所述措施示例性地包括用于与所述一个或多个载波上的网络性能相关的自动终端测量的一个或多个载波的配置，所述一个或多个载波是载波聚合中的载波，一个或多个终端，其中所述配置可以取决于一个或多个终端在单载波或多载波终端测量方面的能力。根据这样的配置，可以基于每个载波的预定优先级，在配置的一个或多个载波上或配置的一个或多个载波上同时执行自动终端测量。所述措施可以示例性地应用于MDT上下文中。

97. 发明申请

WO2012083818A1 SHORT-RANGE WIRELESS RELAY METHOD AND SYSTEM 审中-公开
标题翻译：短距离无线中继方法与系统
公开(公告)号：WO2012083818A1
公开(公告)日：2012-06-28
申请号：PCT/CN2011/084094
申请日：2011-12-15
申请人： BEIJING GREEN STONE TECHNOLOGY LIMITED , GE, Ning , ZHANG, Yi , MENG, Zhiwei
发明人： GE, Ning , ZHANG, Yi , MENG, Zhiwei
IPC分类号： H04B7/14 , H04B5/00
CPC分类号： H04W88/04 , H04B7/15557 , H04W60/005 , H04W88/06
摘要： A wireless relay apparatus is provided. The wireless relay apparatus includes a telephone module configured to couple with a public switched telephone network (PSTN) to receive a telephone call, and a wireless module coupled to the telephone module to process the telephone call and configured to wirelessly connect to a mobile terminal such that the telephone call is forwarded to the mobile terminal over a short-range wireless link. Further, the wireless module is configured to operate in one of a transparent mode and a translation mode so as to exchange voice data with the mobile terminal.
摘要翻译：提供一种无线中继装置。所述无线中继装置包括被配置为与公共交换电话网络（PSTN）耦合以接收电话呼叫的电话模块，以及耦合到所述电话模块以处理所述电话呼叫并被配置为无线地连接到移动终端的无线模块，通过短距离无线链路将电话呼叫转发到移动终端。此外，无线模块被配置为以透明模式和转换模式之一操作，以便与移动终端交换语音数据。

98. 发明申请

WO2012079059A3 POST-TREATMENT BREAST CANCER PROGNOSIS 审中-公开
公开(公告)号：WO2012079059A3
公开(公告)日：2012-06-14
申请号：PCT/US2011/064290
申请日：2011-12-09
申请人： BIOTHERANOSTICS, INC. , GENERAL HOSPITAL CORPORATION , SGROI, Dennis , ERLANDER, Mark, G. , ZHANG, Yi , SCHNABEL, Catherine A
发明人： SGROI, Dennis , ERLANDER, Mark, G. , ZHANG, Yi , SCHNABEL, Catherine A
IPC分类号： A61K48/00 , A61K31/7105 , A61K31/7088 , A61P35/00
摘要： The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correlation with benefit in a switch in endocrine therapy used to treat a patient. The levels of gene expression are disclosed as a molecular index for predicting clinical outcome, and so prognosis, for the patient. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer, after initial treatment with an anti-estrogen agent. The disclosure further includes methods for determining or selecting the treatment of a subject based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.

99. 发明申请

WO2012054569A2 NON-HOMOPOLYMERS EXHIBITING GAS HYDRATE INHIBITION, SALT TOLERANCE AND HIGH CLOUD POINT 审中-公开
标题翻译：非共聚物展示气体水合物的抑制，耐盐性和高气候
公开(公告)号：WO2012054569A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056834
申请日：2011-10-19
申请人： ISP INVESTMENTS INC. , MUSA, Osama, M. , CHUANG, Jui-chang , ZHANG, Yi , ZHENG, Jun
发明人： MUSA, Osama, M. , CHUANG, Jui-chang , ZHANG, Yi , ZHENG, Jun
IPC分类号： C09K8/88
CPC分类号： C08F226/06 , C08F220/56 , C08F220/60 , C08F226/10 , C09K8/52 , C09K2208/22
摘要： Polymers are provided that offer gas hydrate inhibition, salt tolerance, and high cloud point. The polymers are polymerized from at least (A) 50 mole percent or more of a monomer selected from the group consisting of: N-vinyl-2-caprolactam, one of its analogues, and combinations thereof, (B) an alkenyl sulfonic acid monomer, salt thereof, or combinations thereof, and (C) an TV-vinyl amide, a (meth)acrylamide or one of its analogues, or combinations thereof. In one embodiment, the (A) monomer is N-vinyl-2-caprolactam, the (B) monomer is 2-acrylamido-2- methylpropane sulfonic acid or salt thereof, and the (C) monomer is N-vinyl-2-pyrrolidone, acrylamide, methacrylamide, or combinations thereof.
摘要翻译：提供了提供气体水合物抑制，耐盐性和高浊点的聚合物。聚合物至少从（A）的50摩尔％以上的单体聚合，所述单体选自：N-乙烯基-2-己内酰胺，其类似物之一及其组合，（B）链烯基磺酸单体，其盐或其组合，和（C）TV-乙烯基酰胺，（甲基）丙烯酰胺或其类似物之一或其组合。在一个实施方案中，（A）单体是N-乙烯基-2-己内酰胺，（B）单体是2-丙烯酰胺基-2-甲基丙磺酸或其盐，（C）单体是N-乙烯基-2- 吡咯烷酮，丙烯酰胺，甲基丙烯酰胺或其组合。

100. 发明申请

WO2012021749A1 GENOTYPING DNA 审中-公开
标题翻译：基因DNA
公开(公告)号：WO2012021749A1
公开(公告)日：2012-02-16
申请号：PCT/US2011/047485
申请日：2011-08-11
申请人： CELULA, INC. , KRUMMEL, Kurt, A. , ZHANG, Haichuan , KATZ, Andrew, S. , BALDOCCHI, Russell , GHATTI, Rama , ZHANG, Yi , GUNNING, Kerry , TU, Eugene
发明人： KRUMMEL, Kurt, A. , ZHANG, Haichuan , KATZ, Andrew, S. , BALDOCCHI, Russell , GHATTI, Rama , ZHANG, Yi , GUNNING, Kerry , TU, Eugene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6827 , C12Q2561/125 , C12Q2525/307 , C12Q2525/101 , C12Q2563/179 , C12Q2525/131 , C12Q2535/125 , C12Q2525/155
摘要： Described herein are compositions and methods useful for the detection of nucleic acid variations. Ligation within a probe or between probes is used to distinguish between probes perfectly complementary to a target and those containing a mismatch. Nucleotide fill-in/extension steps are optionally applied according to the type of assay performed. A circularization and relinearization step can be applied to create a template for further amplification and detection. In certain aspects, portions of a target sequence or its complement are not amplified.
摘要翻译：本文描述的是用于检测核酸变异的组合物和方法。探针之间或探针之间的连接用于区分完全与靶标互补的探针和包含不匹配的探针。任选地根据所进行的测定的类型来应用核苷酸填充/延伸步骤。可以应用圆化和再定位步骤以创建用于进一步扩增和检测的模板。在某些方面，目标序列或其补体的部分不被扩增。

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