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91. 发明申请

US20130005002A1 AMIDASE AND USE THEREOF FOR PRODUCING 3-AMINOCARBOXYLIC ACID ESTERS 审中-公开
标题翻译：用于生产3-氨基羧酸酯的氨基酸及其用途
公开(公告)号：US20130005002A1
公开(公告)日：2013-01-03
申请号：US13497985
申请日：2010-09-24
申请人： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
发明人： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
IPC分类号： C12P13/00 , C12N9/80
CPC分类号： C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
摘要： Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
摘要翻译：制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到根据权利要求1的通过加入多肽的对映选择性脱酰作用。

92. 发明申请

US20120225932A1 PROCESS FOR THE PRODUCTION OF POLYAMINES 有权
标题翻译：生产聚氨酯的方法
公开(公告)号：US20120225932A1
公开(公告)日：2012-09-06
申请号：US13505675
申请日：2010-10-29
申请人： Bernhard Hauer , David Karim Engelmark Cassimjee , Per Berglund
发明人： Bernhard Hauer , David Karim Engelmark Cassimjee , Per Berglund
IPC分类号： A61K31/7088 , C07C215/18 , A61K47/18 , C12P19/36 , C12P13/00
CPC分类号： C12P13/001 , A61K8/84 , A61K47/18 , A61Q19/00 , C08G73/0206 , C08G73/0213 , C12N9/0014 , D21C9/08 , D21H17/56 , D21H21/02
摘要： The present invention relates to a process for the production of a polyamine involving the use of enzymes; in particular to a process performed in aqueous environment; to the polyamines produced by said method; as well as the use of said polyamines for manufacturing paper, for immobilizing enzymes, or for preparing pharmaceutical or cosmetical compositions. The invention also relates to a novel method for in situ regeneration of cofactors NAD(P)+.
摘要翻译：本发明涉及生产涉及使用酶的多胺的方法; 特别涉及在水环境中进行的方法; 通过所述方法生产的多胺; 以及所述多胺用于制造纸，用于固定酶或用于制备药物或美容组合物的用途。本发明还涉及一种辅助因子NAD（P）+的原位再生的新方法。

93. 发明授权

US08227218B2 Method for the enzymatic reduction of alkyne derivates 有权
标题翻译：炔烃衍生物的酶还原方法
公开(公告)号：US08227218B2
公开(公告)日：2012-07-24
申请号：US12439427
申请日：2007-08-30
申请人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
发明人： Rainer Stürmer , Bernhard Hauer , Bettina Rosche , André Mueller
IPC分类号： C12P7/26
CPC分类号： C12P7/26 , C12N9/0036
摘要： The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein R1 represents H, C1-C6-alkyl, C2-C6-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, R2 represents H, C1-C6-alkyl, C2-C6-alkenyl, by reaction in the presence of special reductases.
摘要翻译：本发明涉及一种用于酶还原式（1）的炔衍生物的方法，其中R 1表示H，C 1 -C 6 - 烷基，C 2 -C 6 - 烯基或任选取代的碳环或杂环，芳族或非芳族基团，R2表示H，C1-C6-烷基，C2-C6-烯基，通过在特殊的还原酶存在下反应。

94. 发明申请

US20120171738A1 ENZYMATICALLY CATALYZED METHOD OF PREPARING MONO-ACYLATED POLYOLS 失效
标题翻译：制备单取代多元醇的酶催化方法
公开(公告)号：US20120171738A1
公开(公告)日：2012-07-05
申请号：US13496342
申请日：2010-09-16
申请人： Bernhard Hauer , Cecilia Kvarnström Branneby , Karl Hult , Anders Mangnusson , Anders Hamberg
发明人： Bernhard Hauer , Cecilia Kvarnström Branneby , Karl Hult , Anders Mangnusson , Anders Hamberg
IPC分类号： C12P7/62 , C12N1/21 , C12N15/63 , C12N9/20 , C12N15/56
CPC分类号： C12P7/62 , C12N9/20 , C12P41/004
摘要： The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacyl-glycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.
摘要翻译：本发明涉及由三酰基甘油脂肪酶突变体催化的单酰化多元醇的生物催化方法，例如衍生自南极假丝酵母脂肪酶B（CALB）; 通过相同的酶突变体催化的对映选择性制备不对称单酰化多元醇的生物催化方法; 以及在制备单酰化多元醇的方法中使用突变的三酰基甘油脂肪酶。本发明还提供了新的突变体，其编码序列和携带所述编码序列的重组微生物。

95. 发明授权

US08206969B2 CALB muteins and their use 有权
标题翻译： CALB突变体及其用途
公开(公告)号：US08206969B2
公开(公告)日：2012-06-26
申请号：US12809118
申请日：2008-12-18
申请人： Bernhard Hauer , Cecilia Kvarnström Branneby , Rolf Schmid , Steffen Maurer , Peter Trodler , Danni Liu , Monika Müller
发明人： Bernhard Hauer , Cecilia Kvarnström Branneby , Rolf Schmid , Steffen Maurer , Peter Trodler , Danni Liu , Monika Müller
IPC分类号： C12N9/84
CPC分类号： C12N9/20 , C12P7/62
摘要： A protein having acrylation activity having a polypeptide sequence derived from SEQ ID NO: 1 or NO:2 by introducing at least one of the following amino acid substitutions: L278A, L278V, W104F, T42A, S47A.
摘要翻译：具有丙烯酸酯化活性的蛋白质通过引入至少一种下列氨基酸取代：具有SEQ ID NO：1或NO：2的多肽序列：L278A，L278V，W104F，T42A，S47A。

96. 发明授权

US08008051B2 Butynol I esterase 有权
标题翻译：丁醇I酯酶
公开(公告)号：US08008051B2
公开(公告)日：2011-08-30
申请号：US12422785
申请日：2009-04-13
申请人： Bernhard Hauer , Thomas Friedrich , Christoph Nübling , Rainer Stürmer , Wolfgang Ladner
发明人： Bernhard Hauer , Thomas Friedrich , Christoph Nübling , Rainer Stürmer , Wolfgang Ladner
IPC分类号： C12P7/64 , C12P7/62 , C12N9/18
CPC分类号： C12N9/16 , C12P41/00
摘要： The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.
摘要翻译：本发明涉及具有酯酶活性，特别是丁酸酯酶活性的来自假单胞菌的新型蛋白质，涉及编码的核酸序列，表达盒，载体和重组微生物; 涉及用于制备所述蛋白质的方法及其用于酶，特别是对映选择性酶，酯水解或酯交换有机酯的用途。

97. 发明申请

US20110171700A1 METHOD FOR PRODUCING L-PHENYLEPHRINE USING AN ALCOHOL DEHYDROGENASE OF AROMATOLEUM AROMATICUM EBN1 (AZOARCUS SP. EBN1) 有权
标题翻译：使用芳香木香酚EBN1（AZOARCUS SP.EBN1）的酒精脱氢酶生产L-苯丙胺的方法
公开(公告)号：US20110171700A1
公开(公告)日：2011-07-14
申请号：US13063630
申请日：2009-09-15
申请人： Michael Breuer , Andreas Pletsch , Bernhard Hauer , Wolfgang Siegel
发明人： Michael Breuer , Andreas Pletsch , Bernhard Hauer , Wolfgang Siegel
IPC分类号： C12P13/00 , C07C45/63 , C12P7/22
CPC分类号： C12P13/001 , C12P7/22
摘要： The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
摘要翻译：本发明涉及一种制备取代的光学活性醇的多阶段方法，其包括酶催化的合成步骤，特别是由醇脱氢酶催化的合成步骤。本发明的方法特别适用于生产去氧肾上腺素，即3 - [（1R）-1-羟基-2-甲基氨基 - 乙基] - 苯酚。

98. 发明授权

US07888080B2 Enzymatic reduction for producing optically active alcohols 有权
标题翻译：用于制备光学活性醇的酶还原
公开(公告)号：US07888080B2
公开(公告)日：2011-02-15
申请号：US12158390
申请日：2006-12-13
申请人： Rainer Stürmer , Maria Keβeler , Bernhard Hauer , Thomas Friedrich , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Maria Keβeler , Bernhard Hauer , Thomas Friedrich , Michael Breuer , Hartwig Schröder
IPC分类号： C12P17/00 , C12N9/14
CPC分类号： C07D333/16 , C07D333/20 , C12P7/02 , C12P11/00 , C12P41/002
摘要： A process for preparing optically active alkanols of the formula I in which n is an integer from 0 to 5; Cyc is an optionally substituted, mono- or polynuclear, saturated or unsaturated, carbocyclic or heterocyclic ring, and R1 is halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, with R2, R3 and R4 independently of one another being hydrogen or a lower alkyl or lower alkoxy radical and X− being a counterion, which process comprises incubating in a medium comprising alkanone of the formula II in which n, Cyc and R1 are as defined above, an enzyme having a polypeptide sequence (i) SEQ ID NO: 1 or (ii) in which, compared to SEQ ID NO:1, up to 25% of the amino acid radicals have been altered by deletion, insertion, substitution or a combination thereof and which retains at least 50% of the enzymic activity of SEQ ID NO:1, with the compound of the formula II being enzymically reduced to give the compound of the formula I, and isolating the product formed.
摘要翻译：一种制备式I的光学活性链烷醇的方法，其中n为0至5的整数; Cyc是任选取代的单或多核饱和或不饱和的碳环或杂环，R1是卤素，SH，OH，NO2，NR2R3或NR2R3R4 + X-，R2，R3和R4彼此独立地是氢或低级烷基或低级烷氧基，X是抗衡离子，该方法包括在包含式II的烷酮的培养基中孵育，其中n，Cyc和R 1如上定义，具有多肽序列（i）SEQ ID NO： SEQ ID NO：1或（ii）其中与SEQ ID NO：1相比，通过缺失，插入，取代或其组合改变多达25％的氨基酸基团，并且其保留至少50％的酶活性为SEQ ID NO：1，其中式II化合物被酶还原，得到式I化合物，并分离形成的产物。

99. 发明申请

US20100273223A1 New Calb Muteins and Their Use 有权
标题翻译：新咳嗽突变体及其使用
公开(公告)号：US20100273223A1
公开(公告)日：2010-10-28
申请号：US12809118
申请日：2008-12-18
申请人： Bernhard Hauer , Cecilia Kvarnström Branneby , Rolf Schmid , Steffen Maurer , Peter Trodler , Danni Liu , Monika Müller
发明人： Bernhard Hauer , Cecilia Kvarnström Branneby , Rolf Schmid , Steffen Maurer , Peter Trodler , Danni Liu , Monika Müller
IPC分类号： C12P7/62 , C12N9/00 , C12N9/20 , C12N15/63 , C07H21/04
CPC分类号： C12N9/20 , C12P7/62
摘要： A protein having acrylation activity having a polypeptide sequence derived from SEQ ID NO: 1 or NO:2 by introducing at least one of the following amino acid substitutions: L278A, L278V, W104F, T42A, S47A.
摘要翻译：具有丙烯酸酯化活性的蛋白质通过引入至少一种下列氨基酸取代：具有SEQ ID NO：1或NO：2的多肽序列：L278A，L278V，W104F，T42A，S47A。

100. 发明申请

US20100189777A1 FUNCTIONALIZED NANOCOMPARTMENTS WITH A TRANSPORT SYSTEM 审中-公开
标题翻译：功能齐全的运输系统的纳米技术
公开(公告)号：US20100189777A1
公开(公告)日：2010-07-29
申请号：US12669581
申请日：2008-07-07
申请人： Ulrich Schwaneberg , Ozana Onaca , Prasenjit Sarkar , Bernhard Hauer , Thomas Friedrich
发明人： Ulrich Schwaneberg , Ozana Onaca , Prasenjit Sarkar , Bernhard Hauer , Thomas Friedrich
IPC分类号： A61K9/127 , B32B15/02 , B01J13/02
CPC分类号： A61K9/1273 , A61K47/6911 , A61K47/6919 , B82Y5/00 , Y10T428/2984
摘要： The invention is directed to vesicles comprising at least one transmembrane triggered transport system for controlled transmembrane efflux and/or influx.
摘要翻译：本发明涉及包含至少一个跨膜触发的转运系统用于受控跨膜流出和/或流入的囊泡。

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