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91. 发明申请

US20070142374A1 PYRROLIDINE DERIVATIVES AS FACTOR XA INHIBITORS 失效
标题翻译：吡咯烷酮衍生物作为因子XA抑制剂
公开(公告)号：US20070142374A1
公开(公告)日：2007-06-21
申请号：US11548402
申请日：2006-10-11
申请人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Carolin Whitworth , Robert Young
发明人： Chuen CHAN , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Carolin Whitworth , Robert Young
IPC分类号： A61K31/5377
CPC分类号： C07D413/14 , A61K31/5377 , C07D207/12 , C07D413/06 , C07D417/14 , C07D495/04
摘要： The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物的制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

92. 发明申请

US20070099202A1 Methods and compositions for assessment of pulmonary function and disorders 有权
标题翻译：用于评估肺功能和障碍的方法和组合物
公开(公告)号：US20070099202A1
公开(公告)日：2007-05-03
申请号：US11437823
申请日：2006-05-19
申请人： Robert Young
发明人： Robert Young
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided.
摘要翻译：本发明提供了利用遗传多态性分析评估吸烟者和非吸烟者发展肺癌风险的方法。本发明还涉及遗传多态性在评估受试者发展肺癌风险中的应用。还提供了适用于这种评估的核苷酸探针和引物，试剂盒和微阵列。

93. 发明申请

US20060166985A1 Pyrrolydin-2-one derivatives as inhibitors of thrombin and factor xa 审中-公开
标题翻译：吡咯赖丁-2-酮衍生物作为凝血酶抑制剂和因子xa
公开(公告)号：US20060166985A1
公开(公告)日：2006-07-27
申请号：US10537646
申请日：2003-12-04
申请人： Alan Borthwick , Chuen Chan , Henry Kelly , Simon Peace , Stefan Senger , Gita Shah , Stefan Smith , Steven Smith , Nigel Watson , Robert West , Robert Young
发明人： Alan Borthwick , Chuen Chan , Henry Kelly , Simon Peace , Stefan Senger , Gita Shah , Stefan Smith , Steven Smith , Nigel Watson , Robert West , Robert Young
IPC分类号： A61K31/5377 , A61K31/4015 , C07D413/02 , C07D207/273
CPC分类号： C07D207/273 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to novel chemical compounds, pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical compositions containing them, and to their use in medicine, particularly use in the amelioration of a clinical condition for which a thrombin inhibitor is indicated.
摘要翻译：本发明涉及新型化合物，其药学上可接受的衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途，特别是用于改善指示凝血酶抑制剂的临床病症。

94. 发明申请

US20060058363A1 Nitric oxide releasing selective cyclooxygenase-2 inhibitors 审中-公开
标题翻译：一氧化氮释放选择性环加氧酶-2抑制剂
公开(公告)号：US20060058363A1
公开(公告)日：2006-03-16
申请号：US10530214
申请日：2003-10-21
申请人： Zhaoyin Wang , Robert Young , Robert Zamboni
发明人： Zhaoyin Wang , Robert Young , Robert Zamboni
IPC分类号： C07D261/06 , C07D231/12 , A61K31/42 , A61K31/415
CPC分类号： C07D231/12 , C07D261/08
摘要： The invention encompasses novel compounds of Formula (I) and Formula (II), which are nitric oxide-releasing prodrugs useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) or Formula (II). The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
摘要翻译：本发明包括式（I）和式（II）的新型化合物，其是用于治疗环加氧酶-2介导的疾病的一氧化氮释放前药。本发明还包括用于治疗环氧合酶-2介导的疾病的某些药物组合物和方法，其包括使用式（I）或式（II）的化合物。上述化合物可用作与低剂量阿司匹林联合治疗以治疗慢性环氧合酶-2介导的疾病或病症，同时降低血栓性心血管事件的风险。

95. 发明申请

US20050274259A1 Desiccant container and method of manufacture 有权
标题翻译：干燥剂容器及其制造方法
公开(公告)号：US20050274259A1
公开(公告)日：2005-12-15
申请号：US11150735
申请日：2005-06-10
申请人： Robert Young , Stephen Derby
发明人： Robert Young , Stephen Derby
IPC分类号： B01D53/02 , B01D53/04 , B01D53/26 , F24F3/14
CPC分类号： B01D53/0415 , B01D53/261 , B01D2259/455
摘要： A desiccant container (10) includes a cylindrical body (12) having a first end (14) and an opposed second end (16). The cylindrical body (12) defines a desiccant chamber (18) within the cylindrical body (12) for holding the desiccant material within the chamber (18) between the first and second ends (14, 16). The cylindrical body (12) is made of a flexible, gas permeable, liquid impermeable material. A first disk (20) is secured adjacent the first end (14), and a second disk (22) secured adjacent the second end (16) to facilitate closing of the ends (14, 16) and to support maintenance of a cylindrical shape of the container (10) during usage of the desiccant container (10) in high-speed automated packaging machinery.
摘要翻译：干燥剂容器（10）包括具有第一端（14）和相对的第二端（16）的圆筒体（12）。圆柱体（12）在圆柱体（12）内限定干燥剂室（18），用于将干燥剂材料保持在第一和第二端（14,16）之间的腔室（18）内。圆柱体（12）由柔性的，透气的液体不可渗透材料制成。第一盘（20）固定在第一端（14）附近，并且第二盘（22）固定在邻近第二端（16）的位置，以便于封闭端部（14,16）并支撑维持圆柱形状在高速自动包装机械中使用干燥剂容器（10）时的容器（10）。

96. 发明申请

US20050261245A1 Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors 失效
标题翻译：二芳基-2-（5h） - 呋喃酮作为环加氧酶-2抑制剂的一氧化氮释放前药
公开(公告)号：US20050261245A1
公开(公告)日：2005-11-24
申请号：US10521075
申请日：2003-07-24
申请人： Carl Berthelette , Nicholas Lachance , Lianhai Li , Claudio Sturino , Zhaoyin Wang , Robert Young , Claude Dufresne
发明人： Carl Berthelette , Nicholas Lachance , Lianhai Li , Claudio Sturino , Zhaoyin Wang , Robert Young , Claude Dufresne
IPC分类号： A61K31/422 , A61K31/427 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/675 , A61P29/00 , C07C317/46
CPC分类号： C07C317/46
摘要： The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
摘要翻译：本发明包括式I的新化合物，其是可用于治疗环氧合酶-2介导的疾病的二芳基-2-（5H）呋喃酮的一氧化氮释放前药。本发明还包括用于治疗环氧合酶-2介导的疾病的某些药物组合物和方法，其包括使用式I化合物。上述化合物可用作与低剂量阿司匹林联合治疗以治疗慢性环氧合酶-2介导的疾病或同时降低血栓性心血管事件的风险。

97. 发明申请

US20050239872A1 1,5-distributed pyrrolid-2-one derivatives for use as ep4 receptor agonists in the teatment of eye diseases such as glaucoma 审中-公开
标题翻译： 1,5-分布的吡咯烷-2-酮衍生物，用作眼部疾病如青光眼的ep4受体激动剂
公开(公告)号：US20050239872A1
公开(公告)日：2005-10-27
申请号：US10511736
申请日：2003-06-02
申请人： Xavier Billot , Robert Young , Yongxin Han
发明人： Xavier Billot , Robert Young , Yongxin Han
IPC分类号： C07D403/06 , A61K31/13 , A61K31/137 , A61K31/138 , A61K31/382 , A61K31/4015 , A61K31/41 , A61K31/416 , A61K31/4164 , A61K31/4168 , A61K31/4178 , A61K31/433 , A61K31/4412 , A61K31/498 , A61K31/5377 , A61K31/5575 , A61K31/559 , A61K45/00 , A61K45/06 , A61P3/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07D207/26 , C07D403/12
CPC分类号： A61K31/41 , A61K31/4015 , A61K45/06 , C07D403/12 , A61K2300/00
摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of formula (1), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of the patient.
摘要翻译：本发明涉及式（1）的前列腺素E2受体的EP 4亚型的有效选择性激动剂，它们在治疗与眼内压升高有关的青光眼和其它病症中的用途或制剂在病人眼中。

98. 发明申请

US20050189527A1 Aerial cable placing machine 审中-公开
标题翻译：架空电缆放置机
公开(公告)号：US20050189527A1
公开(公告)日：2005-09-01
申请号：US11045798
申请日：2005-01-28
申请人： Robert Young
发明人： Robert Young
IPC分类号： H02G1/04 , H02G1/06
CPC分类号： H02G1/04
摘要： An aerial cable placing truck is provided. The truck includes a stringing apparatus which includes a full castoring bullwheel system for positioning a cable. The stringing apparatus pivots from side to side for placing cable on either side of the truck. The truck also includes a cantilevered turret for supporting a boom. The cantilevered turret is positioned to provide an open deck cable route along the truck deck for the cable so that the cable may taken off the truck without cutting the cable from the cable reel. A live fairlead may also be included to provide an indication of fairlead load separate from basket load.
摘要翻译：提供架空缆车。该卡车包括一个穿线装置，该装置包括一个用于定位电缆的完整的脚轮轮系。穿线装置从一侧到另一侧枢转，用于将电缆放置在卡车的两侧。该卡车还包括一个用于支撑吊杆的悬臂式转塔。悬臂式转塔定位成为电缆提供沿着卡车甲板的开放甲板电缆路线，以便电缆可以从卡车上取下而不从电缆卷轴切断电缆。还可以包括一个活的弹道，以提供与篮子负载分开的弹道载荷的指示。

99. 发明申请

US20050015089A1 Locking bone plate 有权
标题翻译：锁骨板
公开(公告)号：US20050015089A1
公开(公告)日：2005-01-20
申请号：US10809034
申请日：2004-03-25
申请人： Robert Young , Patrick White , Michael Khowaylo
发明人： Robert Young , Patrick White , Michael Khowaylo
IPC分类号： A61B17/80 , A61B17/58
CPC分类号： A61B17/8014 , A61B17/8052 , A61B17/8057 , A61B17/8061 , A61B17/8095
摘要： A bone plate(s) of complex form is provided, particularly suited to tibial plateau-leveling osteotomy and a distal femoral osteotomy. The bone plate has a main longitudinal axis, a bone-contacting bottom side (not shown) and a top side with at least three sets of overlapping holes which communicate through the plate from the top to the bottom side. The sets of overlapping holes define threaded apertures having multifaceted surfaces. When applied to a bone, two sets of such overlapping holes are located so as to lie on opposite sides of an osteotomy site and on the tibial plate; a third is aligned at approximately 60 degrees with the longitudinal axis. The configuration of this complex bone plate vary, depending on the physiology of the patient. An object of the invention is to provide an orthopaedic surgeon greater flexibility of choice in that a threaded peg providing secure fixing can be positioned at any interval along the bone plate, including at its extreme ends or on its elbow.
摘要翻译：提供复合形式的骨板，特别适用于胫骨平台矫形截骨术和远端股骨截骨术。骨板具有主纵向轴线，骨接触底侧（未示出）和具有至少三组重叠孔的顶侧，所述至少三个重叠孔从顶部至底部通过板连通。这些重叠的孔限定具有多面面的螺纹孔。当应用于骨骼时，将两组这样的重叠孔定位成位于截骨部位和胫骨板的相对侧上; 第三个与纵向轴线约60度对齐。该复合骨板的构型根据患者的生理情况而变化。本发明的目的是为矫形外科医生提供更大的选择灵活性，因为提供安全固定的螺纹钉可以沿着骨板的任何间隔定位，包括在其最终端或其肘部处。

100. 发明授权

US4948316A Quick action fastener assembly 失效
标题翻译：快速动作紧固件组件
公开(公告)号：US4948316A
公开(公告)日：1990-08-14
申请号：US280631
申请日：1989-01-30
申请人： John A. Duran , Robert Young , Peter Chang
发明人： John A. Duran , Robert Young , Peter Chang
IPC分类号： F16B5/02 , F16B21/18 , F16B41/00
CPC分类号： F16B21/18 , F16B41/002 , F16B5/0208 , Y10S411/999
摘要： A fastener assembly for joining a panel to a sub-panel comprising a receptacle assembly having a threaded stud secured to the undersurface of the sub-panel. The assembly includes a bolt having an enlarged head at one end and a nose at the other end. The panel has a countersunk opening aligned with an opening in the sub-panel. The bolt is threaded for threaded engagement to the stud. The body of the bolt includes a plurality of spaced grooves extending longitudinally along the outer surface of the bolt body. A retainer surrounds the bolt body having spaced ears riding in the grooves and a stop ring in a groove adjacent the nose of the bolt stops the downward movement of the retainer.In this manner, the bolt may be disposed in the countersunk opening in the panel with the retainer on the blind side of the panel and the stop ring preventing movement of the retainer off of the bolt body thus retaining the bolt to the panel. The bolt can remain in the up or extracted portion while the panel is being attached to the installation. A plate is provided on the underside of the panel trapping the retainer between the plate and the panel. The stop ring prevents downward movement of the bolt when in a hold out position with respect to the panel and restraining meaning on the bolt prevents inward movement of the bolt when in the hold out position with respect to the panel.
摘要翻译：一种用于将面板连接到子面板的紧固件组件，包括具有固定到子面板的下表面的螺柱的插座组件。组件包括在一端具有扩大的头部并且在另一端具有鼻部的螺栓。面板具有与子面板中的开口对准的埋头孔。螺栓螺纹用于与螺柱螺纹接合。螺栓的主体包括沿着螺栓本体的外表面纵向延伸的多个间隔开的槽。保持器围绕螺栓体，其具有悬挂在槽中的隔开的耳朵，并且邻近螺栓的鼻部的槽中的止动环阻止保持器的向下运动。以这种方式，螺栓可以设置在面板的埋头孔中，其中保持器在面板的盲侧上，止动环防止保持器从螺栓体移动，从而将螺栓保持在面板上。当面板连接到设备时，螺栓可以保持在向上或抽出的部分。在板的下侧设置有板，其将保持器捕获在板和面板之间。当处于相对于面板的保持位置时，止动环防止螺栓的向下运动，并且当相对于面板处于保持位置时，螺栓上的限制意义防止螺栓向内运动。

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