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91. 发明申请

US20050209635A1 Embolic protection device 审中-公开
标题翻译：栓塞保护装置
公开(公告)号：US20050209635A1
公开(公告)日：2005-09-22
申请号：US11068529
申请日：2005-03-01
申请人： Paul Gilson , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
发明人： Paul Gilson , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
IPC分类号： A61F2/06 , A61B17/00 , A61B17/22 , A61F2/01 , A61M25/00 , A61M25/09 , A61M29/00 , A61M31/00
CPC分类号： A61F2/01 , A61B2017/22051 , A61B2017/22067 , A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0093 , A61F2230/0097
摘要： An embolic protection device has a collapsible filter element (105) mounted on a carrier such as a guidewire (101). The filter element (105) collapses into the outer end of a catheter (118) for deployment and retrieval through a vascular system of a patient. The filter element (105) has a collapsible filter body with a proximal inlet end and a distal outlet end. The proximal inlet end has inlet openings sized to allow blood and embolic material enter the filter body. The outlet end has outlet openings which allow through passage of blood but retain embolic material within the filter body. After use, the catheter (118) is movable along the guidewire (101) to engage the proximal end of the filter element and close the inlet openings before sliding over the filter element from the proximal end to the distal end to progressively collapse the filter body on the guidewire (101) for retrieval. The filter element (105) may conveniently be mounted on a tubular sleeve (104) which is slidable and rotatable on the guidewire (101) between spaced-apart stops (106, 120) on the guidewire (101) which allows some manipulation of the guidewire independently of the filter when the filter is in use.
摘要翻译：栓塞保护装置具有安装在诸如导丝（101）的载体上的可折叠过滤元件（105）。过滤元件（105）塌陷进入导管（118）的外端，用于通过患者的血管系统进行展开和回收。过滤元件（105）具有可折叠的过滤器本体，其具有近端入口端和远端出口端。近端入口端具有入口开口，其尺寸允许血液和栓塞物质进入过滤体。出口端具有允许血液通过但保持栓塞材料在过滤器主体内的出口。在使用之后，导管（118）可沿导丝（101）移动以接合过滤器元件的近端并且在从过滤元件从近端滑动到远端之前关闭入口开口，以使过滤体逐渐收缩在导丝（101）上进行检索。过滤元件（105）可以方便地安装在管状套筒（104）上，管状套筒（104）可在引导线（101）上的间隔开的止动件（106,120）之间在导丝（101）上滑动和旋转，当过滤器使用时，导丝与过滤器无关。

92. 发明授权

US08777976B2 Clot capture systems and associated methods 有权
标题翻译：凝块捕获系统及相关方法
公开(公告)号：US08777976B2
公开(公告)日：2014-07-15
申请号：US12737527
申请日：2009-07-22
申请人： Eamon Brady , Mahmood Razavi , David Vale , John O'Shaughnessy
发明人： Eamon Brady , Mahmood Razavi , David Vale , John O'Shaughnessy
IPC分类号： A61M29/00 , A61B17/221 , A61B17/22 , A61B17/00
CPC分类号： A61B17/221 , A61B17/22031 , A61B2017/00867 , A61B2017/22035 , A61B2017/22038 , A61B2017/22051 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/2217 , A61F2/01 , A61F2230/0008 , A61F2230/001 , A61F2230/005 , A61F2230/0058
摘要： A clot capture system for disengaging a clot 2001 from a vessel wall 2002 and removing the clot 2001 from the vessel 202, includes a clot capture device 2140 for placement on a distal side of a clot 2001. The clot capture device 2140 has a retracted delivery configuration and an expanded deployed configuration. The clot removal device has a proximal support frame 2012, and a distal fiber net 2130. The support frame 2012 has a retracted delivery configuration and an expanded deployed configuration. The proximal support frame 2012 in the expanded configuration defines a proximal inlet mouth for engaging a clot 2001 and a net 2130 for confining the clot 2001. An elongate member facilitates capture and/or withdrawal of a clot 2001 from a vessel 2002. The system also includes a clot debonding device 2091 for placement on a proximal side of a clot 2001. The clot debonding device 2091 has a retracted delivery configuration and an expanded deployed configuration and includes a clot engagement element 2112 which defines a distal abutment in the deployed configuration for urging a clot 2001 into the clot capture device 2140.
摘要翻译：用于将血块2001与血管壁2002分离并从血管202移除血块2001的血块捕获系统包括用于放置在凝块2001的远侧上的凝块捕获装置2140.凝块捕获装置2140具有缩回输送配置和扩展部署配置。凝块移除装置具有近端支撑框架2012和远端纤维网2130.支撑框架2012具有缩回的输送构型和扩张的展开构型。处于扩展构型的近端支撑框架2012限定了用于接合凝块2001的近端入口和用于限制凝块2001的网2130.细长构件有利于从血管2002捕获和/或撤出凝块2001.系统还包括用于放置在凝块2001的近侧的凝块脱粘装置2091.凝块脱粘装置2091具有缩回的输送构型和扩张的展开构型，并且包括凝块接合元件2112，该凝块接合元件2112限定了展开构型中的远端邻接，凝块2001进入血块捕获装置2140。

93. 发明授权

US08002790B2 Support frame for an embolic protection device 有权
标题翻译：用于栓塞保护装置的支撑框架
公开(公告)号：US08002790B2
公开(公告)日：2011-08-23
申请号：US11166803
申请日：2005-06-27
申请人： Eamon Brady , David Vale , Ronald Kelly , John Neilan , Steven Horan , Gerard Rabitte , Gerry McCaffrey
发明人： Eamon Brady , David Vale , Ronald Kelly , John Neilan , Steven Horan , Gerard Rabitte , Gerry McCaffrey
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B2017/2212 , A61B2017/2215 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0093
摘要： An embolic protection device comprises a collapsible filter body and a filter support for the filter body. The filter support comprises a support frame defined by at least two wire segments having terminations. The terminations of adjacent segments are fixed relative to one another and extend generally parallel in a bifilar manner for enhanced trackability and flexibility.
摘要翻译：栓塞保护装置包括可折叠过滤器主体和用于过滤器主体的过滤器支撑件。过滤器支撑件包括由具有终端的至少两个线段限定的支撑框架。相邻段的终端相对于彼此固定，并且以双向方式大致平行延伸，以增强可跟踪性和灵活性。

94. 发明申请

US20110125181A1 CLOT CAPTURE SYSTEMS AND ASSOCIATED METHODS 有权
标题翻译：收集系统和相关方法
公开(公告)号：US20110125181A1
公开(公告)日：2011-05-26
申请号：US12737527
申请日：2009-07-22
申请人： Eamon Brady , Mahmood Razavi , David Vale , John O'Shaughnessy
发明人： Eamon Brady , Mahmood Razavi , David Vale , John O'Shaughnessy
IPC分类号： A61F2/01
CPC分类号： A61B17/221 , A61B17/22031 , A61B2017/00867 , A61B2017/22035 , A61B2017/22038 , A61B2017/22051 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/2217 , A61F2/01 , A61F2230/0008 , A61F2230/001 , A61F2230/005 , A61F2230/0058
摘要： A clot capture system for disengaging a clot 2001 from a vessel wall 2002 and removing the clot 2001 from the vessel 202, comprises a clot capture device 2140 for placement on a distal side of a clot 2001. The clot capture device 2140 has a retracted delivery configuration and an expanded deployed configuration. The clot removal device has a proximal support frame 2012, and a distal fibre net 2130. The support frame 2012 has a retracted delivery configuration and an expanded deployed configuration. The proximal support frame 2012 in the expanded configuration defines a proximal inlet mouth for engaging a clot 2001 and a net 2130 for confining the clot 2001. An elongate member facilitates capture and/or withdrawal of a clot 2001 from a vessel 2002. The system also comprises a clot debonding device 2091 for placement on a proximal side of a clot 2001. The clot debonding device 2091 has a retracted delivery configuration and an expanded deployed configuration and comprises a clot engagement element 2112 which defines a distal abutment in the deployed configuration for urging a clot 2001 into the clot cap 2140.
摘要翻译：用于使凝块2001与血管壁2002分离并从血管202移除血块2001的血块捕获系统包括用于放置在凝块2001的远侧上的凝块捕获装置2140.凝块捕获装置2140具有缩回的输送配置和扩展部署配置。凝块移除装置具有近端支撑框架2012和远端纤维网2130.支撑框架2012具有缩回的输送构型和扩张的展开构型。处于扩展构型的近端支撑框架2012限定了用于接合凝块2001的近端入口和用于限制凝块2001的网2130.细长构件有利于从血管2002捕获和/或撤出凝块2001.系统还包括用于放置在凝块2001的近侧的凝块剥离装置2091.凝块脱粘装置2091具有缩回的输送构型和扩张的展开构型，并且包括凝块接合元件2112，其在展开构型中限定了远端邻接件，用于推动 2001年的凝块进入血块盖2140。

95. 发明授权

US07837701B2 Embolic protection device 有权
标题翻译：栓塞保护装置
公开(公告)号：US07837701B2
公开(公告)日：2010-11-23
申请号：US11073936
申请日：2005-03-08
申请人： Paul Gilson , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
发明人： Paul Gilson , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B2017/22051 , A61B2017/22067 , A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0093 , A61F2230/0097
摘要： An embolic protection device has a collapsible filter element (105) mounted on a carrier such as a guidewire (101). The filter element (105) collapses into the outer end of a catheter (118) for deployment and retrieval through a vascular system of a patient. The filter element (105) has a collapsible filter body with a proximal inlet end and a distal outlet end. The proximal inlet end has inlet openings sized to allow blood and embolic material enter the filter body. The outlet end has outlet openings which allow through passage of blood but retain embolic material within the filter body. After use, the catheter (118) is movable along the guidewire (101) to engage the proximal end of the filter element and close the inlet openings before sliding over the filter element from the proximal end to the distal end to progressively collapse the filter body on the guidewire (101) for retrieval. The filter element (105) may conveniently be mounted on a tubular sleeve (104) which is slidable and rotatable on the guidewire (101) between spaced-apart slops (106, 120) on the guidewire (101) which allows some manipulation of the guidewire independently of the filter when the filter is in use.
摘要翻译：栓塞保护装置具有安装在诸如导丝（101）的载体上的可折叠过滤元件（105）。过滤元件（105）塌陷进入导管（118）的外端，用于通过患者的血管系统进行展开和回收。过滤元件（105）具有可折叠的过滤器本体，其具有近端入口端和远端出口端。近端入口端具有入口开口，其尺寸允许血液和栓塞物质进入过滤体。出口端具有允许血液通过但保持栓塞材料在过滤器主体内的出口。在使用之后，导管（118）可沿导丝（101）移动以接合过滤器元件的近端并且在从过滤元件从近端滑动到远端之前关闭入口开口，以使过滤体逐渐收缩在导丝（101）上进行检索。过滤元件（105）可以方便地安装在管状套筒（104）上，管状套筒（104）可在引导线（101）上的间隔开的斜面（106,120）之间在引导线（101）上滑动和旋转，从而允许一些操纵当过滤器使用时，导丝与过滤器无关。

96. 发明授权

US07799051B2 Support frame for an embolic protection device 有权
标题翻译：用于栓塞保护装置的支撑框架
公开(公告)号：US07799051B2
公开(公告)日：2010-09-21
申请号：US11166805
申请日：2005-06-27
申请人： Eamon Brady , David Vale , Ronald Kelly , John Neilan , Steven Horan , Gerard Rabitte , Gerry McCaffrey
发明人： Eamon Brady , David Vale , Ronald Kelly , John Neilan , Steven Horan , Gerard Rabitte , Gerry McCaffrey
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B2017/2212 , A61B2017/2215 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0093
摘要： An embolic protection device comprises a collapsible filter element for delivery through a vascular system of a patient The filter element comprises a collapsible filter body 2 and a filter support 3 for the filter body. The filter body has an inlet end 4 and an outlet end 5, the inlet end 4 of the filter body has one or more inlet openings 6 sized to allow blood and embolic material enter the filter body 2 and the outlet end 5 of the filter body has a plurality of outlet openings 107 sized to allow through passage of blood but to retain undesired embolic material within the filter body 2. The filter support 3 is movable between a collapsed position for movement through the vascular system, and an extended outwardly projecting position to support the filter body in an expanded position The filter support 3 comprises a generally tubular support frame defined by at least one wire 16.
摘要翻译：栓塞保护装置包括用于通过患者的血管系统输送的可折叠过滤器元件。过滤元件包括可折叠过滤器主体2和用于过滤器主体的过滤器支撑件3。过滤器本体具有入口端4和出口端5，过滤体的入口端4具有一个或多个入口开口6，其尺寸允许血液和栓塞物质进入过滤体2和过滤体的出口端5 具有多个出口开口107，其尺寸允许通过血液通过，但是将不期望的栓塞材料保持在过滤器本体2内。过滤器支撑件3可在通过血管系统运动的收缩位置和延伸向外突出的位置之间移动，将过滤器主体支撑在扩展位置。过滤器支撑件3包括由至少一根线16限定的大体上管状的支撑框架。

97. 发明授权

US07662165B2 Embolic protection device 有权
标题翻译：栓塞保护装置
公开(公告)号：US07662165B2
公开(公告)日：2010-02-16
申请号：US10442259
申请日：2003-05-21
申请人： Paul Gilson , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
发明人： Paul Gilson , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B2017/22051 , A61B2017/22067 , A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0093 , A61F2230/0097
摘要： An embolic protection device has a filter assembly having a collar and a collapsible filter element mounted on a carrier such as a guidewire. The filter element has a collapsible filter body with a proximal inlet end and a distal outlet end and a filter support frame. The proximal inlet end has inlet openings sized to allow blood and embolic materiel to enter the filter body. The outlet end has outlet openings which allow the passage of blood but retain embolic material within the filter body.
摘要翻译：栓塞保护装置具有过滤器组件，该过滤器组件具有安装在诸如导丝的载体上的套环和可折叠的过滤元件。过滤元件具有可折叠的过滤体，其具有近端入口端和远端出口端以及过滤器支撑框架。近端入口端具有入口开口，其尺寸允许血液和栓塞物质进入过滤体。出口端具有允许血液通过但将栓塞材料保持在过滤器主体内的出口。

98. 发明申请

US20090254115A1 EMBOLIC PROTECTION SYSTEM 有权
标题翻译：嵌入式保护系统
公开(公告)号：US20090254115A1
公开(公告)日：2009-10-08
申请号：US12259700
申请日：2008-10-28
申请人： Eamon Brady , Gary Fahey , Brendan Casey , Ann Marie Cannon , David Vale , Martin Keegan
发明人： Eamon Brady , Gary Fahey , Brendan Casey , Ann Marie Cannon , David Vale , Martin Keegan
IPC分类号： A61F2/01 , A61F2/06
CPC分类号： A61F2/01 , A61F2/0095 , A61F2/013 , A61F2002/011 , A61F2230/0006 , A61F2230/0008
摘要： An embolic protection system comprises an embolic protection filter 1 having a collapsed delivery configuration and an expanded deployed configuration. The filter 1 is housed in the collapsed configuration in a reception space of a delivery catheter 20. The delivery catheter 20 containing the filter 1 is housed in a sealed sterile pouch 35. The filter 1 may be coated with a non-thrombogenic coating and an adhesion preventer 9 such as a silicon gel is used to substantially prevent adhesion of adjacent folds of the filter 1 when the filter is in the collapsed configuration in the delivery catheter 20.
摘要翻译：栓塞保护系统包括具有折叠输送配置和扩展展开配置的栓塞保护过滤器1。过滤器1在输送导管20的接收空间中收纳在收缩构型中。包含过滤器1的输送导管20容纳在密封的无菌袋35中。过滤器1可以涂覆有非致血性涂层和当过滤器处于输送导管20中的折叠构造时，使用诸如硅胶的粘合防止剂9基本上防止过滤器1的相邻褶皱的粘附。

99. 发明申请

US20090149881A1 FILTER ELEMENT FOR EMBOLIC PROTECTION DEVICE 审中-公开
标题翻译：滤波器元件保护装置
公开(公告)号：US20090149881A1
公开(公告)日：2009-06-11
申请号：US12349209
申请日：2009-01-06
申请人： David Vale , Eamon Brady
发明人： David Vale , Eamon Brady
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A collapsible filter element for a transcatheter embolic protection device comprises a collapsible filter body which is movable between a collapsed stored position for movement through a vascular system and an expanded position for extension across a blood vessel such that blood passing through the blood vessel is delivered through the filter element. A proximal inlet portion of the filter body has one or more inlet openings sized to allow blood and embolic material enter the filter body and a distal outlet portion of the filter body has a plurality of outlet openings sized to allow through-passage of blood, but to retain embolic material within the filter body. The filter body is at least partially of laminate construction comprising a membrane coated with a coating which is biocompatible, the thickness of the coating being from 4% to 40% of the thickness of the membrane. The coating may be of hydrophilic material. To facilitate retrieval of captured embolic material the distal portion and/or an intermediate portion of the filter membrane may be stretchable. The filter body may have regions of varying hardness or stiffness.
摘要翻译：用于经导管栓塞保护装置的可折叠过滤器元件包括可折叠过滤器主体，其可在通过血管系统移动的折叠存储位置和用于延伸穿过血管的扩张位置之间移动，使得穿过血管的血液通过过滤元件。过滤器主体的近侧入口部分具有一个或多个入口开口，其尺寸设置成允许血液和栓塞物质进入过滤器本体，并且过滤器主体的远端出口部分具有尺寸允许血液通过的多个出口开口，但是以将栓塞材料保持在过滤器体内。过滤器主体至少部分地是层压结构，其包括涂覆有生物相容的涂层的膜，涂层的厚度为膜的厚度的4％至40％。涂层可以是亲水材料。为了便于捕获的栓塞材料的取出，过滤膜的远端部分和/或中间部分可以是可拉伸的。过滤体可以具有不同硬度或刚度的区域。

100. 发明申请

US20090143814A1 EMBOLIC PROTECTION DEVICE 审中-公开
标题翻译：嵌入式保护装置
公开(公告)号：US20090143814A1
公开(公告)日：2009-06-04
申请号：US12366249
申请日：2009-02-05
申请人： Paul GILSON , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
发明人： Paul GILSON , Eamon Brady , Padraig Maher , David Vale , Charles Taylor
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61B2017/22051 , A61B2017/22067 , A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0093 , A61F2230/0097
摘要： An embolic protection device has a collapsible filter element (105) mounted on a carrier such as a guidewire (101). The filter element (105) collapses into the outer end of a catheter (118) for deployment and retrieval through a vascular system of a patient. The filter element (105) has a collapsible filter body with a proximal inlet end and a distal outlet end. The proximal inlet end has inlet openings sized to allow blood and embolic material enter the filter body. The outlet end has outlet openings which allow through passage of blood but retain embolic material within the filter body. After use, the catheter (118) is movable along the guidewire (101) to engage the proximal end of the filter element and close the inlet openings before sliding over the filter element from the proximal end to the distal end to progressively collapse the filter body on the guidewire (101) for retrieval. The filter element (105) may conveniently be mounted on a tubular sleeve (104) which is slidable and rotatable on the guidewire (101) between spaced-apart stops (106, 120) on the guidewire (101) which allows some manipulation of the guidewire independently of the filter when the filter is in use.
摘要翻译：栓塞保护装置具有安装在诸如导丝（101）的载体上的可折叠过滤元件（105）。过滤元件（105）塌陷进入导管（118）的外端，用于通过患者的血管系统进行展开和回收。过滤元件（105）具有可折叠的过滤器本体，其具有近端入口端和远端出口端。近端入口端具有入口开口，其尺寸允许血液和栓塞物质进入过滤体。出口端具有允许血液通过但保持栓塞材料在过滤器主体内的出口。在使用之后，导管（118）可沿导丝（101）移动以接合过滤器元件的近端并且在从过滤元件从近端滑动到远端之前关闭入口开口，以使过滤体逐渐收缩在导丝（101）上进行检索。过滤元件（105）可以方便地安装在管状套筒（104）上，管状套筒（104）可在引导线（101）上的间隔开的止动件（106,120）之间在导丝（101）上滑动和旋转，当过滤器使用时，导丝与过滤器无关。

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