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91. 发明申请

US20050065326A1 Antibodies that specifically bind to TR2 审中-公开
标题翻译：特异性结合TR2的抗体
公开(公告)号：US20050065326A1
公开(公告)日：2005-03-24
申请号：US10939359
申请日：2004-09-14
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C07K14/715 , C07K16/28 , C07H21/04 , C12N5/06
CPC分类号： C07K16/2878 , A61K2039/505 , C07K14/7151 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that specifically bind to TR2 proteins. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders, autoimmune disorders, immunodeficiencies and/or HSV infection. The invention also relates to nucleic acid molecules encoding anti-TR2 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TR2.
摘要翻译：本发明涉及特异性结合TR2蛋白的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病，自身免疫疾病，免疫缺陷和/或HSV感染。本发明还涉及编码抗TR2抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或与TR2特异性结合的相关分子。

92. 发明申请

US20050037467A1 83 human secreted proteins 审中-公开
标题翻译： 83人分泌蛋白
公开(公告)号：US20050037467A1
公开(公告)日：2005-02-17
申请号：US10936773
申请日：2004-09-09
申请人： Steven Ruben , Ping Feng , David LaFleur , Paul Moore , Yanggu Shi , Hla Kyaw , Yi Li , ZhiZhen Zeng , Kenneth Carter , Gregory Endress , Ying-Fei Wei , Ping Fan , Craig Rosen
发明人： Steven Ruben , Ping Feng , David LaFleur , Paul Moore , Yanggu Shi , Hla Kyaw , Yi Li , ZhiZhen Zeng , Kenneth Carter , Gregory Endress , Ying-Fei Wei , Ping Fan , Craig Rosen
IPC分类号： A61K38/00 , C07K14/47 , C12N5/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

93. 发明申请

US20080103090A1 Human Secreted Proteins 审中-公开
标题翻译：人类分泌蛋白
公开(公告)号：US20080103090A1
公开(公告)日：2008-05-01
申请号：US11687755
申请日：2007-03-19
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： A61K38/02 , C07H21/00 , C07K16/18 , C07K2/00 , C12N15/63 , C12P21/00 , C12Q1/02 , C12Q1/68 , G01N33/00 , G01N33/574
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗癌症及其它过度增殖性疾病和病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

94. 发明申请

US20070298491A1 Human Secreted Proteins 审中-公开
公开(公告)号：US20070298491A1
公开(公告)日：2007-12-27
申请号：US11781665
申请日：2007-07-23
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12N5/00 , C07H21/00 , C07K14/00 , C07K16/00 , G01N33/53 , C12N1/00 , C12N15/63
CPC分类号： A61K38/17 , C07K14/47 , G01N33/566 , G01N2500/00 , Y02A50/401
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

95. 发明申请

US20070244047A1 Albumin fusion proteins 审中-公开
公开(公告)号：US20070244047A1
公开(公告)日：2007-10-18
申请号：US11714841
申请日：2007-03-07
申请人： Craig Rosen , William Haseltine , Steven Ruben
发明人： Craig Rosen , William Haseltine , Steven Ruben
IPC分类号： A61K38/38 , C07H21/04 , C07K14/76 , C12N1/16 , C12N1/20 , C12N15/63 , C12N5/06 , C12N5/14 , C12P21/00
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

96. 发明申请

US20070048297A1 Human secreted proteins 审中-公开
公开(公告)号：US20070048297A1
公开(公告)日：2007-03-01
申请号：US10994608
申请日：2004-11-23
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： A61K39/395 , A61K38/17 , A61K48/00 , C07H21/04
CPC分类号： A61K38/17 , C07K14/47 , G01N33/566 , G01N2500/00 , Y02A50/401
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

97. 发明申请

US20070032413A1 Human secreted proteins 失效
标题翻译：人体分泌的蛋白质
公开(公告)号：US20070032413A1
公开(公告)日：2007-02-08
申请号：US10105299
申请日：2002-03-26
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/53 , C07K16/40 , A61K38/17 , A61K48/00
CPC分类号： A61K38/17 , C07K14/47 , G01N33/566 , G01N2500/00 , Y02A50/401
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

98. 发明申请

US20070027306A1 Albumin fusion proteins 有权
标题翻译：白蛋白融合蛋白
公开(公告)号：US20070027306A1
公开(公告)日：2007-02-01
申请号：US11500508
申请日：2006-08-08
申请人： Craig Rosen , William Haseltine , Steven Ruben
发明人： Craig Rosen , William Haseltine , Steven Ruben
IPC分类号： C07K14/605 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明涵盖白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

99. 发明申请

US20070015696A1 621 human secreted proteins 审中-公开
标题翻译： 621人分泌蛋白
公开(公告)号：US20070015696A1
公开(公告)日：2007-01-18
申请号：US10664356
申请日：2003-09-20
申请人： Craig Rosen , Steven Ruben
发明人： Craig Rosen , Steven Ruben
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/705 , A61K38/17
CPC分类号： C12Q1/6886 , A61K38/00 , C12Q2600/136
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗癌症及其它过度增殖性疾病和病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

100. 发明申请

US20060276396A1 Albumin fusion proteins 有权
公开(公告)号：US20060276396A1
公开(公告)日：2006-12-07
申请号：US11429373
申请日：2006-05-08
申请人： Craig Rosen , William Haseltine , Steven Ruben
发明人： Craig Rosen , William Haseltine , Steven Ruben
IPC分类号： A61K38/26
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.

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