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91. 发明申请

US20080246610A1 RF Enabled Surgical Cart and Use of Same in Operating Room Environment 失效
标题翻译：射频使用手术室和手术室环境使用相同
公开(公告)号：US20080246610A1
公开(公告)日：2008-10-09
申请号：US11928800
申请日：2007-10-30
申请人： Tom Packert , Jay Pierce , Robert J. Griffin , John K. Stevens
发明人： Tom Packert , Jay Pierce , Robert J. Griffin , John K. Stevens
IPC分类号： H04B7/00
CPC分类号： H04B5/0062
摘要： Activities of individuals and the movements/usage of products are monitored in an operating room during a surgical procedure by disposing in the operating room a first transceiver operating in a long wavelength mode in which 99.99% or more of radiated energy is in the form of a magnetic field, for example 131 KHz. A distinguishable radio frequency-enabled identification tag is associated with each of a plurality of persons assigned to the surgical procedure, including for example, doctors, nurses, and/or the patient, and optionally with products to be monitored. A signal is transmitted from the first transceiver and responses from the identification tags are monitored. A log is created from the monitored responses indicative activities of each of the persons in the operating room or of movements of tagged products.
摘要翻译：个人的活动和产品的运动/使用在外科手术过程中在手术室中进行监测，通过在手术室中放置以长波长模式操作的第一收发器，其中99.99％或更多的辐射能量为磁场，例如131KHz。可分辨的无线电频率识别标签与分配给外科手术的多个人中的每一个相关联，包括例如医生，护士和/或患者，以及可选地与待监测的产品。信号从第一收发器发送，并且来自识别标签的响应被监视。记录是从监控的响应中创建的，指示手术中每个人的指示性活动或标记产品的移动。

92. 发明申请

US20080100454A1 CART-BASED VISIBILITY SYSTEM 审中-公开
标题翻译：基于CART的可视系统
公开(公告)号：US20080100454A1
公开(公告)日：2008-05-01
申请号：US11768702
申请日：2007-06-26
申请人： John K. Stevens , Robert J. Griffin , Alexander Tkanchenko
发明人： John K. Stevens , Robert J. Griffin , Alexander Tkanchenko
IPC分类号： G08B13/14
CPC分类号： H01Q7/00 , G06K7/10336 , H01Q1/2208
摘要： A cart has at least three wheels. It has one or more loop antennas, and a radio transceiver connected with the antennas. The antennas and transceiver operate at a frequency lower than 1 megahertz. The loop antennas are each at least 0.2 square meters in area. The cart is moved to an area such as a room, and the transceiver communicates with various RF tags in the room. Because of the antenna configuration, the portion of spectrum employed, and the power levels used, the cart is able to communicate with most if not all of the RF tags in the room. The cart can then be moved to another area such as another room, and the process repeated. In this way an inventory of tags can be made without expensive permanently installed infrastructure. The system is robust against interferers such as large metal objects and intervening objects.
摘要翻译：车子至少有三个轮子。它具有一个或多个环形天线，以及与天线连接的无线电收发器。天线和收发器工作频率低于1兆赫兹。环形天线的面积至少为0.2平方米。将推车移动到诸如房间的区域，并且收发器与房间中的各种RF标签通信。由于天线配置，采用的频谱部分和使用的功率电平，车可以与室内的大多数（如果不是全部）RF标签通信。然后可以将推车移动到另一区域，例如另一房间，并重复该过程。以这种方式，可以制作标签的库存，而不需要昂贵的永久安装的基础设施。该系统对于诸如大型金属物体和居间物体的干扰源是强大的。

93. 发明授权

US5900131A Method and apparatus for automated electrophoresis using light polarization detector 失效
标题翻译：使用光偏振检测器的自动电泳方法和装置
公开(公告)号：US5900131A
公开(公告)日：1999-05-04
申请号：US691541
申请日：1996-08-28
申请人： John K. Stevens , Alexandre M. Ismailov
发明人： John K. Stevens , Alexandre M. Ismailov
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44721
摘要： Changes in polarized light incident on a detection zone within a separation matrix are used to detect optically active molecules within the separation matrix. The separation and detection of optically active molecules within the detection zone is done by loading a sample containing optically active molecules onto a separation matrix; applying a motive force to cause the sample to migrate though the separation matrix and to separate into a plurality of subgroups of optically active molecules; directing an incident beam of polarized radiation to the detection zone; processing the collected exiting beam with an optical component which discriminates between radiation having the same polarization as the incident beam and radiation having a different polarization from the incident beam; and measuring the intensity of the processed exiting beam. A difference between the intensity of the processed exiting beam and a standard intensity obtained for the separation matrix in the absence of sample is indicative of the presence of an optically active molecule in the detection zone. Alternatively, an incident beam of alternately left and right circularly polarized radiation, in which case differences in the intensity of left and right circularly polarized radiation indicate the present of optically acid species within the detection zone.
摘要翻译：入射在分离基质内的检测区上的偏振光的变化用于检测分离基质内的光学活性分子。检测区内光学活性分子的分离和检测是通过将含有光学活性分子的样品加载到分离基质上来进行的; 施加动力以使样品通过分离基质迁移并分离成多个光学活性分子亚组; 将偏振辐射的入射光束引导到检测区域; 用识别具有与入射光束相同极化的辐射和具有与入射光束不同的偏振的辐射的光学部件处理收集的退出光束; 并测量经处理的出射光束的强度。在不存在样品的情况下，经处理的出射光束的强度与对于分离基质获得的标准强度之间的差异指示在检测区域中光学活性分子的存在。或者，交替地左右圆偏振辐射的入射光束，在这种情况下，左右圆偏振辐射强度的差异表示检测区域内的光学酸物质的存在。

94. 发明授权

US5550020A Method, reagents and kit for diagnosis and targeted screening for retinoblastoma 失效
标题翻译：视网膜母细胞瘤诊断和靶向筛选方法，试剂和试剂盒
公开(公告)号：US5550020A
公开(公告)日：1996-08-27
申请号：US271942
申请日：1994-07-08
申请人： Brenda L. Gallie , James M. Dunn , John K. Stevens
发明人： Brenda L. Gallie , James M. Dunn , John K. Stevens
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/16
摘要： Reliable and cost effective testing for mutations in the RB1 gene can be accomplished by quantitatively amplifying exons of the sample RB1 gene using primers complementary to intron regions flanking each exon; and then determining the lengths and/or quantities of the amplification products for each exon and comparing that length or quantity to the length or quantity of amplification products obtained when a wild-type RB1 gene is amplified using the same primers. Differences in length between an amplified sample exon and the corresponding amplified wild-type exon reflect the occurrence of an insertion or deletion mutation in the sample RB1 gene. Differences in quantity reflect the complete absence of an exon, or heterozygosity for a mutant exon. Next, the nucleic acid sequence of each exon found to contain an insertion or deletion mutation is determined, or of all exons in the event no insertion or deletion mutations are identified. Preferably, the amplification of the exons is multiplexed so that more than one exon is amplified in a single vessel using sets of primers which provide gene fragments of distinctive lengths when used to amplify a normal RB1 gene.
摘要翻译：可以通过使用与每个外显子侧翼的内含子区域互补的引物定量扩增样本RB1基因的外显子来实现RB1基因突变的可靠和成本有效的测试。然后确定每个外显子的扩增产物的长度和/或数量，并将该长度或数量与使用相同引物扩增野生型RB1基因时获得的扩增产物的长度或数量进行比较。扩增样本外显子与相应的扩增野生型外显子之间的长度差异反映了样本RB1基因中插入或缺失突变的发生。量的差异反映了突变外显子完全不存在外显子或杂合性。接下来，确定发现含有插入或缺失突变的每个外显子的核酸序列，或者在没有鉴定插入或缺失突变的情况下所有外显子的核酸序列。优选地，外显子的扩增被多重化，使得在用于扩增正常RB1基因时提供具有特异长度的基因片段的引物组在单个容器中扩增多于一个外显子。

95. 发明授权

US5545527A Method for testing for mutations in DNA from a patient sample 失效
标题翻译：用于测试来自患者样品的DNA突变的方法
公开(公告)号：US5545527A
公开(公告)日：1996-08-13
申请号：US271946
申请日：1994-07-08
申请人： John K. Stevens , James M. Dunn
发明人： John K. Stevens , James M. Dunn
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/566 , C07H21/04 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q1/6886 , C12Q2600/156 , C12Q2600/16
摘要： A hierarchy of at least two assay techniques is utilized in testing for disease-associated mutations. The first assay in the hierarchy is selected to provide a highly specific test for the existence of the disease-associated mutation, although the accuracy of the test need not be high. The final assay in the hierarchy is selected to provide a highly accurate and highly specific test for the existence of the disease associated mutation. Intermediate tests of progressively greater accuracy may also be included in the hierarchy. Once the hierarchy has been selected for a given mutation-associated disease, a patient sample is analyzed the patient sample using the first, lowest accuracy assay in the hierarchy. If the result of the first assay is negative for the presence of a disease-associated mutation, then the next assay in the hierarchy is performed. This process is repeated until the final assay has been performed on all samples which gave negative results when tested by all less-accurate assays in the hierarchy. The test may be used for diagnosis and targeted screening for p53 mutations and mutations in the RB1 gene.
摘要翻译：使用至少两种测定技术的层次来测试疾病相关突变。选择层次结构中的第一个测定法为疾病相关突变的存在提供高度特异性的测试，尽管测试的准确性不需要很高。选择层次结构中的最终测定法为疾病相关突变的存在提供高度准确和高度特异性的检验。渐进更高精度的中间测试也可能包含在层次结构中。一旦为给定的突变相关疾病选择了层次结构，则使用层次结构中的第一种最低精度的分析方法对患者样本进行分析。如果第一次测定的结果对于存在疾病相关突变是阴性的，则进行层次结构中的下一个测定。重复此过程，直到对所有样品进行最终测定，当通过层次结构中的所有较不准确的测定进行测试时，会产生阴性结果。该检测可用于诊断和靶向筛选p53突变和RB1基因突变。

96. 发明授权

US5543018A Method and apparatus for automated electrophoresis using light polarization detector 失效
标题翻译：使用光偏振检测器的自动电泳方法和装置
公开(公告)号：US5543018A
公开(公告)日：1996-08-06
申请号：US387272
申请日：1995-02-13
申请人： John K. Stevens , Alexandre M. Ismailov
发明人： John K. Stevens , Alexandre M. Ismailov
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44721
摘要： Changes in polarized light incident on a detection zone within a separation matrix are used to detect optically active molecules within the separation matrix. The separation and detection of optically active molecules within the detection zone is done by loading a sample containing optically active molecules onto a separation matrix; applying a motive force to cause the sample to migrate through the separation matrix and to separate into a plurality of subgroups of optically active molecules; directing an incident beam of polarized radiation to the detection zone; processing the collected exiting beam with an optical component which discriminates between radiation having the same polarization as the incident beam and radiation having a different polarization from the incident beam; and measuring the intensity of the processed exiting beam. A difference between the intensity of the processed exiting beam and a standard intensity obtained for the separation matrix in the absence of sample is indicative of the presence of an optically active molecule in the detection zone. Alternatively, an incident beam of alternately left and right circularly polarized radiation, in which case differences in the intensity of left and right circularly polarized radiation indicate the present of optically active species within the detection zone.
摘要翻译：入射在分离基质内的检测区上的偏振光的变化用于检测分离基质内的光学活性分子。检测区内光学活性分子的分离和检测是通过将含有光学活性分子的样品加载到分离基质上来进行的; 施加动力以使样品迁移穿过分离基质并分离成多个光学活性分子亚组; 将偏振辐射的入射光束引导到检测区域; 用识别具有与入射光束相同极化的辐射和具有与入射光束不同的偏振的辐射的光学部件处理收集的退出光束; 并测量经处理的出射光束的强度。在不存在样品的情况下，经处理的出射光束的强度与对于分离基质获得的标准强度之间的差异指示在检测区域中光学活性分子的存在。或者，交替地左右的圆偏振光的入射光束，在这种情况下，左右的圆偏振辐射的强度的差异表示在检测区域内光学活性物质的存在。

97. 发明授权

US4937586A Radio broadcast communication systems with multiple loop antennas 失效
标题翻译：具有多个环形天线的无线电广播通信系统
公开(公告)号：US4937586A
公开(公告)日：1990-06-26
申请号：US141246
申请日：1988-01-06
申请人： John K. Stevens , Paul I. Waterhouse
发明人： John K. Stevens , Paul I. Waterhouse
IPC分类号： G06K17/00 , H04L5/14 , H04L27/18
CPC分类号： G06K17/0022 , H04L27/18 , H04L5/1492 , G09G2370/16 , G09G2380/04
摘要： The invention comprises a low power broadcast system that is applicable especially to the so-called "electronic shelf" for retail stores, wherein the shelf edge carries price displaying modules that can be addressed and controlled from a central computer operated station. The system also permits the modules to broadcast back to the central station to confirm safe receipt of data and to give information as to stock levels, etc. A broadcast system avoids the need for wiring so that location changes are facilitated. To overcome the extremely noisy environment and to conserve power consumption, and hence battery life, the system employs a low frequency (132 kHz) reference carrier transmitted by the base station in discrete segmented packages, each of which frames a base data word transmitted by the base station and a corresponding module data word transmitted by the module a fixed period after the end of the base word; the base receiver than has precise time information for receipt of the module word and can "look" for it among the noise. The carrier received by the module is divided and the lower frequency used to demodulate the information-carrying transmission from the base station of the same frequency, avoiding the need for a phase locked loop detector; this lower frequency is also used for the module transmission. The module employs an air-cored loop antenna coil for the lower frequency and a ferrite-cored loop antenna for the higher reference frequency, while the store antenna is segmented for selection of the group of modules to be addressed; the antenna contacts the metal shelving to provide electromagnetic coupling thereto. Each module contains a microprocessor which controls the operation. Each module has "concealed" buttons which can be enabled and used to insert data to be transmitted therefrom. A charging circuit can be used as the power source employing the received RF carrier energy.
摘要翻译：本发明包括一种低功率广播系统，其特别适用于零售商店的所谓“电子货架”，其中货架边缘携带可从中央计算机操作的站址寻址和控制的价格显示模块。该系统还允许模块广播回到中央站，以确认数据的安全接收并提供关于库存等级的信息等。广播系统避免了对布线的需要，从而便于位置改变。为了克服极其嘈杂的环境并节省电力消耗，并因此节省电池寿命，该系统采用由基站在离散分段封装中传输的低频（132kHz）参考载波，其中每个包含由基站和相应的模块数据字在模块结束后固定的时间段发送; 基本接收机具有用于接收模块字的精确时间信息，并且可以在噪声中“查找”它。由模块接收的载波被划分，较低的频率用于解调来自相同频率的基站的信息传输传输，避免了对锁相环检测器的需要; 该较低频率也用于模块传输。该模块采用较低频率的空心环形天线线圈和用于更高参考频率的铁氧体磁芯环形天线，而存储天线被分段以选择要寻址的模块组; 天线接触金属搁架以提供电磁耦合。每个模块都包含一个控制操作的微处理器。每个模块都具有“隐藏”按钮，可以启用并将其用于插入要传输的数据。充电电路可以用作采用所接收的RF载波能量的电源。

98. 发明授权

US4821291A Improvements in or relating to signal communication systems 失效
标题翻译：对信号通信系统的改进或涉及
公开(公告)号：US4821291A
公开(公告)日：1989-04-11
申请号：US909548
申请日：1986-09-22
申请人： John K. Stevens , Paul I. Waterhouse
发明人： John K. Stevens , Paul I. Waterhouse
IPC分类号： G06K17/00 , H04L5/14 , H04L27/18 , H04L27/00
CPC分类号： H04L27/18 , G06K17/0022 , H04L5/1492 , G09G2380/04
摘要： The invention comprises a low power broadcast system that is applicable especially to the so-called "electronic shelf" for retail stores, wherein the shelf edge carries price displaying modules that can be addressed and controlled from a central computer operated station. The system also permits the modules to broadcast back to the central station to confirm safe receipt of data and to give information as to stock levels, etc. A broadcast system avoids the need for wiring so that location changes are facilitated. To overcome the extremely noisy environment and to conserve power consumption, and hence battery life, the system employs a low frequency (132 kHz) reference carrier transmitted by the base station in discrete segmented packages, each of which frames a base data word transmitted by the base station and a corresponding module data word transmitted by the module a fixed period after the end of the base word; the base receiver then has precise time information for receipt of the module word and can "look" for it among the noise. The carrier received by the module is divided and the lower frequency used to demodulate the information-carrying transmission from the base station of the same frequency, avoiding the need for a phase locked loop detector; this lower frequency is also used for the module transmission. The module employs an air-cored loop antenna coil for the lower frequency and a ferrite-cored loop antenna for the higher reference frequency, while the store antenna is segmented for selection of the group of modules to be addressed; the antenna contacts the metal shelving to provide electromagnetic coupling thereto. Each module contains a microprocessor which controls the operation. Each module has "concealed" buttons which can be enabled and used to insert data to be transmitted therefrom. A charging circuit can be used as the power source employing the received RF carrier energy.
摘要翻译：本发明包括一种低功率广播系统，其特别适用于零售商店的所谓“电子货架”，其中货架边缘携带可从中央计算机操作的站址寻址和控制的价格显示模块。该系统还允许模块广播回到中央站，以确认数据的安全接收并提供关于库存等级的信息等。广播系统避免了对布线的需要，从而便于位置改变。为了克服极其嘈杂的环境并节省电力消耗，并因此节省电池寿命，该系统采用由基站在离散分段封装中传输的低频（132kHz）参考载波，其中每个包含由基站和相应的模块数据字在模块结束后固定的时间段发送; 基地接收机然后具有用于接收模块字的精确时间信息，并且可以在噪声中“寻找”它。由模块接收的载波被划分，较低的频率用于解调来自相同频率的基站的信息传输传输，避免了对锁相环检测器的需要; 该较低频率也用于模块传输。该模块采用较低频率的空心环形天线线圈和用于更高参考频率的铁氧体磁芯环形天线，而存储天线被分段以选择要寻址的模块组; 天线接触金属搁架以提供电磁耦合。每个模块都包含一个控制操作的微处理器。每个模块都具有“隐藏”按钮，可以启用并将其用于插入要传输的数据。充电电路可以用作采用所接收的RF载波能量的电源。

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