专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明专利

SI2588101T1 Derivati N-acil amino kisline za zdravljenje koĹľnih stanj, kot je celulitis 未知
公开(公告)号：SI2588101T1
公开(公告)日：2015-01-30
申请号：SI201130336
申请日：2011-06-28
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： A61K31/00 , A61K8/00

92. 发明专利

CA2915174A1 TETRAPEPTIDES DERIVED FROM HUMAN C-X-C CHEMOKINES USEFUL FOR TREATMENT OF VARIOUS SKIN CONDITIONS 未知
公开(公告)号：CA2915174A1
公开(公告)日：2014-12-18
申请号：CA2915174
申请日：2014-05-14
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K38/07 , C07K14/52
摘要： Tetrapeptides consisting of (I or V)-X1-K-X2, where X1 can be selected from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit diverse bioactivities. They are multi-functional effector molecules to stimulate keratinocytes migration; neutralize the proinflammatory effect of bacterial cell wall components such as lipoteichoic acids of the Gram-positive S. aureus; and induce angiogenesis in cultured human umbilical vein endothelial cells. The downregulation of pro-inflammatory condition was also demonstrated using SOR-300-FT psoriasis skin model for representative peptide. The bioactivity was also supported by gene profiling study upon treatment of normal skin tissues using EPIDERMTM skin substitutes. The inventive peptides with diverse bioactivities are useful for treating various skin conditions including, but not limited to, acute or chronic wounds, striae distensae, aging skin, hair control, inflammatory skins such as psoriasis, atopic dermatitis and rosacea and for unwanted hair removal or for conditions such as removal of skin tags.

93. 发明专利

SG11201405244RA SHORT ANTIMICROBIAL LIPOPEPTIDES 未知
公开(公告)号：SG11201405244RA
公开(公告)日：2014-10-30
申请号：SG11201405244R
申请日：2013-03-07
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , CARMICHAEL ROBIN
IPC分类号： A61K47/48 , A61K38/34 , C07K5/09
摘要： Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

94. 发明专利

NZ605804A New aminopyrazoloquinazolines 未知
公开(公告)号：NZ605804A
公开(公告)日：2014-03-28
申请号：NZ60580411
申请日：2011-07-22
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： A61K31/20 , A61K8/44
摘要： 605804 Disclosed is the use of a compound of the formula:

95. 发明专利

SI2125878T1 Kratki bioaktivni peptidi za celično in imunološko modulacijo 未知
公开(公告)号：SI2125878T1
公开(公告)日：2013-06-28
申请号：SI200731182
申请日：2007-12-27
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： C07K5/00 , C07K7/00

96. 发明专利

AU2011271466A1 N-acyl amino acid derivatives for treating skin conditions such as cellulite 未知
公开(公告)号：AU2011271466A1
公开(公告)日：2012-12-20
申请号：AU2011271466
申请日：2011-06-28
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY J , ZHANG LIJUAN
IPC分类号： A61K31/20 , A61K8/44
摘要： The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.

97. 发明专利

ES2378242T3 Hexapéptidos antimicrobianos 未知
公开(公告)号：ES2378242T3
公开(公告)日：2012-04-10
申请号：ES06720369
申请日：2006-02-07
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY , ZHANG LIJUAN , HARRIS SCOTT
IPC分类号： C07K7/06
摘要： Un hexapéptido antimicrobiano que comprende restos cargados hidrófilos (X) en las posiciones uno y tres; restos hidrófobos (B) en las posiciones dos, cuatro y seis; y una naftilalanina (Nal), un resto alifático o uno aromático (O) en la posición cinco; estando representada la estructura del hexapéptido por la fórmula XBXBOB, y seleccionándose el hexapéptido del grupo que consiste en SEC ID Nº : 1, SEC ID Nº : 55, SEC ID Nº : 56, SEC ID Nº : 62, SEC ID Nº : 63, SEC ID Nº : 70, SEC ID Nº : 72, SEC ID Nº : 77, SEC ID Nº : 78, SEC ID Nº : 79, SEC ID Nº : 80, SEC ID Nº : 81, SEC ID Nº : 83 y SEC ID Nº : 85.

98. 发明专利

AT540969T 未知
公开(公告)号：AT540969T
公开(公告)日：2012-01-15
申请号：AT06720369
申请日：2006-02-07
申请人： HELIX BIOMEDIX INC
发明人： FALLA TIMOTHY , ZHANG LIJUAN , HARRIS SCOTT
IPC分类号： C07K7/06
摘要： The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

99. 发明专利

AU2007258387A2 Peptide fragments for inducing synthesis of extracellular matrix proteins 未知
公开(公告)号：AU2007258387A2
公开(公告)日：2009-02-19
申请号：AU2007258387
申请日：2007-06-12
申请人： HELIX BIOMEDIX INC
发明人： HARRIS SCOTT M , ZHANG LIJUAN , FALLA TIMOTHY J
IPC分类号： C07K5/10 , C07K14/78
摘要： A tetrapeptide comprising SEQ ID NO: 10 (PKGP) or SEQ ID NO: 9 (PEKP) for use as a medicament. Use of a tetrapeptide comprising SEQ ID NO: 10 (PKGP) or SEQ ID NO: 9 (PEKP) as a cosmetic product. A pharmaceutical composition for use as a medicament comprising a tetrapeptide comprising SEQ ID NO: 10 (PKGP) or SEQ ID NO: 9 (PEKP) and a pharmaceutical carrier. An in vitro method for stimulating the production of collagen by a cell, the method comprising exposing a cell to a tetrapeptide comprising SEQ ID NO: 10 (PKGP) or SEQ ID NO: 9 (PEKP) thereby inducing collagen production by the cell.

100. 发明专利

CA2673791A1 SHORT BIO-ACTIVE PEPTIDES FOR CELLULAR AND IMMUNOLOGICAL MODULATION 未知
公开(公告)号：CA2673791A1
公开(公告)日：2008-07-17
申请号：CA2673791
申请日：2007-12-27
申请人： HELIX BIOMEDIX INC
发明人： ZHANG LIJUAN , HARRIS SCOTT M , FALLA TIMOTHY J
IPC分类号： C07K14/435 , A61K38/00
摘要： Peptides having four to fourteen residues are disclosed that possess biol ogical activity. These peptides constitute short fragments of the peptide HB -107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory pr operties. As keratinocytes are especially sensitive to these effects, the di sclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various envir onmental insults. Importantly, the therapeutic effects of the peptides manif est at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effecti ve therapies. Methods for the production and use of these peptides are also disclosed.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式