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91. 发明授权

US06479254B2 Apoptosis inducing molecule II 失效
标题翻译：凋亡诱导分子II
公开(公告)号：US06479254B2
公开(公告)日：2002-11-12
申请号：US09027287
申请日：1998-02-20
申请人： Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben
发明人： Reinhard Ebner , Guo-Liang Yu , Steven M. Ruben
IPC分类号： C12P2102
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/00 , C12N2799/026 , Y02A50/411 , Y10S930/144
摘要： The present invention relates to a novel member of the TNF-Ligand superfamily, Apoptosis Inducing Molecule II (AIM II). In particular, isolated nucleic acid molecules are provided encoding the human AIM II protein. AIM II polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, autoimmune disease, graft versus host disease, and to inhibit neoplasia, such as tumor cell growth.
摘要翻译：本发明涉及TNF-配体超家族，细胞凋亡诱导分子II（AIM II）的新成员。特别地，提供编码人AIM II蛋白质的分离的核酸分子。还提供AIM II多肽，载体，宿主细胞以及用于制备其的重组方法。本发明还涉及用于鉴定AIM II活性的激动剂和拮抗剂的筛选方法。还提供了用于治疗淋巴结病，自身免疫疾病，移植物抗宿主病和抑制肿瘤形成如肿瘤细胞生长的治疗方法。

92. 发明授权

US08303951B2 Neutrokine-alpha antibodies and methods of use thereof 有权
标题翻译：中性粒细胞α抗体及其使用方法
公开(公告)号：US08303951B2
公开(公告)日：2012-11-06
申请号：US12393693
申请日：2009-02-26
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C07K16/18 , C12P21/08
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译：本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

93. 发明申请

US20110135639A1 B LYMPHOCYTE STIMULATOR ASSAYS 审中-公开
标题翻译： B LYMPHOCYTE刺激仪测定
公开(公告)号：US20110135639A1
公开(公告)日：2011-06-09
申请号：US12952091
申请日：2010-11-22
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , G01N33/68 , A61K39/00 , G01N33/53 , A61P37/00 , A61P37/06 , A61P35/00
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

94. 发明申请

US20100330073A1 METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 审中-公开
标题翻译：使用抗体治疗中耳炎的方法
公开(公告)号：US20100330073A1
公开(公告)日：2010-12-30
申请号：US12870394
申请日：2010-08-27
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C12N5/02 , A61P35/00 , C07K16/18
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

95. 发明授权

US06716576B1 Method of assaying Neutrokine-&agr; mRNA level 有权
标题翻译：测定中性粒细胞αmRNA水平的方法
公开(公告)号：US06716576B1
公开(公告)日：2004-04-06
申请号：US09255794
申请日：1999-02-23
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： C12Q168
CPC分类号： C07H21/04 , A61K38/00 , C07K14/52
摘要： The present invention relates to a novel Neutrokine-a, and a splice variant thereof designated Neutrokine-aSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-a and/or Neutrokine-aSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-a and/or Neutrokine-aSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-a and/or Neutrokine-aSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种名为Neutrokine-aSV的新型Neutrokine-a及其剪接变体，其是TNF家族成员的多核苷酸和多肽。特别地，提供了分离的核酸分子，其编码人Neutrokine-a和/或Neutrokine-aSV多肽，包括细胞外结构域的可溶形式。还提供了中和型和/或Neutrokine-aSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定Neutrokine-a和/或Neutrokine-aSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

96. 发明授权

US08212004B2 Neutrokine-alpha fusion proteins 有权
标题翻译： Neutrokine-α融合蛋白
公开(公告)号：US08212004B2
公开(公告)日：2012-07-03
申请号：US11054539
申请日：2005-02-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： C07K14/475 , A61K38/16
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素-α和/或中枢神经素-αSV的抗体或其部分以及诊断和治疗方法。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

97. 发明申请

US20120045432A9 B LYMPHOCYTE STIMULATOR ASSAYS 审中-公开
标题翻译： B LYMPHOCYTE刺激仪测定
公开(公告)号：US20120045432A9
公开(公告)日：2012-02-23
申请号：US12952091
申请日：2010-11-22
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , A61K39/00 , A61P35/00 , A61P37/00 , A61P37/06 , G01N33/68 , G01N33/53
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

98. 发明授权

US08071092B1 Methods of inhibiting B lymphocytes using antibodies to Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α抗体抑制B淋巴细胞的方法
公开(公告)号：US08071092B1
公开(公告)日：2011-12-06
申请号：US09589288
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , C07K16/22 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

99. 发明申请

US20060193861A1 Tumor necrosis factor receptors 6 alpha & 6 beta 有权
标题翻译：肿瘤坏死因子受体6α和6β
公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N1/18 , C12N5/06
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

100. 发明申请

US20050186637A1 Neutrokine-alpha and neutrokine-alpha splice variant 有权
标题翻译： Neutrokine-alpha和中性粒细胞-α剪接变体
公开(公告)号：US20050186637A1
公开(公告)日：2005-08-25
申请号：US11054539
申请日：2005-02-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen , Stephen Ullrich
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen , Stephen Ullrich
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K14/715 , C07K16/24 , C07K16/28 , G01N33/564 , A61K39/395 , G01N33/53
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

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