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91. 发明授权

US06602952B1 Hydrogels derived from chitosan and poly(ethylene glycol) or related polymers 失效
标题翻译：衍生自壳聚糖和聚（乙二醇）或相关聚合物的水凝胶
公开(公告)号：US06602952B1
公开(公告)日：2003-08-05
申请号：US09590622
申请日：2000-06-08
申请人： Michael David Bentley , Xuan Zhao
发明人： Michael David Bentley , Xuan Zhao
IPC分类号： C08G6348
CPC分类号： A61K47/60
摘要： The invention provides a polymeric structure comprising a multifunctional poly(alkylene oxide), such as a poly(ethylene glycol) derivative, covalently cross-linked to a polymer selected from the group consisting of chitosan and conjugates of chitosan and a monofunctional poly(alkylene oxide), such as methoxy poly(ethylene glycol). In aqueous media, the polymeric structure forms a hydrogel that is useful as a drug delivery device, a surgical sealant, or as a delivery system for a medical imaging agent.
摘要翻译：本发明提供了一种聚合物结构，其包含与选自壳聚糖和壳聚糖的共轭物和单官能聚（环氧烷烃）的聚合物共价交联的多官能聚（环氧烷），例如聚（乙二醇）衍生物），如甲氧基聚（乙二醇）。在水性介质中，聚合物结构形成水凝胶，其可用作药物递送装置，手术密封剂或用作医学成像剂的递送系统。

92. 发明授权

US09446139B2 Polymer-based compositions and conjugates of HIV entry inhibitors 有权
标题翻译：基于聚合物的组合物和HIV入口抑制剂的缀合物
公开(公告)号：US09446139B2
公开(公告)日：2016-09-20
申请号：US11082229
申请日：2005-03-15
申请人： Michael D. Bentley , Xuan Zhao , Harold Zappe
发明人： Michael D. Bentley , Xuan Zhao , Harold Zappe
IPC分类号： A61K47/48
CPC分类号： A61K47/48215 , A61K47/60
摘要： Provided herein are water-soluble polymer conjugates and polymer-based compositions of HIV entry inhibitors. Also provided are methods for synthesizing and administering such conjugates and compositions.
摘要翻译：本文提供了HIV入口抑制剂的水溶性聚合物缀合物和基于聚合物的组合物。还提供了用于合成和施用这种缀合物和组合物的方法。

93. 发明授权

US08338545B2 Multi-arm block copolymers as drug delivery vehicles 有权
标题翻译：多臂嵌段共聚物作为药物输送载体
公开(公告)号：US08338545B2
公开(公告)日：2012-12-25
申请号：US13287852
申请日：2011-11-02
申请人： Xuan Zhao
发明人： Xuan Zhao
IPC分类号： C08F283/00 , C08G63/91
CPC分类号： C08G63/914 , A61K31/724 , A61K31/74 , A61K31/77 , A61K47/593 , A61K47/60 , A61K47/6949 , B82Y5/00 , C08G65/2609 , C08G81/00 , C08G2650/24 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
摘要翻译：本发明提供了制备用作药物递送载体的共聚物和多臂嵌段共聚物的方法。多臂嵌段共聚物包括中心核心分子，例如多元醇的残基，以及共价连接到中心核心分子上的至少三个共聚物臂，每个共聚物臂包含共价连接到中心核心分子上的内部疏水性聚合物链段和共价连接到疏水性聚合物链段上的外部亲水性聚合物链段，其中中心核心分子和疏水聚合物链段限定疏水核心区域。疏水性生物活性剂的溶解度可以通过在嵌段共聚物的疏水核心区域内捕获来改善。本发明还包括药物组合物，包括这种嵌段共聚物，药物组合物和使用嵌段共聚物作为药物递送载体的方法。

94. 发明申请

US20120282671A1 MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVES, CONJUGATES AND GELS OF PHARMACEUTICALS AND THE SAME 有权
标题翻译：多臂聚乙烯衍生物，药物与其相同的凝胶和凝胶
公开(公告)号：US20120282671A1
公开(公告)日：2012-11-08
申请号：US13518940
申请日：2010-12-23
申请人： Xuan Zhao , Meina Lin
发明人： Xuan Zhao , Meina Lin
IPC分类号： C08G65/34 , C12N9/96 , C08G65/48
CPC分类号： A61K47/48215 , A61K31/727 , A61K47/60 , A61K47/6903 , C08G65/2609 , C08G65/329 , C08G65/3322 , C08G65/33337 , C08G2650/24 , C08L2203/02
摘要： A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m-, the average value of m is an integer of 2-250; I is an integer of 1 or more. The method for producing the multi-arm polyethylene glycol having different kinds of reactive groups, the multi-arm polyethylene glycol active derivatives comprising linking groups X attached to PEG and terminal reactive groups F attached to X, the gels formed by the multi-arm polyethylene glycol active derivatives, the drug conjugates formed by the multi-arm polyethylene glycol active derivatives and drug molecules, and the uses thereof in preparing drugs are also disclosed.
摘要翻译：公开了具有不同种类的反应性基团的多臂聚乙二醇（I）及其用途，其通过将环氧乙烷与低聚季戊四醇作为引发剂聚合形成，其中PEG相同或不同，为 - （CH 2 CH 2 O） m-，m的平均值为2-250的整数; 我是1或更多的整数。制备具有不同反应性基团的多臂聚乙二醇的方法，包括连接到PEG的连接基团X和连接到X的末端反应性基团F的多臂聚乙二醇活性衍生物，由多臂聚乙烯形成的凝胶乙二醇活性衍生物，由多臂聚乙二醇活性衍生物和药物分子形成的药物缀合物及其在制备药物中的用途。

95. 发明申请

US20110286956A1 NOVEL MULTI-ARM POLYETHYLENE GLYCOL, PREPARATION METHOD AND USES THEREOF 审中-公开
标题翻译：新型多臂聚乙烯甘油，其制备方法及其用途
公开(公告)号：US20110286956A1
公开(公告)日：2011-11-24
申请号：US13127349
申请日：2009-09-28
申请人： Xuan Zhao , Yuhe Zhao
发明人： Xuan Zhao , Yuhe Zhao
IPC分类号： A61K31/77 , C08L71/02 , C08G65/333 , C08G65/332 , C12N9/96 , C08G65/28
CPC分类号： C08G65/2609 , A61K47/60 , C08G65/3322 , C08G65/33337 , C08G65/33396 , C08G65/3344 , C08G65/337 , C08G2650/24 , C08L2203/02
摘要： A novel multi-arm polyethylene glycol (PEG) (I) and preparation method thereof. Active derivatives (II) based on the multi-arm PEG. Gels formed of the active derivatives. Drug conjugates formed of the active derivatives and drug molecules and uses thereof in medical preparation. The multi-arm PEG is formed by polymerizing ethylene oxide with pentaerythritol oligomers as initiator, wherein PEG is the same or different and is a —(CH2CH2O)m-, the average value of m is an integer of 3-1000, l is an integer more than or equal to 2. An 8-arm PEG is preferred, wherein l is equal to 3. The active derivatives (II) comprise link groups X attached to PEG and active end groups F attached to X.
摘要翻译：一种新型多臂聚乙二醇（PEG）（I）及其制备方法。基于多臂PEG的活性衍生物（II）。由活性衍生物形成的凝胶。由活性衍生物和药物分子形成的药物偶联物及其在医疗制剂中的用途。多臂PEG通过将环氧乙烷与季戊四醇低聚物作为引发剂聚合形成，其中PEG相同或不同，为 - （CH 2 CH 2 O）m - ，m的平均值为3-1000的整数，l为整数大于或等于2.优选8-臂PEG，其中l等于3.活性衍生物（II）包含连接于PEG的连接基团X和连接至X的活性末端基团F.

96. 发明授权

US07812849B2 Event memory assisted synchronization in multi-GPU graphics subsystem 有权
标题翻译：事件记忆辅助同步在多GPU图形子系统
公开(公告)号：US07812849B2
公开(公告)日：2010-10-12
申请号：US11582020
申请日：2006-10-17
申请人： Guofeng Zhang , Xuan Zhao
发明人： Guofeng Zhang , Xuan Zhao
IPC分类号： G09G5/399 , G06F15/16 , G09G5/36 , G09G5/397
CPC分类号： G06T15/005 , G06F13/102
摘要： A method and system are disclosed for synchronizing graphics processing events in a multi-GPU computer system. A master GPU renders a first image into a first portion of a master buffer associated with a display interface, and then writes a first predetermined value corresponding to the first image in a first memory unit. A slave GPU renders a second image into a slave buffer, and then transfers the second image to a second portion of the master buffer, and writes a second predetermined value corresponding to the second image in the first memory unit. The first and second predetermined values represent a queuing sequence of the rendered images. The master GPU flips the first image to display only after examining the first predetermined value in the first memory unit, and flips the second image to display only after examining the second predetermined value in the first memory unit.
摘要翻译：公开了用于在多GPU计算机系统中同步图形处理事件的方法和系统。主GPU将第一图像呈现到与显示接口相关联的主缓冲器的第一部分中，然后将对应于第一图像的第一预定值写入第一存储器单元。从属GPU将第二图像呈现到从属缓冲器中，然后将第二图像传送到主缓冲器的第二部分，并将对应于第二图像的第二预定值写入第一存储器单元。第一和第二预定值表示渲染图像的排队序列。主GPU翻转第一图像仅在检查第一存储器单元中的第一预定值之后显示，并且仅在检查第一存储器单元中的第二预定值之后翻转第二图像才显示。

97. 发明申请

US20090299050A1 Multi-Arm Block Copolymers as Drug Delivery Vehicles 有权
标题翻译：多臂嵌段共聚物作为药物递送载体
公开(公告)号：US20090299050A1
公开(公告)日：2009-12-03
申请号：US12538013
申请日：2009-08-07
申请人： Xuan Zhao
发明人： Xuan Zhao
IPC分类号： C08B37/16
CPC分类号： C08G63/914 , A61K31/724 , A61K31/74 , A61K31/77 , A61K47/593 , A61K47/60 , A61K47/6949 , B82Y5/00 , C08G65/2609 , C08G81/00 , C08G2650/24 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
摘要翻译：本发明提供了制备用作药物递送载体的共聚物和多臂嵌段共聚物的方法。多臂嵌段共聚物包括中心核心分子，例如多元醇的残基，以及共价连接到中心核心分子上的至少三个共聚物臂，每个共聚物臂包含共价连接到中心核心分子上的内部疏水性聚合物链段和共价连接到疏水性聚合物链段上的外部亲水性聚合物链段，其中中心核心分子和疏水聚合物链段限定疏水核心区域。疏水性生物活性剂的溶解度可以通过在嵌段共聚物的疏水核心区域内捕获来改善。本发明还包括药物组合物，包括这种嵌段共聚物，药物组合物和使用嵌段共聚物作为药物递送载体的方法。

98. 发明申请

US20070091098A1 Transparent multi-buffering in multi-GPU graphics subsystem 有权
标题翻译：多GPU图形子系统中的透明多缓冲
公开(公告)号：US20070091098A1
公开(公告)日：2007-04-26
申请号：US11582019
申请日：2006-10-17
申请人： Guofeng Zhang , Xuan Zhao
发明人： Guofeng Zhang , Xuan Zhao
IPC分类号： G06T1/00
CPC分类号： G06T15/005 , G06F13/102
摘要： This invention discloses a method and system for implementing transparent multi-buffering in multi-GPU graphics subsystems. The purpose of multi-buffering is to reduce GPU idle time. In one example, after rendering a first image by a first GPU in a back buffer, the first image is displayed by flipping to the back buffer. After that, the front buffer and back buffer are exchanged, and then shifting the back buffer and internal buffers in a predetermined sequence. A second image is rendered to current back buffer by a second GPU. The second image is displayed by flipping to a current back buffer. After that, the front buffer and back buffer are exchanged again, and shifting the back buffer and internal buffers again.
摘要翻译：本发明公开了一种在多GPU图形子系统中实现透明多缓冲的方法和系统。多缓冲的目的是减少GPU空闲时间。在一个示例中，在通过后缓冲器中的第一GPU渲染第一图像之后，通过翻转到后缓冲器来显示第一图像。之后，前缓冲器和后缓冲器被交换，然后以预定顺序移动后缓冲器和内缓冲器。第二个图像由第二个GPU呈现给当前的后台缓冲区。第二个图像通过翻转到当前的后台缓冲区来显示。之后，再次交换前缓冲区和后缓冲区，并再次移回后缓冲区和内部缓冲区。

99. 发明申请

US20050147681A1 Multi-arm block copolymers as drug delivery vehicles 有权
标题翻译：多臂嵌段共聚物作为药物输送载体
公开(公告)号：US20050147681A1
公开(公告)日：2005-07-07
申请号：US10984679
申请日：2004-11-08
申请人： Xuan Zhao
发明人： Xuan Zhao
IPC分类号： A61K31/724 , A61K31/77 , A61K47/48 , C08G65/26 , C08G81/00 , C08L71/02 , A61K38/13 , A61K9/14 , A61K31/337 , A61K31/366 , A61K31/405
CPC分类号： A61K31/724 , A61K31/77 , A61K47/593 , A61K47/60 , C08G65/2609 , C08G81/00 , C08G2650/24 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
摘要翻译：本发明提供了制备用作药物递送载体的共聚物和多臂嵌段共聚物的方法。多臂嵌段共聚物包括中心核心分子，例如多元醇的残基，以及共价连接到中心核心分子上的至少三个共聚物臂，每个共聚物臂包含共价连接到中心核心分子上的内部疏水性聚合物链段和共价连接到疏水性聚合物链段上的外部亲水性聚合物链段，其中中心核心分子和疏水聚合物链段限定疏水核心区域。疏水性生物活性剂的溶解度可以通过在嵌段共聚物的疏水核心区域内捕获来改善。本发明还包括药物组合物，包括这种嵌段共聚物，药物组合物和使用嵌段共聚物作为药物递送载体的方法。

100. 发明授权

US06914121B2 PEG-LHRH analog conjugates 失效
标题翻译： PEG-LHRH类似物共轭物
公开(公告)号：US06914121B2
公开(公告)日：2005-07-05
申请号：US10184126
申请日：2002-06-28
申请人： Nabil El-Tayar , Xuan Zhao , Michael D. Bentley
发明人： Nabil El-Tayar , Xuan Zhao , Michael D. Bentley
IPC分类号： A61K47/48 , A61K38/24 , C07K17/00 , C07K7/00
CPC分类号： G06Q10/06 , A61K47/62 , G06F9/546 , G06F2209/548 , G06Q30/00
摘要： PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog either directly or via a bifunctional linker molecule, such as an amino acid, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathologies in which LHRH analog administration is beneficial.
摘要翻译： PEG-LHRH类似物缀合物，其中PEG部分直接或通过双功能连接分子例如氨基酸共价结合LHRH类似物的丝氨酸残基，以及用于制备这些缀合物的方法在本发明中提供。还提供了用于治疗LHRH类似物给药有益的病理学的药物组合物和方法。

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