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91. 发明授权

US07939549B2 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof 有权
标题翻译： 1,2-二氢吡啶化合物及其制备方法和用途
公开(公告)号：US07939549B2
公开(公告)日：2011-05-10
申请号：US12395378
申请日：2009-02-27
申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito
发明人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito
IPC分类号： C07D401/04 , A61K31/44
CPC分类号： C07D213/70 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D471/06 , C07F7/1804
摘要： The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).
摘要翻译：本发明提供了具有优异的AMPA受体抑制作用和/或红藻氨酸盐抑制作用的新型化合物。由下式表示的化合物，其盐或其水合物。在该式中，Q表示NH，O或S; 并且R 1，R 2，R 3，R 4和R 5彼此相同或不同，各自表示氢原子，卤素原子，C 1-6烷基或由式-XA表示的基团（其中X表示单键，任选取代的C 1-6亚烷基等; A表示任选取代的C 6-14芳族烃基环基或5至14元芳族杂环基等）。

92. 发明授权

US07923563B2 Amorphous object of cinnamide compound 失效
标题翻译：肉桂酰胺化合物的无定形物
公开(公告)号：US07923563B2
公开(公告)日：2011-04-12
申请号：US11663550
申请日：2005-10-25
申请人： Ikuo Kushida , Eriko Doi , Koichi Ito
发明人： Ikuo Kushida , Eriko Doi , Koichi Ito
IPC分类号： C07D401/06
CPC分类号： C07D401/10
摘要： An amorphous object of (3E)-1-[l(s)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4methyl-1H-imidazol-1-yl)benzylidene]piperidine-2-one, which is represented by the formula (1) and has Aβ-production inhibitory activity. The amorphous object has such satisfactory properties that it has excellent solubility, is stable, does not readily become a crystalline form, and has low hygroscopicity. It is hence suitable for use in pharmaceutical preparations.
摘要翻译：（3E）-1- [1（S）-1-（4-氟苯基）乙基] -3- [3-甲氧基-4-（4-甲基-1H-咪唑-1-基）亚苄基] （1）表示并具有生产抑制活性。无定形物具有这样令人满意的性质，其具有优异的溶解性，稳定性，不容易变成结晶形式，并且具有低吸湿性。因此适用于药物制剂。

93. 发明申请

US20100105904A1 UREA TYPE CINNAMIDE DERIVATIVE 审中-公开
标题翻译：尿素类型CINNAMIDE衍生物
公开(公告)号：US20100105904A1
公开(公告)日：2010-04-29
申请号：US12301428
申请日：2007-05-18
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Takehiko Miyagawa , Nobuaki Sato , Toshihiko Kaneko , Kogyoku Shin , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Takehiko Miyagawa , Nobuaki Sato , Toshihiko Kaneko , Kogyoku Shin , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号： C07D233/64 , C07D405/12 , C07D403/10
CPC分类号： C07D233/64 , C07D249/06 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/10 , C07D405/12
摘要： Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group; X1 represents a single bond; R1 and R2 respectively represent a C1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R3 represents a hydrogen atom or the like.)
摘要翻译：公开了由下式（I）表示的化合物或其药理学上可接受的盐。还公开了化合物或盐作为药物产品的用途。（式中，Ar 1表示可被C 1-6烷基取代的咪唑基，Ar 2表示可被C 1-6烷氧基取代的苯基，X 1表示单键; R 1，R 2分别表示可以被诸如5至14元芳族杂环基团的取代基取代的C 1-6烷基等; R 3表示氢原子等。

94. 发明申请

US20090274997A1 System And Method For Comparing Dental X-Ray Images 有权
标题翻译：用于比较牙科X射线图像的系统和方法
公开(公告)号：US20090274997A1
公开(公告)日：2009-11-05
申请号：US12165961
申请日：2008-07-01
申请人： Eiko Kosuge , Koichi Ito , Takafumi Aoki
发明人： Eiko Kosuge , Koichi Ito , Takafumi Aoki
IPC分类号： A61C19/00
CPC分类号： G06K9/522 , A61B6/14 , G06K9/6206 , G06T7/33 , G06T2207/10116 , G06T2207/30036
摘要： A system for comparing dental X-ray images includes a positional displacement calculator calculating a positional displacement between dental X-ray test and reference images by using phase-only correlation, a positional displacement corrector correcting the positional displacement, a base point extractor defining, as a base image, any one of the dental X-ray test and reference images, and defining, as a corresponding image, the other one of the two dental images, and extracting base points from the base image, a corresponding point extractor extracting corresponding points, which correspond to the base points, from the corresponding image, a correspondence calculator calculating correspondence between the base points and the corresponding points, a nonlinear distortion corrector correcting a nonlinear distortion between the base image and the corresponding image, based on the correspondence, and a similarity calculator finding, by using phase-only correlation, a similarity between the base image and the corresponding image.
摘要翻译：用于比较牙齿X射线图像的系统包括位置偏移计算器，其通过使用相位相关来计算牙科X射线测试和参考图像之间的位置偏移，校正位置偏移的位置偏移校正器，将基点提取器定义为基础图像，牙科X射线测试和参考图像中的任一个，并且将两个牙齿图像中的另一个定义为相应的图像，并且从基本图像提取基点，相应的点提取器提取相应的点对应于基点的对应计算器，计算基点与对应点之间的对应关系，基于对应关系校正基图像与对应图像之间的非线性失真的非线性失真校正器，以及相似度计算器通过使用相位相关来找出相似度基本图像和相应的图像。

95. 发明申请

US20090048448A1 SALTS OF CYNNAMIDE COMPOUND OR SOLVATES THEREOF 审中-公开
标题翻译：氰化合物或其溶剂的盐
公开(公告)号：US20090048448A1
公开(公告)日：2009-02-19
申请号：US12093929
申请日：2006-11-17
申请人： Ikuo Kushida , Eriko Doi , Koichi Ito , Taiju Nakamura
发明人： Ikuo Kushida , Eriko Doi , Koichi Ito , Taiju Nakamura
IPC分类号： C07D401/10
CPC分类号： C07D401/10
摘要： The invention provides crystals of dihydrochloride monohydrate of the compound of the following formula having an Aβ production inhibiting effect which crystals are characterized by exhibiting a diffraction peak at an angle of diffraction (2θ±0.2°) of 10.9° in powder X-ray diffractometry. Further, the invention also provides the compound in the form of various salts, crystal forms and amorphous forms which are suitable for the development of drugs.
摘要翻译：本发明提供下式化合物的二盐酸盐一水合物晶体，其具有抑制Aβ生成的作用，其结晶的特征在于在粉末X射线衍射中以衍射角（2θ±0.2°）为10.9°的衍射峰。此外，本发明还提供了适合于开发药物的各种盐，晶型和无定形形式的化合物。

96. 发明申请

US20080243108A1 Ophthalmic laser treatment apparatus 有权
标题翻译：眼科激光治疗仪
公开(公告)号：US20080243108A1
公开(公告)日：2008-10-02
申请号：US12076496
申请日：2008-03-19
申请人： Naho Murakami , Koichi Ito
发明人： Naho Murakami , Koichi Ito
IPC分类号： A61F9/008 , A61B18/20
CPC分类号： A61F9/008 , A61B2018/2035 , A61F9/00821 , A61F2009/00863
摘要： An ophthalmic laser treatment apparatus comprises: a laser source that emits a laser beam for treatment of an affected part of a patient's eye; an optical fiber that transmits the laser beam emitted from the laser source; and a delivery optical system that irradiates the laser beam emitted from the optical fiber to the affected part of the patient's eye, the delivery optical system including: a plurality of diffraction optical elements each being configured to shape a beam profile of the laser beam at an emission end face of the optical fiber into a beam profile having one of a uniform intensity and a lower intensity in the center than on the periphery on the affected part and also to shape the laser beam to have a different spot size on the affected part of the patient's eye; and a changing unit which selectively disposing one of the diffraction optical elements on an optical path.
摘要翻译：一种眼科激光治疗装置，包括：激光源，其发射用于治疗患者眼睛的患部的激光束; 透射从激光源发射的激光束的光纤; 以及输送光学系统，其将从所述光纤发射的激光束照射到所述患者眼睛的受影响部分，所述输送光学系统包括：多个衍射光学元件，每个衍射光学元件被配置为在所述激光束的一个光纤的发射端面变成具有在中心上的均匀强度和较低强度之一的光束轮廓，而不是在受影响的部分上的周边上，并且还使激光束的形状在受影响的部分具有不同的光斑尺寸病人的眼睛; 以及在光路上选择性地配置衍射光学元件中的一个的改变单元。

97. 发明申请

US20080104876A1 Fishing lure 审中-公开
标题翻译：钓鱼诱惑
公开(公告)号：US20080104876A1
公开(公告)日：2008-05-08
申请号：US11819059
申请日：2007-06-25
申请人： Koichi Ito
发明人： Koichi Ito
IPC分类号： A01K85/18 , A01K85/00
CPC分类号： A01K85/16
摘要： A fishing lure includes a lure body which is formed in an appearance imitating a small fish. A lower jaw which is vertically pivotable is provided on the front end of the lure body, and the pivot angle of the lower jaw is adjustable. The lower jaw is pivotally supported by the lure body at the base, and has an angle adjusting mechanism to control the pivot angle of the lower jaw around the pivot.
摘要翻译：钓鱼诱饵包括形成在模仿小鱼的外观的诱惑体。垂直枢转的下颚设置在诱饵体的前端，下颚的枢转角度是可调节的。下颚由引导体枢转地支撑在基座处，并且具有角度调节机构，以控制下颌围绕枢轴的枢转角度。

98. 发明申请

US20070117839A1 Two cyclic cinnamide compound 审中-公开
标题翻译：两种环状肉桂酰胺化合物
公开(公告)号：US20070117839A1
公开(公告)日：2007-05-24
申请号：US11594150
申请日：2006-11-08
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
IPC分类号： C07D455/02 , A61K31/4745
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.
摘要翻译：本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。由通式（I）表示的两种环状肉桂酰胺化合物：其中表示单键或双键; Ar 1代表可被1至3个取代基取代的苯基或吡啶基; R 1和R 2各自表示C 1-6烷基，羟基等; Z 1表示亚甲基或亚乙烯基，其可以被1或2个选自取代基组A1，氧原子或亚氨基的取代基取代，所述取代基可以被选自取代基 A1组; 并且p，q和r各自表示0〜2的整数，其具有降低Abeta40和Abeta42产生的作用，因此特别可用作由Abeta如阿尔茨海默病或阿尔茨海默病引起的神经变性疾病的预防或治疗剂唐氏综合症。

99. 发明申请

US20070117798A1 Morpholine type cinnamide compound 失效
标题翻译：吗啉型肉桂酰胺化合物
公开(公告)号：US20070117798A1
公开(公告)日：2007-05-24
申请号：US11594130
申请日：2006-11-08
申请人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
发明人： Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Nobuaki Sato , Takehiko Miyagawa , Hiroaki Hagiwara
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/454 , C07D413/04
CPC分类号： C07D413/10 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The present invention relates to a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein R1, R2, R3, and R4 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group; X1 represents a C1-6 alkylene group that may be substituted; Xa represents a methoxy group or a fluorine atom; Xb represents an oxygen atom or a methylene group, provided that Xb is only an oxygen atom when Xa is a methoxy group; and Ar1 represents an aryl group, pyridinyl group, aryloxy group, or pyridinyloxy group that may have a substituent such as a halogen atom; and to use of the compound or salt as a pharmaceutical agent.
摘要翻译：本发明涉及由式（I）表示的化合物或其药理学上可接受的盐，其中R 1，R 2，R 3， SUP>和R 4相同或不同，各自表示氢原子或C 1-6烷基; X 1表示可以被取代的C 1-6亚烷基; X a a表示甲氧基或氟原子; X B表示氧原子或亚甲基，条件是当X a a为甲氧基时，X B b仅为氧原子; 和Ar 1表示可以具有卤素原子等取代基的芳基，吡啶基，芳氧基或吡啶氧基; 并使用化合物或盐作为药剂。

100. 发明申请

US20060051567A1 Method for coating porous polyurethane resin 审中-公开
标题翻译：多孔聚氨酯树脂涂层方法
公开(公告)号：US20060051567A1
公开(公告)日：2006-03-09
申请号：US11266517
申请日：2005-11-02
申请人： Koichi Ito
发明人： Koichi Ito
IPC分类号： B32B3/26 , B01J19/08 , G21H1/00 , G21H5/00 , H01F41/00
CPC分类号： C08J9/365 , B05D7/02 , B05D7/544 , C08J2375/04 , C08J2429/00 , Y10T428/249953 , Y10T428/249987 , Y10T428/249992
摘要： A method for coating a porous polyurethane resin substrate with an aromatic isocyanate coating composition is provided comprising the steps of (i) providing a porous substrate of a polyurethane foam resin comprising at least one surface upon which the aromatic isocyanate coating composition is to be applied; (ii) applying at least one coating of a primary layer to the substrate surface, the primary layer comprising an aqueous solution of a compound that includes at least one —OH reactive group in its non-aqueous, dry state, and capable, upon drying, of forming a self-supporting, continuous film on the substrate surface at room temperature; (iii) optionally subjecting the applied primary layer to forced drying conditions at a temperature below the softening point of the porous polyurethane resin substrate; and (iv) after allowing the primary layer to substantially dry, applying a secondary layer comprising an aromatic isocyanate compound to the primary layer to form a continuous, film-forming coating on the substrate surface, preferably one having the property of being water-impermeable or water-impermeable and water vapor-permeable.
摘要翻译：提供一种用芳族异氰酸酯涂料组合物涂覆多孔聚氨酯树脂基材的方法，其包括以下步骤：（i）提供聚氨酯泡沫树脂的多孔基材，其包含至少一个表面，所述表面上涂有芳族异氰酸酯涂料组合物; （ii）将至少一个初级层的涂层施加到基底表面，所述主层包含化合物的水溶液，所述化合物的水溶液包含至少一个-OH反应性基团，其非水，干燥状态，并且能够在干燥时在室温下在衬底表面上形成自支撑的连续膜; （iii）任选地使所施加的主层在低于多孔聚氨酯树脂基材的软化点的温度下进行强制干燥条件; 和（iv）在允许主层基本上干燥之后，将包含芳族异氰酸酯化合物的第二层施加到初级层，以在基材表面上形成连续的成膜涂层，优选具有不透水性的物质或不透水和透水蒸气。

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