专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明申请

WO1992004333A1 PYRIMIDINE DERIVATIVE AND MEDICINE 审中-公开
标题翻译：吡嗪衍生物和药物
公开(公告)号：WO1992004333A1
公开(公告)日：1992-03-19
申请号：PCT/JP1991001152
申请日：1991-08-29
申请人： NIPPON SHINYAKU CO., LTD. , CHOKAI, Shoichi , AOKI, Tomiyoshi , KIMURA, Kiyoshi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D239/34
CPC分类号： C07D453/02 , C07D239/34 , C07D239/42 , C07D401/12
摘要： The invention aims at obtaining a novel compound which is excellent in central nervous system selectivity and reduced in side effects and has an activity of improving the function of learning and memory, thus providing an excellent medicine for dementia. The invention relates to a compound represented by general formula (I), a pharmacologically acceptable salt thereof, and an agent for remedying the disturbance of learning and memory containing the same as the active ingredient of formula (I), wherein R?1 and R2¿ may be the same or different from each other and each represents hydrogen, hydroxy, alkoxy, trifluoromethyl or halogen; A represents methyl, trifluoromethyl or tertbutyl; and Y represents O or NH.

92. 发明申请

WO1991007973A1 FAT EMULSION 审中-公开
标题翻译： FAT乳液
公开(公告)号：WO1991007973A1
公开(公告)日：1991-06-13
申请号：PCT/JP1990001531
申请日：1990-11-26
申请人： NIPPON SHINYAKU CO., LTD.
发明人： NIPPON SHINYAKU CO., LTD. , SEKI, Junzo , USHIMARU, Kouichi , SUGIYAMA, Makoto
IPC分类号： A61K31/71
CPC分类号： A61K9/1075 , A61K31/7048
摘要： A fat emulsion developed to solve the problems of polyene antifungal antibiotics that they have such a severe toxicity as to limit the administration range thereof by suitably designing the administration form, thereby reducing the hemolytic toxicity and nephrotoxicity and facilitating the migration of a drug toward infected parts without adversely affecting the pharmacological action (antifungal action) on a molecular level. The emulsion comprises 0.005 to 5 % of a polyene antifungal antibiotic, 0.5 to 30 % of a simple lipid, and a phospholipid in an amount 0.15 to 2 times as large as that of the simple lipid, wherein the relative proportion of each ingredient is controlled to give a fine microemulsion of a mean particle diameter of at least 10 nm up to 100 nm. This emulsion can remarkably enhance the efficacy of polyene antifungal antibiotics such as Amphotericin B and is very useful for the development of medicines.
摘要翻译：为了解决多烯抗真菌抗生素的问题，开发了一种脂肪乳剂，它们具有如此严重的毒性，通过适当地设计给药形式来限制其给药范围，从而降低溶血毒性和肾毒性，并促进药物向感染部位的迁移而不会对分子水平的药理作用（抗真菌作用）产生不利影响。乳液含有0.005〜5％的多烯抗真菌抗生素，0.5〜30％的单一脂质，磷脂的量为单质脂的0.15〜2倍，其中各成分的相对比例被控制得到至少10nm至100nm的平均粒径的细微乳液。这种乳液可以显着提高多烯抗真菌抗生素如两性霉素B的功效，对于开发药物非常有用。

93. 发明申请

WO1991007971A1 COMPOSITION FOR RECTAL ADMINISTRATION 审中-公开
标题翻译：组合物的正确管理
公开(公告)号：WO1991007971A1
公开(公告)日：1991-06-13
申请号：PCT/JP1990001536
申请日：1990-11-28
申请人： NIPPON SHINYAKU CO., LTD. , USHIMARU, Kouichi , HAMAKAWA, Tomoaki , KOGA, Tomio , SUGIYAMA, Makoto
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K9/0031
摘要： A parenteral preparation, other than injections, containing cytarabine which is only poorly absorbable through the digestive tract, wherein cytarabine is dispersed in a mixture comprising a nonionic surfactant and fat or oil as the essential ingredients. Cytarabine can rapidly be absorbed and achieve a high plasma level when the preparation is administered to the rectum. Since it thus becomes possible to administer cytarabine, often used as a remedy for various cancers, without resort to intravenous drip infusion or subcutaneous injection, mental and physical pains of a cancer patient can be relieved.
摘要翻译：除了注射剂外，含有阿糖胞苷的肠胃外制剂，其通过消化道吸收不良，其中阿糖胞苷分散在包含非离子表面活性剂和脂肪或油的混合物中作为必要成分。当将制剂施用于直肠时，阿糖胞苷可以快速吸收并达到高血浆水平。因为这样就可以施用阿糖胞苷，通常用作各种癌症的补救剂，而不需要静脉滴注或皮下注射，可以减轻癌症患者的精神和身体疼痛。

94. 发明申请

WO1991006640A1 STABILIZED IMMOBILIZED ENZYME 审中-公开
标题翻译：稳定的固化酶
公开(公告)号：WO1991006640A1
公开(公告)日：1991-05-16
申请号：PCT/JP1990001395
申请日：1990-10-31
申请人： NIPPON SHINYAKU CO., LTD. , MARUO, Shigeaki , MIYAZAKI, Katsunori , YAMADA, Naoyoshi , EZURE, Yohji
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C12N11/00
CPC分类号： C12N11/00 , C12N9/96 , C12N11/02 , C12N11/10
摘要： A technology for effectively stabilizing immobilized enzymes related to carbonhydrates, by immobilizing an enzyme stabilizer together with an enzyme on a carrier. The stabilizer includes a compound represented by general formula (I), (wherein R represents hydrogen, a lower alkyl, a hydroxyalkyl, a phenylalkyl, a phenylalkenyl, a phenylalkynyl, a phenoxyalkyl, a phenoxyalkenyl or a phenoxyalkynyl, each of the phenyl groups being optionally substituted, and X represents hydrogen or an axial or equatorial hydroxyl group), a glucose oligomer thereof and an α-cyclodextrin. According to the invention, the amount of the stabilizer can be minimized and the stabilizer can readily be recovered from the reaction mixture.

95. 发明申请

WO1991006281A1 GASTRIC PREPARATION 审中-公开
标题翻译：气体制备
公开(公告)号：WO1991006281A1
公开(公告)日：1991-05-16
申请号：PCT/JP1990001365
申请日：1990-10-24
申请人： NIPPON SHINYAKU CO., LTD. , USHIMARU, Kouichi , NAKAMICHI, Kouichi , YASUURA, Hiroyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K09/00
CPC分类号： A61K9/0065 , A61K9/4808
摘要： A gastric preparation developed in order to solve the technical problems of conventional preparations, which is prepared by the bilayer packing technique and comprises 5 to 60 %, desirably 10 to 40 % of a rapid release portion which can establish the therapeutic level of a drug shortly after the administration and 95 to 40 %, desirably 90 to 60 % of a sustained release portion which has a specific gravity of 1 or less and can maintain a satisfactory release rate.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式