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91. 发明授权

US11406890B1 Skateboard assembly 有权
公开(公告)号：US11406890B1
公开(公告)日：2022-08-09
申请号：US16124192
申请日：2018-09-07
申请人： David Jackson
发明人： David Jackson
IPC分类号： A63C17/12 , A63C17/01 , B60L15/20
摘要： A motorized or non-motorized multi-wheeled skateboard assembly including a board deck to support the user, a board having a top side, a bottom side, a flat and a rounded end, linkages, hinges, a steered wheel assembly, an input device and a drive assembly. The steered wheel assembly improves maneuverability, turn radius, and stability. The user steers the skateboard assembly by altering pressure between the top side first end and the top side second end causing the steered wheel to turn, thus manually steering the board. This change in pressure is also altered between the first linkage and second linkage in direct or inverse relation to altering pressure between the top side first end and the top side second end of the board deck.

92. 发明申请

US20210017782A1 Systems and Methods for Swimming Pool Filtration 有权
公开(公告)号：US20210017782A1
公开(公告)日：2021-01-21
申请号：US17018070
申请日：2020-09-11
申请人： David Jackson
发明人： David Jackson
IPC分类号： E04H4/12 , C02F1/40 , B01D29/27 , B01D39/16
摘要： Apparatus, systems, and methods for a pool filtration system including a basket with a flexible netting that is customizably designed and versatile in its functionality. The basket can be made from modern plastic or plastic-like materials. The weather-resistant, durable materials benefit the netting design for capturing and holding debris in a pool filtration system.

93. 发明授权

US10467994B2 String pulling mechanisms for stringed musical instruments and related methods 有权
公开(公告)号：US10467994B2
公开(公告)日：2019-11-05
申请号：US15875877
申请日：2018-01-19
申请人： David Jackson
发明人： David Jackson
IPC分类号： G10D3/14
摘要： Disclosed are apparatus and related methods for adjusting the pitch of a string on a stringed instrument. In one embodiment, the disclosed devices enable a musician to adjust the tautness and, accordingly, the pitch of individual strings of a stringed instrument by simply pushing a lever or rotating a threaded piston or on or adjacent to the bridge of the guitar. The disclosed devices can preferably be outfitted on electric or acoustic stringed instruments, including guitars. The more specific aspects of the preferred embodiments are discussed in greater detail with reference to the figures.

94. 发明授权

US09934762B1 Pitch changing mechanisms for stringed musical instruments 有权
公开(公告)号：US09934762B1
公开(公告)日：2018-04-03
申请号：US15390950
申请日：2016-12-27
申请人： David Jackson
发明人： David Jackson
IPC分类号： G10D3/06 , G10D1/08 , G10D3/14
CPC分类号： G10D3/06 , G10D1/08 , G10D3/14
摘要： Disclosed are pitch changing mechanisms, including fine-tuning and micro adjustment mechanisms. One mechanism is an adjustable tuning rod holder for a stringed instrument that is configured for both (A) fine tuning of the height of a pull-rod relative to a rod puller and pitch changer and (B) alignment the rod puller 1000 with the string 2500 on the instrument 2000. Other embodiments include roller nut and roller bridge housings. Yet still, disclosed are embodiments of pivot plates for fine or micro adjustments of the angle of a neck of a stringed instrument relative to the instruments body.

95. 发明授权

US09340622B2 Synthetic immunogen useful for generating long lasting immunity and protection against pathogens 有权
标题翻译：用于产生持久免疫力和防止病原体的合成免疫原
公开(公告)号：US09340622B2
公开(公告)日：2016-05-17
申请号：US13822881
申请日：2011-09-14
申请人： Javed N. Agrewala , Uthaman Gowthaman , David Jackson , Weiguang Zeng
发明人： Javed N. Agrewala , Uthaman Gowthaman , David Jackson , Weiguang Zeng
IPC分类号： A61K39/04 , A61K39/02 , A61K39/00 , C07K19/00
CPC分类号： C07K19/00 , A61K39/04 , A61K2039/55516 , A61K2039/6018 , Y02A50/41 , Y02A50/412 , Y02A50/484
摘要： The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. wherein, X1=a promiscuous CD4 T helper epitope selected from SEQ ID No. 1 to 98 OR nil; X2=a promiscuous CD8 T cytotoxic epitope selected from SEQ ID No. 99 to 103 OR nil; when X1=nil; X2=SEQ ID No. 99 to 103 and when X2=nil; X1=SEQ ID No. 1 to 98; Y=Lysine; and S=Serine.
摘要翻译：本发明涉及由通式1表示的合成免疫原，其可用于产生针对结核病，利什曼原虫病，艾滋病，艾滋病，锥虫病，疟疾和过敏，癌症的致病因子的各种细胞内病原体的长期保护性免疫，以及用于其制备。发达的免疫原能够规避人类和家畜的HLA限制。本发明还涉及包含所述免疫原的疫苗，用于产生针对各种疾病的持久的保护性免疫。在这种情况下，所述疫苗针对细胞内病原体，特别是病原体结核分枝杆菌。在本发明中，结核分枝杆菌杂交肽特别与TLR配体结合; Pam2Cys将其主要靶向树突细胞，从而引发持久的保护性免疫。其中X1 =选自SEQ ID No.1至98的杂交CD4T辅助表位或无; X2 =选自SEQ ID NO：99至103的混杂CD8 T细胞毒性表位或无; 当X1 = nil; X2 = SEQ ID No.99至103，当X2 = nil时; X1 = SEQ ID No.1至98; Y =赖氨酸; 和S =丝氨酸。

96. 发明授权

US08986700B2 Immunogenic lipopeptides comprising T-helper and cytotoxic T-lymphocyte (CTL) epitopes 有权
标题翻译：包含T辅助细胞和细胞毒性T淋巴细胞（CTL）表位的免疫原性脂肽
公开(公告)号：US08986700B2
公开(公告)日：2015-03-24
申请号：US12901457
申请日：2010-10-08
申请人： David Jackson , Weiguang Zeng
发明人： David Jackson , Weiguang Zeng
IPC分类号： A61K39/00 , A61K39/145 , A61K39/29 , A61K39/385 , A61K39/39 , C07K14/005 , C07K14/195 , C07K19/00
CPC分类号： A61K39/39 , A61K39/07 , A61K39/12 , A61K39/145 , A61K39/29 , A61K39/385 , A61K2039/5158 , A61K2039/55516 , A61K2039/55544 , A61K2039/55566 , A61K2039/57 , A61K2039/6018 , A61K2039/6031 , A61K2039/6037 , A61K2039/6075 , C07K14/005 , C07K14/195 , C07K19/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/18422 , C12N2770/24222 , C12N2770/24234
摘要： The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.
摘要翻译：本发明提供了包含共线T-辅助和CTL表位的合成的免疫原性脂肽分子，及其生产和用于产生初级和次级免疫应答的方法，以及针对特定CTL表位的动物受试者的疫苗接种。更具体地，本发明提供高可溶性脂肽，其中脂质部分连接到内部赖氨酸或赖氨酸类似物的末端侧链基团，优选连接到内部二氨基酸残基的末端侧链基团。优选地，内部赖氨酸或赖氨酸类似物位于T辅助表位和CTL表位之间。

97. 发明申请

US20140367483A1 DETERMINATION OF COMPOSITION AND STRUCTURE OF A CO2 COMPOSITE SPRAY 有权
标题翻译：二氧化碳复合喷雾的组成和结构的测定
公开(公告)号：US20140367483A1
公开(公告)日：2014-12-18
申请号：US14308697
申请日：2014-06-18
申请人： David Jackson , Liviu Marian
发明人： David Jackson , Liviu Marian
IPC分类号： B05B12/08 , B05B7/14
CPC分类号： B05B12/082 , B05B7/1486 , B08B7/00 , B24C1/003 , B24C7/0046 , B65D83/42 , B65D83/752
摘要： A method and apparatus for analyzing, maintaining or adjusting the chemical and physical structure of a CO2 Composite Spray in real-time. A light beam is passed through a portion of the CO2 Composite Spray plume, following which the transmitted light is collected using a detector and analyzed using a computer processing device. Light absorption, reflection and/or florescence data are correlated with CO2 particle density and particle size, spray plume length, organic and inorganic spray additives, and water vapor content. The treatment spray geometry is used to optimize and control a CO2 Composite Spray in precision cleaning, machining, and cooling processes.
摘要翻译：一种用于实时分析，维护或调整CO2复合喷雾的化学和物理结构的方法和装置。光束穿过CO 2复合喷雾羽流的一部分，随后使用检测器收集透射光并使用计算机处理装置进行分析。光吸收，反射和/或荧光数据与CO2颗粒密度和颗粒尺寸，喷雾长度，有机和无机喷涂添加剂以及水蒸汽含量相关。处理喷雾几何用于优化和控制CO2复合喷涂在精密清洗，机加工和冷却过程中。

98. 发明授权

US08766656B2 Systems and methods for thermal control 有权
标题翻译：热控制系统和方法
公开(公告)号：US08766656B2
公开(公告)日：2014-07-01
申请号：US13865005
申请日：2013-04-17
申请人： Zafar Malik , David Jackson
发明人： Zafar Malik , David Jackson
IPC分类号： G01R31/10 , G01R31/28
CPC分类号： G01R31/2875 , G01R31/2877
摘要： The present invention relates generally to a system and a method for thermal control. More particularly, the invention encompasses an apparatus for thermal control and management of at least one device under test (DUT). The inventive thermal control and management apparatus also allows for the management of a plurality of devices under test, and with each device under test having its own testing regimen. The thermal control and management of the device under test (DUT) is managed using at least one thermoelectric element or cooler (TEC), which can be used to either heat or cool the corresponding device under test (DUT).
摘要翻译：本发明一般涉及用于热控制的系统和方法。更具体地，本发明包括用于对至少一个待测器件（DUT）进行热控制和管理的装置。本发明的热控制和管理装置还允许对被测试的多个设备进行管理，并且每个待测设备都具有其自己的测试方案。被测设备（DUT）的热控制和管理使用至少一个热电元件或冷却器（TEC）进行管理，该热电元件或冷却器可用于加热或冷却相应的被测器件（DUT）。

99. 发明申请

US20130179091A1 SYSTEMS AND METHODS FOR IDENTIFYING UNKNOWN DRUG TARGETS VIA ADVERSE EVENT DATA 有权
公开(公告)号：US20130179091A1
公开(公告)日：2013-07-11
申请号：US13446871
申请日：2012-04-13
申请人： David Jackson , Theodoros Soldatos , Guillaume Taglang , Alexander Zien , Stephan Brock
发明人： David Jackson , Theodoros Soldatos , Guillaume Taglang , Alexander Zien , Stephan Brock
IPC分类号： G06F19/00
CPC分类号： G06F19/345 , G06F19/00 , G06F19/18 , G06F19/326 , G06F19/3437 , G16H50/20 , G16H50/50
摘要： The present disclosure is directed to systems and methods for identifying unknown drug targets via adverse event data. An analyzer receives an identification of a first drug having one or more unknown target proteins and identifies a second drug related to the first drug. The analyzer retrieves, from an adverse event database, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug. The analyzer generates a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile, and identifies a third drug having a fourth side effect profile comprising the third side effect profile. The analyzer retrieves a list of one or more target proteins of the third drug not targeted by the second drug, and presents the retrieved list as potential target proteins of the first drug.

100. 发明授权

US08038472B2 Compression coaxial cable connector with center insulator seizing mechanism 失效
标题翻译：带中心导体扣压机构的压缩同轴电缆连接器
公开(公告)号：US08038472B2
公开(公告)日：2011-10-18
申请号：US12421894
申请日：2009-04-10
申请人： Noah Montena , David Jackson , Daniel Robb
发明人： Noah Montena , David Jackson , Daniel Robb
IPC分类号： H01R9/05
CPC分类号： H01R24/564 , H01R4/4818 , H01R9/0524 , H01R2103/00
摘要： A coaxial cable connector for terminating a prepared coaxial cable end includes a connector body having a center passageway. A compression sleeve attached to one end of the connector body is axially movable wherein movement of the sleeve causes the center conductor of an engaged coaxial cable end to be engaged by a plurality of spring contacts that are radially disposed in relation to a conductive member into which the center conductor is advanced. The center conductor is seized when advanced a predetermined distance into the conductive member.
摘要翻译：用于端接准备的同轴电缆端的同轴电缆连接器包括具有中心通道的连接器主体。附接到连接器主体的一端的压缩套筒是可轴向移动的，其中套筒的运动使得所接合的同轴电缆端部的中心导体由相对于导电构件径向设置的多个弹簧触头接合，中心导体先进。当向导电构件前进预定距离时，中心导体被卡住。

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