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91. 发明专利

CA2692079A1 MASS SPECTROMETER 未知
公开(公告)号：CA2692079A1
公开(公告)日：2009-01-15
申请号：CA2692079
申请日：2008-07-14
申请人： MICROMASS LTD
发明人： KENNY DANIEL JAMES , GREEN MARTIN , WILDGOOSE JASON LEE , LANGRIDGE DAVID
IPC分类号： H01J49/42
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions wit hin the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but whic h instead acts to extract the ions and hence causes the ions to be ejected a xially from the ion trap (2, 3).

92. 发明专利

GB2450959A Dynamic removal of background noise during the acquisition of mass spectral data 未知
公开(公告)号：GB2450959A
公开(公告)日：2009-01-14
申请号：GB0808828
申请日：2008-05-14
申请人： MICROMASS LTD
发明人： GILBERT ANTHONY JAMES , GREEN MARTIN
IPC分类号： H01J49/02
摘要： A mass spectrometer, preferably a time-of-flight mass spectrometer, is disclosed wherein a signal output from an ion detector is digitised using an analogue to digital converter. A background or baseline level is dynamically subtracted from the digitised signal whilst the time of flight data is still being acquired. A threshold is also applied dynamically to the digitised signal in order to reduce electronic noise. The background or baseline level is determined by preferably determining a median, other percentile or, less preferably, an average of the digitised signal.

93. 发明专利

HK1113857A1 MASS SPECTROMETER 未知
公开(公告)号：HK1113857A1
公开(公告)日：2008-10-17
申请号：HK08109510
申请日：2008-08-26
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J20060101 , H01J49/02
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.

94. 发明专利

GB2447325A The simultaneous ejection of ions of different polarities or mass ranges from an ion trap 未知
公开(公告)号：GB2447325A
公开(公告)日：2008-09-10
申请号：GB0803193
申请日：2008-02-21
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
摘要： A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods to allow ions to be ejected radially from the ion trap. The 3D ion trap (see Figure 12) comprises a central, radially segmented ring electrode, wherein a slot is provided in each radial segment to allow ions to be radially ejected from the trap. Ions having different mass to charge ratios may be simultaneously ejected via different exit pathways by applying multiple supplementary AC voltages to the electrodes of the trap, while ions having opposite polarities may be simultaneously ejected by the application of an additional DC voltage.

95. 发明专利

CA2670871A1 MASS SPECTROMETER 未知
公开(公告)号：CA2670871A1
公开(公告)日：2008-06-12
申请号：CA2670871
申请日：2007-12-10
申请人： MICROMASS LTD
发明人： WILDGOOSE JASON LEE , GREEN MARTIN
IPC分类号： H01J49/40 , H01J49/06
摘要： A mass spectrometer is disclosed comprising a time of flight mass analyse r (7). The time of flight mass analyser (7) comprises an ion guide comprisin g a plurality of electrodes (1) which are interconnected by. a series of res istors (2) forming a potential divider. Ions are confined radially within th e ion guide by the application of a two-phase RF voltage to the electrodes ( 1). A single phase additional RF voltage is applied across the potential div ider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.

96. 发明专利

GB2439794A Obtaining mass spectra from a time-of-flight mass spectrometer 未知
公开(公告)号：GB2439794A
公开(公告)日：2008-01-09
申请号：GB0710512
申请日：2007-06-01
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE , GILBERT ANTHONY JAMES , PRINGLE STEVEN DEREK
IPC分类号： H01J49/02 , H01J49/40
摘要： A mass spectrometer is disclosed comprising a time-of-flight mass analyser comprising an ion detector comprising an analogue to digital converter (ADC). Signals from the analogue-to-digital converter are digitized and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+1) which are stored in neighbouring time bins T(n),T(n+1). Preferably, second differentials of the digitized signals from the analogue to digital recorder are obtained and used to determine the arrival time and intensity of ions.

97. 发明专利

GB2436201A Axial ion ejection from a segmented linear ion trap 未知
公开(公告)号：GB2436201A
公开(公告)日：2007-09-19
申请号：GB0625621
申请日：2006-12-21
申请人： MICROMASS LTD
发明人： GREEN MARTIN
IPC分类号： H01J49/42
摘要： An ion trap mass analyzer is disclosed comprising a segmented rod set. Ions are trapped radially within the mass analyzer by a radial pseudo-potential well. The ions are also confined axially within the ion trap by an axial electric field. The axial electric field is substantially linear across the central section of the ion trap, i.e. has a quadratic potential profile, but the electric field is distorted across both ends of the ion trap (see Figures 7 & 12). A supplemental AC voltage or potential is applied to the electrodes comprising the ion trap mass analyser in order to resonantly or parametrically excite ions within the ion trap 1. The distortions in the electric field at the ends of the ion trap cause the resonant frequency of ions within the ion trap to shift to either a higher or lower frequency (see Figures 8, 10, 13 & 15). If the frequency of the supplemental AC voltage or potential is scanned appropriately then ions are ejected from the ion trap in a shorter/longer period of time leading to an improvement in mass resolution (see Figures 9,11,14 & 16).

98. 发明专利

CA2609594A1 MASS SPECTROMETER 未知
公开(公告)号：CA2609594A1
公开(公告)日：2006-12-07
申请号：CA2609594
申请日：2006-06-01
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/02
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.

99. 发明专利

GB2423863A Mass-selective non-resonant ejection of ions from a linear ion trap 未知
公开(公告)号：GB2423863A
公开(公告)日：2006-09-06
申请号：GB0600920
申请日：2006-01-17
申请人： MICROMASS LTD
发明人： GILES KEVIN , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
摘要： A linear ion guide or ion trap 1 in which ions are confined radially by the application of an AC or RF voltage. At least one DC, real or static potential well, or a substantially static inhomogeneous electric field, is maintained along at least a portion of the axial length of the guide/trap. In addition, a time-varying substantially homogeneous axial electric field is also applied along at least a portion of the ion guide/trap. This arrangement causes ions to oscillate at a frequency different to their fundamental/first harmonic frequency, thereby allowing ions to be mass-selectively ejected from the guide/trap 1 in substantially non-resonant manner. The 2D ion trap/guide may comprise a segmented multipole device, an ion tunnel or funnel, or an array of planar plate or mesh electrodes.

100. 发明专利

GB2417125B Mass spectrometer 未知
公开(公告)号：GB2417125B
公开(公告)日：2006-08-09
申请号：GB0521631
申请日：2005-04-04
申请人： MICROMASS LTD
发明人： GREEN MARTIN , WILDGOOSE JASON LEE , PRINGLE STEVEN DEREK
IPC分类号： H01J49/04 , H01J49/06 , H01J49/16

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