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91. 发明授权

US5981221A Histone fusion protein 失效
公开(公告)号：US5981221A
公开(公告)日：1999-11-09
申请号：US824878
申请日：1997-03-26
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06 , C07H21/02 , C07H21/04 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.

92. 发明授权

US5976528A Glutathione s-transferase 失效
标题翻译：谷胱甘肽转移酶
公开(公告)号：US5976528A
公开(公告)日：1999-11-02
申请号：US96571
申请日：1998-06-12
申请人： Surya K. Goli , Jennifer L. Hillman
发明人： Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P35/00 , C12N9/10 , C12N15/54 , A61K38/45
CPC分类号： C12N9/1088 , A61K38/00 , Y10S424/809 , Y10S530/866
摘要： The present invention provides a human glutathione S-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HGST and a method for producing HGST. The invention also provides for agonists, antibodies, or antagonists specifically binding HGST, and their use, in the prevention and treatment of cancer and other diseases associated with the expression of HGST. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HGST for the treatment of cancer and other diseases associated with the expression of HGST. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HGST.
摘要翻译：本发明提供了人谷胱甘肽S-转移酶（HGST）和识别和编码HGST的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HGST的核酸序列和生产HGST的方法。本发明还提供了特异性结合HGST的激动剂，抗体或拮抗剂及其在预防和治疗与HGST表达相关的癌症和其它疾病中的用途。另外，本发明提供反义分子用于编码HGST的多核苷酸用于治疗与HGST表达相关的癌症和其它疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HGST的抗体的诊断测定法。

93. 发明授权

US5955314A Regulator of cell signaling 失效
标题翻译：细胞信号调节剂
公开(公告)号：US5955314A
公开(公告)日：1999-09-21
申请号：US748483
申请日：1996-11-08
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61P9/12 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C12N15/00 , C07H21/04 , C12N1/20 , C12P21/02
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human regulator of G-protein signaling (HRGS) and polynucleotides which identify and encode HRGS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRGS and a method for producing HRGS. The invention also provides for agonists, antibodies, or antagonists specifically binding HRGS, and their use, in the prevention and treatment of diseases associated with expression of HRGS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRGS for the treatment of diseases associated with the expression of HRGS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRGS.
摘要翻译：本发明提供了鉴定和编码HRGS的G蛋白信号传导（HRGS）和多核苷酸的人调节剂。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HRGS的核酸序列和生产HRGS的方法。本发明还提供了特异性结合HRGS的激动剂，抗体或拮抗剂及其在预防和治疗与HRGS表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码HRGS的多核苷酸用于治疗与HRGS表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HRGS的抗体的诊断测定法。

94. 发明授权

US5871964A Human C-type lectin 失效
标题翻译：人类C型凝集素
公开(公告)号：US5871964A
公开(公告)日：1999-02-16
申请号：US688342
申请日：1996-07-30
申请人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Benjamin Graeme Cocks , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C12N15/54 , C12N15/00
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.
摘要翻译：本发明提供鉴定和编码新型人C型凝集素（MCTL）的多核苷酸（mct1）。本发明提供了包含编码MCTL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质和用于治疗与MCTL表达相关的疾病的药物组合物中使用基本上纯化的MCTL及其激动剂。另外，本发明提供了用于治疗与MCTL表达相关的疾病的药物组合物中的mct1的反义分子的用途。本发明还描述了使用包含与mct1的基因组序列或转录物杂交的多核苷酸，其片段或其互补体的诊断组合物的诊断测定法。本发明还涉及特异性结合MCTL的抗MCTL抗体。

95. 发明授权

US5863898A Human lim proteins 失效
标题翻译：人体蛋白质
公开(公告)号：US5863898A
公开(公告)日：1999-01-26
申请号：US739485
申请日：1996-10-28
申请人： Surya K. Goli , Jennifer L. Hillman , Olga Bandman
发明人： Surya K. Goli , Jennifer L. Hillman , Olga Bandman
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides three human LIM proteins (designated individually as HLIM-1, HLIM-2, and HLIM-3, and collectively as HLIM) and polynucleotides which identify and encode HLIM. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HLIM and a method for producing HLIM. The invention also provides for use of HLIM and agonists, antibodies, or antagonists specifically binding HLIM, in the prevention and treatment of diseases associated with expression of HLIM. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HLIM for the treatment of diseases associated with the expression of HLIM. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HLIM.
摘要翻译：本发明提供了三种人LIM蛋白（分别命名为HLIM-1，HLIM-2和HLIM-3，并且共同称为HLIM）和鉴定和编码HLIM的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HLIM的核酸序列的宿主细胞和生产HLIM的方法。本发明还提供了用于预防和治疗与HLIM表达相关的疾病的HLIM和特异性结合HLIM的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码HLIM的多核苷酸用于治疗与HLIM表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合HLIM的抗体的诊断测定法。

96. 发明授权

US5837493A Human galectins 失效
标题翻译：人类半乳凝素
公开(公告)号：US5837493A
公开(公告)日：1998-11-17
申请号：US788584
申请日：1997-01-23
申请人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding GAL-5H and a method for producing GAL-5H. The invention also provides for use of GAL-5H and agonists, antibodies, or antagonists specifically binding GAL-5H, in the prevention and treatment of diseases associated with expression of GAL-5H. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding GAL-5H for the treatment of diseases associated with the expression of GAL-5H. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding GAL-5H.
摘要翻译：本发明提供两种新型人半乳凝素（单独命名为GAL-5HA和GAL-5HB，统称为GAL-5H）和识别和编码GAL-5H的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码GAL-5H的核酸序列和产生GAL-5H的方法。本发明还提供使用GAL-5H和特异性结合GAL-5H的激动剂，抗体或拮抗剂来预防和治疗与GAL-5H表达相关的疾病。另外，本发明提供了反义分子用于编码GAL-5H的多核苷酸用于治疗与GAL-5H表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合GAL-5H的抗体的诊断测定法。

97. 发明授权

US5831052A New human translocation associated protein 失效
标题翻译：新的人易位相关蛋白
公开(公告)号：US5831052A
公开(公告)日：1998-11-03
申请号：US852809
申请日：1997-05-07
申请人： Jennifer L. Hillman , Neil C. Corley , Surya K. Goli
发明人： Jennifer L. Hillman , Neil C. Corley , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C07H21/02 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a human translocation associated protein (Gp25L-H) and polynucleotides which identify and encode Gp25L-H. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Gp25L-H, as well as diagnostic assays.
摘要翻译：本发明提供了识别和编码Gp25L-H的人易位相关蛋白（Gp25L-H）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体和拮抗剂。本发明还提供了用于预防和治疗与Gp25L-H表达相关的疾病以及诊断测定法的方法。

98. 发明授权

US5817497A Glutathione s-transferase 失效
公开(公告)号：US5817497A
公开(公告)日：1998-10-06
申请号：US756771
申请日：1996-11-26
申请人： Surya K. Goli , Jennifer L. Hillman
发明人： Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P35/00 , C12N9/10 , C12N15/54 , C12N1/20
CPC分类号： C12N9/1088 , A61K38/00 , Y10S424/809 , Y10S530/866
摘要： The present invention provides a human glutathione S-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HGST and a method for producing HGST. The invention also provides for agonists, antibodies, or antagonists specifically binding HGST, and their use, in the prevention and treatment of cancer and other diseases associated with the expression of HGST. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HGST for the treatment of cancer and other diseases associated with the expression of HGST. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HGST.

99. 发明授权

US5814480A DNA encoding human metallothioein 失效
标题翻译：编码人金属硫蛋白的DNA
公开(公告)号：US5814480A
公开(公告)日：1998-09-29
申请号：US785530
申请日：1997-01-17
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P37/00 , A61P39/02 , C07K14/825 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/825 , A61K38/00
摘要： The present invention provides a human metallothionein (HMBP-I) and polynucleotides which identify and encode HMBP-I. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HMBP-I and a method for producing HMBP-I. The invention also provides for agonists, antibodies, or antagonists specifically binding HMBP-I, and their use, in the prevention and treatment of diseases associated with expression of HMBP-I. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HMBP-I for the treatment of diseases associated with the expression of HMBP-I. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HMBP-I.
摘要翻译：本发明提供人金属硫蛋白（HMBP-1）和识别和编码HMBP-1的多核苷酸。本发明还提供了包含编码HMBP-1的核酸序列和生产HMBP-1的方法的遗传工程表达载体和宿主细胞。本发明还提供了特异性结合HMBP-1的激动剂，抗体或拮抗剂及其用于预防和治疗与HMBP-1表达有关的疾病的用途。此外，本发明提供了反义分子用于编码HMBP-1的多核苷酸用于治疗与HMBP-1表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HMBP-1的抗体的诊断测定法。

100. 发明授权

US5756299A Human carbonyl reductase 失效
标题翻译：人羰基还原酶
公开(公告)号：US5756299A
公开(公告)日：1998-05-26
申请号：US762129
申请日：1996-12-09
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/04 , C12N15/53 , C12Q1/68
CPC分类号： C12N9/0006 , A61K38/00
摘要： The present invention provides a human carbonyl reductase (HCRD) and polynucleotides which identify and encode HCRD. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCRD and a method for producing HCRD. The invention also provides for agonists, antibodies, or antagonists specifically binding HCRD, and their use, in the prevention and treatment of diseases associated with expression of HCRD. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCRD for the treatment of diseases associated with the expression of HCRD. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCRD.
摘要翻译：本发明提供了人羰基还原酶（HCRD）和识别和编码HCRD的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HCRD的核酸序列和生产HCRD的方法。本发明还提供了特异性结合HCRD的激动剂，抗体或拮抗剂及其在预防和治疗与HCRD表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码HCRD的多核苷酸用于治疗与HCRD表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HCRD的抗体的诊断测定法。

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