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91. 发明授权

US5747422A Substituted 2-phenylpiridines 失效
标题翻译：取代的2-苯基吡啶
公开(公告)号：US5747422A
公开(公告)日：1998-05-05
申请号：US860031
申请日：1997-07-03
申请人： Peter Schafer , Gerhard Hamprecht , Elisabeth Heistracher , Ralf Klintz , Hartmann Konig , Helmut Walter , Karl-Otto Westphalen , Ulf Misslitz
发明人： Peter Schafer , Gerhard Hamprecht , Elisabeth Heistracher , Ralf Klintz , Hartmann Konig , Helmut Walter , Karl-Otto Westphalen , Ulf Misslitz
IPC分类号： C07D213/24 , A01N43/40 , C07D213/61 , C07D405/12 , C07D409/12 , C07D411/12 , C07D213/89
CPC分类号： C07D405/12 , A01N43/40 , C07D213/61 , C07D409/12
摘要： Substituted 2-phenylpyridines I ##STR1## where substituents have the meaning described in the specification and their use as herbicides; for the desiccation/defoliation of plants.
摘要翻译： PCT No.PCT / EP96 / 00008 Sec。 371日期1997年7月3日 102（e）1997年7月3日PCT 1996年1月4日PCT PCT。公开号WO96 / 21646 日期1996年7月18日取代的2-苯基吡啶I其中取代基具有说明书中描述的含义及其作为除草剂的用途; 用于植物的干燥/脱叶。

92. 发明授权

US5258163A Test carrier for analysis of fluids 失效
标题翻译：测试载体用于分析流体
公开(公告)号：US5258163A
公开(公告)日：1993-11-02
申请号：US960222
申请日：1992-10-13
申请人： Manfred Krause , Bernd Klein , Gerhard Schindler , Peter Schafer , Siegfried Notzel
发明人： Manfred Krause , Bernd Klein , Gerhard Schindler , Peter Schafer , Siegfried Notzel
IPC分类号： G01N33/52 , G01N33/543
CPC分类号： G01N33/54386 , G01N33/525 , G01N33/528 , Y10S435/805 , Y10S435/97
摘要： Test carrier for the analysis of fluids with a frame (2) consisting of at least two parts surrounding a test field opening (6) and with a test field disposed in the test field opening (6). In order to provide such a test carrier with frame with which it is possible to assemble the test field out of several test layers manufactured separately from one another, it is proposed that the test field be designed as a test layer package (7) with test layers (10, 11, 12) resting loosely on one another, the frame (2) comprise two shaped pieces of plastics material, one of which serves as base part (4) and comprises a seat (16) for accommodating the test layers (10, 11, 12), while the other serves as lid part (3) and comprises a bearing surface (17) resting on the topmost layer (10) of the test layer package (7). The lid part (3) and the base part (4) are in addition designed with elastic properties so that the pressure with which the bearing surface (17) presses onto the test layer package (7) is substantially constant in the tolerance range of the thickness of the test field package (7).
摘要翻译：用于分析流体的测试载体，框架（2）由围绕测试场开口（6）的至少两个部分组成，并且具有设置在测试场开口（6）中的测试场。为了提供这种具有框架的测试载体，可以通过框架来组装彼此分开制造的几个测试层的测试场，建议将测试场设计为具有测试的测试层封装（7）所述框架（2）包括两个成形的塑料件，其中一个塑料件用作基座部分（4），并且包括用于容纳测试层的座（16） 10,11,12），而另一个用作盖部分（3），并且包括搁置在测试层封装（7）的最上层（10）上的支承表面（17）。盖部分（3）和基部部分（4）另外设计有弹性特性，使得支承表面（17）压在测试层包装（7）上的压力在测试场包装的厚度（7）。

93. 发明授权

US4483100A Pane guide for a sliding window capable of being lowered into the window shaft of an automobile 失效
标题翻译：用于能够下降到汽车的窗轴中的滑动窗的叶片导轨
公开(公告)号：US4483100A
公开(公告)日：1984-11-20
申请号：US445789
申请日：1982-12-01
申请人： Heinz Blankenburg , Peter Schafer , Fritz Marr , Harald Kollner , Rainer Grimm , Wilhelm Scherf , Horst Bohm
发明人： Heinz Blankenburg , Peter Schafer , Fritz Marr , Harald Kollner , Rainer Grimm , Wilhelm Scherf , Horst Bohm
IPC分类号： B60J1/17 , B60J10/24 , B60J10/32 , B60J10/79 , E05F11/42 , E05F11/48
CPC分类号： E05F11/426 , B60J10/24 , B60J10/32 , B60J10/79 , E05Y2900/55
摘要： In a pane guide for a sliding window capable of being lowered into the window shaft (8) of an automobile, the windowpane (1) is laterally guided on windowframe components (4,5), in which back-cut guide channels (18,18') are provided, in which slide elements (23,23') are displaceably guided. The slide elements are connected with the windowpane (1), covering the windowframe components on the outer side of the vehicle, by carrier elements (19 to 22). Due to the mounting of the windowpane outside the windowframe, a projectionless lateral glazing of an automobile is made possible. At the lower end of at least one of the lateral windowframe components (4,5), the guide tube (11, 11') of a cable/tube window winder is connected in alignment with the guide channel (18, 18'). The threaded cable (12, 12') of the window winder extends into the guide channel (18, 18') and is fixed at least to one of the slide elements (19 to 22) situated therein. In this manner a low overall height of the windowshaft is achieved, so that the windowpane and the window shaft can have approximately the same height. With the windowpane (1) is associated a seal (46) disposed on the windowframe (4 to 7), which seal is either continually in sealing contact with the windowpane or, by a movable mounting of the seal or of the windowpane, is arranged so that it can be pressed automatically onto the windowpane (1).
摘要翻译：在能够下降到汽车的窗口轴（8）中的滑动窗口的窗格导板中，窗玻璃（1）在窗框部件（4,5）上被横向地引导，其中后向导向通道（18， 18'），其中滑动元件（23,23'）可移动地被引导。滑动元件与窗玻璃（1）连接，通过载体元件（19至22）覆盖车辆外侧的窗框部件。由于窗玻璃在窗框外部的安装，使得汽车的无投影侧面玻璃成为可能。在至少一个侧窗框架部件（4,5）的下端，电缆/管窗卷绕机的导管（11,11'）与引导通道（18,18'）对准连接。窗纱卷绕机的螺纹电缆（12,12'）延伸到引导通道（18,18'）中，并且至少固定在位于其中的滑动元件（19至22）中的一个上。以这种方式实现了较低的总体高度，使得窗玻璃和窗轴可以具有大致相同的高度。与窗玻璃（1）相连接设置在窗框（4至7）上的密封件（46），该密封件连续地与窗玻璃密封接触，或通过密封件或窗玻璃的可移动安装被布置使其可以自动按压到窗玻璃（1）上。

94. 发明授权

US4216624A Window winder for slidable windows, especially for automobiles 失效
标题翻译：用于可滑动窗户的窗式卷取机，特别适用于汽车
公开(公告)号：US4216624A
公开(公告)日：1980-08-12
申请号：US19523
申请日：1979-03-12
申请人： Heinz Blankenburg , Peter Schafer , Friedrich Herrmann
发明人： Heinz Blankenburg , Peter Schafer , Friedrich Herrmann
IPC分类号： B60J1/17 , E05F11/42 , E05F11/48 , F16H19/00 , F16H27/02
CPC分类号： F16H19/04 , E05F11/426 , E05Y2900/55 , Y10T74/18832 , Y10T74/19637 , Y10T74/2186
摘要： The window winder for a slidable window, especially a window capable of being lowered into the window shaft of an automobile, has a threaded cable displaceably guided in a tension resistant and compression resistant manner in a guide tube. The threaded cable engages, in a two part drive casing, a drive pinion which is non-rotatably keyed to a drive shaft journalled in the two half casing of a gear wheel drive equipped with a drag spring brake. The threaded cable is directly or indirectly connected to the window by one or more entraining devices fixed to the cable and penetrating through a longitudinal slit in the guide tube. The guide tube is a slit metal tube in the region of the path of movement of the entraining devices and elsewhere is a plastic tube connected to the drive casing and the metal tube in a non-displacing, non-rotatable manner by means of sleeves injection molded onto the plastic tube. The two parts of the drive casing are injection molded from plastic material and their parting plane is situated outside the threaded cable passing through the casing and outside the drive pinion between the drive pinion and the drag spring barke. The guide duct guides the threaded cable substantially in alignment with the internal surface of the guide tube and open towards the drive pinion and the parting plane is disposed in one casing part and the sleeves which receive the guide tube are formed integrally with the casing part.
摘要翻译：用于可滑动窗的窗起毛机，特别是能够下降到汽车的窗轴中的窗户，具有在导向管中以可抗张力和抗压缩的方式可移动地引导的螺纹电缆。螺纹电缆在两部分驱动器壳体中接合驱动小齿轮，该驱动小齿轮不可旋转地连接到装备有拖拉弹簧制动器的齿轮驱动器的两个半壳体中的驱动轴。螺纹电缆通过固定到电缆并穿过导管中的纵向狭缝的一个或多个夹带装置直接或间接地连接到窗户。引导管是夹带装置的移动路径区域中的狭缝金属管，而其它地方是通过套筒注射以不移动的，不可旋转的方式连接到驱动壳体和金属管的塑料管模塑在塑料管上。驱动壳体的两个部分由塑料材料注射成型，并且它们的分开平面位于穿过壳体的螺纹电缆的外侧，并且在驱动小齿轮和拖曳弹簧槌之间的驱动小齿轮外部。引导管引导螺纹电缆与引导管的内表面基本相对并且朝向驱动小齿轮打开，并且分离平面设置在一个壳体部分中，并且容纳引导管的套筒与壳体部分一体地形成。

95. 发明申请

US20080027123A1 (+)-2-[1-(3-Ethoxy-4methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3,-dione:methods of using and compositions thereof 有权
标题翻译：（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异二氢吲哚-1,3， - 二酮：使用方法和组合物
公开(公告)号：US20080027123A1
公开(公告)日：2008-01-31
申请号：US11824523
申请日：2007-06-29
申请人： George Muller , Peter Schafer , Hon-Wah Man , Chuansheng Ge
发明人： George Muller , Peter Schafer , Hon-Wah Man , Chuansheng Ge
IPC分类号： A61K31/4035 , A61P29/00 , A61P31/08 , A61P9/00
CPC分类号： A61K31/4035 , A61K45/06 , C07B2200/07 , C07C317/28 , C07D209/48 , Y02A50/411
摘要： Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
摘要翻译：基本上不含其（ - ）异构体的立体纯的（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮，以及前体药物，讨论了多晶型物，盐，溶剂合物，水合物和包合物。还讨论了使用的方法和包含2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮的（+）对映异构体的药物组合物。所述方法包括通过降低TNF-α水平或抑制PDE4而改善的治疗和/或预防疾病的方法。

96. 发明申请

US20060183788A1 Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione 有权
标题翻译：使用（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮处理或预防运动性哮喘的方法
公开(公告)号：US20060183788A1
公开(公告)日：2006-08-17
申请号：US11392846
申请日：2006-03-28
申请人： George Muller , Peter Schafer , Patricia Rohane
发明人： George Muller , Peter Schafer , Patricia Rohane
IPC分类号： A61K31/4035
CPC分类号： A61K31/4035 , C07B2200/07 , C07C317/28 , C07D209/48
摘要： Methods of treating, managing or preventing exercise-induced asthma are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione alone or in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms are also disclosed.
摘要翻译：公开了治疗，治疗或预防运动性哮喘的方法。具体方法包括单独或与第二活性剂组合施用（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮。还公开了药物组合物和单一单位剂型。

97. 发明申请

US20060183787A1 Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione 有权
标题翻译：使用（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮处理牛皮癣关节炎的方法
公开(公告)号：US20060183787A1
公开(公告)日：2006-08-17
申请号：US11392845
申请日：2006-03-28
申请人： George Muller , Peter Schafer , Patricia Rohane
发明人： George Muller , Peter Schafer , Patricia Rohane
IPC分类号： A61K31/4035
CPC分类号： A61K31/4035
摘要： Methods of treating, managing or preventing psoriatic arthritis are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione alone or in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms are also disclosed.
摘要翻译：公开了治疗，治疗或预防银屑病关节炎的方法。具体方法包括单独或与第二活性剂组合施用（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮。还公开了药物组合物和单一单位剂型。

98. 发明申请

US20060148882A1 Methods of using and compositions comprising PDE4 modulators for treatment, prevention and management airway inflammation 审中-公开
标题翻译：使用方法和包含PDE4调节剂的治疗，预防和管理气道炎症的组合物
公开(公告)号：US20060148882A1
公开(公告)日：2006-07-06
申请号：US11299702
申请日：2005-12-13
申请人： Jerome Zeldis , Patricia Rohane , Peter Schafer
发明人： Jerome Zeldis , Patricia Rohane , Peter Schafer
IPC分类号： A61K31/4035 , A61K31/522 , A61K31/557
CPC分类号： A61K31/4245 , A61K31/00 , A61K31/403 , A61K31/4035 , A61K31/522 , A61K31/557 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing, and managing airway inflammation and other airway or pulmonary diseases and disorders are disclosed. Specific methods comprise the administration of a PDE4 modulator, or a pharmaceutically acceptable salt, solvate, stereoisomer, or prodrug thereof, alone or in combination with a second active agent and/or other conventional therapies. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译：公开了治疗，预防和管理气道炎症和其它气道或肺部疾病和病症的方法。具体方法包括单独或与第二活性剂和/或其它常规疗法组合施用PDE4调节剂或其药学上可接受的盐，溶剂合物，立体异构体或前药。还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

99. 发明申请

US20050192336A1 (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione:methods of using and compositions thereof 有权
标题翻译：（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异二氢吲哚-1,3-二酮的制备方法及其组合物
公开(公告)号：US20050192336A1
公开(公告)日：2005-09-01
申请号：US11106142
申请日：2005-04-13
申请人： George Muller , Peter Schafer , Hon-Wah Man , Chuansheng Ge
发明人： George Muller , Peter Schafer , Hon-Wah Man , Chuansheng Ge
IPC分类号： A61K45/00 , A61K31/4035 , A61P1/04 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/24 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07C317/28 , C07D209/48
CPC分类号： A61K31/4035 , A61K45/06 , C07B2200/07 , C07C317/28 , C07D209/48 , Y02A50/411
摘要： Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
摘要翻译：基本上不含其（ - ）异构体的立体纯的（+） - 2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮，以及前体药物，讨论了多晶型物，盐，溶剂合物，水合物和包合物。还讨论了使用的方法和包含2- [1-（3-乙氧基-4-甲氧基苯基）-2-甲基磺酰基乙基] -4-乙酰氨基异吲哚啉-1,3-二酮的（+）对映异构体的药物组合物。所述方法包括通过降低TNF-α水平或抑制PDE4而改善的治疗和/或预防疾病的方法。

100. 发明申请

US20050182097A1 Methods and compositions using thalidomide for the treatment and management of central nervous system disorders or diseases 审中-公开
标题翻译：使用沙利度胺治疗和治疗中枢神经系统疾病或疾病的方法和组合
公开(公告)号：US20050182097A1
公开(公告)日：2005-08-18
申请号：US11022065
申请日：2004-12-23
申请人： Jerome Zeldis , Herbert Faleck , Peter Schafer
发明人： Jerome Zeldis , Herbert Faleck , Peter Schafer
IPC分类号： A61K31/454
CPC分类号： A61K31/445 , A61K31/00 , A61K31/425 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing and/or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) and related syndromes are disclosed. Specific methods encompass the administration of thalidomide, or a pharmaceutically acceptable salt, solvate, hydrate, or stereoisomer thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
摘要翻译：公开了治疗，预防和/或控制中枢神经系统疾病如肌萎缩性侧索硬化症（ALS或Lou Gehrig's disease）及相关综合征的方法。具体方法包括单独或与第二活性成分组合施用沙利度胺或其药学上可接受的盐，溶剂合物，水合物或立体异构体。还公开了适用于本发明方法的药物组合物，单一单位剂型和试剂盒。

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