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91. 发明授权

US08025624B2 System and method for assessing cardiac performance through cardiac vibration monitoring 有权
标题翻译：通过心脏振动监测评估心脏性能的系统和方法
公开(公告)号：US08025624B2
公开(公告)日：2011-09-27
申请号：US11367852
申请日：2006-03-03
申请人： Ramesh Wariar , Gerrard M. Carlson
发明人： Ramesh Wariar , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B5/021 , A61B7/00
摘要： A system and method for assessing cardiac performance through cardiac vibration monitoring is described. Cardiac vibration measures are directly collected through an implantable medical device. Cardiac events including at least one first heart sound reflected by the cardiac vibration measures are identified. The first heart sound is correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.
摘要翻译：描述了通过心脏振动监测来评估心脏性能的系统和方法。通过植入式医疗设备直接收集心脏振动。识别心脏事件，包括由心脏振动测量反射的至少一个第一心音。第一个心音与胸腔内压力作用的心脏尺寸相关。心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。

92. 发明授权

US07938781B2 Hemodynamic stability assessment based on heart sounds 有权
标题翻译：基于心音的血流动力学稳定性评估
公开(公告)号：US07938781B2
公开(公告)日：2011-05-10
申请号：US12813073
申请日：2010-06-10
申请人： Gerrard M. Carlson , Yayun Lin
发明人： Gerrard M. Carlson , Yayun Lin
IPC分类号： A61B5/02
CPC分类号： A61N1/3962 , A61B5/02028 , A61B5/024 , A61B5/02405 , A61B7/04 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36578 , A61N1/37247 , A61N1/37282
摘要： A method comprises detecting at least one episode of ventricular tachyarrhythmia in a subject using an implantable medical device (IMD), sensing at least one heart sound signal for the subject using the IMD, the heart sound signal associated with mechanical vibration of a heart of the subject; initiating, in response to and during the detected episode of tachyarrhythmia, a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal, and deeming whether the ventricular tachyarrhythmia is stable according to the measurement of hemodynamic stability. The measurement of hemodynamic stability is determined using linear prediction.
摘要翻译：一种方法包括使用可植入医疗装置（IMD）检测受试者中的至少一次心室快速性心律失常，使用IMD感测对象的至少一个心音信号，与心脏的心脏的机械振动相关的心音信号学科; 响应于和在检测到的快速性心律失常发作期间，从心脏声音信号测量心室快速性心律失常的血液动力学稳定性，并且根据血液动力学稳定性的测量来确定心室性心律失常是否稳定。使用线性预测确定血液动力学稳定性的测量。

93. 发明授权

US07930019B2 Method and apparatus for phonocardiographic image acquisition and presentation 有权
标题翻译：用于心律图像获取和呈现的方法和装置
公开(公告)号：US07930019B2
公开(公告)日：2011-04-19
申请号：US11780405
申请日：2007-07-19
申请人： Krzysztof Z. Siejko , Gerrard M. Carlson , William C. Lincoln , Qingsheng Zhu
发明人： Krzysztof Z. Siejko , Gerrard M. Carlson , William C. Lincoln , Qingsheng Zhu
IPC分类号： A61B5/04
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/36578 , A61N1/3682 , A61N1/3702
摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The stack of acoustic sensor signal segments are aligned by a selected type of the heart's mechanical or electrical events and are grouped by a cardiac timing parameter for presentation.
摘要翻译：心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像。心音图像包括表示多个心动周期的一组声传感器信号段。每个声学传感器信号段包括指示心脏的机械事件和心脏电气事件的表示的心脏声音。声学传感器信号段的堆叠通过所选择的心脏的机械或电气事件的类型对准，并且通过心脏定时参数分组以进行呈现。

94. 发明申请

US20100280564A1 MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权
标题翻译：使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统
公开(公告)号：US20100280564A1
公开(公告)日：2010-11-04
申请号：US12836441
申请日：2010-07-14
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/02 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译：使用至少一个可植入装置自动评价或预测受试者的健康状况。在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。也可以使用昼夜节律以外的其他时间生理节律。可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

95. 发明授权

US07780606B2 Hemodynamic stability assessment based on heart sounds 有权
标题翻译：基于心音的血流动力学稳定性评估
公开(公告)号：US07780606B2
公开(公告)日：2010-08-24
申请号：US11277773
申请日：2006-03-29
申请人： Gerrard M. Carlson , Yayun Lin
发明人： Gerrard M. Carlson , Yayun Lin
IPC分类号： A61B5/02
CPC分类号： A61N1/3962 , A61B5/02028 , A61B5/024 , A61B5/02405 , A61B7/04 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36578 , A61N1/37247 , A61N1/37282
摘要： A system comprising an implantable medical device (IMD). The IMD includes an implantable sensor operable to produce an electrical signal representative of mechanical activity of a heart of a subject and a controller circuit coupled to the sensor. The IMD also includes a heart sound sensor interface circuit to produce a heart sound signal, a tachyarrhythmia detector, and a controller circuit. The controller circuit includes a hemodynamic stability assessment module configured to determine that at least one episode of ventricular tachyarrhythmia is detected in a subject and obtain a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal.
摘要翻译：一种包括可植入医疗装置（IMD）的系统。 IMD包括可植入传感器，其可操作以产生代表受试者心脏的机械活动的电信号和耦合到传感器的控制器电路。 IMD还包括产生心脏声音信号的心脏声音传感器接口电路，快速心律失常检测器和控制器电路。控制器电路包括血液动力学稳定性评估模块，其被配置为确定在受试者中检测到至少一次心室快速性心律失常发作，并且从心脏声音信号获得心室快速性心律失常的血液动力学稳定性的测量。

96. 发明申请

US20090312659A1 MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS 有权
标题翻译：通过用心脏声音追踪心室操作点来管理前端保留
公开(公告)号：US20090312659A1
公开(公告)日：2009-12-17
申请号：US12547207
申请日：2009-08-25
申请人： Gerrard M. Carlson , Ramesh Wariar , Krzysztof Z. Siejko
发明人： Gerrard M. Carlson , Ramesh Wariar , Krzysztof Z. Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
摘要翻译：一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。测量S1心音作为直接测量行程体积的代理。可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。

97. 发明申请

US20080262368A1 HEART SOUND TRACKING SYSTEM AND METHOD 有权
标题翻译：心音追踪系统及方法
公开(公告)号：US20080262368A1
公开(公告)日：2008-10-23
申请号：US11736055
申请日：2007-04-17
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译：一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。

98. 发明申请

US20080162183A1 METHOD AND SYSTEM TO ENABLE PHYSICIAN LABELS ON A REMOTE SERVER AND USE LABELS TO VERIFY AND IMPROVE ALGORITHM RESULTS 审中-公开
标题翻译：在远程服务器上使用医学标签的方法和系统，并使用标签进行验证并提高算法结果
公开(公告)号：US20080162183A1
公开(公告)日：2008-07-03
申请号：US11616460
申请日：2006-12-27
申请人： Haresh G. Sachanandani , Shelley Cazares , Jon Peterson , Robert J. Sweeney , Kevin J. Stalsberg , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Haresh G. Sachanandani , Shelley Cazares , Jon Peterson , Robert J. Sweeney , Kevin J. Stalsberg , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , G06F19/00 , G06Q10/10 , G16H50/20
摘要： This document discusses, among other things, systems and methods to enable physician labels on a remote server and use labels to verify and improve algorithm results. A method comprises using patient data in an automated analysis to obtain a result; receiving a message from the user, wherein the message is related to the result; and using at least a portion of the message to automatically modify the analysis.
摘要翻译：本文档讨论了在远程服务器上启用医师标签的系统和方法，并使用标签来验证和改进算法结果。一种方法包括在自动分析中使用患者数据以获得结果; 从所述用户接收消息，其中所述消息与所述结果相关; 并使用消息的至少一部分来自动修改分析。

99. 发明申请

US20080162182A1 BETWEEN-PATIENT COMPARISONS FOR RISK STRATIFICATION OF FUTURE HEART FAILURE DECOMPENSATION 有权
标题翻译：风险分析未来心脏衰竭解除的患者比较
公开(公告)号：US20080162182A1
公开(公告)日：2008-07-03
申请号：US11616430
申请日：2006-12-27
申请人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
发明人： Shelley Cazares , Jon Peterson , Haresh G. Sachanandani , Kevin J. Stalsberg , Robert J. Sweeney , Krzysztof Z. Siejko , Gerrard M. Carlson
IPC分类号： G06Q10/00
CPC分类号： G06Q50/22 , A61B5/0031 , A61N1/37282 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
摘要： This document discusses, among other things, systems and methods for using between-patient comparisons for risk stratification of future heart failure decompensation. A method comprises receiving patient data of a current patient, the patient data collected by a patient monitoring device; determining a reference group related to the patient; determining a reference group dataset selected from the reference group, wherein the dataset includes patient data that is of a similar type received from the patient monitoring device; generating a model of the reference group dataset; and automatically comparing the received physiological data to a model to derive an index for the patient.
摘要翻译：本文件除了其他内容之外还讨论了使用患者间比较以预测未来心力衰竭代偿失调的风险分层的系统和方法。一种方法包括接收当前患者的患者数据，由患者监测装置收集的患者数据; 确定与患者相关的参考组; 确定从所述参考组中选择的参考组数据集，其中所述数据集包括从所述患者监视装置接收到的类似类型的患者数据; 生成参考组数据集的模型; 并且将接收到的生理数据自动地与模型进行比较以导出患者的指标。

100. 发明申请

US20080103399A1 SYSTEM AND METHOD FOR SYSTOLIC INTERVAL ANALYSIS 有权
标题翻译：用于协同间隔分析的系统和方法
公开(公告)号：US20080103399A1
公开(公告)日：2008-05-01
申请号：US11553179
申请日：2006-10-26
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson , Loell Boyce Moon
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Gerrard M. Carlson , Loell Boyce Moon
IPC分类号： A61B5/02
CPC分类号： A61B5/0265 , A61B5/0031 , A61B5/029 , A61B5/042 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61B5/4836 , A61B5/686 , A61B5/7239 , A61B5/7282 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36571 , A61N1/36578 , A61N1/36585
摘要： A system and method provide for systolic interval analysis. In an example, an implantable device measures a cardiac impedance signal. A transformation of the cardiac impedance interval is generated. The device also measures a heart sound signal. A time interval between a point on the transformed signal of the cardiac impedance signal and a point on the heart sound signal is calculated.
摘要翻译：系统和方法提供收缩期间隔分析。在一个示例中，可植入装置测量心脏阻抗信号。产生心脏阻抗间隔的变换。该装置还测量心音信号。计算心脏阻抗信号的变换信号上的点与心音信号上的点之间的时间间隔。

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