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    • 92. 发明授权
    • Mirror image generator for composite signals with chroma inversion
    • 具有色度反演的复合信号的镜像发生器
    • US4727411A
    • 1988-02-23
    • US853146
    • 1986-04-17
    • Shinichi YamaguchiYasuo TakemuraTadashi Sugiki
    • Shinichi YamaguchiYasuo TakemuraTadashi Sugiki
    • H04N9/74
    • H04N9/74
    • The mirror image generator for composite signals with chroma inversion includes a first step of orthogonally modulating first and second color difference signals by first and second subcarriers where the subcarriers have 0.degree. and 270.degree. phases with respect to a 90.degree. reference phase; a second step of digitalizing the orthogonal modulation signals; a third step of writing the digitalized orthogonal modulation signals into 2 one horizontal period memories in a predetermined address sequence; and a fourth step of processing a phase transition order of the orthogonal modulation signals resulting in a different phase transition order in which the orthogonal modulation signals are read out of the horizontal period memory such that for a first predetermined amount of data, both the write address sequence and the read address sequence are the same with respect to each other, and for a second predetermined amount of data, the read address sequence is in reverse order from the write address sequence, and for a third predetermined amount of data, both the write and read address sequences are the same with respect to each other.
    • 用于具有色度反转的复合信号的镜像发生器包括:第一和第二子载波正交调制第一和第二色差信号的第一步骤,其中副载波相对于90°参考相位具有0°和270°相位; 将正交调制信号数字化的第二步骤; 将数字化正交调制信号以预定地址序列写入2个水平周期存储器的第三步骤; 以及第四步骤,处理所述正交调制信号的相变顺序,导致不同的相变顺序,其中从水平周期存储器读出正交调制信号,使得对于第一预定量的数据,写入地址 序列和读取地址序列相对于彼此相同,对于第二预定量的数据,读取地址序列与写入地址序列相反,并且对于第三预定量的数据,写入 并且读取地址序列相对于彼此是相同的。
    • 93. 发明申请
    • METHOD AND SYSTEM FOR MASS SPECTROMETRY DATA ANALYSIS
    • 用于质谱分析数据分析的方法和系统
    • US20140249766A1
    • 2014-09-04
    • US14349425
    • 2011-10-07
    • Hiroaki KozawaShinichi Yamaguchi
    • Hiroaki KozawaShinichi Yamaguchi
    • H01J49/00
    • H01J49/0036G06F19/703
    • In estimating a structural formula of an unknown substance produced through partial structural change of an original substance having a known structure caused by metabolism or the like, structural change is considered in two stages, the elimination of a partial structure and the addition of another partial structure. First, an additional partial structure is collected as known information in addition to an MSn spectrum of the unknown substance and a structural formula of the original substance. A structural formula at the time when a partial structure is eliminated from the original substance is estimated, and a structural formula of each of product ions is estimated. The structural formula of the unknown substance is determined by estimating a structure that can produce the candidates for structural formulas of the product ions by dissociation.
    • 在估计通过由代谢等引起的具有已知结构的原始物质的部分结构变化产生的未知物质的结构式时,结构变化分为两个阶段,消除部分结构和添加另一部分结构 。 首先,除了未知物质的MSn谱和原始物质的结构式之外,还收集附加的部分结构作为已知信息。 估计当从原始物质中去除部分结构时的结构式,并估计各产物离子的结构式。 未知物质的结构式通过估计可以通过解离产生产物离子的结构式的候选物的结构来确定。
    • 94. 发明申请
    • MASS ANALYSIS DATA ANALYZING METHOD AND APPARATUS
    • 质量分析数据分析方法和装置
    • US20140163902A1
    • 2014-06-12
    • US14236497
    • 2011-08-03
    • Shinichi Yamaguchi
    • Shinichi Yamaguchi
    • G01N21/31
    • G01N21/31G06F19/703H01J49/0036H01J49/0045
    • A method and apparatus for estimating the structure of an unidentified substance produced from an original substance having a known structural formula through partial structural change caused by metabolism or the like. A mass difference between a product ion, originating from the unidentified substance and having a partial structure including a structural change site, and a product ion, originating from the original substance and having a partial structure prior to the structural change, is equal to the mass difference between the original substance and the unidentified substance. Therefore, when pairs of product ions each having such a mass difference are selected to be compared with partial structures obtained from the known structural formula of the original substance, a minimum common partial structure having the structural change site is obtained.
    • 一种用于通过由代谢等引起的部分结构变化来估计由具有已知结构式的原始物质产生的不明物质的结构的方法和装置。 来源于不确定物质的产物离子与具有结构变化部位的部分结构之间的质量差异以及源于原始物质并在结构变化之前具有部分结构的产物离子等于质量 原物质与不明物质之间的差异。 因此,当选择具有这种质量差异的成对离子与从原始物质的已知结构式获得的部分结构进行比较时,获得具有结构变化部位的最小公共部分结构。
    • 95. 发明授权
    • Mass-analyzing method and mass spectrometer
    • 质谱法和质谱仪
    • US08735806B2
    • 2014-05-27
    • US12444811
    • 2006-11-15
    • Shinichi Yamaguchi
    • Shinichi Yamaguchi
    • H01J49/26H01J49/00
    • H01J49/0036G01N27/62H01J49/004
    • Based on the mass spectrum obtained by mass-analyzing a sample, the composition of the unknown substance is deduced, and after that, an MS/MS analysis is performed in which the unknown substance is set to be a precursor ion. Then, based on the peaks appearing on the MS/MS spectrum, the actually measured mass of each product ion is obtained (S1 through S4). On the other hand, the compositions of the product ion generated by the dissociation of the unknown substance are obtained by the combination, i.e. the condition, of the kind of the constituent element and the number of each element of the unknown substance's deduced component. Then, it is checked whether or not the theoretical mass in consistency with the actually measured mass of the product ion exists (S5). In the case where one which is consistent with a theoretical mass is not existent, it is possible to determine that the original deduction of the known substance's composition has been incorrect. Therefore, this result is given to the composition deduction as feedback to refine the candidates for the unknown substance's composition (S6).
    • 基于通过质量分析样品获得的质谱,推导出未知物质的组成,然后进行将未知物质设定为前体离子的MS / MS分析。 然后,基于MS / MS光谱中出现的峰,得到每个产物离子的实际测量质量(S1至S4)。 另一方面,通过未知物质的解离产生的产物离子的组成通过组合,即条件,构成元素的种类和未知物质的推导成分的各元素的数量的组合来获得。 然后,检查与产物离子的实测质量一致的理论质量是否存在(S5)。 在不存在与理论质量一致的情况下,可以确定已知物质组成的原始扣除是不正确的。 因此,这个结果是作为反馈的组合扣除来改进未知物质组成的候选人(S6)。
    • 98. 发明申请
    • Mass Analysis Data Processing Method and Mass Analysis Data Processing Apparatus
    • 质量分析数据处理方法和质量分析数据处理装置
    • US20120191369A1
    • 2012-07-26
    • US13263066
    • 2009-04-07
    • Shinichi Yamaguchi
    • Shinichi Yamaguchi
    • G06F19/00
    • H01J49/0036G01D7/02G06F17/40G06F19/00G06F19/703H01J49/26
    • From the data obtained by an LC/MS analysis in which an automatic MSn analysis is performed, all MS2 spectrum data are collected (S1), and a data matrix is created whose elements are peak intensity data with different precursor ions being arrayed in the horizontal direction and the mass-to-charge ratio of the product ions in the vertical direction (S2). By using the data in this data matrix, the correlation coefficients between two precursor ions are computed to create a correlation coefficient matrix (S3). In the correlation coefficient matrix, the diagonal elements whose value is “1” are all replaced by “0” to create an adjacency matrix (S4). A network analysis is performed for the adjacency matrix to create a network map showing the correlations among different precursor ions (MS2spectra) (S5). The network map is displayed on a window of a display unit simultaneously with the result of an MS1 analysis to provide an analysis operator with information on the compounds contained in a sample or the structure thereof (S6).
    • 从通过执行自动MSn分析的LC / MS分析获得的数据,收集所有MS2频谱数据(S1),并且创建数据矩阵,其元素是峰值强度数据,其中不同的前体离子排列在水平 方向和产品离子在垂直方向上的质荷比(S2)。 通过使用该数据矩阵中的数据,计算两个前体离子之间的相关系数以产生相关系数矩阵(S3)。 在相关系数矩阵中,值为“1”的对角线元素全部替换为“0”,以创建邻接矩阵(S4)。 对邻接矩阵执行网络分析以创建显示不同前体离子(MS2spectra)之间的相关性的网络图(S5)。 网络图与MS1分析结果同时显示在显示单元的窗口上,以向分析操作者提供关于样本中包含的化合物或其结构的信息(S6)。
    • 99. 发明授权
    • Chromatograph mass spectrometer
    • 色谱质谱仪
    • US08198585B2
    • 2012-06-12
    • US12166707
    • 2008-07-02
    • Shinichi Yamaguchi
    • Shinichi Yamaguchi
    • H01J49/26
    • H01J49/0027G01N30/72G01N30/8624G06F19/703H01J49/004
    • A chromatograph mass spectrometer is provided for obtaining the information pertinent to a structural analysis, with a simple operation, on a compound series including a plurality of compounds whose structures and characters are similar. First, based on the data obtained by a normal LC/MS analysis, a two-dimensional isointensity line graph is created and displayed with a retention time and a mass-to-charge ratio on the two axes and with a signal intensity represented in contour (S1 and S2). When the operator specifies a desired range by a drag operation or the like by a mouse (S3), peaks included in the range specified are extracted and based on the peaks, precursor ions are selected (S4 through S6). Then a schedule is created so that an MS2 analysis is performed for the precursor ions selected in the course of an LC/MS analysis for the sample to be targeted (S7). Analyses are performed while properly performing the precursor ions' selection/dissociation process in accordance with the schedule to collect the MS2 spectrum data (S8).
    • 提供了一种色谱质谱仪,用于通过简单的操作获得与包括其结构和特征相似的多种化合物的化合物系列相关的信息。 首先,基于通过正常LC / MS分析获得的数据,创建并显示二维等距线图,其中在两轴上具有保持时间和质荷比,并且以轮廓表示的信号强度 (S1和S2)。 当操作者通过鼠标的拖动操作等来指定期望的范围时(S3),提取包括在指定范围内的峰值,并且基于峰值,选择前体离子(S4至S6)。 然后创建一个时间表,以便对LC / MS分析过程中所选择的前体离子进行MS2分析,以进行对象样本(S7)。 在根据调度来适当地执行前体离子的选择/解离过程以收集MS2光谱数据的同时进行分析(S8)。
    • 100. 发明授权
    • Mass spectrometer
    • 质谱仪
    • US08093555B2
    • 2012-01-10
    • US12743932
    • 2007-11-21
    • Shinichi Yamaguchi
    • Shinichi Yamaguchi
    • H01J49/40G01N27/62
    • H01J49/061H01J49/408
    • A mass analysis is initially performed while applying appropriate voltages to the electrodes so that ions injected through an entrance gate electrode (5) into a loop orbit (3) are guided through approximately one half of the loop orbit (3) and diverted at an exit gate electrode (6) toward an ion detector (7). Based on the intensities of the peaks appearing on a mass spectrum obtained by this mass analysis, one or more objective ions are selected and a time parameter is specified so that the voltage applied to the exit gate electrode (6) changes when none of the ions flying along the loop orbit (3) are passing through the exit gate electrode (6). As a result, the orbit of the objective ions will assuredly changed so that they will be directed toward the ion detector (7) after flying through the loop orbit (3) multiple times. Thus, the mass information of the objective ions can be assuredly obtained.
    • 最初执行质量分析,同时向电极施加适当的电压,使得通过入口栅电极(5)注入环形轨道(3)的离子被引导通过环路轨道(3)的大约一半,并在出口 栅电极(6)朝向离子检测器(7)。 基于通过该质量分析获得的质谱出现的峰的强度,选择一个或多个目标离子,并且指定时间参数,使得当没有离子时,施加到出口栅极(6)的电压发生变化 沿环路轨道(3)飞行通过出口栅电极(6)。 结果,目标离子的轨道将确实改变,使得它们在通过环轨道(3)多次之后被引向离子检测器(7)。 因此,可以确实地获得目标离子的质量信息。