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91. 发明授权

US07125845B2 Aza-peptide macrocyclic hepatitis C serine protease inhibitors 有权
标题翻译： Aza-peptide大环丙型肝炎丝氨酸蛋白酶抑制剂
公开(公告)号：US07125845B2
公开(公告)日：2006-10-24
申请号：US10613206
申请日：2003-07-03
申请人： Frank X. H. Wu , Suanne Nakajima , Zhi-Hui Lu , Ying Sun , Zhenwei Miao , Yat Sun Or , Zhe Wang
发明人： Frank X. H. Wu , Suanne Nakajima , Zhi-Hui Lu , Ying Sun , Zhenwei Miao , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/00
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06165
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐，酯或前药。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

92. 发明申请

US20060142214A1 3,6-bicyclolides 有权
标题翻译： 3,6-双环氯化物
公开(公告)号：US20060142214A1
公开(公告)日：2006-06-29
申请号：US11295736
申请日：2005-12-06
申请人： Yat Or , Datong Tang , Ying Sun , Yonghua Gai , Guoyou Xu , Zhe Wang
发明人： Yat Or , Datong Tang , Ying Sun , Yonghua Gai , Guoyou Xu , Zhe Wang
IPC分类号： C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

93. 发明授权

US07005408B2 Warming and nonirritating lubricant compositions and method of comparing irritation 有权
公开(公告)号：US07005408B2
公开(公告)日：2006-02-28
申请号：US10137509
申请日：2002-05-01
申请人： Nawaz Ahmad , Ying Sun , Shun Y. Lin
发明人： Nawaz Ahmad , Ying Sun , Shun Y. Lin
IPC分类号： C10M105/14 , A61K9/06
CPC分类号： A61K47/38 , A61K9/0034 , A61K9/06 , A61K31/415 , A61K31/4174 , A61K31/496 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/46 , Y10S424/14 , Y10S514/944 , Y10S514/967 , A61K2300/00
摘要： This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent. The invention also relates to methods of using such compositions for lubrication, administration of active ingredients and for preventing or treating dysmenorrhea.

94. 发明申请

US20060008538A1 Methods of treating the skin 审中-公开
标题翻译：治疗皮肤的方法
公开(公告)号：US20060008538A1
公开(公告)日：2006-01-12
申请号：US11156404
申请日：2005-06-20
申请人： Jeffrey Wu , Jue-Chen Liu , Jeannette Chantalat , Ying Sun , Stefanie Johnsen , Hanuman Jampani
发明人： Jeffrey Wu , Jue-Chen Liu , Jeannette Chantalat , Ying Sun , Stefanie Johnsen , Hanuman Jampani
IPC分类号： A61K33/04
CPC分类号： A61K45/06 , A61K8/368 , A61K8/37 , A61K8/416 , A61K8/42 , A61K31/14 , A61K31/22 , A61K31/23 , A61K31/60 , A61Q19/00 , A61Q19/02 , A61K2300/00
摘要： The invention features a method of (i) reducing the appearance of pores or oil on the skin and (ii) evening skin tone or smoothing skin by applying to an area of skin in need of such treatment a composition including an anti-acne agent, an antimicrobial agent, and a lactate.
摘要翻译：本发明的特征在于：（i）通过施用于需要这种治疗的皮肤区域，减少皮肤上的孔或油的外观和（ii）晚上的肤色或平滑的皮肤，包括抗痤疮剂，抗微生物剂和乳酸盐。

95. 发明申请

US20050238215A1 System and method for segmenting the left ventricle in a cardiac image 有权
标题翻译：用于在心脏图像中分割左心室的系统和方法
公开(公告)号：US20050238215A1
公开(公告)日：2005-10-27
申请号：US11049188
申请日：2005-02-02
申请人： Marie-Pierre Jolly , Ying Sun , Nicole Duta
发明人： Marie-Pierre Jolly , Ying Sun , Nicole Duta
IPC分类号： A61B5/055 , G06T5/00 , G06K9/00 , G06K9/34 , G06K9/48
CPC分类号： A61B5/055 , A61B2576/023 , G06K9/34 , G06T7/0012 , G06T7/12 , G06T7/162 , G06T2207/10081 , G06T2207/10088 , G06T2207/20061 , G06T2207/20164 , G06T2207/30048
摘要： A method is provided for segmenting an image of interest of a left ventricle. The method includes determining a myocardium contour according to a graph cut of candidate endocardium contours, and a spline fitting to candidate epicardium contours in the absence of shape propagation. The method further includes applying a plurality of shape constraints to candidate endocardium contours and candidate epicardium contours to determine the myocardium contour, wherein a template is determined by shape propagation of a plurality of images in a sequence including the image of interest in the presence of shape propagation.
摘要翻译：提供了一种用于分割左心室感兴趣的图像的方法。该方法包括根据候选心内膜轮廓的图形剪切来确定心肌轮廓，以及在没有形状传播的情况下与候选心外膜轮廓拟合样条。该方法还包括对候选心内膜轮廓和候选心外膜轮廓应用多个形状约束以确定心肌轮廓，其中模板通过包含形状存在的感兴趣图像的序列中的多个图像的形状传播来确定传播。

96. 发明申请

US20050153877A1 Macrocyclic hepatitis C serine protease inhibitors 有权
标题翻译：大环丙型肝炎丝氨酸蛋白酶抑制剂
公开(公告)号：US20050153877A1
公开(公告)日：2005-07-14
申请号：US10774047
申请日：2004-02-06
申请人： Zhenwei Miao , Ying Sun , Suanne Nakajima , Datong Tang , Frank Wu , Guoyou Xu , Yat Or , Zhe Wang
发明人： Zhenwei Miao , Ying Sun , Suanne Nakajima , Datong Tang , Frank Wu , Guoyou Xu , Yat Or , Zhe Wang
IPC分类号： A61K38/12 , C07K5/083 , C07K5/12 , E05F15/20 , G01S7/52 , G01S15/04
CPC分类号： C07D487/04 , A61K38/12 , C07K5/0806 , E05F15/73 , E05F2015/763
摘要： The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及式I，II或III的化合物或其药学上可接受的盐，酯或前药：其中W是取代或未取代的杂环体系。该化合物抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

97. 发明授权

US06833786B1 Pneumatic demultiplexer for controlling multiple assistive technology devices 失效
标题翻译：用于控制多个辅助技术装置的气动解复用器
公开(公告)号：US06833786B1
公开(公告)日：2004-12-21
申请号：US10314457
申请日：2002-12-06
申请人： Ying Sun , Kaylen J. Haley , Kerri-Anne Lachance , Kerri Pinnock
发明人： Ying Sun , Kaylen J. Haley , Kerri-Anne Lachance , Kerri Pinnock
IPC分类号： G08B108
CPC分类号： A61F4/00
摘要： A pneumatic demultiplexer that allows a person with a disability to control multiple assistive technology devices by the use of a single sip-and-puff tube. The devices to be controlled are operated by a single pneumatic or electrical switch input. The pneumatic demultiplexer is under the control of a microprocessor. In a scan stage the user selects the target device via scrolling LED indicators. When a specific device is chosen, the corresponding solenoid valve is activated to connect the input sip-and-puff port to the pneumatic output port. In the activation stage, the input sip-and-puff tube controls the target device directly via the pneumatic demultiplexer. The microprocessor monitors the line activity via a sip-or-puff switch. A watchdog timer is implemented by the microprocessor. After there is a lack of activity for preprogrammed time period, the system switches from the activation stage back to the scan stage.
摘要翻译：气动解复用器，其允许残疾人通过使用单个吸嘴管来控制多个辅助技术装置。要控制的设备由单个气动或电气开关输入操作。气动解复用器处于微处理器的控制之下。在扫描阶段，用户通过滚动LED指示器选择目标设备。当选择了特定的设备时，相应的电磁阀被激活以将输入的吸入口与气动输出端口连接。在激活阶段，输入吸嘴管通过气动解复用器直接控制目标装置。微处理器通过吹扫开关监视线路活动。看门狗定时器由微处理器实现。在预编程时间段没有活动之后，系统从激活阶段切换回扫描阶段。

98. 发明授权

US09462602B2 Systems and methods for prioritizing a UE in an uplink scheduler 有权
标题翻译：用于在上行链路调度器中优先化UE的系统和方法
公开(公告)号：US09462602B2
公开(公告)日：2016-10-04
申请号：US14407838
申请日：2012-06-14
申请人： Ying Sun , Hongwei Wang
发明人： Ying Sun , Hongwei Wang
IPC分类号： H04W72/12 , H04W72/10 , H04L1/18 , H04W72/04 , H04W88/08
CPC分类号： H04W72/1247 , H04L1/1854 , H04W72/0413 , H04W72/0446 , H04W72/10 , H04W72/1268 , H04W88/08
摘要： Methods and devices to improve the efficiency of uplink scheduling among user equipment (UEs) are disclosed. In one aspect, a base station with a scheduler utilizes a notional or holding “LCG,” in addition to LCGs that correspond to an LCG to which a UE maps one or more logical channels. This notional LCG is a dedicated LCG for maintaining temporary priority information based on the receipt of a scheduling request (SR) from the UE.
摘要翻译：公开了用于提高用户设备（UE）之间上行链路调度效率的方法和设备。在一个方面，具有调度器的基站除了与UE映射一个或多个逻辑信道的LCG对应的LCG之外，还使用理想或保持“LCG”。该名义LCG是专用LCG，用于基于从UE接收到调度请求（SR）来维护临时优先级信息。

99. 发明授权

US09380603B2 Scheduling of delay-sensitive traffic 有权
标题翻译：调度延迟敏感的流量
公开(公告)号：US09380603B2
公开(公告)日：2016-06-28
申请号：US14360592
申请日：2011-12-09
申请人： Girum Fantaye , Ying Sun
发明人： Girum Fantaye , Ying Sun
IPC分类号： H04W74/04 , H04W72/04 , H04W72/12 , H04W74/00 , H04W72/14 , H04L5/00
CPC分类号： H04W72/1226 , H04L5/0057 , H04W72/1252 , H04W72/14 , H04W74/04 , H04W76/28 , H04W84/042
摘要： The present disclosure concerns a method, uplink traffic control device and computer program product. The method comprises determining that predictive scheduling is to be applied for the mobile station. Thereafter an uplink transmission scheme is determined for the predictive scheduling. Thereafter periodic messages comprising uplink transmission grants, according to the uplink transmission scheme, are sent to the mobile station, said messages further comprising a request for a downlink channel quality indicator, CQI, report.
摘要翻译：本公开涉及一种方法，上行链路业务控制设备和计算机程序产品。该方法包括确定对移动台应用预测调度。此后，为预测调度确定上行链路传输方案。此后，根据上行链路传输方案，包括上行链路传输许可的周期性消息被发送到移动台，所述消息还包括对下行链路信道质量指示符CQI报告的请求。

100. 发明申请

US20150282198A1 DEVICE AND METHOD FOR ACKNOWLEDGED MODE QoS 有权
标题翻译：用于确认模式QoS的设备和方法
公开(公告)号：US20150282198A1
公开(公告)日：2015-10-01
申请号：US14408472
申请日：2012-06-25
申请人： Hongwei Wang , Ying Sun
发明人： Hongwei Wang , Ying Sun
IPC分类号： H04W72/10 , H04L12/801 , H04L1/00 , H04W28/02
CPC分类号： H04W72/10 , H04L1/0033 , H04L1/1854 , H04L47/14 , H04W28/0205 , H04W72/1247
摘要： A method (200) for a controlling node of a cell (110) in a cellular system, the method comprising (205) the use of Radio Link Control Acknowledged Mode, RLC AM, and scheduling (210) transmissions in the downlink and uplink directions to/from User Equipments, UEs (115, 120, 125), in the cell (110). The scheduling comprises taking into account a priority which each UE has for its transmissions, and counting (215) the number of scheduled transmissions for a UE in a first of said directions since its latest scheduled transmission in the other of said directions. If (220) the count has reached a predetermined value, the priority of the UE in the other of said directions is increased (225), and when (230) the UE has been scheduled for a transmission in said other direction, the counting in said first direction is restarted (235) from an initial value.
摘要翻译：一种用于蜂窝系统中小区（110）的控制节点的方法（200），所述方法包括（205）在下行链路和上行链路方向上使用无线链路控制确认模式，RLC AM和调度（210）传输来自/来自所述小区（110）中的用户设备UE（115,120,125）。调度包括考虑每个UE对其传输的优先级，并且在其中的另一个方向上的最近的调度传输之后，对于所述方向中的第一个方向上的UE的调度传输次数进行计数（215）。如果（220）计数已经达到预定值，则在另一个所述方向上的UE的优先级增加（225），并且当（230）UE已经被调度为在所述另一个方向上进行传输时，计数所述第一方向从初始值重新开始（235）。

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