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91. 外观设计

USD540833S1 Refrigerator with three doors 有权
公开(公告)号：USD540833S1
公开(公告)日：2007-04-17
申请号：US29247538
申请日：2006-06-26
申请人： Dongning Wang , Xiaofeng Li , Lei Zou , Falin Yang , Jianru Liu , Jian Wang
设计人： Dongning Wang , Xiaofeng Li , Lei Zou , Falin Yang , Jianru Liu , Jian Wang

92. 发明申请

US20050215784A1 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效
标题翻译：药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂
公开(公告)号：US20050215784A1
公开(公告)日：2005-09-29
申请号：US11036258
申请日：2005-01-13
申请人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
发明人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
IPC分类号： A61K31/551 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D43/02
CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译：本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物。

93. 发明申请

US20050196349A1 Compositions and methods for bone formation and remodeling 有权
标题翻译：用于骨形成和重塑的组合物和方法
公开(公告)号：US20050196349A1
公开(公告)日：2005-09-08
申请号：US10849067
申请日：2004-05-19
申请人： Dianqing Wu , Yazhou Zhang , Peng Liu , Xiaofeng Li , Jie Zhang , Jufang Shan , Dean Engelhardt
发明人： Dianqing Wu , Yazhou Zhang , Peng Liu , Xiaofeng Li , Jie Zhang , Jufang Shan , Dean Engelhardt
IPC分类号： A61K9/68 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/68 , G06F19/00 , A61K7/28
CPC分类号： G01N33/6893 , A61K38/00 , G01N33/6887 , G01N2500/00 , G01N2800/10 , G01N2800/108
摘要： The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine Dkk1, we believe that the G171V mutation may cause an increase in Wnt activity in osteoblasts by reducing the number of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.
摘要翻译：研究了Wnt共同受体LRP5的高骨量（HBM）突变（G171V）调节规范Wnt信号传导的机制。以前显示突变可以降低Dkk蛋白-1介导的拮抗作用，这表明G171位于第一个YWTD重复结构域可能是Dkk蛋白介导的拮抗作用的原因。然而，我们发现第三个YWTD重复，但不是第一个重复结构域，是DKK1介导的拮抗作用所必需的。相反，我们发现G171V突变破坏了LRP5与Mesd的相互作用，Mesd是共受体转运到细胞表面所需的LRP5 / 6的伴侣蛋白，导致细胞表面上较少的LRP5分子。尽管细胞表面LRP5分子水平的降低导致旁分泌范例中Wnt信号传导的降低，但突变似乎不影响共表达Wnt在自分泌范式中的活性。连同观察到成骨细胞产生自分泌的正常Wnt，Wnt7b，并且该骨细胞产生旁分泌的Dkk1，我们认为G171V突变可能通过减少旁分泌Dkk1靶向拮抗的数目而引起成骨细胞中Wnt活性的增加，而不影响自分泌Wnt的活性。

94. 外观设计

USD1017491S1 Car navigation cover 有权
公开(公告)号：USD1017491S1
公开(公告)日：2024-03-12
申请号：US29848616
申请日：2022-08-03
申请人： Xiaofeng Li
设计人： Xiaofeng Li
摘要： FIG. 1 is a perspective view of a car navigation cover showing my new design;
FIG. 2 is another perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side elevational view thereof;
FIG. 6 is a right side elevational view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.

95. 外观设计

USD987462S1 Watch strap 有权
公开(公告)号：USD987462S1
公开(公告)日：2023-05-30
申请号：US29760824
申请日：2020-12-04
申请人： Xiaofeng Li
设计人： Xiaofeng Li
摘要： FIG. 1 is a perspective view of a watch strap showing my new design;
FIG. 2 is another perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side elevational view thereof;
FIG. 6 is a right side elevational view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof; and
FIG. 9 is a perspective view of the watch strap where the watch strap is in a configuration of use.
The broken lines shown in the drawings represent environmental subject matter only and form no part of the claimed design.

96. 发明授权

US10539301B2 Electronic candle 有权
公开(公告)号：US10539301B2
公开(公告)日：2020-01-21
申请号：US16026936
申请日：2018-07-03
申请人： Xiaofeng Li
发明人： Xiaofeng Li
IPC分类号： F21V15/01 , F21V23/04 , F21S10/04
摘要： Methods, systems and devices associated with an electronic candle are described. One example, electronic candle device includes a housing with a through-hole at its top, a transfer device including a driver motor and one or more gears positioned inside the housing, and a light emitting component coupled to the transfer device such that the transfer device causes the light emitting component to move vertically up or down to protrude from the housing or to retract into the housing. The electronic candle also includes a movable lid positioned below the through-hole inside the housing and movable to remain in at least one of an open configuration or a closed configuration, and a controller configured to turn on or off the light emitting component.

97. 发明授权

US10371356B2 Electronic candle 有权
公开(公告)号：US10371356B2
公开(公告)日：2019-08-06
申请号：US16026936
申请日：2018-07-03
申请人： Xiaofeng Li
发明人： Xiaofeng Li
IPC分类号： F21V15/01 , F21V23/04 , F21S10/04
摘要： Methods, systems and devices associated with an electronic candle are described. One example, electronic candle device includes a housing with a through-hole at its top, a transfer device including a driver motor and one or more gears positioned inside the housing, and a light emitting component coupled to the transfer device such that the transfer device causes the light emitting component to move vertically up or down to protrude from the housing or to retract into the housing. The electronic candle also includes a movable lid positioned below the through-hole inside the housing and movable to remain in at least one of an open configuration or a closed configuration, and a controller configured to turn on or off the light emitting component.

98. 发明授权

US10357587B2 Electronic scent producing imitation candle device 有权
公开(公告)号：US10357587B2
公开(公告)日：2019-07-23
申请号：US15908718
申请日：2018-02-28
申请人： Xiaofeng Li
发明人： Xiaofeng Li
IPC分类号： A61L9/03 , F21S10/04 , H05B37/02 , F21W121/00
摘要： Electronic imitation candle devices are described that produce a scent while including a flame-like element that simulates a real fire flame. One example device includes a support assembly having a base, a top plate and a support rod that connects the base and the top plate, as well as a flame element and a light source to simulate a real candle flame. The device also includes a fragrance compartment above the top plate that includes a lid removably positioned on top of the fragrance container. The device is further provided with a heating element above the top plate and below the fragrance container to provide heat to the fragrance container, and a switch coupled to the lid of the fragrance container and operable to sense that the fragrance container is covered by the lid and to deactivate the heating element when the fragrance container is covered by the lid.

99. 发明授权

US10302263B2 Scented imitation candle device 有权
公开(公告)号：US10302263B2
公开(公告)日：2019-05-28
申请号：US15886781
申请日：2018-02-01
申请人： Xiaofeng Li
发明人： Xiaofeng Li
IPC分类号： F21S10/04 , F21S9/02 , F21S6/00 , A61L9/03 , F21W121/00 , F21Y115/10
摘要： Methods, systems, and devices relating to an electronic scented candle that is convenient to use and enables rapid generation and dissipation of scented materials are described. One electronic candle device includes a shell that has a through hole, a flame element protruding through the through hole, an installation lid including a locking base to allow removable coupling of a fragrance container, a scent chamber including a locking clip, a first channel, a second channel, a third channel, and a fourth channel. The scent chamber is removably coupled to the locking base by the locking clip, and an air pump provided to supply pressurized air.

100. 外观设计

USD848459S1 Display screen with graphical user interface for controlling an electronic candle 有权
公开(公告)号：USD848459S1
公开(公告)日：2019-05-14
申请号：US29571995
申请日：2016-07-22
申请人： Xiaofeng Li
设计人： Xiaofeng Li
摘要： The FIGURE is a front view of a display screen with graphical user interface for controlling an electronic candle.
The outermost broken lines shown in the drawing illustrate a display screen or portion thereof. The remaining broken lines, including the dotted lines illustrating all text and the two icons to the left and right of the slider-like element, illustrate portions of the graphical user interface. None of the broken lines form part of the claimed design.

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