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91. 发明申请

WO1990011354A1 PROCESS FOR THE SPECIFIC REPLACEMENT OF A COPY OF A GENE PRESENT IN THE RECEIVER GENOME VIA THE INTEGRATION OF A GENE 审中-公开
标题翻译：通过基因整合在接受者基因组中特异性替代基因的复制方法
公开(公告)号：WO1990011354A1
公开(公告)日：1990-10-04
申请号：PCT/FR1990000185
申请日：1990-03-19
申请人： INSTITUT PASTEUR , LE MOUELLIC, Hervé , BRULLET, Philippe
发明人： INSTITUT PASTEUR
IPC分类号： C12N15/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A61K38/00 , A61K48/00 , C07K14/47 , C12N15/85 , C12N15/8509 , C12N15/907 , C12N2800/108 , C12N2800/30 , C12N2830/00 , C12N2830/85
摘要： The invention concerns the targeted insertion of a foreign DNA in a site selected in the genome of eucaryote cell. The insertion site selected is found in a gene. The targeted insertion is accomplished by transfecting eucaryote cells with a vector containing the foreign DNA to be inserted flanked by two genomic sequences which are adjacent to the desired insertion site in the receiver gene. The DNA to be inserted may comprise either a coding sequence, or a regulating sequences. The flanking sequences are chosen so as to allow via homologus recombination, according to the case, either the expression of the coding sequence of the DNA to be inserted under to control of regulating sequences of the receiver gene, or the expression of a coding sequences of the receiver gene under the control of the regulating sequence of the DNA to be inserted.

92. 发明申请

WO1989012009A1 PROCESS FOR PRESENTING AND PRESERVING PRODUCTS NECESSARY FOR RECONSTITUTING A SOLUTION OR SUSPENSION, AND DEVICE FOR USING SAID PROCESS 审中-公开
标题翻译：提供和保存用于重新解决方案或暂停的产品的过程和使用上述过程的设备
公开(公告)号：WO1989012009A1
公开(公告)日：1989-12-14
申请号：PCT/FR1989000256
申请日：1989-05-29
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ... , LABROUSSE, Hubert , AVRAMEAS, Eustrate
发明人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ...
IPC分类号： B65D81/32
CPC分类号： B65D51/244 , B65D51/30 , B65D81/32
摘要： Process and device (10) for presenting and preserving, in predetermined quantities, at least one product (5) and a solvant (2), in which said product is not durably preserved, in order to be able to prepare without notice, and prior to use, a solution or a suspension (21) by mixing the product with the solvant. Said device comprises: a recepticle (1) for storing the solvant (2), temporarily closed by a throw-away stopper (3); a device (4) for storing said product (5), acting as a hollow stopper, intended to replace the throw-away stopper (3) and providing, in its place, a sealed closure for the recepticle (1) in order to effect mixture by placing the solvant (2) in contact with the product (5); means for removably fixing (6) the storage device (4) to the recepticle (1). Applications: pharmaceutical, foodstuffs and biological analysis industries.

93. 发明申请

WO1989001941A1 CHEMICAL PROCESS FOR OBTAINING LABELLED OLIGONUCLEOTIDES AND BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：用于获得标记的寡核苷酸和生物应用的化学方法
公开(公告)号：WO1989001941A1
公开(公告)日：1989-03-09
申请号：PCT/FR1988000435
申请日：1988-09-02
申请人： INSTITUT PASTEUR , HUYNH DINH, Tam , LE BRUN, Sophie , IGOLEN, Jean , DUCHANGE, Nathalie , ZAKIN, Mario
发明人： INSTITUT PASTEUR
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： The process described is characterized in that activated thymidines are incorporated in the 4 position, in the place of cytidines, in an oligonucleotide sequence during construction, the sequence formed is reacted with a bifunctional compound, and a marker is attached to the function which remains free.

94. 发明申请

WO1983002276A1 MODIFIED ADENOSINE 5'-TRIPHOSPHORIC ACID AND METHOD FOR DOSING BIOLOGICAL SUBSTANCES CAPABLE OF FIXING DEGRADATION PRODUCTS OF ADENOSINE 5'-TRIPHOSPHORIC ACID 审中-公开
标题翻译：修饰的腺苷5'-磷酸和用于制备能够固定腺苷5'-三磷酸的降解产物的生物物质的方法
公开(公告)号：WO1983002276A1
公开(公告)日：1983-07-07
申请号：PCT/FR1982000222
申请日：1982-12-29
申请人： INSTITUT PASTEUR , KOURILSKY, Philippe , VINCENT, Christian , TCHEN, Paul
发明人： INSTITUT PASTEUR
IPC分类号： C07H19/20
CPC分类号： C07H21/00 , C07H19/20 , C12Q1/48
摘要： Un ATP modifié susceptible de donner naissance à un ADP ou AMP également modifié, incorporable à des substances biologiques et permettant la détection et éventuellement le dosage de ces dernières. Cet ATP modifié est caractérisé par la fixation covalente, sur le cycle adénine de l'ATP, d'un groupe chimique couplable directement ou indirectement avec une molécule affine, de préférence marquée par une enzyme, permettant la reconnaissance de cet ATP, ADP ou AMP.

95. 发明申请

WO1998008937A1 METHOD FOR SORTING ANTIFUNGAL MOLECULES ACTING ON THE GLUCANOSYLTRANSFERASE ACTIVITY 审中-公开
标题翻译：用于分离葡萄糖转运酶活性的抗真菌分子的方法
公开(公告)号：WO1998008937A1
公开(公告)日：1998-03-05
申请号：PCT/FR1997001540
申请日：1997-08-29
申请人： INSTITUT PASTEUR , FONTAINE, Thierry , HARTLAND, Robbert , MOUYNA, Isabelle , LATGE, Jean-Paul
发明人： INSTITUT PASTEUR
IPC分类号： C12N09/10
CPC分类号： C12Q1/18 , C12N9/1051 , C12Q1/48 , G01N2333/37 , G01N2333/39 , G01N2333/91091 , G01N2333/91097 , G01N2500/04 , H01L27/10852 , H01L28/92
摘要： The invention discloses proteins having beta (1-3)glucanosyltransferase type activities. These proteins can be used for detecting the antifungal activity of molecules.
摘要翻译：本发明公开了具有β（1-3）葡聚糖转移酶类型活性的蛋白质。这些蛋白质可用于检测分子的抗真菌活性。

97. 发明申请

WO1996017056A1 HYPERMUTAGENESIS 审中-公开
公开(公告)号：WO1996017056A1
公开(公告)日：1996-06-06
申请号：PCT/EP1995004749
申请日：1995-12-01
申请人： INSTITUT PASTEUR
发明人： INSTITUT PASTEUR , WAIN-HOBSON, Simon
IPC分类号： C12N15/10
CPC分类号： C12N15/102 , A61K38/00 , C07K14/005 , C12N9/003 , C12N9/1252 , C12N9/1276 , C12N2740/16122
摘要： The present invention features a method for introducing hypermutations into a target DNA or RNA sequence of interest, characterized in that said method comprises the steps of: (a) transcribing a RNA into DNA in a reaction mixture comprising a reverse transcriptase, varying biased concentrations of deoxynucleoside triphosphates to produce hypermutations and an oligonucleotide primer that is partially complementary to the 3' end of said RNA; and (b) recovering said DNA sequences.
摘要翻译：本发明的特征在于将超临界引入目标DNA或RNA目的序列中的方法，其特征在于所述方法包括以下步骤：（a）将RNA转录到包含逆转录酶的反应混合物中的DNA中，脱氧核苷三磷酸以产生高突变和与所述RNA的3'末端部分互补的寡核苷酸引物; 和（b）回收所述DNA序列。

98. 发明申请

WO1996015261A2 NUCLEOTIDE SEQUENCES HYBRIDIZING SPECIFICALLY WITH A GENOMIC NUCLEIC SEQUENCE OF CAMPYLOBACTER 审中-公开
标题翻译：核苷酸序列与CAMPYLOBACTER的基因核序列特异性杂交
公开(公告)号：WO1996015261A2
公开(公告)日：1996-05-23
申请号：PCT/FR1995001491
申请日：1995-11-13
申请人： INSTITUT PASTEUR , STONNET, Véronique , GUESDON, Jean-Luc
发明人： INSTITUT PASTEUR
IPC分类号： C12Q01/68
CPC分类号： C12Q1/689 , Y02A50/451
摘要： The present invention relates to a nucleic acid sequence isolated from C. coli which hybrizes specifically with the genomic nucleic acid of strains belonging to the species C. coli and which does not hybridize in usual conditions with the nucleic acids of campylobacteria which do not belong to said species, neither with the genomic nucleic acids of bacteria close to the genus Campylobacter. Fragments of said sequence may be used as specific primers for the amplification of specific sequences of Campylobacter coli and as nucleic probes specific to nucleic sequences of Campylobacter coli. The invention also relates to a method for detecting the presence of strains of Campylobacter coli in a biological sample as well as to a kit for implementing such method.
摘要翻译：本发明涉及从大肠杆菌分离的核酸序列，其特异性地与属于大肠杆菌菌种的菌株的基因组核酸杂交，并且在常规条件下不与不属于肠杆菌属的弯曲杆菌核酸杂交所述物种，也不与细菌的基因组核酸接近弯曲杆菌属。所述序列的片段可以用作用于扩增弯曲杆菌特异性序列的特异性引物和作为针对弯曲杆菌的核酸序列特异性的核酸探针。本发明还涉及用于检测生物样品中肠杆菌菌株的存在以及用于实施该方法的试剂盒的方法。

99. 发明申请

WO1996014408A2 NUCLEOTIDE SEQUENCE ENCODING THE ENZYME I-SCEI AND THE USES THEREOF 审中-公开
标题翻译：编码ENZYME I-SCEI的核苷酸序列及其用途
公开(公告)号：WO1996014408A2
公开(公告)日：1996-05-17
申请号：PCT/EP1995004351
申请日：1995-11-06
申请人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE
发明人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE , CHOULIKA, André , PERRIN, Arnaud , DUJON, Bernard , NICOLAS, Jean-François
IPC分类号： C12N15/11
CPC分类号： C12Q1/683 , A01K2217/05 , C12N9/22 , C12N15/66 , C12Q1/6841 , Y10S530/824
摘要： An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site directed insertion of genes.
摘要翻译：提供编码酶I-SceI的分离的DNA。 DNA序列可以并入克隆和表达载体，转化细胞系和转基因动物中。载体可用于基因作图和基因定点插入。

100. 发明申请

WO1996007745A3 MYCOBACTERIA FUNCTIONAL SCREENING AND/OR EXPRESSION VECTORS 审中-公开
公开(公告)号：WO1996007745A3
公开(公告)日：1996-03-14
申请号：PCT/FR1995001133
申请日：1995-08-30
申请人： INSTITUT PASTEUR , GICQUEL, Brigitte , LIM, Eng, Mong , PORTNOI, Denis , BERTHET, François-Xavier , TIMM, Juliano
发明人： INSTITUT PASTEUR
IPC分类号： C12N15/74

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