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91. 发明申请

WO9933981A3 HUMAN SIGNAL PEPTIDE-CONTAINING PROTEINS 审中-公开
标题翻译：含人类信号肽的蛋白质
公开(公告)号：WO9933981A3
公开(公告)日：1999-11-04
申请号：PCT/US9827598
申请日：1998-12-22
申请人： INCYTE PHARMA INC , LAL PREETI , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , SATHER SUSAN K , SHAH PURVI
发明人： LAL PREETI , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , BAUGHN MARIAH R , SATHER SUSAN K , SHAH PURVI
IPC分类号： G01N33/68 , A61K31/711 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , C07K14/47 , C07K14/52 , C07K14/715 , C07K16/18 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , A61K38/17 , C07K14/705 , C07K16/28
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/523 , C07K14/7158 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622
摘要： The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP.
摘要翻译：本发明提供了识别和编码SIGP的含人信号肽的蛋白质（SIGP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与SIGP表达相关的病症的方法。

92. 发明申请

WO9938976A3 HUMAN GROWTH FACTOR HOMOLOGS 审中-公开
标题翻译：人类生长因子同源
公开(公告)号：WO9938976A3
公开(公告)日：1999-11-25
申请号：PCT/US9900654
申请日：1999-01-12
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , LAL PREETI , CORLEY NEIL C , BAUGHN MARIAH , GUEGLER KARL J , TANG Y TOM
发明人： HILLMAN JENNIFER L , LAL PREETI , CORLEY NEIL C , BAUGHN MARIAH , GUEGLER KARL J , TANG Y TOM
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P43/00 , C07K14/475 , C07K16/22 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00
摘要： The invention provides human growth factor homologs (HGFH) and polynucleotides which identify and encode HGFH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HGFH.
摘要翻译：本发明提供了鉴定和编码HGFH的人生长因子同系物（HGFH）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与HGFH表达相关的病症的方法。

93. 发明申请

WO0000594A2 HUMAN TRANSFERASES 审中-公开
标题翻译：人类转移
公开(公告)号：WO0000594A2
公开(公告)日：2000-01-06
申请号：PCT/US9914651
申请日：1999-06-29
申请人： INCYTE PHARMA INC , LAL PREETI , BANDMAN OLGA , HILLMAN JENNIFER L , GUEGLER KARL J , GORGONE GINA A , CORLEY NEIL C , PATTERSON CHANDRA
发明人： LAL PREETI , BANDMAN OLGA , HILLMAN JENNIFER L , GUEGLER KARL J , GORGONE GINA A , CORLEY NEIL C , PATTERSON CHANDRA
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K39/395 , A61P1/00 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12Q1/68 , C12N9/00
CPC分类号： C12N9/1007 , A61K38/00 , C12N9/1096 , C12Y206/01039 , C12Y206/01064
摘要： The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HUTRAN.
摘要翻译：本发明提供了三种人转移酶（HUTRAN）和识别和编码HUTRAN的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HUTRAN表达相关的障碍的方法。

94. 发明申请

WO9936550A3 HUMAN PROTEASE MOLECULES 审中-公开
标题翻译：人类蛋白质分子
公开(公告)号：WO9936550A3
公开(公告)日：1999-11-18
申请号：PCT/US9900655
申请日：1999-01-12
申请人： INCYTE PHARMA INC , BANDMAN OLGA , HILLMAN JENNIFER L , YUE HENRY , GUEGLER KARL J , CORLEY NEIL C , TANG Y TOM , SHAH PURVI
发明人： BANDMAN OLGA , HILLMAN JENNIFER L , YUE HENRY , GUEGLER KARL J , CORLEY NEIL C , TANG Y TOM , SHAH PURVI
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , C07K16/40 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/57 , C12Q1/68 , A61K38/48
CPC分类号： C12N9/6424 , A61K38/00 , C12N9/48 , C12N9/6472 , C12N9/6478
摘要： The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.
摘要翻译：本发明提供了人类蛋白酶分子（HUPM）和识别和编码HUPM的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与HUPM表达相关的病症的方法。

95. 发明申请

WO9949038A3 HUMAN CALCIUM-BINDING PROTEINS 审中-公开
标题翻译：人钙结合蛋白
公开(公告)号：WO9949038A3
公开(公告)日：2000-02-10
申请号：PCT/US9905555
申请日：1999-03-15
申请人： INCYTE PHARMA INC , BANDMAN OLGA , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , LAL PREETI , PATTERSON CHANDRA
发明人： BANDMAN OLGA , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , LAL PREETI , PATTERSON CHANDRA
IPC分类号： G01N33/68 , A61K38/00 , A61P15/08 , A61P25/00 , A61P35/00 , A61P37/02 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12Q1/68 , A61K38/17
CPC分类号： C07K14/4728 , A61K38/00
摘要： The invention provides human calcium-binding proteins (CaBPs) and polynucleotides which identify and encode CaBP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CaBP.
摘要翻译：本发明提供了人钙结合蛋白（CaBPs）和鉴定和编码CaBP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与CaBP表达相关的障碍的方法。

96. 发明申请

WO9943829A3 CELL CYCLE RELATED PROTEINS 审中-公开
标题翻译：细胞周期相关蛋白
公开(公告)号：WO9943829A3
公开(公告)日：2000-01-06
申请号：PCT/US9902633
申请日：1999-02-08
申请人： INCYTE PHARMA INC , BANDMAN OLGA , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , YUE HENRY , LAL PREETI
发明人： BANDMAN OLGA , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARL J , YUE HENRY , LAL PREETI
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N15/12 , C12N15/55 , C12P21/02 , C12Q1/68 , A61K38/17 , C12N15/11 , C12N15/72
CPC分类号： C07K14/4738 , A61K38/00 , C07K14/47 , C12N9/14
摘要： The invention provides human cell cycle related proteins (CCRP) and polynucleotides which identify and encode CCRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CCRP.
摘要翻译：本发明提供识别和编码CCRP的人类细胞周期相关蛋白（CCRP）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与CCRP表达相关的病症的方法。

97. 发明申请

WO9960133A3 HUMAN NUCLEIC ACID METHYLASES 审中-公开
标题翻译：人类核酸甲酯
公开(公告)号：WO9960133A3
公开(公告)日：1999-12-29
申请号：PCT/US9910661
申请日：1999-05-14
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , LAL PREETI , CORLEY NEIL C , GUEGLER KARL J , YUE HENRY
发明人： HILLMAN JENNIFER L , LAL PREETI , CORLEY NEIL C , GUEGLER KARL J , YUE HENRY
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K16/40 , C12N9/10 , C12N15/54 , C12Q1/68 , A61K38/45
CPC分类号： C12N9/1007 , A61K38/00
摘要： The invention provides a human nucleic acid methylases (HNAM) and polynucleotides which identify and encode HNAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HNAM.
摘要翻译：本发明提供鉴定和编码HNAM的人核酸甲基化酶（HNAM）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HNAM表达相关的病症的方法。

98. 发明申请

WO9921994A3 HUMAN VESICLE MEMBRANE PROTEIN-LIKE PROTEINS 审中-公开
标题翻译：人类膜蛋白样蛋白
公开(公告)号：WO9921994A3
公开(公告)日：1999-07-08
申请号：PCT/US9821730
申请日：1998-10-14
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , YUE HENRY , CORLEY NEIL C , LAL PREETI , SHAH PURVI
发明人： HILLMAN JENNIFER L , YUE HENRY , CORLEY NEIL C , LAL PREETI , SHAH PURVI
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K31/70 , A61K38/17 , A61K39/395 , C07K16/18 , C12N15/11 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides three human vesicle membrane protein-like proteins (VMP) and polynucleotides which identify and encode VMP. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating and preventing disorders associated with expression of VMP.
摘要翻译：本发明提供了三种识别和编码VMP的人类囊泡膜蛋白样蛋白（VMP）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗和预防与VMP表达相关的病症的方法。

99. 发明申请

WO9802456A3 HUMAN C-TYPE LECTIN 审中-公开
标题翻译：人C型LECTIN
公开(公告)号：WO9802456A3
公开(公告)日：2002-10-17
申请号：PCT/US9712342
申请日：1997-07-15
申请人： INCYTE PHARMA INC , AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , GOLI SURYA K , HILLMAN JENNIFER L
发明人： AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , GOLI SURYA K , HILLMAN JENNIFER L
IPC分类号： A61K38/00 , C07K14/47 , C12N15/54 , C12N1/21 , C12N9/12 , C12N15/70
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.
摘要翻译：本发明提供鉴定和编码新型人C型凝集素（MCTL）的多核苷酸（mct1）。本发明提供了包含编码MCTL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与MCTL表达相关的疾病的药物组合物中使用基本上纯化的MCTL及其激动剂。另外，本发明提供了用于治疗与MCTL表达相关的疾病的药物组合物中的mct1的反义分子的用途。本发明还描述了使用包含与mct1的基因组序列或转录物杂交的多核苷酸，其片段或其互补体的诊断组合物的诊断测定法。本发明还涉及特异性结合MCTL的抗MCTL抗体。

100. 发明申请

WO9831805A3 HUMAN ZINC BINDING PROTEINS 审中-公开
标题翻译：人类锌结合蛋白
公开(公告)号：WO9831805A3
公开(公告)日：1998-11-05
申请号：PCT/US9801181
申请日：1998-01-20
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , AU YOUNG JANICE , COLEMAN ROGER , GOLI SURYA K
发明人： HILLMAN JENNIFER L , AU-YOUNG JANICE , COLEMAN ROGER , GOLI SURYA K
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K38/17 , C07K16/18 , C12N9/00 , C12N15/11 , C12Q1/68
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding ZB and a method for producing ZB. The invention also provides for use of ZB and agonists, antibodies, or antagonists specifically binding ZB, in the prevention and treatment of diseases associated with expression of ZB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding ZB for the treatment of diseases associated with the expression of ZB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding ZB.

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